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Aliases for PPIL1 Gene

Aliases for PPIL1 Gene

  • Peptidylprolyl Isomerase Like 1 2 3 5
  • Peptidylprolyl Isomerase (Cyclophilin)-Like 1 2 3
  • Cyclophilin Like 1 2 3
  • Rotamase PPIL1 3 4
  • EC 4 56
  • PPIASE 3 4
  • CYPL1 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase-Like 1 3
  • Peptidyl-Prolyl Cis-Trans Isomerase 3
  • Cyclophilin-Related Gene 1 3
  • CGI-124 3
  • HCyPX 3

External Ids for PPIL1 Gene

Previous GeneCards Identifiers for PPIL1 Gene

  • GC06M036824
  • GC06M036869
  • GC06M036930
  • GC06M036540

Summaries for PPIL1 Gene

Entrez Gene Summary for PPIL1 Gene

  • This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIL1 Gene

PPIL1 (Peptidylprolyl Isomerase Like 1) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPWD1.

UniProtKB/Swiss-Prot for PPIL1 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Gene Wiki entry for PPIL1 Gene

Additional gene information for PPIL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIL1 Gene

Genomics for PPIL1 Gene

GeneHancer (GH) Regulatory Elements for PPIL1 Gene

Promoters and enhancers for PPIL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I036873 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 601.5 +0.4 384 2.3 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC PPIL1 MAPK14 SRSF3 STK38 ENSG00000237719 CMTR1 FGD2 C6orf89
GH06I036875 Enhancer 0.7 ENCODE dbSUPER 562.2 -0.9 -876 0.2 FOXK2 GTF2E2 MGA ZNF592 PPIL1 C6orf89 GC06P041905 PIR40408
GH06I036884 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 42.5 -12.3 -12317 4.9 CLOCK DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC MEF2D C6orf89 PPIL1 CMTR1 SRSF3 FGD2 CDKN1A RAB44 MTCH1 BRPF3 TBC1D22B
GH06I036848 Enhancer 1.3 Ensembl ENCODE dbSUPER 27.2 +26.1 26091 1.3 HDGF PKNOX1 SMAD1 ATF1 ARID4B SIN3A TCF12 ZNF766 GATA2 ATF7 PPIL1 C6orf89 RAB44 MTCH1 CPNE5 GC06M038600
GH06I036851 Enhancer 1.2 Ensembl ENCODE dbSUPER 27.3 +22.4 22350 3.3 ZNF2 THRB RAD21 ZNF766 ZNF207 ZNF143 ZNF654 CEBPB USF2 REST GC06M038600 PPIL1 RAB44 MTCH1 FGD2 CPNE5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPIL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPIL1 gene promoter:

Genomic Locations for PPIL1 Gene

Genomic Locations for PPIL1 Gene
20,198 bases
Minus strand

Genomic View for PPIL1 Gene

Genes around PPIL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIL1 Gene

Proteins for PPIL1 Gene

  • Protein details for PPIL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 1
    Protein Accession:
    Secondary Accessions:
    • O15001
    • Q5TDC9

    Protein attributes for PPIL1 Gene

    166 amino acids
    Molecular mass:
    18237 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with SNW1.

    Three dimensional structures from OCA and Proteopedia for PPIL1 Gene

neXtProt entry for PPIL1 Gene

Selected DME Specific Peptides for PPIL1 Gene


Post-translational modifications for PPIL1 Gene

  • Ubiquitination at isoforms=58 and Lys80

Other Protein References for PPIL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPIL1 Gene

Suggested Antigen Peptide Sequences for PPIL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
  • Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
genes like me logo Genes that share domains with PPIL1: view

Function for PPIL1 Gene

Molecular function for PPIL1 Gene

GENATLAS Biochemistry:
peptidylprolyl isomerase (cyclophilin)-like 1,cellular target of cyclosporin A
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=230 uM for N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide {ECO:0000269 PubMed:16595688};
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Cyclosporin A.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for PPIL1 Gene

Phenotypes From GWAS Catalog for PPIL1 Gene

Gene Ontology (GO) - Molecular Function for PPIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 16595688
GO:0016853 isomerase activity IEA --
GO:0097718 disordered domain specific binding IPI 20007319
genes like me logo Genes that share ontologies with PPIL1: view
genes like me logo Genes that share phenotypes with PPIL1: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIL1 Gene

Localization for PPIL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIL1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PPIL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPIL1 Gene

Pathways & Interactions for PPIL1 Gene

genes like me logo Genes that share pathways with PPIL1: view

Pathways by source for PPIL1 Gene

Gene Ontology (GO) - Biological Process for PPIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006397 mRNA processing IEA --
GO:0006457 protein folding IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with PPIL1: view

