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Aliases for PPIAL4G Gene

Aliases for PPIAL4G Gene

  • Peptidylprolyl Isomerase A Like 4G 2 3 5
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4 3 4
  • PPIase A-Like 4G 3 4
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4G 3
  • Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4G 3
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4A 3
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4G 3
  • Chromosome 1-Amplified Sequence 2 3
  • PPIase A-Like 4A 3
  • EC 4
  • COAS-2 3

External Ids for PPIAL4G Gene

Previous GeneCards Identifiers for PPIAL4G Gene

  • GC01M142557
  • GC01M143767

Summaries for PPIAL4G Gene

GeneCards Summary for PPIAL4G Gene

PPIAL4G (Peptidylprolyl Isomerase A Like 4G) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIAL4C.

UniProtKB/Swiss-Prot for PPIAL4G Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Additional gene information for PPIAL4G Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIAL4G Gene

Genomics for PPIAL4G Gene

GeneHancer (GH) Regulatory Elements for PPIAL4G Gene

Promoters and enhancers for PPIAL4G Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J148482 Enhancer 0.2 Ensembl 650.7 +1.5 1478 0.4 PPIAL4G ENSG00000285062 LINC01138
GH01J148480 Enhancer 0.3 Ensembl 0.7 +2.4 2378 1 CEBPB PPIAL4G ENSG00000285062 LINC01138
GH01J148502 Enhancer 0.3 Ensembl 0.4 -19.0 -19022 0.2 SPI1 GC01M148511 PPIAL4G LINC01138
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPIAL4G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPIAL4G gene promoter:
  • ZIC2
  • POU2F1a
  • POU2F1
  • PPAR-alpha
  • Nkx6-1
  • NF-1/L
  • NF-1
  • HOXA3
  • C/EBPalpha

Genomic Locations for PPIAL4G Gene

Genomic Locations for PPIAL4G Gene
3,856 bases
Minus strand
738 bases
Minus strand

Genomic View for PPIAL4G Gene

Genes around PPIAL4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIAL4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIAL4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIAL4G Gene

Proteins for PPIAL4G Gene

  • Protein details for PPIAL4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A-like 4G
    Protein Accession:
    Secondary Accessions:
    • A1L431
    • A2BFH1

    Protein attributes for PPIAL4G Gene

    164 amino acids
    Molecular mass:
    18166 Da
    Quaternary structure:
    No Data Available
    • It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.

neXtProt entry for PPIAL4G Gene

Post-translational modifications for PPIAL4G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPIAL4G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPIAL4G Gene

Domains & Families for PPIAL4G Gene

Gene Families for PPIAL4G Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PPIAL4G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIAL4G: view

Function for PPIAL4G Gene

Molecular function for PPIAL4G Gene

UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme Numbers (IUBMB) for PPIAL4G Gene

Gene Ontology (GO) - Molecular Function for PPIAL4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIAL4G: view
genes like me logo Genes that share phenotypes with PPIAL4G: view

Animal Model Products

miRNA for PPIAL4G Gene

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIAL4G Gene

Localization for PPIAL4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4G Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIAL4G gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PPIAL4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPIAL4G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPIAL4G Gene

Pathways & Interactions for PPIAL4G Gene

SuperPathways for PPIAL4G Gene

No Data Available

Interacting Proteins for PPIAL4G Gene

Gene Ontology (GO) - Biological Process for PPIAL4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIAL4G: view

No data available for Pathways by source and SIGNOR curated interactions for PPIAL4G Gene

Drugs & Compounds for PPIAL4G Gene

No Compound Related Data Available

Transcripts for PPIAL4G Gene

mRNA/cDNA for PPIAL4G Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPIAL4G Gene

Peptidylprolyl isomerase A (cyclophilin A)-like 4G:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIAL4G Gene

No ASD Table

Relevant External Links for PPIAL4G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIAL4G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIAL4G Gene

Protein differential expression in normal tissues from HIPED for PPIAL4G Gene

This gene is overexpressed in Brain (34.0), Skin (18.4), and Heart (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPIAL4G Gene

Protein tissue co-expression partners for PPIAL4G Gene

NURSA nuclear receptor signaling pathways regulating expression of PPIAL4G Gene:


SOURCE GeneReport for Unigene cluster for PPIAL4G Gene:

genes like me logo Genes that share expression patterns with PPIAL4G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIAL4G Gene

Orthologs for PPIAL4G Gene

This gene was present in the common ancestor of animals.

Orthologs for PPIAL4G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100612700 33
  • 98.16 (n)
(Canis familiaris)
Mammalia -- 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
(Mus musculus)
Mammalia Gm12728 34
  • 66 (a)
(Gallus gallus)
Aves PPIA 34
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 78 (a)
(Danio rerio)
Actinopterygii PPIA 34
  • 1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 34
  • 6 (a)
(Caenorhabditis elegans)
Secernentea T22F3.12 34
  • 41 (a)
Y17G9B.4 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 34
  • 5 (a)
Species where no ortholog for PPIAL4G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPIAL4G Gene

Gene Tree for PPIAL4G (if available)
Gene Tree for PPIAL4G (if available)

Paralogs for PPIAL4G Gene

(22) SIMAP similar genes for PPIAL4G Gene using alignment to 1 proteins:

  • PAL4G_HUMAN Pseudogenes for PPIAL4G Gene

genes like me logo Genes that share paralogs with PPIAL4G: view

Variants for PPIAL4G Gene

Sequence variations from dbSNP and Humsavar for PPIAL4G Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs111334863 -- 148,482,247(-) C/T downstream_transcript_variant
rs11485934 -- 148,484,940(-) C/T upstream_transcript_variant
rs11488510 -- 148,484,988(-) T/C upstream_transcript_variant
rs12407726 -- 148,483,033(-) C/T coding_sequence_variant, missense_variant
rs12563955 -- 148,483,774(-) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPIAL4G Gene

Variant ID Type Subtype PubMed ID
dgv190n106 CNV duplication 24896259
dgv327n100 CNV gain 25217958
dgv66e199 CNV deletion 23128226
esv2761299 CNV gain+loss 21179565
esv27827 CNV gain 19812545
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1076343 CNV duplication 25765185
nsv1118444 CNV duplication 24896259
nsv1132304 CNV duplication 24896259
nsv1151024 CNV duplication 26484159
nsv509457 CNV insertion 20534489
nsv510962 OTHER complex 20534489
nsv510984 OTHER inversion 20534489
nsv8225 CNV gain 18304495
nsv824509 CNV gain 20364138
nsv951870 CNV duplication 24416366

Variation tolerance for PPIAL4G Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.78; 94.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIAL4G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIAL4G Gene

Disorders for PPIAL4G Gene

Additional Disease Information for PPIAL4G

No disorders were found for PPIAL4G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIAL4G Gene

Publications for PPIAL4G Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for PPIAL4G Gene

Sources for PPIAL4G Gene

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