The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008] See more...

Aliases for PPIC Gene

Aliases for PPIC Gene

  • Peptidylprolyl Isomerase C 2 3 5
  • Cyclophilin C 2 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase C 3 4
  • Rotamase C 3 4
  • EC 5.2.1.8 4 52
  • PPIase C 3 4
  • CYPC 3 4
  • Parvulin 3

External Ids for PPIC Gene

Previous GeneCards Identifiers for PPIC Gene

  • GC05M121989
  • GC05M122686
  • GC05M122389
  • GC05M122435
  • GC05M122386
  • GC05M117547
  • GC05M122363

Summaries for PPIC Gene

Entrez Gene Summary for PPIC Gene

  • The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIC Gene

PPIC (Peptidylprolyl Isomerase C) is a Protein Coding gene. Diseases associated with PPIC include Disseminated Intravascular Coagulation and Fish Allergy. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPIB.

UniProtKB/Swiss-Prot Summary for PPIC Gene

  • PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.

Gene Wiki entry for PPIC Gene

Additional gene information for PPIC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPIC Gene

Genomics for PPIC Gene

GeneHancer (GH) Regulatory Elements for PPIC Gene

Promoters and enhancers for PPIC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPIC on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPIC

Top Transcription factor binding sites by QIAGEN in the PPIC gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • NF-Y
  • NF-YA
  • NF-YB
  • SRY

Genomic Locations for PPIC Gene

Genomic Locations for PPIC Gene
chr5:123,023,250-123,036,730
(GRCh38/hg38)
Size:
13,481 bases
Orientation:
Minus strand
chr5:122,358,945-122,372,436
(GRCh37/hg19)
Size:
13,492 bases
Orientation:
Minus strand

Genomic View for PPIC Gene

Genes around PPIC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIC Gene

Proteins for PPIC Gene

  • Protein details for PPIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45877-PPIC_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase C
    Protein Accession:
    P45877
    Secondary Accessions:
    • A4LBB5

    Protein attributes for PPIC Gene

    Size:
    212 amino acids
    Molecular mass:
    22763 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PPIC Gene

neXtProt entry for PPIC Gene

Selected DME Specific Peptides for PPIC Gene

P45877:
  • FMIQGGD
  • TNGSQFF
  • PKTVENF
  • ALATGEKG
  • KGSKFHR
  • DENFKLKH
  • LDGKHVVFG

Post-translational modifications for PPIC Gene

  • Glycosylation at Asn190
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for PPIC Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPIC Gene

Gene Families for PPIC Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PPIC Gene

Blocks:
  • Peptidyl-prolyl cis-trans isomerase, cyclophilin type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPIC Gene

GenScript: Design optimal peptide antigens:
  • Rotamase C (PPIC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P45877

UniProtKB/Swiss-Prot:

PPIC_HUMAN :
  • Belongs to the cyclophilin-type PPIase family.
Family:
  • Belongs to the cyclophilin-type PPIase family.
genes like me logo Genes that share domains with PPIC: view

Function for PPIC Gene

Molecular function for PPIC Gene

UniProtKB/Swiss-Prot Function:
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by cyclosporin A (CsA).

Enzyme Numbers (IUBMB) for PPIC Gene

Phenotypes From GWAS Catalog for PPIC Gene

Gene Ontology (GO) - Molecular Function for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA,IDA 20676357
GO:0005515 protein binding IPI 25416956
GO:0016018 cyclosporin A binding IDA 1652374
GO:0016853 isomerase activity IEA --
GO:0051082 unfolded protein binding IBA 21873635
genes like me logo Genes that share ontologies with PPIC: view
genes like me logo Genes that share phenotypes with PPIC: view

Animal Model Products

CRISPR Products

miRNA for PPIC Gene

miRTarBase miRNAs that target PPIC

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIC

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIC Gene

Localization for PPIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIC Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIC gene
Compartment Confidence
extracellular 2
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with PPIC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPIC Gene

Pathways & Interactions for PPIC Gene

PathCards logo

SuperPathways for PPIC Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 20676357
GO:0006457 protein folding IEA --
GO:0042026 protein refolding IBA 21873635
genes like me logo Genes that share ontologies with PPIC: view

No data available for Pathways by source and SIGNOR curated interactions for PPIC Gene

