Aliases for PPM1D Gene
- Protein Phosphatase, Mg2+/Mn2+ Dependent 1D 2 3 5
- Protein Phosphatase 1D Magnesium-Dependent, Delta Isoform 2 3
- Wild-Type P53-Induced Phosphatase 1 2 3
- Protein Phosphatase 1D 3 4
- WIP1 3 4
- Protein Phosphatase Magnesium-Dependent 1 Delta 4
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D 2
- Protein Phosphatase 2C, Delta Isoform 2
External Ids for PPM1D Gene
Previous GeneCards Identifiers for PPM1D Gene
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPM1D Gene
PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent 1D) is a Protein Coding gene. Diseases associated with PPM1D include Jansen-De Vries Syndrome and Breast Cancer. Among its related pathways are DNA Damage Response and DNA Damage. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1B.
UniProtKB/Swiss-Prot Summary for PPM1D Gene
Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).