This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008] See more...

Aliases for PPIL3 Gene

Aliases for PPIL3 Gene

  • Peptidylprolyl Isomerase Like 3 2 3 5
  • Cyclophilin J 2 3 4
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 3 2 3
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 3 3 4
  • Cyclophilin-Like Protein PPIL3 3 4
  • Rotamase PPIL3 3 4
  • EC 5.2.1.8 4 52
  • PPIase 3 4
  • Peptidylprolyl Cis-Trans Isomerase-Like Protein 3 3
  • Cyclophilin-Like Protein 3 3
  • PPIase-Like Protein 3 3
  • CYPJ 3
  • CyPJ 4

External Ids for PPIL3 Gene

Previous GeneCards Identifiers for PPIL3 Gene

  • GC02M199952
  • GC02M200460
  • GC02M201699
  • GC02M201938
  • GC02M201561
  • GC02M201443
  • GC02M201736
  • GC02M201718
  • GC02M193587
  • GC02M201737

Summaries for PPIL3 Gene

Entrez Gene Summary for PPIL3 Gene

  • This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]

GeneCards Summary for PPIL3 Gene

PPIL3 (Peptidylprolyl Isomerase Like 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIL2.

UniProtKB/Swiss-Prot Summary for PPIL3 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Gene Wiki entry for PPIL3 Gene

Additional gene information for PPIL3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPIL3 Gene

Genomics for PPIL3 Gene

GeneHancer (GH) Regulatory Elements for PPIL3 Gene

Promoters and enhancers for PPIL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPIL3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPIL3

Top Transcription factor binding sites by QIAGEN in the PPIL3 gene promoter:
  • CBF-A
  • CBF-B
  • FOXO4
  • PPAR-gamma1
  • PPAR-gamma2
  • SRY

Genomic Locations for PPIL3 Gene

Genomic Locations for PPIL3 Gene
chr2:200,870,907-200,889,333
(GRCh38/hg38)
Size:
18,427 bases
Orientation:
Minus strand
chr2:201,735,630-201,754,026
(GRCh37/hg19)
Size:
18,397 bases
Orientation:
Minus strand

Genomic View for PPIL3 Gene

Genes around PPIL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL3 Gene

Proteins for PPIL3 Gene

  • Protein details for PPIL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2H8-PPIL3_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 3
    Protein Accession:
    Q9H2H8
    Secondary Accessions:
    • Q86WF9
    • Q96IA9
    • Q9BXZ1

    Protein attributes for PPIL3 Gene

    Size:
    161 amino acids
    Molecular mass:
    18155 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for PPIL3 Gene

    Alternative splice isoforms for PPIL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIL3 Gene

Selected DME Specific Peptides for PPIL3 Gene

Q9H2H8:
  • VTLHTDVGDIKIE
  • FHRNIKGFM
  • TNGSQFF
  • GDPTGTG
  • QTGDPTG
  • PKTCENF
  • GDIKIEVFCE
  • GPNTNGSQ
  • ENFLALC
  • KYTVFGKVIDG
  • FMVQTGDP

Post-translational modifications for PPIL3 Gene

  • Ubiquitination at Lys47
  • Modification sites at PhosphoSitePlus

Domains & Families for PPIL3 Gene

Gene Families for PPIL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PPIL3 Gene

Blocks:
  • Peptidyl-prolyl cis-trans isomerase, cyclophilin type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPIL3 Gene

GenScript: Design optimal peptide antigens:
  • Peptidyl-prolyl cis-trans isomerase (C9K058_HUMAN)
  • Rotamase PPIL3 (PPIL3_HUMAN)
  • Peptidylprolyl isomerase-like protein 3 isoform PPIL3d (Q86UR0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H2H8

UniProtKB/Swiss-Prot:

PPIL3_HUMAN :
  • Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
genes like me logo Genes that share domains with PPIL3: view

Function for PPIL3 Gene

Molecular function for PPIL3 Gene

UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8;.