No data available for SIGNOR curated interactions for PPIL1 Gene

Drugs & Compounds for PPIL1 Gene

No Compound Related Data Available

Transcripts for PPIL1 Gene

mRNA/cDNA for PPIL1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(311) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPIL1 Gene

Peptidylprolyl isomerase (cyclophilin)-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: -

Relevant External Links for PPIL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPIL1 Gene

Protein tissue co-expression partners for PPIL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIL1 Gene:


SOURCE GeneReport for Unigene cluster for PPIL1 Gene:


mRNA Expression by UniProt/SwissProt for PPIL1 Gene:

Tissue specificity: Ubiquitous, with the most abundant expression in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for PPIL1 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with PPIL1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIL1 Gene

Orthologs for PPIL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPIL1 33 34
  • 100 (n)
(Ornithorhynchus anatinus)
Mammalia PPIL1 34
  • 95 (a)
(Monodelphis domestica)
Mammalia PPIL1 34
  • 94 (a)
(Canis familiaris)
Mammalia PPIL1 33 34
  • 92.57 (n)
(Bos Taurus)
Mammalia PPIL1 33 34
  • 92.37 (n)
(Mus musculus)
Mammalia Ppil1 33 16 34
  • 88.15 (n)
(Rattus norvegicus)
Mammalia Ppil1 33
  • 88.15 (n)
(Gallus gallus)
Aves PPIL1 34
  • 84 (a)
LOC100859332 33
  • 73.29 (n)
(Anolis carolinensis)
Reptilia PPIL1 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppil1 33
  • 73.69 (n)
Str.6409 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398596 33
(Danio rerio)
Actinopterygii ppil1 33 34
  • 77.37 (n)
wufe11h12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12744 33
fruit fly
(Drosophila melanogaster)
Insecta Cypl 35 33 34
  • 67.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012376 33
  • 64.39 (n)
(Caenorhabditis elegans)
Secernentea cyp-12 35
  • 68 (a)
cyn-12 33 34
  • 61.67 (n)
cyp-16 35
  • 52 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G36130 33
  • 62.08 (n)
(Oryza sativa)
Liliopsida Os08g0559400 33
  • 65.34 (n)
Os.5480 33
(Hordeum vulgare)
Liliopsida Hv.10736 33
(Triticum aestivum)
Liliopsida Ta.22715 33
(Zea mays)
Liliopsida Zm.13687 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 67 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00578 33
  • 65.11 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp1 33
  • 63.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14063 33
Species where no ortholog for PPIL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPIL1 Gene

Gene Tree for PPIL1 (if available)
Gene Tree for PPIL1 (if available)

Paralogs for PPIL1 Gene

Paralogs for PPIL1 Gene

(22) SIMAP similar genes for PPIL1 Gene using alignment to 1 proteins: Pseudogenes for PPIL1 Gene

genes like me logo Genes that share paralogs with PPIL1: view

Variants for PPIL1 Gene

Sequence variations from dbSNP and Humsavar for PPIL1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000115008 -- 36,860,852(-) G/A intron_variant
rs1000152373 -- 36,862,870(-) G/T intron_variant
rs1000161101 -- 36,866,663(-) A/C intron_variant
rs1000300670 -- 36,854,558(-) T/C downstream_transcript_variant
rs1000719316 -- 36,866,969(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPIL1 Gene

Variant ID Type Subtype PubMed ID
nsv1015689 CNV gain 25217958
nsv5262 CNV deletion 18451855

Variation tolerance for PPIL1 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIL1 Gene

Disorders for PPIL1 Gene

Additional Disease Information for PPIL1

No disorders were found for PPIL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIL1 Gene

Publications for PPIL1 Gene

  1. Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain. (PMID: 8978786) Ozaki K … Shin S (Cytogenetics and cell genetics 1996) 2 3 4 22 58
  2. The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. (PMID: 20368803) Stegmann CM … Wahl MC (PloS one 2010) 3 4 22 58
  3. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. (PMID: 16595688) Xu C … Zhang Q (The Journal of biological chemistry 2006) 3 4 22 58
  4. Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization. (PMID: 10072585) Mann SS … Hart TC (Cytogenetics and cell genetics 1998) 2 3 22 58
  5. A large intrinsically disordered region in SKIP and its disorder-order transition induced by PPIL1 binding revealed by NMR. (PMID: 20007319) Wang X … Shi Y (The Journal of biological chemistry 2010) 3 22 58

Products for PPIL1 Gene

Sources for PPIL1 Gene

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