Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPIL3 Gene

Aliases for PPIL3 Gene

  • Peptidylprolyl Isomerase Like 3 2 3 5
  • Cyclophilin J 2 3 4
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 3 2 3
  • Cyclophilin-Like Protein PPIL3 3 4
  • Rotamase PPIL3 3 4
  • PPIase 3 4
  • Peptidylprolyl Cis-Trans Isomerase-Like Protein 3 3
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 3 3
  • Cyclophilin-Like Protein 3 3
  • PPIase-Like Protein 3 3
  • EC 5.2.1.8 4
  • CYPJ 3
  • CyPJ 4

External Ids for PPIL3 Gene

Previous GeneCards Identifiers for PPIL3 Gene

  • GC02M199952
  • GC02M200460
  • GC02M201699
  • GC02M201938
  • GC02M201561
  • GC02M201443
  • GC02M201736
  • GC02M201718
  • GC02M193587
  • GC02M201737

Summaries for PPIL3 Gene

Entrez Gene Summary for PPIL3 Gene

  • This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]

GeneCards Summary for PPIL3 Gene

PPIL3 (Peptidylprolyl Isomerase Like 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIL2.

UniProtKB/Swiss-Prot for PPIL3 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Gene Wiki entry for PPIL3 Gene

Additional gene information for PPIL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL3 Gene

Genomics for PPIL3 Gene

GeneHancer (GH) Regulatory Elements for PPIL3 Gene

Promoters and enhancers for PPIL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J200887 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 737.5 +0.1 145 3.6 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 ZNF610 GLIS1 PPIL3 CLK1 NIF3L1 ORC2 TYW5 LOC100420110 RNU6-762P CASP10 RNU6-312P
GH02J200962 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 81.4 -74.5 -74473 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ORC2 LOC105373835 PPIL3 CDK15 LOC100420110 KCTD18 SGO2 CLK1 CASP8 FAM126B
GH02J201114 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 65.3 -234.9 -234883 19 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CFLAR PPIL3 CLK1 ORC2 CASP10 CFLAR-AS1 CDK15 KCTD18 FAM126B LOC105373835
GH02J200866 Enhancer 1.2 Ensembl ENCODE dbSUPER 83.7 +22.2 22239 1.4 INSM2 FEZF1 GTF3C2 ZNF335 ZNF366 ZNF548 ZNF362 CEBPB ZEB2 ZNF843 PPIL3 ORC2 CLK1 RNU6-762P CDK15 TYW5 LOC100420110 RNU6-312P
GH02J200859 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 40.6 +26.6 26594 6 HDGF PKNOX1 CLOCK SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 CLK1 ENSG00000252759 GC02M200864 PPIL3 ORC2 LOC100420110 TYW5 NIF3L1 LOC101927795 BZW1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPIL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPIL3 gene promoter:
  • SRY
  • PPAR-gamma2
  • PPAR-gamma1
  • FOXO4
  • CBF-B
  • CBF-A

Genomic Locations for PPIL3 Gene

Genomic Locations for PPIL3 Gene
chr2:200,870,907-200,889,333
(GRCh38/hg38)
Size:
18,427 bases
Orientation:
Minus strand
chr2:201,735,630-201,754,026
(GRCh37/hg19)
Size:
18,397 bases
Orientation:
Minus strand

Genomic View for PPIL3 Gene

Genes around PPIL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL3 Gene

Proteins for PPIL3 Gene

  • Protein details for PPIL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2H8-PPIL3_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 3
    Protein Accession:
    Q9H2H8
    Secondary Accessions:
    • Q86WF9
    • Q96IA9
    • Q9BXZ1

    Protein attributes for PPIL3 Gene

    Size:
    161 amino acids
    Molecular mass:
    18155 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for PPIL3 Gene

    Alternative splice isoforms for PPIL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIL3 Gene

Post-translational modifications for PPIL3 Gene

  • Ubiquitination at Lys47
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPIL3 Gene

Domains & Families for PPIL3 Gene

Gene Families for PPIL3 Gene

Suggested Antigen Peptide Sequences for PPIL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2H8

UniProtKB/Swiss-Prot:

PPIL3_HUMAN :
  • Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
genes like me logo Genes that share domains with PPIL3: view

Function for PPIL3 Gene

Molecular function for PPIL3 Gene

UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme Numbers (IUBMB) for PPIL3 Gene

Phenotypes From GWAS Catalog for PPIL3 Gene

Gene Ontology (GO) - Molecular Function for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA,IEA --
GO:0005515 protein binding IPI 16189514
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIL3: view
genes like me logo Genes that share phenotypes with PPIL3: view

