The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that g... See more...

Aliases for PPIB Gene

Aliases for PPIB Gene

  • Peptidylprolyl Isomerase B 2 3 5
  • Peptidyl-Prolyl Cis-Trans Isomerase B 2 3 4
  • S-Cyclophilin 2 3 4
  • Rotamase B 2 3 4
  • CYP-S1 2 3 4
  • SCYLP 2 3 4
  • CYPB 2 3 4
  • Cyclophilin B 2 4
  • EC 5.2.1.8 4 50
  • PPIase B 3 4
  • OI9 2 3
  • B 2 3
  • Peptidylprolyl Isomerase B (Cyclophilin B) 3
  • Epididymis Secretory Protein Li 39 3
  • Cyclophilin-Like Protein 3
  • HEL-S-39 3
  • PPIase 2
  • PPIB 5

External Ids for PPIB Gene

Previous GeneCards Identifiers for PPIB Gene

  • GC15M060234
  • GC15M057607
  • GC15M062026
  • GC15M062163
  • GC15M062235
  • GC15M064448
  • GC15M041272

Summaries for PPIB Gene

Entrez Gene Summary for PPIB Gene

  • The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

GeneCards Summary for PPIB Gene

PPIB (Peptidylprolyl Isomerase B) is a Protein Coding gene. Diseases associated with PPIB include Osteogenesis Imperfecta, Type Ix and Osteogenesis Imperfecta, Type Ii. Among its related pathways are Degradation of the extracellular matrix and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is PPIC.

UniProtKB/Swiss-Prot Summary for PPIB Gene

  • PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.

Gene Wiki entry for PPIB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPIB Gene

Genomics for PPIB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPIB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPIB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPIB

Top Transcription factor binding sites by QIAGEN in the PPIB gene promoter:
  • AP-1
  • AREB6
  • Bach1
  • E47
  • FAC1
  • Hand1
  • Pax-3
  • Tal-1

Genomic Locations for PPIB Gene

Latest Assembly
chr15:64,155,740-64,163,134
(GRCh38/hg38)
Size:
7,395 bases
Orientation:
Minus strand

Previous Assembly
chr15:64,448,016-64,455,221
(GRCh37/hg19 by Entrez Gene)
Size:
7,206 bases
Orientation:
Minus strand

chr15:64,448,011-64,455,404
(GRCh37/hg19 by Ensembl)
Size:
7,394 bases
Orientation:
Minus strand

Genomic View for PPIB Gene

Genes around PPIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIB Gene

Proteins for PPIB Gene

  • Protein details for PPIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23284-PPIB_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase B
    Protein Accession:
    P23284
    Secondary Accessions:
    • A8K534
    • Q6IBH5
    • Q9BVK5

    Protein attributes for PPIB Gene

    Size:
    216 amino acids
    Molecular mass:
    23743 Da
    Quaternary structure:
    • Interacts with DYM. Interacts with CALR, CLGN and CANX. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (PubMed:12475965).
    • (Microbial infection) Interacts with measles virus nucleoprotein.
    SequenceCaution:
    • Sequence=AAA52150.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPIB Gene

neXtProt entry for PPIB Gene

Selected DME Specific Peptides for PPIB Gene

P23284:
  • FMIQGGD
  • QGGDFTRG
  • NGSQFFITTV
  • TNGSQFF
  • ALATGEKG
  • TGEKGFGY
  • DENFKLKH
  • GKTVPKT
  • GGKSIYG
  • LDGKHVVFG

Post-translational modifications for PPIB Gene

  • Glycosylation at Asn148
  • Ubiquitination at Lys67, Lys98, Lys131, Lys158, Lys165, and Lys209
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIB Gene

Domains & Families for PPIB Gene

Gene Families for PPIB Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted secreted proteins

Protein Domains for PPIB Gene

InterPro:
Blocks:
  • Peptidyl-prolyl cis-trans isomerase, cyclophilin type

Suggested Antigen Peptide Sequences for PPIB Gene

GenScript: Design optimal peptide antigens:
  • S-cyclophilin (PPIB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P23284

UniProtKB/Swiss-Prot:

PPIB_HUMAN :
  • Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
genes like me logo Genes that share domains with PPIB: view

