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Aliases for PPM1A Gene

Aliases for PPM1A Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1A 2 3 5
  • Protein Phosphatase 1A (Formerly 2C), Magnesium-Dependent, Alpha Isoform 2 3
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 2
  • Protein Phosphatase 2C, Alpha Isoform 2
  • Protein Phosphatase 2C Isoform Alpha 4
  • Protein Phosphatase 1A 3
  • Protein Phosphatase IA 4
  • Phosphatase 2C Alpha 2
  • EC 3.1.3.16 4
  • PP2C-ALPHA 3
  • PP2C-Alpha 4
  • PP2Calpha 3
  • PPPM1A 4
  • PP2CA 3

External Ids for PPM1A Gene

Previous GeneCards Identifiers for PPM1A Gene

  • GC14P058042
  • GC14P054506
  • GC14P058702
  • GC14P059782
  • GC14P060712
  • GC14P040876

Summaries for PPM1A Gene

Entrez Gene Summary for PPM1A Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPM1A Gene

PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent 1A) is a Protein Coding gene. Among its related pathways are Gene Expression and Development Dopamine D2 receptor transactivation of EGFR. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and protein C-terminus binding. An important paralog of this gene is PPM1B.

UniProtKB/Swiss-Prot for PPM1A Gene

  • Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Gene Wiki entry for PPM1A Gene

Additional gene information for PPM1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1A Gene

Genomics for PPM1A Gene

GeneHancer (GH) Regulatory Elements for PPM1A Gene

Promoters and enhancers for PPM1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J060247 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 668.9 +4.1 4055 5.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 PPM1A LOC101927702 TRMT5 GC14P060294
GH14J060245 Promoter 0.9 EPDnew 650.7 0.0 -21 0.1 HDGF ATF2 ZNF366 ZNF512 VEZF1 PRDM10 ATF7 CREM PRDM1 PPM1A LOC101927702 RPL17P2
GH14J060277 Enhancer 0.7 Ensembl ENCODE 31.6 +32.7 32673 1.5 BCOR ZNF217 ZNF3 NANOG ZMYM3 ETS1 PPM1A LOC101927702 GC14P060294
GH14J060178 Enhancer 1 Ensembl ENCODE dbSUPER 18.5 -66.0 -66001 1.6 PKNOX1 JUNB BATF ZNF316 NFE2 PRDM1 MAFK RUNX3 NFE2L2 GC14P060180 PSMA3P PPM1A RTN1 LOC101927702 PCNX4 C14orf39 RPL17P2
GH14J060640 Promoter/Enhancer 2.9 VISTA EPDnew Ensembl ENCODE dbSUPER 5.2 +404.4 404432 19.2 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 SIX1 TRMT5 SLC38A6 PCNX4 C14orf39 LOC101927702 SIX4 TMEM30B MNAT1 SIX6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPM1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPM1A gene promoter:
  • p53
  • RSRFC4
  • STAT5B

Genomic Locations for PPM1A Gene

Genomic Locations for PPM1A Gene
chr14:60,245,752-60,299,087
(GRCh38/hg38)
Size:
53,336 bases
Orientation:
Plus strand
chr14:60,712,470-60,765,805
(GRCh37/hg19)
Size:
53,336 bases
Orientation:
Plus strand

Genomic View for PPM1A Gene

Genes around PPM1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1A Gene

Proteins for PPM1A Gene

  • Protein details for PPM1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35813-PPM1A_HUMAN
    Recommended name:
    Protein phosphatase 1A
    Protein Accession:
    P35813
    Secondary Accessions:
    • B5BU11
    • J3KNM0
    • O75551

    Protein attributes for PPM1A Gene

    Size:
    382 amino acids
    Molecular mass:
    42448 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with the phosphorylated form of IKBKB/IKKB.

    Three dimensional structures from OCA and Proteopedia for PPM1A Gene

    Alternative splice isoforms for PPM1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPM1A Gene

Post-translational modifications for PPM1A Gene

  • N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
  • Ubiquitination at Lys278
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPM1A Gene

Domains & Families for PPM1A Gene

Gene Families for PPM1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PPM1A Gene

Graphical View of Domain Structure for InterPro Entry

P35813

UniProtKB/Swiss-Prot:

PPM1A_HUMAN :
  • Belongs to the PP2C family.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1A: view

Function for PPM1A Gene

Molecular function for PPM1A Gene

UniProtKB/Swiss-Prot Function:
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for PPM1A Gene

Phenotypes From GWAS Catalog for PPM1A Gene

Gene Ontology (GO) - Molecular Function for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA,TAS --
GO:0004871 obsolete signal transducer activity HMP --
genes like me logo Genes that share ontologies with PPM1A: view
genes like me logo Genes that share phenotypes with PPM1A: view

Animal Models for PPM1A Gene

MGI Knock Outs for PPM1A:
  • Ppm1a Ppm1a<tm1.2Lavi>
  • Ppm1a Ppm1a<tm1.1Xya>
  • Ppm1a Ppm1a<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPM1A

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPM1A Gene

Localization for PPM1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPM1A Gene

Nucleus. Cytoplasm, cytosol. Membrane; Lipid-anchor. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250 UniProtKB:P49443}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPM1A gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 16751101
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with PPM1A: view