Enzyme Numbers (IUBMB) for PPIL3 Gene

Phenotypes From GWAS Catalog for PPIL3 Gene

Gene Ontology (GO) - Molecular Function for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA,IEA 21873635
GO:0005515 protein binding IPI 16189514
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIL3: view
genes like me logo Genes that share phenotypes with PPIL3: view

Animal Models for PPIL3 Gene

MGI Knock Outs for PPIL3:
  • Ppil3 Ppil3<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for PPIL3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIL3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIL3 Gene

Localization for PPIL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIL3 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PPIL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPIL3 Gene

Pathways & Interactions for PPIL3 Gene

PathCards logo

SuperPathways for PPIL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0000413 protein peptidyl-prolyl isomerization IBA,IEA 21873635
GO:0006397 mRNA processing IEA --
GO:0006457 protein folding IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with PPIL3: view

No data available for Pathways by source and SIGNOR curated interactions for PPIL3 Gene

Drugs & Compounds for PPIL3 Gene

No Compound Related Data Available

Transcripts for PPIL3 Gene

mRNA/cDNA for PPIL3 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIL3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL3 Gene

No ASD Table

Relevant External Links for PPIL3 Gene

GeneLoc Exon Structure for
PPIL3

Expression for PPIL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPIL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPIL3 Gene

This gene is overexpressed in Lavage (10.0), Nasal epithelium (8.9), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPIL3 Gene



Protein tissue co-expression partners for PPIL3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPIL3

SOURCE GeneReport for Unigene cluster for PPIL3 Gene:

Hs.121076

mRNA Expression by UniProt/SwissProt for PPIL3 Gene:

Q9H2H8-PPIL3_HUMAN
Tissue specificity: Ubiquitous. Detected at low levels.

Evidence on tissue expression from TISSUES for PPIL3 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PPIL3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIL3 Gene

Orthologs for PPIL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIL3 31 30
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPIL3 30
  • 94.41 (n)
-- 31
  • 84 (a)
OneToMany
-- 31
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ppil3 17 31 30
  • 93.37 (n)
cow
(Bos Taurus)
Mammalia PPIL3 31 30
  • 92.96 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppil3 30
  • 92.75 (n)
oppossum
(Monodelphis domestica)
Mammalia PPIL3 31
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIL3 31
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIL3 31 30
  • 81.46 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIL3 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil3 30
  • 74.58 (n)
Str.17154 30
zebrafish
(Danio rerio)
Actinopterygii zgc:86715 30
  • 76.67 (n)
PPIL3 31
  • 70 (a)
OneToOne
Dr.16990 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3441 30
fruit fly
(Drosophila melanogaster)
Insecta CG11777 31 32 30
  • 67.08 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009996 30
  • 65.62 (n)
worm
(Caenorhabditis elegans)
Secernentea cyn-10 31 30
  • 65.62 (n)
OneToOne
cyp-10 32
  • 49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01940 30
  • 65.62 (n)
rice
(Oryza sativa)
Liliopsida Os06g0130500 30
  • 61.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10388 30
  • 57.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.12592 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12592 30
Species where no ortholog for PPIL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL3 Gene

ENSEMBL:
Gene Tree for PPIL3 (if available)
TreeFam:
Gene Tree for PPIL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPIL3: view image

Paralogs for PPIL3 Gene

(24) SIMAP similar genes for PPIL3 Gene using alignment to 7 proteins:

  • PPIL3_HUMAN
  • B8ZZ77_HUMAN
  • C9J4N2_HUMAN
  • C9K058_HUMAN
  • F8WC82_HUMAN
  • H7BZ14_HUMAN
  • Q86UR0_HUMAN
genes like me logo Genes that share paralogs with PPIL3: view

Variants for PPIL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPIL3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs7562391 - p.Asp146Glu

Additional dbSNP identifiers (rs#s) for PPIL3 Gene

Variation tolerance for PPIL3 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPIL3 Gene

Disorders for PPIL3 Gene

Additional Disease Information for PPIL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPIL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL3 Gene

Publications for PPIL3 Gene

  1. Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain. (PMID: 11435694) Zhou Z … Mao Y (Cytogenetics and cell genetics 2001) 2 3 4 23 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Interaction with Ppil3 leads to the cytoplasmic localization of Apoptin in tumor cells. (PMID: 18474220) Huo DH … Yang J (Biochemical and biophysical research communications 2008) 3 23 54
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  5. Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family. (PMID: 15735342) Huang LL … Xia ZX (Acta crystallographica. Section D, Biological crystallography 2005) 3 4 54

Products for PPIL3 Gene

Sources for PPIL3 Gene