Function for PPIB Gene

Molecular function for PPIB Gene

UniProtKB/Swiss-Prot Function:
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000269|PubMed:20676357};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by cyclosporin A (CsA).
GENATLAS Biochemistry:
peptidyl-propyl isomerase B

Enzyme Numbers (IUBMB) for PPIB Gene

Phenotypes From GWAS Catalog for PPIB Gene

Gene Ontology (GO) - Molecular Function for PPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA,NAS 2000394
GO:0005515 protein binding ISS --
GO:0005518 contributes_to collagen binding ISS --
GO:0016018 cyclosporin A binding IDA 20676357
genes like me logo Genes that share ontologies with PPIB: view
genes like me logo Genes that share phenotypes with PPIB: view

Human Phenotype Ontology for PPIB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PPIB Gene

MGI Knock Outs for PPIB:
  • Ppib Ppib<tm1.1Rjb>

Animal Models for research

  • Taconic Biosciences Mouse Models for PPIB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIB

No data available for Transcription Factor Targets and HOMER Transcription for PPIB Gene

Localization for PPIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIB Gene

Virion. Note=(Microbial infection).
Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269 PubMed:17081065}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIB gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 5
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum TAS,IDA 20089953
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with PPIB: view

Pathways & Interactions for PPIB Gene

genes like me logo Genes that share pathways with PPIB: view

Pathways by source for PPIB Gene

2 Sino Biological pathways for PPIB Gene
1 GeneGo (Thomson Reuters) pathway for PPIB Gene
  • Apoptosis and survival APRIL and BAFF signaling

Gene Ontology (GO) - Biological Process for PPIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization ISS --
GO:0006457 protein folding IBA 21873635
GO:0030593 neutrophil chemotaxis IDA 11688976
GO:0040018 positive regulation of multicellular organism growth IMP 20089953
GO:0044794 positive regulation by host of viral process IMP 15989969
genes like me logo Genes that share ontologies with PPIB: view

No data available for SIGNOR curated interactions for PPIB Gene

Drugs & Compounds for PPIB Gene

(4) Drugs for PPIB Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Immunosuppressive agent, Calcineurin inhibitor 0
1,4-Dithiothreitol Experimental Pharma Target 0
Proline Nutra Target, binder 52

(2) Additional Compounds for PPIB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for PPIB Gene

Compound Action Cas Number
Cyclosporin A Immunosuppressive agent 59865-13-3
genes like me logo Genes that share compounds with PPIB: view

Transcripts for PPIB Gene

mRNA/cDNA for PPIB Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIB

Alternative Splicing Database (ASD) splice patterns (SP) for PPIB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for PPIB Gene

GeneLoc Exon Structure for
PPIB

Expression for PPIB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPIB Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPIB Gene



Protein tissue co-expression partners for PPIB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPIB

SOURCE GeneReport for Unigene cluster for PPIB Gene:

Hs.434937

Evidence on tissue expression from TISSUES for PPIB Gene

  • Skin(4.8)
  • Nervous system(4.8)
  • Liver(4.7)
  • Lung(4)
  • Stomach(3.9)
  • Pancreas(3.8)
  • Intestine(3.6)
  • Kidney(3.2)
  • Heart(3.1)
  • Spleen(3)
  • Eye(3)
  • Lymph node(3)
  • Thyroid gland(2.9)
  • Muscle(2.9)
  • Bone marrow(2.9)
  • Blood(2.9)
  • Adrenal gland(2.8)
  • Bone(2.6)
  • Gall bladder(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIB Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • skull
  • tongue
  • tooth
  • vocal cord
Thorax:
  • chest wall
  • clavicle
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • biliary tract
  • intestine
  • kidney
  • liver
  • stomach
Pelvis:
  • pelvis
  • ureter
  • uterus
  • vagina
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with PPIB: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIB Gene

