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Aliases for PPM1E Gene

Aliases for PPM1E Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1E 2 3 5
  • Partner Of PIX 1 2 3 4
  • Ca(2+)/Calmodulin-Dependent Protein Kinase Phosphatase N 3 4
  • Nuclear Calmodulin-Dependent Protein Kinase Phosphatase 2 3
  • Protein Phosphatase 1E (PP2C Domain Containing) 2 3
  • Partner Of PIX-Alpha 3 4
  • Partner Of PIXA 3 4
  • CaMKP-Nucleus 3 4
  • CaMKP-N 3 4
  • CaMKN 3 4
  • POPX1 3 4
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1E 2
  • Protein Phosphatase 1E 3
  • EC 4
  • KIAA1072 4
  • PP2CH 3

External Ids for PPM1E Gene

Previous GeneCards Identifiers for PPM1E Gene

  • GC17P059314
  • GC17P057175
  • GC17P057307
  • GC17P054188
  • GC17P056833
  • GC17P052193

Summaries for PPM1E Gene

Entrez Gene Summary for PPM1E Gene

  • This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for PPM1E Gene

PPM1E (Protein Phosphatase, Mg2+/Mn2+ Dependent 1E) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1F.

UniProtKB/Swiss-Prot for PPM1E Gene

  • Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity).

Additional gene information for PPM1E Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1E Gene

Genomics for PPM1E Gene

GeneHancer (GH) Regulatory Elements for PPM1E Gene

Promoters and enhancers for PPM1E Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I058755 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 250 1.4 ATF1 SIN3A ZNF2 TCF12 ZNF766 GLIS2 E2F8 ZNF143 ATF7 KLF13 PPM1E LOC105371843 TRIM37 ENSG00000264112 DHX40 RAD51C GC17M058757
GH17I058756 Enhancer 0.8 ENCODE 550.8 +1.0 1046 0.2 ZNF2 ZEB1 GLIS2 ZNF366 EGR2 ZEB2 REST IKZF1 ZNF24 ZBTB26 PPM1E LOC105371843 TRIM37 GC17M058757
GH17I059616 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 +863.8 863806 6.8 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 CLTC ENSG00000273702 TUBD1 RPS6KB1 HEATR6 SKA2 PPM1D DHX40 RNFT1 NDUFB8P2
GH17I058785 Enhancer 1.2 Ensembl ENCODE 11.9 +30.9 30860 1.5 HDGF PKNOX1 ARNT FEZF1 ZNF766 FOS ZNF592 KAT8 MEF2D SMARCA4 ENSG00000276601 TRIM37 TEX14 PPM1E GC17P058810
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPM1E on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPM1E gene promoter:

Genomic Locations for PPM1E Gene

Genomic Locations for PPM1E Gene
229,311 bases
Plus strand

Genomic View for PPM1E Gene

Genes around PPM1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1E Gene

Proteins for PPM1E Gene

  • Protein details for PPM1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1E
    Protein Accession:
    Secondary Accessions:
    • Q68DW1
    • Q7LAF3
    • Q9UPT0

    Protein attributes for PPM1E Gene

    764 amino acids
    Molecular mass:
    85002 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7).
    • Sequence=BAA83024.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPM1E Gene


neXtProt entry for PPM1E Gene

Post-translational modifications for PPM1E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPM1E Gene

No data available for DME Specific Peptides for PPM1E Gene

Domains & Families for PPM1E Gene

Gene Families for PPM1E Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PPM1E Gene

Suggested Antigen Peptide Sequences for PPM1E Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PP2C family.
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1E: view

Function for PPM1E Gene

Molecular function for PPM1E Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity).

Enzyme Numbers (IUBMB) for PPM1E Gene

Phenotypes From GWAS Catalog for PPM1E Gene

Gene Ontology (GO) - Molecular Function for PPM1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IDA 20801214
GO:0005515 protein binding IPI 11864573
GO:0016787 hydrolase activity IEA --
GO:0043169 cation binding IEA --
genes like me logo Genes that share ontologies with PPM1E: view
genes like me logo Genes that share phenotypes with PPM1E: view

Animal Model Products

CRISPR Products

miRNA for PPM1E Gene

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPM1E Gene

Localization for PPM1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1E Gene

Nucleus. Cytoplasm. Note=A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus. {ECO:0000269 PubMed:15496589, ECO:0000269 PubMed:16269004}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPM1E gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPM1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0043234 protein complex IDA 11864573
genes like me logo Genes that share ontologies with PPM1E: view