Pathways & Interactions for PPM1A Gene

genes like me logo Genes that share pathways with PPM1A: view

SIGNOR curated interactions for PPM1A Gene

Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PPM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS --
GO:0006470 protein dephosphorylation IMP,IEA 18930133
GO:0006499 N-terminal protein myristoylation ISS --
GO:0007050 cell cycle arrest TAS --
GO:0010991 negative regulation of SMAD protein complex assembly IDA 16751101
genes like me logo Genes that share ontologies with PPM1A: view

Drugs & Compounds for PPM1A Gene

(7) Drugs for PPM1A Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 37
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0
Magnesium Approved Nutra 0

(1) Additional Compounds for PPM1A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2
genes like me logo Genes that share compounds with PPM1A: view

Transcripts for PPM1A Gene

Unigene Clusters for PPM1A Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPM1A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4:
SP5: -
SP6: - - - -

Relevant External Links for PPM1A Gene

GeneLoc Exon Structure for
PPM1A
ECgene alternative splicing isoforms for
PPM1A

Expression for PPM1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPM1A Gene

Protein differential expression in normal tissues from HIPED for PPM1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.3) and Platelet (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPM1A Gene



Protein tissue co-expression partners for PPM1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPM1A Gene:

PPM1A

SOURCE GeneReport for Unigene cluster for PPM1A Gene:

Hs.130036

Evidence on tissue expression from TISSUES for PPM1A Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Lung(4.3)
  • Nervous system(3.6)
  • Muscle(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with PPM1A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPM1A Gene

Orthologs for PPM1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPM1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPM1A 34 33
  • 99.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PPM1A 34 33
  • 96.42 (n)
OneToMany
-- 34
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PPM1A 34 33
  • 94.29 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPM1A 34
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppm1a 33
  • 93.63 (n)
mouse
(Mus musculus)
Mammalia Ppm1a 16 34 33
  • 93.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPM1A 34
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPM1A 34 33
  • 88.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPM1A 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1a 33
  • 83.77 (n)
Str.7047 33
African clawed frog
(Xenopus laevis)
Amphibia ppm1a-prov 33
zebrafish
(Danio rerio)
Actinopterygii ppm1aa 34 33
  • 73.33 (n)
OneToMany
ppm1ab 34
  • 73 (a)
OneToMany
Dr.11472 33
fruit fly
(Drosophila melanogaster)
Insecta alph 34
  • 52 (a)
ManyToMany
CG1906 35
  • 52 (a)
CG6036 34 35
  • 49 (a)
ManyToMany
CG12169 35
  • 41 (a)
CG17746 35
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea F25D1.1 35
  • 48 (a)
T23F11.1 35
  • 43 (a)
ppm-1 34
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC2 36 34
  • 23 (a)
PTC3 34
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToMany
Species where no ortholog for PPM1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1A Gene

ENSEMBL:
Gene Tree for PPM1A (if available)
TreeFam:
Gene Tree for PPM1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPM1A: view image

Paralogs for PPM1A Gene

Paralogs for PPM1A Gene

(2) SIMAP similar genes for PPM1A Gene using alignment to 8 proteins:

  • PPM1A_HUMAN
  • B5BUD5_HUMAN
  • E9PJN3_HUMAN
  • E9PKB5_HUMAN
  • E9PL75_HUMAN
  • E9PNE1_HUMAN
  • E9PP44_HUMAN
  • L8EAT3_HUMAN

Pseudogenes.org Pseudogenes for PPM1A Gene

genes like me logo Genes that share paralogs with PPM1A: view

Variants for PPM1A Gene

Sequence variations from dbSNP and Humsavar for PPM1A Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000043437 -- 60,271,547(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000075120 -- 60,271,807(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000304460 -- 60,271,809(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000306120 -- 60,248,313(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000372745 -- 60,267,637(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1A Gene

Variant ID Type Subtype PubMed ID
esv2256431 CNV deletion 18987734
esv2453133 CNV insertion 19546169
esv2748750 CNV deletion 23290073
esv3304133 CNV mobile element insertion 20981092
esv3309874 CNV mobile element insertion 20981092
esv3379472 CNV insertion 20981092
esv3417176 CNV insertion 20981092
nsv1071150 CNV deletion 25765185
nsv1129557 CNV tandem duplication 24896259
nsv1136179 CNV deletion 24896259
nsv472366 CNV novel sequence insertion 20440878
nsv832812 CNV loss 17160897
nsv952845 CNV duplication 24416366
nsv983969 CNV duplication 23825009

Variation tolerance for PPM1A Gene

Residual Variation Intolerance Score: 21.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPM1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPM1A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1A Gene

Disorders for PPM1A Gene

Additional Disease Information for PPM1A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPM1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPM1A Gene

Publications for PPM1A Gene

  1. Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. (PMID: 1311954) Mann DJ … Cohen PT (Biochimica et biophysica acta 1992) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. (PMID: 18930133) Sun W … Yang J (Cellular signalling 2009) 3 4 58
  4. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. (PMID: 19404668) Zhang B … Wang H (Histochemistry and cell biology 2009) 3 22 58
  5. PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. (PMID: 16751101) Lin X … Feng XH (Cell 2006) 3 4 58

Products for PPM1A Gene

Sources for PPM1A Gene

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