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Aliases for PPIL4 Gene

Aliases for PPIL4 Gene

  • Peptidylprolyl Isomerase Like 4 2 3 5
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 4 2 3
  • Cyclophilin-Like Protein PPIL4 3 4
  • Rotamase PPIL4 3 4
  • EC 4 56
  • PPIASE 3 4
  • Cyclophilin-Type Peptidyl-Prolyl Cis-Trans Isomerase 3
  • Serologically Defined Breast Cancer Antigen NY-BR-18 3
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 4 3
  • HDCME13P 3

External Ids for PPIL4 Gene

Previous GeneCards Identifiers for PPIL4 Gene

  • GC06M149338
  • GC06M149672
  • GC06M149760
  • GC06M149806
  • GC06M149867
  • GC06M147392

Summaries for PPIL4 Gene

Entrez Gene Summary for PPIL4 Gene

  • This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIL4 Gene

PPIL4 (Peptidylprolyl Isomerase Like 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is CWC27.

UniProtKB/Swiss-Prot for PPIL4 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Gene Wiki entry for PPIL4 Gene

Additional gene information for PPIL4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL4 Gene

Genomics for PPIL4 Gene

GeneHancer (GH) Regulatory Elements for PPIL4 Gene

Promoters and enhancers for PPIL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I149543 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563.6 +0.5 540 3.9 MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC ZNF610 PPIL4 NUP43 LATS1 ENSG00000231760 KATNA1 GINM1 ENSG00000268592 RNU7-3P ENSG00000216906 GC06P149517
GH06I150266 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 36.9 -724.3 -724267 8.3 HDGF PKNOX1 SMAD1 ARNT FEZF1 ZNF2 ZNF766 CBX5 ZNF416 FOS LOC105378054 LATS1 NUP43 PPIL4 ENSG00000231760 KATNA1 RNU4-7P ENSG00000238594 ENSG00000233330 PPP1R14C
GH06I149962 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 21.2 -418.1 -418097 3.1 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF213 ZNF302 ZNF548 ULBP1 LATS1 NUP43 PPIL4 KATNA1 RAET1K ENSG00000216906 ENSG00000233330 ULBP2 ENSG00000219298
GH06I149646 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.7 -101.8 -101786 3.4 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC KATNA1 ENSG00000231760 PPIL4 LATS1 RPS18P9 ENSG00000233330 ENSG00000207292 GC06P149237
GH06I149941 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 24.7 -395.9 -395905 1.2 PKNOX1 ATF1 SIN3A GLI4 GLIS2 ZNF213 ZNF548 FOS ATF7 SP3 ULBP2 LATS1 PPIL4 KATNA1 NUP43 RPS18P9 ENSG00000233330 ENSG00000215094
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPIL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPIL4 gene promoter:

Genomic Locations for PPIL4 Gene

Genomic Locations for PPIL4 Gene
41,608 bases
Minus strand

Genomic View for PPIL4 Gene

Genes around PPIL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL4 Gene

Proteins for PPIL4 Gene

  • Protein details for PPIL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 4
    Protein Accession:
    Secondary Accessions:
    • B2RD34
    • Q7Z3Q5

    Protein attributes for PPIL4 Gene

    492 amino acids
    Molecular mass:
    57225 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPIL4 Gene

Selected DME Specific Peptides for PPIL4 Gene


Post-translational modifications for PPIL4 Gene

  • Ubiquitination at Lys201 and Lys300
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPIL4 Gene

Gene Families for PPIL4 Gene

Suggested Antigen Peptide Sequences for PPIL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
  • Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
genes like me logo Genes that share domains with PPIL4: view

Function for PPIL4 Gene

Molecular function for PPIL4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIL4 Gene

Phenotypes From GWAS Catalog for PPIL4 Gene

Gene Ontology (GO) - Molecular Function for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIL4: view
genes like me logo Genes that share phenotypes with PPIL4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PPIL4

miRNA for PPIL4 Gene

miRTarBase miRNAs that target PPIL4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIL4 Gene

Localization for PPIL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIL4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIL4 gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with PPIL4: view

