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Aliases for PPIC Gene

Aliases for PPIC Gene

  • Peptidylprolyl Isomerase C 2 3 5
  • Cyclophilin C 2 3 4
  • Rotamase C 3 4
  • EC 4 56
  • PPIase C 3 4
  • CYPC 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase C 3
  • Parvulin 3

External Ids for PPIC Gene

Previous GeneCards Identifiers for PPIC Gene

  • GC05M121989
  • GC05M122686
  • GC05M122389
  • GC05M122435
  • GC05M122386
  • GC05M117547
  • GC05M122363

Summaries for PPIC Gene

Entrez Gene Summary for PPIC Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIC Gene

PPIC (Peptidylprolyl Isomerase C) is a Protein Coding gene. Diseases associated with PPIC include Peach Allergy and Fish Allergy. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot for PPIC Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Gene Wiki entry for PPIC Gene

Additional gene information for PPIC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIC Gene

Genomics for PPIC Gene

GeneHancer (GH) Regulatory Elements for PPIC Gene

Promoters and enhancers for PPIC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I123035 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 567.1 +0.1 103 2.5 ARID4B SIN3A DMAP1 ZBTB7B ZNF48 YY1 ETS1 GLIS2 SP3 RXRA PPIC PRDM6 ENSG00000249996 SNX2 KRT8P33 CEP120 ENSG00000260686
GH05I122843 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 16.4 +190.6 190640 4.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF213 SP3 SP5 SNX24 GC05M122843 LOC105379154 SNX2 KRT8P33 PPIC CEP120 ENSG00000260686 PRDM6 RN7SL689P
GH05I122773 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 8 +261.0 260990 4 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SNX2 CEP120 CSNK1G3 SRFBP1 KRT8P33 LOX ENSG00000260686 PRDM6 PPIC RN7SL689P
GH05I123813 Enhancer 1.2 Ensembl ENCODE 12.1 -777.8 -777839 2.7 PKNOX1 NEUROD1 FEZF1 ZNF2 ZNF213 ATF7 FOS SP3 REST TSHZ1 PPIC GC05P123829 GC05P123744
GH05I123119 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.3 -82.9 -82867 0.9 CTCF STAT1 CEBPB EP300 RAD21 ETS1 SP1 ZNF512B SMC3 CTBP2 PPIC PRDM6 GC05P123133 LOC105379152
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPIC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPIC gene promoter:

Genomic Locations for PPIC Gene

Genomic Locations for PPIC Gene
13,492 bases
Minus strand

Genomic View for PPIC Gene

Genes around PPIC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIC Gene

Proteins for PPIC Gene

  • Protein details for PPIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase C
    Protein Accession:
    Secondary Accessions:
    • A4LBB5

    Protein attributes for PPIC Gene

    212 amino acids
    Molecular mass:
    22763 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PPIC Gene

neXtProt entry for PPIC Gene

Selected DME Specific Peptides for PPIC Gene


Post-translational modifications for PPIC Gene

No Post-translational modifications

Other Protein References for PPIC Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPIC Gene

Gene Families for PPIC Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PPIC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclophilin-type PPIase family.
  • Belongs to the cyclophilin-type PPIase family.
genes like me logo Genes that share domains with PPIC: view

Function for PPIC Gene

Molecular function for PPIC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Cyclosporin A (CsA) inhibits CYPC.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Enzyme Numbers (IUBMB) for PPIC Gene

Phenotypes From GWAS Catalog for PPIC Gene

Gene Ontology (GO) - Molecular Function for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0016018 cyclosporin A binding IDA 1652374
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIC: view
genes like me logo Genes that share phenotypes with PPIC: view

Animal Model Products

miRNA for PPIC Gene

miRTarBase miRNAs that target PPIC

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PPIC

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIC Gene

Localization for PPIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIC Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIC gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with PPIC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPIC Gene

Pathways & Interactions for PPIC Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIC: view

No data available for Pathways by source and SIGNOR curated interactions for PPIC Gene

Drugs & Compounds for PPIC Gene

(5) Drugs for PPIC Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
L-Proline Approved Nutra Target 0

(2) Additional Compounds for PPIC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for PPIC Gene