Pathways & Interactions for PPM1E Gene

SuperPathways for PPM1E Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPM1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IDA 11864573
GO:0006470 protein dephosphorylation IEA --
GO:0035690 cellular response to drug IDA 20801214
GO:0035970 peptidyl-threonine dephosphorylation IDA 20801214
GO:0051496 positive regulation of stress fiber assembly IDA 11864573
genes like me logo Genes that share ontologies with PPM1E: view

No data available for Pathways by source and SIGNOR curated interactions for PPM1E Gene

Drugs & Compounds for PPM1E Gene

(5) Drugs for PPM1E Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0
Magnesium Approved Nutra 0
Manganese Approved Nutra 37

(1) Additional Compounds for PPM1E Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with PPM1E: view

Transcripts for PPM1E Gene

mRNA/cDNA for PPM1E Gene

Unigene Clusters for PPM1E Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1E Gene

No ASD Table

Relevant External Links for PPM1E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPM1E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPM1E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPM1E Gene

This gene is overexpressed in Testis (x8.7), Brain - Hippocampus (x4.9), Brain - Frontal Cortex (BA9) (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.6), and Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for PPM1E Gene

This gene is overexpressed in Fetal Brain (33.2), Frontal cortex (11.2), Retina (9.2), and Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPM1E Gene

Protein tissue co-expression partners for PPM1E Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPM1E Gene:


SOURCE GeneReport for Unigene cluster for PPM1E Gene:


Evidence on tissue expression from TISSUES for PPM1E Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with PPM1E: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPM1E Gene

Orthologs for PPM1E Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPM1E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPM1E 33 34
  • 96.93 (n)
(Bos Taurus)
Mammalia PPM1E 33 34
  • 91.6 (n)
(Canis familiaris)
Mammalia PPM1E 33 34
  • 91.45 (n)
(Rattus norvegicus)
Mammalia Ppm1e 33
  • 89.05 (n)
(Mus musculus)
Mammalia Ppm1e 33 16 34
  • 87.87 (n)
(Monodelphis domestica)
Mammalia PPM1E 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia PPM1E 34
  • 77 (a)
(Gallus gallus)
Aves PPM1E 33 34
  • 76.36 (n)
(Anolis carolinensis)
Reptilia PPM1E 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1e 33
  • 69.83 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4149 33
(Danio rerio)
Actinopterygii ppm1e 33 34
  • 69.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10376 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea fem-2 34
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC1 34
  • 32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8295 33
Species where no ortholog for PPM1E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1E Gene

Gene Tree for PPM1E (if available)
Gene Tree for PPM1E (if available)

Paralogs for PPM1E Gene

Paralogs for PPM1E Gene

(1) SIMAP similar genes for PPM1E Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PPM1E: view

Variants for PPM1E Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1E Gene

The poly-Pro-Glu stretch is polymorphic.

Sequence variations from dbSNP and Humsavar for PPM1E Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
VAR_036518 A breast cancer sample p.Leu231Ser
VAR_036519 A breast cancer sample p.Arg320Gly
rs1000002406 -- 58,973,363(+) G/C intron_variant
rs1000045673 -- 58,950,029(+) G/T intron_variant
rs1000050153 -- 58,889,858(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1E Gene

Variant ID Type Subtype PubMed ID
dgv3270n100 CNV gain 25217958
dgv4279n106 CNV deletion 24896259
esv1008894 CNV deletion 20482838
esv2662399 CNV deletion 23128226
esv2671869 CNV deletion 23128226
esv2716080 CNV deletion 23290073
esv3559209 CNV deletion 23714750
esv3582850 CNV loss 25503493
esv3640894 CNV loss 21293372
esv3640895 CNV loss 21293372
esv3640896 CNV loss 21293372
esv3640897 CNV loss 21293372
esv3640898 CNV loss 21293372
nsv1057312 CNV gain 25217958
nsv1065063 CNV gain 25217958
nsv477646 CNV novel sequence insertion 20440878
nsv510719 CNV deletion 20534489
nsv828067 CNV loss 20364138
nsv833498 CNV loss 17160897
nsv955396 CNV deletion 24416366

Variation tolerance for PPM1E Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.80; 94.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPM1E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for PPM1E Gene

Additional Disease Information for PPM1E

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPM1E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPM1E Gene

Publications for PPM1E Gene

  1. The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. (PMID: 11864573) Koh CG … Lim L (Current biology : CB 2002) 2 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  3. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S … Wolf PA (BMC medical genetics 2007) 3 44 58
  4. Identification and characterization of nuclear localization signals of CaMKP-N. (PMID: 15496589) Takeuchi M … Fujisawa H (Journal of biochemistry 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PPM1E Gene

Sources for PPM1E Gene

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