Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPIL6 Gene

Aliases for PPIL6 Gene

  • Peptidylprolyl Isomerase Like 6 2 3 5
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 6 2 3
  • Cyclophilin-Like Protein PPIL6 3 4
  • Rotamase PPIL6 3 4
  • PPIase 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like Variant A 3
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 6 3
  • Radial Spoke 12 Homolog (Chlamydomonas) 2
  • Radial Spoke 12 Homolog 3
  • BA425D10.6 3
  • DJ919F19.1 3
  • EC 4
  • RSPH12 3

External Ids for PPIL6 Gene

Previous GeneCards Identifiers for PPIL6 Gene

  • GC06M109714
  • GC06M109759
  • GC06M109820
  • GC06M109711
  • GC06M107277

Summaries for PPIL6 Gene

GeneCards Summary for PPIL6 Gene

PPIL6 (Peptidylprolyl Isomerase Like 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIL2.

UniProtKB/Swiss-Prot for PPIL6 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Additional gene information for PPIL6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL6 Gene

Genomics for PPIL6 Gene

GeneHancer (GH) Regulatory Elements for PPIL6 Gene

Promoters and enhancers for PPIL6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J109438 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.6 567 3.4 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 ZNF766 ZNF213 ZNF207 ZNF143 SMPD2 PPIL6 ZBTB24 ENSG00000260273 ENSG00000271730 AK9 MICAL1 FIG4 GC06P109389 PIR52905
GH06J109379 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 +58.8 58817 6.3 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 SSRP1 ENSG00000260273 CD164 ZBTB24 SMPD2 MICAL1 AK9 PPIL6 ENSG00000233908 PTCHD3P3 CCDC162P
GH06J109481 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.2 -42.2 -42235 3.1 ATF1 ARID4B SIN3A DMAP1 YY1 ETS1 GLIS2 ZNF213 ELK1 ZNF207 ZBTB24 LOC105377935 SMPD2 ENSG00000260273 PPIL6 MICAL1 SESN1 AK9
GH06J109316 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.5 +122.6 122588 4 FOXA2 ARID4B RAD21 YY1 MIXL1 RXRA SP5 REST KAT8 NR2F2 CD164 CCDC162P PTCHD3P3 ENSG00000233908 SMPD2 PPIL6 RPL7P28 RNY3P11
GH06J109228 Enhancer 0.7 ENCODE 15.5 +211.0 211039 2.8 KLF1 PKNOX1 FOXA2 CTBP1 GATA3 FOS SMARCE1 ZNF687 KLF4 MNT CCDC162P CD164 PPIL6 ENSG00000233908 PTCHD3P3 SMPD2 ZBTB24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPIL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPIL6 gene promoter:
  • MyoD
  • NF-kappaB1
  • NF-kappaB
  • CBF-A
  • CBF(2)

Genomic Locations for PPIL6 Gene

Genomic Locations for PPIL6 Gene
50,957 bases
Minus strand
50,957 bases
Minus strand

Genomic View for PPIL6 Gene

Genes around PPIL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL6 Gene

Proteins for PPIL6 Gene

  • Protein details for PPIL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 6
    Protein Accession:
    Secondary Accessions:
    • A9NIU0
    • A9NIU9
    • E7EX15

    Protein attributes for PPIL6 Gene

    311 amino acids
    Molecular mass:
    35228 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPIL6 Gene


neXtProt entry for PPIL6 Gene

Post-translational modifications for PPIL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPIL6 Gene

Domains & Families for PPIL6 Gene

Gene Families for PPIL6 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PPIL6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclophilin-type PPIase family.
  • Belongs to the cyclophilin-type PPIase family.
genes like me logo Genes that share domains with PPIL6: view

Function for PPIL6 Gene

Molecular function for PPIL6 Gene

UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme Numbers (IUBMB) for PPIL6 Gene

Phenotypes From GWAS Catalog for PPIL6 Gene

Gene Ontology (GO) - Molecular Function for PPIL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIL6: view
genes like me logo Genes that share phenotypes with PPIL6: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIL6 Gene

Localization for PPIL6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIL6 gene
Compartment Confidence
cytosol 3
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPIL6 Gene

Pathways & Interactions for PPIL6 Gene

SuperPathways for PPIL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with PPIL6: view

No data available for Pathways by source and SIGNOR curated interactions for PPIL6 Gene

Drugs & Compounds for PPIL6 Gene

No Compound Related Data Available

Transcripts for PPIL6 Gene

Unigene Clusters for PPIL6 Gene

Peptidylprolyl isomerase (cyclophilin)-like 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP2: -
SP3: - - -

Relevant External Links for PPIL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPIL6 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for PPIL6 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPIL6 Gene

Protein tissue co-expression partners for PPIL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIL6 Gene:


SOURCE GeneReport for Unigene cluster for PPIL6 Gene:

genes like me logo Genes that share expression patterns with PPIL6: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIL6 Gene

Orthologs for PPIL6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPIL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPIL6 34 33
  • 99.7 (n)
(Bos Taurus)
Mammalia PPIL6 34 33
  • 85.99 (n)
(Canis familiaris)
Mammalia PPIL6 34 33
  • 84.92 (n)
(Mus musculus)
Mammalia Ppil6 16 34 33
  • 79.14 (n)
(Rattus norvegicus)
Mammalia Ppil6 33
  • 78.46 (n)
(Monodelphis domestica)
Mammalia PPIL6 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia PPIL6 34
  • 55 (a)
(Gallus gallus)
Aves PPIL6 34 33
  • 66.2 (n)
(Anolis carolinensis)
Reptilia PPIL6 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil6 33
  • 66.43 (n)
(Danio rerio)
Actinopterygii ppil6 34 33
  • 61.27 (n)
(Caenorhabditis elegans)
Secernentea cyn-9 34
  • 24 (a)
cyn-8 34
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR6 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for PPIL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL6 Gene

Gene Tree for PPIL6 (if available)
Gene Tree for PPIL6 (if available)
Evolutionary constrained regions (ECRs) for PPIL6: view image

Paralogs for PPIL6 Gene

Paralogs for PPIL6 Gene

(33) SIMAP similar genes for PPIL6 Gene using alignment to 7 proteins:

  • E7EX15_HUMAN
  • H0Y7C3_HUMAN
  • H0YC62_HUMAN
genes like me logo Genes that share paralogs with PPIL6: view

Variants for PPIL6 Gene

Sequence variations from dbSNP and Humsavar for PPIL6 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000056939 -- 109,437,362(-) G/T intron_variant
rs1000218907 -- 109,398,829(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000232437 -- 109,419,387(-) C/T intron_variant
rs1000299142 -- 109,435,703(-) T/A intron_variant
rs1000315803 -- 109,433,070(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL6 Gene

Variant ID Type Subtype PubMed ID
esv33427 CNV loss 17666407
esv3576210 CNV gain 25503493
nsv823818 CNV gain 20364138

Variation tolerance for PPIL6 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL6 Gene

Disorders for PPIL6 Gene

Additional Disease Information for PPIL6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPIL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL6 Gene

Publications for PPIL6 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for PPIL6 Gene

Sources for PPIL6 Gene

Loading form....