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Aliases for PPIG Gene

Aliases for PPIG Gene

  • Peptidylprolyl Isomerase G 2 3 5
  • Cyclophilin G 2 3 4
  • SR-Related CTD-Associated Factor 10 2 3
  • Clk-Associating RS-Cyclophilin 3 4
  • CARS-Cyclophilin 3 4
  • SR-Cyclophilin 3 4
  • Rotamase G 3 4
  • EC 5.2.1.8 4 56
  • PPIase G 3 4
  • CARS-Cyp 3 4
  • CASP10 3 4
  • SR-Cyp 3 4
  • SRCyp 3 4
  • Peptidyl-Prolyl Isomerase G (Cyclophilin G) 3
  • Peptidyl-Prolyl Cis-Trans Isomerase G 3
  • Peptidyl-Prolyl Isomerase G 4
  • SCAF10 3
  • CYP 3

External Ids for PPIG Gene

Previous GeneCards Identifiers for PPIG Gene

  • GC02P168492
  • GC02P168982
  • GC02P170404
  • GC02P170643
  • GC02P170266
  • GC02P170150
  • GC02P162331

Summaries for PPIG Gene

GeneCards Summary for PPIG Gene

PPIG (Peptidylprolyl Isomerase G) is a Protein Coding gene. Diseases associated with PPIG include Bietti Crystalline Corneoretinal Dystrophy and Chronic Cystitis. Among its related pathways are Translational Control. Gene Ontology (GO) annotations related to this gene include cyclosporin A binding. An important paralog of this gene is NKTR.

UniProtKB/Swiss-Prot for PPIG Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.

Gene Wiki entry for PPIG Gene

Additional gene information for PPIG Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIG Gene

Genomics for PPIG Gene

GeneHancer (GH) Regulatory Elements for PPIG Gene

Promoters and enhancers for PPIG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I169583 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 561.2 +0.8 811 2.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 MEF2D PPIG GC02M169582 PHOSPHO2 FASTKD1 CCDC173 SSB GC02P169639
GH02I168796 Enhancer 1.2 Ensembl ENCODE 39.2 -786.4 -786445 3.6 PKNOX1 SMAD1 ATF1 FOXA2 ARNT TCF12 ZNF766 GATA2 ATF7 RXRA PPIG PHOSPHO2 NOSTRIN G6PC2 CERS6-AS1 GC02M168846
GH02I169363 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 25.3 -220.0 -219998 2.1 PKNOX1 ATF1 ZFP64 SIN3A FEZF1 YY1 ZNF121 GLIS2 MCM3 ZNF662 LRP2 PPIG PHOSPHO2 SSB GC02M169338
GH02I169507 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 17.6 -73.4 -73358 7.9 PKNOX1 FOXA2 FEZF1 FOS JUNB TSHZ1 MEF2D ATF4 MAFF SMARCA4 KLHL41 BBS5 PPIG CCDC173 PHOSPHO2 FASTKD1 KLHL23 GC02P169518 ENSG00000251569
GH02I168889 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.6 -694.1 -694081 1.7 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 ZNF143 SPC25 PPIG PHOSPHO2 G6PC2 GC02P168847
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPIG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPIG gene promoter:

Genomic Locations for PPIG Gene

Genomic Locations for PPIG Gene
chr2:169,584,340-169,641,406
(GRCh38/hg38)
Size:
57,067 bases
Orientation:
Plus strand
chr2:170,440,850-170,497,916
(GRCh37/hg19)

Genomic View for PPIG Gene

Genes around PPIG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIG Gene

Proteins for PPIG Gene

  • Protein details for PPIG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13427-PPIG_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase G
    Protein Accession:
    Q13427
    Secondary Accessions:
    • D3DPC5
    • D3DPC6
    • O00706
    • Q53R40
    • Q53SN4
    • Q96DG9

    Protein attributes for PPIG Gene

    Size:
    754 amino acids
    Molecular mass:
    88617 Da
    Quaternary structure:
    • Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II.

    Three dimensional structures from OCA and Proteopedia for PPIG Gene

    Alternative splice isoforms for PPIG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIG Gene

Selected DME Specific Peptides for PPIG Gene

Q13427:
  • TNGSQFF
  • PKTCENF
  • DKYKNKV
  • GGESIYG
  • LCTGEKG

Post-translational modifications for PPIG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PPIG Gene

Gene Families for PPIG Gene

Graphical View of Domain Structure for InterPro Entry

Q13427

UniProtKB/Swiss-Prot:

PPIG_HUMAN :
  • The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II.
Domain:
  • The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II.
genes like me logo Genes that share domains with PPIG: view

Function for PPIG Gene

Molecular function for PPIG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Cyclosporin A (CsA)-sensitive.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.