Pathways & Interactions for PPIL4 Gene

SuperPathways for PPIL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain IBA --
genes like me logo Genes that share ontologies with PPIL4: view

No data available for Pathways by source and SIGNOR curated interactions for PPIL4 Gene

Drugs & Compounds for PPIL4 Gene

No Compound Related Data Available

Transcripts for PPIL4 Gene

mRNA/cDNA for PPIL4 Gene

Unigene Clusters for PPIL4 Gene

Peptidylprolyl isomerase (cyclophilin)-like 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL4 Gene

No ASD Table

Relevant External Links for PPIL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIL4 Gene

Protein differential expression in normal tissues from HIPED for PPIL4 Gene

This gene is overexpressed in Adrenal (28.2) and Peripheral blood mononuclear cells (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPIL4 Gene

Protein tissue co-expression partners for PPIL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIL4 Gene:


SOURCE GeneReport for Unigene cluster for PPIL4 Gene:


mRNA Expression by UniProt/SwissProt for PPIL4 Gene:

Tissue specificity: Abundantly expressed in kidney but has a ubiquitously low expression pattern in other adult tissues.

Evidence on tissue expression from TISSUES for PPIL4 Gene

  • Nervous system(4.3)
  • Bone marrow(4.2)
  • Intestine(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PPIL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIL4 Gene

Orthologs for PPIL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPIL4 33 34
  • 99.66 (n)
(Canis familiaris)
Mammalia PPIL4 33 34
  • 92.82 (n)
(Bos Taurus)
Mammalia PPIL4 33 34
  • 92.41 (n)
(Rattus norvegicus)
Mammalia Ppil4 33
  • 92.13 (n)
(Mus musculus)
Mammalia Ppil4 33 16 34
  • 91.06 (n)
(Monodelphis domestica)
Mammalia PPIL4 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia PPIL4 34
  • 77 (a)
(Gallus gallus)
Aves PPIL4 33 34
  • 77.48 (n)
(Anolis carolinensis)
Reptilia PPIL4 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil4 33
  • 76.94 (n)
Str.5904 33
(Danio rerio)
Actinopterygii ppil4 33 34
  • 74.08 (n)
wufi40d03 33
fruit fly
(Drosophila melanogaster)
Insecta CG5808 33 34
  • 60.52 (n)
BcDNA:GH01073 35
  • 54 (a)
(Caenorhabditis elegans)
Secernentea sig-7 33 34
  • 61.25 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR649W 33
  • 45.54 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 34
  • 30 (a)
CPR5 34
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP59 33
  • 59.66 (n)
(Oryza sativa)
Liliopsida Os06g0670500 33
  • 59.95 (n)
Os.21014 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rct1 33
  • 59.7 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10166 33
  • 55.52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5628 34
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5330 33
Species where no ortholog for PPIL4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL4 Gene

Gene Tree for PPIL4 (if available)
Gene Tree for PPIL4 (if available)

Paralogs for PPIL4 Gene

Paralogs for PPIL4 Gene

(9) SIMAP similar genes for PPIL4 Gene using alignment to 4 proteins: Pseudogenes for PPIL4 Gene

genes like me logo Genes that share paralogs with PPIL4: view

Variants for PPIL4 Gene

Sequence variations from dbSNP and Humsavar for PPIL4 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000146145 -- 149,535,993(-) T/C intron_variant
rs1000207476 -- 149,547,863(-) T/G upstream_transcript_variant
rs1000255004 -- 149,511,457(-) C/T intron_variant
rs1000287239 -- 149,529,533(-) C/T intron_variant
rs1000314723 -- 149,531,328(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL4 Gene

Variant ID Type Subtype PubMed ID
esv3359949 CNV insertion 20981092

Variation tolerance for PPIL4 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL4 Gene

Disorders for PPIL4 Gene

Additional Disease Information for PPIL4

No disorders were found for PPIL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL4 Gene

Publications for PPIL4 Gene

  1. Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain. (PMID: 11978968) Zeng L … Mao Y (Cytogenetics and cell genetics 2001) 3 4 22 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for PPIL4 Gene

Sources for PPIL4 Gene

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