Compound Action Cas Number
Cyclosporin A Immunosuppressive agent 59865-13-3
genes like me logo Genes that share compounds with PPIC: view

Drug Products

Transcripts for PPIC Gene

mRNA/cDNA for PPIC Gene

Unigene Clusters for PPIC Gene

Peptidylprolyl isomerase C (cyclophilin C):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PPIC

Alternative Splicing Database (ASD) splice patterns (SP) for PPIC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - -
SP2: - - -

Relevant External Links for PPIC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPIC Gene

This gene is overexpressed in Bone marrow stromal cell (10.4), Milk (9.1), and Synovial fluid (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPIC Gene

NURSA nuclear receptor signaling pathways regulating expression of PPIC Gene:


SOURCE GeneReport for Unigene cluster for PPIC Gene:


Evidence on tissue expression from TISSUES for PPIC Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with PPIC: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIC Gene

Orthologs for PPIC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPIC 33 34
  • 99.06 (n)
(Bos Taurus)
Mammalia PPIC 33 34
  • 89.62 (n)
(Mus musculus)
Mammalia Ppic 33 16 34
  • 86.32 (n)
(Rattus norvegicus)
Mammalia Ppic 33
  • 84.75 (n)
(Canis familiaris)
Mammalia PPIC 33 34
  • 84.69 (n)
(Monodelphis domestica)
Mammalia PPIC 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia PPIC 34
  • 73 (a)
(Gallus gallus)
Aves PPIC 33 34
  • 74.83 (n)
(Anolis carolinensis)
Reptilia PPIC 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppic 33
  • 72.5 (n)
Str.20449 33
(Danio rerio)
Actinopterygii LOC100333141 33
  • 68.54 (n)
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2852 35 34
  • 66 (a)
ninaA 35
  • 51 (a)
(Caenorhabditis elegans)
Secernentea cyp-6 35
  • 67 (a)
cyp-5 35
  • 66 (a)
cyn-6 34
  • 63 (a)
cyn-5 34
  • 62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 33 34
  • 58.69 (n)
CPR5 34
  • 44 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ROC4 33
  • 65.24 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7094 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5529 34
  • 60 (a)
Species where no ortholog for PPIC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIC Gene

Gene Tree for PPIC (if available)
Gene Tree for PPIC (if available)

Paralogs for PPIC Gene

Paralogs for PPIC Gene

(22) SIMAP similar genes for PPIC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPIC: view

Variants for PPIC Gene

Sequence variations from dbSNP and Humsavar for PPIC Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000915658 -- 123,026,816(-) C/G intron_variant
rs1001074038 -- 123,034,355(-) A/G intron_variant
rs1001178867 -- 123,028,002(-) T/C intron_variant
rs1001295742 -- 123,027,192(-) T/C intron_variant
rs1001733446 -- 123,031,239(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPIC Gene

Variant ID Type Subtype PubMed ID
nsv520349 CNV loss 19592680
nsv1017500 CNV loss 25217958

Variation tolerance for PPIC Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.19; 80.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIC Gene

Disorders for PPIC Gene

MalaCards: The human disease database

(2) MalaCards diseases for PPIC Gene - From: DISEASES

Disorder Aliases PubMed IDs
peach allergy
  • prunus persica fruit allergy
fish allergy
  • allergy to fish
- elite association - COSMIC cancer census association via MalaCards
Search PPIC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PPIC

genes like me logo Genes that share disorders with PPIC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPIC Gene

Publications for PPIC Gene

  1. Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins. (PMID: 8031755) Schneider H … Movva NR (Biochemistry 1994) 2 3 4 22 58
  2. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan RS … Blankenberg S (JAMA 2009) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Use of an epitope-tagged cDNA library to isolate cDNAs encoding proteins with nuclear localization potential. (PMID: 1383094) Sugano S … Yamaguchi N (Gene 1992) 2 3 58
  5. PPIC, EMP3 and CHI3L1 Are Novel Prognostic Markers for High Grade Glioma. (PMID: 27801851) Gao YF … Liu ZQ (International journal of molecular sciences 2016) 3 58

Products for PPIC Gene

Sources for PPIC Gene

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