Aliases for PPL Gene
External Ids for PPL Gene
Previous GeneCards Identifiers for PPL Gene
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPL Gene
PPL (Periplakin) is a Protein Coding gene. Diseases associated with PPL include Pemphigus and Paraneoplastic Pemphigus. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Butyrophilin (BTN) family interactions. Gene Ontology (GO) annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is EVPL.
UniProtKB/Swiss-Prot Summary for PPL Gene
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.