Drugs & Compounds for PPIC Gene

(6) Drugs for PPIC Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor Immunosuppressive agent, Immunosuppressant drug, Calcineurin inhibitor 0
palmitoleic acid Experimental Pharma Target 0
Proline Nutra Target 41

(2) Additional Compounds for PPIC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for PPIC Gene

Compound Action Cas Number
Cyclosporin A Immunosuppressive agent 59865-13-3
genes like me logo Genes that share compounds with PPIC: view

Drug Products

Transcripts for PPIC Gene

mRNA/cDNA for PPIC Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIC

Alternative Splicing Database (ASD) splice patterns (SP) for PPIC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - -
SP2: - - -
SP3:
SP4:

Relevant External Links for PPIC Gene

GeneLoc Exon Structure for
PPIC

Expression for PPIC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPIC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPIC Gene

This gene is overexpressed in Bone marrow stromal cell (10.4), Milk (9.1), and Synovial fluid (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPIC Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPIC

SOURCE GeneReport for Unigene cluster for PPIC Gene:

Hs.110364

mRNA Expression by UniProt/SwissProt for PPIC Gene:

P45877-PPIC_HUMAN
Tissue specificity: Expressed in kidney, skeletal muscle, pancreas, heart, lung, liver and to a lower extent in brain.

Evidence on tissue expression from TISSUES for PPIC Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with PPIC: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIC Gene

Orthologs for PPIC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIC 31 30
  • 99.06 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PPIC 31 30
  • 89.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ppic 17 31 30
  • 86.32 (n)
rat
(Rattus norvegicus)
Mammalia Ppic 30
  • 84.75 (n)
dog
(Canis familiaris)
Mammalia PPIC 31 30
  • 84.69 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPIC 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPIC 31
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPIC 31 30
  • 74.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPIC 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppic 30
  • 72.5 (n)
Str.20449 30
zebrafish
(Danio rerio)
Actinopterygii LOC100333141 30
  • 68.54 (n)
PPIC 31
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2852 31 32
  • 62 (a)
OneToMany
ninaA 32
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea cyp-6 32
  • 67 (a)
cyp-5 32
  • 66 (a)
cyn-6 31
  • 63 (a)
ManyToMany
cyn-5 31
  • 62 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR2 31 30
  • 58.69 (n)
ManyToMany
CPR5 31
  • 44 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ROC4 30
  • 65.24 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7094 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5529 31
  • 60 (a)
OneToMany
Species where no ortholog for PPIC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIC Gene

ENSEMBL:
Gene Tree for PPIC (if available)
TreeFam:
Gene Tree for PPIC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPIC: view image

Paralogs for PPIC Gene

(22) SIMAP similar genes for PPIC Gene using alignment to 1 proteins:

  • PPIC_HUMAN
genes like me logo Genes that share paralogs with PPIC: view

Variants for PPIC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPIC Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs34341374 - p.Lys86Arg
rs451195 - p.Asn190Ser
rs45560036 - p.His160Leu

Additional dbSNP identifiers (rs#s) for PPIC Gene

Structural Variations from Database of Genomic Variants (DGV) for PPIC Gene

Variant ID Type Subtype PubMed ID
nsv1017500 CNV loss 25217958
nsv520349 CNV loss 19592680

Variation tolerance for PPIC Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.19; 80.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIC Gene

Disorders for PPIC Gene

MalaCards: The human disease database

(7) MalaCards diseases for PPIC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
disseminated intravascular coagulation
  • defibrination syndrome
fish allergy
  • allergy to fish
crab allergy
  • green mud crab allergy
post-cardiac arrest syndrome
  • post cardiac syndrome
peach allergy
  • prunus persica fruit allergy
- elite association - COSMIC cancer census association via MalaCards
Search PPIC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PPIC

genes like me logo Genes that share disorders with PPIC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPIC Gene

Publications for PPIC Gene

  1. Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins. (PMID: 8031755) Schneider H … Movva NR (Biochemistry 1994) 2 3 4 23 54
  2. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. (PMID: 20676357) Davis TL … Dhe-Paganon S (PLoS biology 2010) 3 4 54
  3. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan RS … Blankenberg S (JAMA 2009) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Use of an epitope-tagged cDNA library to isolate cDNAs encoding proteins with nuclear localization potential. (PMID: 1383094) Sugano S … Yamaguchi N (Gene 1992) 2 3 54

Products for PPIC Gene

Sources for PPIC Gene