Animal Models for PPIL3 Gene

MGI Knock Outs for PPIL3:
  • Ppil3 Ppil3<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for PPIL3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIL3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIL3 Gene

Localization for PPIL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIL3 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PPIL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPIL3 Gene

Pathways & Interactions for PPIL3 Gene

SuperPathways for PPIL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006397 mRNA processing IEA --
GO:0006457 protein folding IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with PPIL3: view

No data available for Pathways by source and SIGNOR curated interactions for PPIL3 Gene

Drugs & Compounds for PPIL3 Gene

No Compound Related Data Available

Transcripts for PPIL3 Gene

Unigene Clusters for PPIL3 Gene

Peptidylprolyl isomerase (cyclophilin)-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIL3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL3 Gene

No ASD Table

Relevant External Links for PPIL3 Gene

GeneLoc Exon Structure for
PPIL3
ECgene alternative splicing isoforms for
PPIL3

Expression for PPIL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPIL3 Gene

This gene is overexpressed in Lavage (10.0), Nasal epithelium (8.9), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPIL3 Gene



Protein tissue co-expression partners for PPIL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIL3 Gene:

PPIL3

SOURCE GeneReport for Unigene cluster for PPIL3 Gene:

Hs.121076

mRNA Expression by UniProt/SwissProt for PPIL3 Gene:

Q9H2H8-PPIL3_HUMAN
Tissue specificity: Ubiquitous. Detected at low levels.

Evidence on tissue expression from TISSUES for PPIL3 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PPIL3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIL3 Gene

Orthologs for PPIL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIL3 34 33
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPIL3 33
  • 94.41 (n)
-- 34
  • 84 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ppil3 16 34 33
  • 93.37 (n)
cow
(Bos Taurus)
Mammalia PPIL3 34 33
  • 92.96 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppil3 33
  • 92.75 (n)
oppossum
(Monodelphis domestica)
Mammalia PPIL3 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIL3 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIL3 34 33
  • 81.46 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIL3 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil3 33
  • 74.58 (n)
Str.17154 33
zebrafish
(Danio rerio)
Actinopterygii zgc:86715 33
  • 76.67 (n)
PPIL3 34
  • 70 (a)
OneToOne
Dr.16990 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3441 33
fruit fly
(Drosophila melanogaster)
Insecta CG11777 34 35 33
  • 67.08 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009996 33
  • 65.62 (n)
worm
(Caenorhabditis elegans)
Secernentea cyn-10 34 33
  • 65.62 (n)
OneToOne
cyp-10 35
  • 49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01940 33
  • 65.62 (n)
rice
(Oryza sativa)
Liliopsida Os06g0130500 33
  • 61.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10388 33
  • 57.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.12592 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12592 33
Species where no ortholog for PPIL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIL3 Gene

ENSEMBL:
Gene Tree for PPIL3 (if available)
TreeFam:
Gene Tree for PPIL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPIL3: view image

Paralogs for PPIL3 Gene

Paralogs for PPIL3 Gene

(24) SIMAP similar genes for PPIL3 Gene using alignment to 7 proteins:

  • PPIL3_HUMAN
  • B8ZZ77_HUMAN
  • C9J4N2_HUMAN
  • C9K058_HUMAN
  • F8WC82_HUMAN
  • H7BZ14_HUMAN
  • Q86UR0_HUMAN
genes like me logo Genes that share paralogs with PPIL3: view

Variants for PPIL3 Gene

Sequence variations from dbSNP and Humsavar for PPIL3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000618467 -- 200,873,927(-) C/G intron_variant
rs1000810807 -- 200,887,174(-) C/T intron_variant
rs1001104223 -- 200,879,334(-) T/C intron_variant
rs1001237722 -- 200,873,796(-) C/T intron_variant
rs1001252818 -- 200,879,860(-) T/A intron_variant

Variation tolerance for PPIL3 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPIL3 Gene

Disorders for PPIL3 Gene

Additional Disease Information for PPIL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPIL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL3 Gene

Publications for PPIL3 Gene

  1. Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain. (PMID: 11435694) Zhou Z … Mao Y (Cytogenetics and cell genetics 2001) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Interaction with Ppil3 leads to the cytoplasmic localization of Apoptin in tumor cells. (PMID: 18474220) Huo DH … Yang J (Biochemical and biophysical research communications 2008) 3 22 58
  4. Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family. (PMID: 15735342) Huang LL … Xia ZX (Acta crystallographica. Section D, Biological crystallography 2005) 3 4 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58

Products for PPIL3 Gene

Sources for PPIL3 Gene

Content
Loading form....