Orthologs for PPIB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPIB 29 30
  • 99.85 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPIB 29 30
  • 90.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPIB 29 30
  • 90.22 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ppib 29 16 30
  • 90.12 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppib 29
  • 89.1 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PPIB 30
  • 89 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPIB 30
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPIB 29 30
  • 80.84 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPIB 30
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppib 29
  • 76.76 (n)
Str.806 29
African clawed frog
(Xenopus laevis)
Amphibia ppib-prov 29
Zebrafish
(Danio rerio)
Actinopterygii ppib 29 30
  • 76.08 (n)
OneToOne
wufa97f08 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8306 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG2852 29 30 31
  • 68.17 (n)
OneToMany
ninaA 31
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007088 29
  • 65.62 (n)
Worm
(Caenorhabditis elegans)
Secernentea cyp-5 31
  • 71 (a)
cyp-6 31
  • 69 (a)
cyn-6 30
  • 64 (a)
ManyToMany
cyn-5 29 30
  • 63.35 (n)
ManyToMany
cyp-3 31
  • 62 (a)
cyp-8 31
  • 52 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AAL056C 29
  • 58.28 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10208g 29
  • 58.09 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR5 29 30 32
  • 55.56 (n)
ManyToMany
CPR2 30
  • 50 (a)
ManyToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CYP20-2 29
  • 62.13 (n)
Rice
(Oryza sativa)
Liliopsida Os05g0103200 29
  • 63.04 (n)
Wheat
(Triticum aestivum)
Liliopsida Ta.28895 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5529 30
  • 71 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU01200 29
  • 65.46 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyp4 29
  • 61.29 (n)
Species where no ortholog for PPIB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPIB Gene

ENSEMBL:
Gene Tree for PPIB (if available)
TreeFam:
Gene Tree for PPIB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPIB: view image
Alliance of Genome Resources:
Additional Orthologs for PPIB

Paralogs for PPIB Gene

(23) SIMAP similar genes for PPIB Gene using alignment to 1 proteins:

  • PPIB_HUMAN
genes like me logo Genes that share paralogs with PPIB: view

Variants for PPIB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPIB Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
884248 Uncertain Significance: Osteogenesis imperfecta type 9 64,163,078(-) G/T
NC_000015.10:g.64163078G>T
885311 Uncertain Significance: Osteogenesis imperfecta type 9 64,155,869(-) G/A
NM_000942.5(PPIB):c.*154C>T
NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR
885312 Uncertain Significance: Osteogenesis imperfecta type 9 64,155,943(-) G/A
NM_000942.5(PPIB):c.*80C>T
NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR
885313 Uncertain Significance: Osteogenesis imperfecta type 9 64,155,958(-) C/G
NM_000942.5(PPIB):c.*65G>C
NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR
886214 Benign: Osteogenesis imperfecta type 9 64,156,002(-) A/T
NM_000942.5(PPIB):c.*21T>A
NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPIB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PPIB Gene

Variant ID Type Subtype PubMed ID
nsv827360 CNV loss 20364138
nsv833036 CNV loss 17160897

Variation tolerance for PPIB Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIB Gene

Human Gene Mutation Database (HGMD)
PPIB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIB
Leiden Open Variation Database (LOVD)
PPIB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIB Gene

Disorders for PPIB Gene

MalaCards: The human disease database

(12) MalaCards diseases for PPIB Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search PPIB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PPIB_HUMAN
  • Osteogenesis imperfecta 9 (OI9) [MIM:259440]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder. {ECO:0000269 PubMed:19781681, ECO:0000269 PubMed:20089953}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for PPIB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PPIB: view

No data available for Genatlas for PPIB Gene

Publications for PPIB Gene

  1. Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. (PMID: 20089953) Barnes AM … Marini JC (The New England journal of medicine 2010) 2 3 4 22
  2. Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. (PMID: 2000394) Price ER … Walsh CT (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 22
  3. PPIB mutations cause severe osteogenesis imperfecta. (PMID: 19781681) van Dijk FS … Pals G (American journal of human genetics 2009) 3 4 22
  4. A novel secreted cyclophilin-like protein (SCYLP). (PMID: 2040592) Spik G … Kocher HP (The Journal of biological chemistry 1991) 3 4 22
  5. Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and golgi organization and is associated with protein secretion pathways critical in bone development. (PMID: 21280149) Denais C … Machado RD (Human mutation 2011) 3 4

Products for PPIB Gene

Sources for PPIB Gene