Enzyme Numbers (IUBMB) for PPIG Gene

Gene Ontology (GO) - Molecular Function for PPIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA,IEA --
GO:0005515 protein binding IPI 21516116
GO:0016018 cyclosporin A binding TAS 9153302
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIG: view

Phenotypes for PPIG Gene

genes like me logo Genes that share phenotypes with PPIG: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PPIG

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIG Gene

Localization for PPIG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIG Gene

Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIG gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9153302
GO:0005654 nucleoplasm TAS 9153302
GO:0005829 cytosol IDA --
GO:0016363 nuclear matrix IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with PPIG: view

Pathways & Interactions for PPIG Gene

SuperPathway Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with PPIG: view

Pathways by source for PPIG Gene

1 Cell Signaling Technology pathway for PPIG Gene

Gene Ontology (GO) - Biological Process for PPIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA --
GO:0008380 RNA splicing TAS 9153302
genes like me logo Genes that share ontologies with PPIG: view

No data available for SIGNOR curated interactions for PPIG Gene

Drugs & Compounds for PPIG Gene

(93) Drugs for PPIG Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target 0

(69) Additional Compounds for PPIG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PPIG: view

Transcripts for PPIG Gene

Unigene Clusters for PPIG Gene

Peptidylprolyl isomerase G (cyclophilin G):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PPIG

Alternative Splicing Database (ASD) splice patterns (SP) for PPIG Gene

No ASD Table

Relevant External Links for PPIG Gene

GeneLoc Exon Structure for
PPIG
ECgene alternative splicing isoforms for
PPIG

Expression for PPIG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIG Gene

Protein differential expression in normal tissues from HIPED for PPIG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.5), Testis (9.2), and Liver (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPIG Gene



Protein tissue co-expression partners for PPIG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIG Gene:

PPIG

SOURCE GeneReport for Unigene cluster for PPIG Gene:

Hs.470544

mRNA Expression by UniProt/SwissProt for PPIG Gene:

Q13427-PPIG_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PPIG Gene

  • Liver(4.8)
  • Blood(4.7)
  • Nervous system(3.6)
  • Kidney(3.5)
  • Lung(3.4)
  • Heart(3.3)
  • Intestine(3.2)
  • Muscle(3.2)
  • Spleen(2.9)
  • Urine(2.5)
  • Pancreas(2.4)
  • Skin(2.4)
  • Adrenal gland(2.2)
  • Bone marrow(2.2)
  • Thyroid gland(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with PPIG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIG Gene

Orthologs for PPIG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPIG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIG 33 34
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia PPIG 33 34
  • 94.15 (n)
cow
(Bos Taurus)
Mammalia PPIG 33 34
  • 92.08 (n)
mouse
(Mus musculus)
Mammalia Ppig 33 16 34
  • 88.73 (n)
rat
(Rattus norvegicus)
Mammalia Ppig 33
  • 88.42 (n)
oppossum
(Monodelphis domestica)
Mammalia PPIG 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIG 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIG 33 34
  • 74.54 (n)
lizard
(Anolis carolinensis)
Reptilia PPIG 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12514 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4513 33
zebrafish
(Danio rerio)
Actinopterygii ppig 34
  • 58 (a)
OneToOne
Dr.18174 33
fruit fly
(Drosophila melanogaster)
Insecta Moca-cyp 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyp-8 35
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR6 34
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3359 34
  • 56 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10778 33
Species where no ortholog for PPIG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIG Gene

ENSEMBL:
Gene Tree for PPIG (if available)
TreeFam:
Gene Tree for PPIG (if available)

Paralogs for PPIG Gene

Paralogs for PPIG Gene

Pseudogenes.org Pseudogenes for PPIG Gene

genes like me logo Genes that share paralogs with PPIG: view

Variants for PPIG Gene

Sequence variations from dbSNP and Humsavar for PPIG Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000039045 -- 169,640,782(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000052548 -- 169,630,070(+) T/G intron_variant
rs1000092050 -- 169,608,016(+) C/T intron_variant
rs1000206227 -- 169,608,317(+) C/T intron_variant
rs1000278307 -- 169,600,417(+) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPIG Gene

Variant ID Type Subtype PubMed ID
dgv7157n54 CNV loss 21841781
esv2721115 CNV deletion 23290073
esv2721116 CNV deletion 23290073
nsv1011368 CNV loss 25217958
nsv3025 CNV deletion 18451855
nsv518894 CNV gain 19592680
nsv520764 CNV loss 19592680
nsv834454 CNV loss 17160897

Variation tolerance for PPIG Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.14; 93.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIG Gene

Human Gene Mutation Database (HGMD)
PPIG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIG Gene

Disorders for PPIG Gene

MalaCards: The human disease database

(17) MalaCards diseases for PPIG Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bietti crystalline corneoretinal dystrophy
  • bcd
chronic cystitis
hemorrhagic cystitis
tinea cruris
  • dermatophytosis of groin and perianal area
bladder disease
  • urinary bladder disease
- elite association - COSMIC cancer census association via MalaCards
Search PPIG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PPIG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PPIG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPIG Gene

Publications for PPIG Gene

  1. A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II. (PMID: 9153302) Bourquin JP … Schaffner W (Nucleic acids research 1997) 2 3 4 58
  2. RS cyclophilins: identification of an NK-TR1-related cyclophilin. (PMID: 8973360) Nestel FP … Anderson SK (Gene 1996) 2 3 4 58
  3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 44 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. (PMID: 15358154) Lin CL … Ouyang P (Biochemical and biophysical research communications 2004) 3 4 58

Products for PPIG Gene

  • Addgene plasmids for PPIG

Sources for PPIG Gene

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