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Aliases for PPIAL4D Gene

Aliases for PPIAL4D Gene

  • Peptidylprolyl Isomerase A Like 4D 2 3 5
  • PPIase A-Like 4D 4
  • EC 4

External Ids for PPIAL4D Gene

Previous GeneCards Identifiers for PPIAL4D Gene

  • GC01M146569
  • GC01M148202

Summaries for PPIAL4D Gene

GeneCards Summary for PPIAL4D Gene

PPIAL4D (Peptidylprolyl Isomerase A Like 4D) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIAL4F.

UniProtKB/Swiss-Prot for PPIAL4D Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Additional gene information for PPIAL4D Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIAL4D Gene

Genomics for PPIAL4D Gene

GeneHancer (GH) Regulatory Elements for PPIAL4D Gene

Promoters and enhancers for PPIAL4D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I145239 Enhancer 0.2 Ensembl 550.8 +1.8 1798 1.2 PPIAL4D LOC729086
GH01I145232 Promoter 0.7 Ensembl 0.4 +9.2 9199 0.4 L3MBTL2 ZBTB26 EZH2 LOC729086 PPIAL4D
GH01I145261 Enhancer 0.2 Ensembl 0.4 -19.5 -19502 0.2 ENSG00000271291 PPIAL4D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPIAL4D on UCSC Golden Path with GeneCards custom track

Genomic Locations for PPIAL4D Gene

Genomic Locations for PPIAL4D Gene
785 bases
Minus strand

Genomic View for PPIAL4D Gene

Genes around PPIAL4D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIAL4D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIAL4D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIAL4D Gene

Proteins for PPIAL4D Gene

  • Protein details for PPIAL4D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A-like 4D
    Protein Accession:

    Protein attributes for PPIAL4D Gene

    164 amino acids
    Molecular mass:
    18167 Da
    Quaternary structure:
    No Data Available
    • It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.

neXtProt entry for PPIAL4D Gene

Post-translational modifications for PPIAL4D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPIAL4D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPIAL4D Gene

Domains & Families for PPIAL4D Gene

Gene Families for PPIAL4D Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIAL4D: view

No data available for Suggested Antigen Peptide Sequences for PPIAL4D Gene

Function for PPIAL4D Gene

Molecular function for PPIAL4D Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIAL4D Gene

Gene Ontology (GO) - Molecular Function for PPIAL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIAL4D: view

Phenotypes for PPIAL4D Gene

genes like me logo Genes that share phenotypes with PPIAL4D: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPIAL4D Gene

Localization for PPIAL4D Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4D Gene


Gene Ontology (GO) - Cellular Components for PPIAL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPIAL4D: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PPIAL4D Gene

Pathways & Interactions for PPIAL4D Gene

SuperPathways for PPIAL4D Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPIAL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIAL4D: view

No data available for Pathways by source and SIGNOR curated interactions for PPIAL4D Gene

Drugs & Compounds for PPIAL4D Gene

No Compound Related Data Available

Transcripts for PPIAL4D Gene

mRNA/cDNA for PPIAL4D Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIAL4D Gene

No ASD Table

Relevant External Links for PPIAL4D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIAL4D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIAL4D Gene

mRNA differential expression in normal tissues according to GTEx for PPIAL4D Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.4), Whole Blood (x7.0), Spleen (x5.0), and Brain - Cerebellum (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPIAL4D Gene

NURSA nuclear receptor signaling pathways regulating expression of PPIAL4D Gene:


SOURCE GeneReport for Unigene cluster for PPIAL4D Gene:

genes like me logo Genes that share expression patterns with PPIAL4D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIAL4D Gene

Orthologs for PPIAL4D Gene

This gene was present in the common ancestor of animals.

Orthologs for PPIAL4D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100612700 33
  • 97.55 (n)
(Bos Taurus)
Mammalia PPIA 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 74 (a)
(Canis familiaris)
Mammalia -- 34
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
(Mus musculus)
Mammalia Gm12728 34
  • 68 (a)
(Gallus gallus)
Aves PPIA 34
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 78 (a)
(Danio rerio)
Actinopterygii PPIA 34
  • 1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 34
  • 6 (a)
(Caenorhabditis elegans)
Secernentea T22F3.12 34
  • 42 (a)
Y17G9B.4 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 34
  • 5 (a)
Species where no ortholog for PPIAL4D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPIAL4D Gene

Gene Tree for PPIAL4D (if available)
Gene Tree for PPIAL4D (if available)

Paralogs for PPIAL4D Gene

(23) SIMAP similar genes for PPIAL4D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPIAL4D: view

Variants for PPIAL4D Gene

Sequence variations from dbSNP and Humsavar for PPIAL4D Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs111960529 -- 145,241,232(-) T/A downstream_transcript_variant
rs112572112 -- 145,241,231(-) A/T downstream_transcript_variant
rs200071858 -- 145,242,327(-) A/G upstream_transcript_variant
rs201764814 -- 145,241,904(-) C/T coding_sequence_variant, missense_variant
rs2671721 -- 145,243,437(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPIAL4D Gene

Variant ID Type Subtype PubMed ID
dgv172n106 CNV deletion 24896259
dgv380n100 CNV gain+loss 25217958
dgv381n100 CNV gain 25217958
dgv383n100 CNV loss 25217958
dgv397n100 CNV loss 25217958
dgv89e212 CNV gain 25503493
dgv99e212 CNV loss 25503493
esv3569786 CNV gain 25503493
esv3894156 CNV loss 25118596
esv3894189 CNV gain+loss 25118596
nsv1076732 CNV deletion 25765185
nsv547842 CNV loss 21841781
nsv946229 CNV duplication 23825009
nsv950889 CNV deletion 24416366
nsv952718 CNV duplication 24416366

Additional Variant Information for PPIAL4D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PPIAL4D Gene

Disorders for PPIAL4D Gene

Additional Disease Information for PPIAL4D

No disorders were found for PPIAL4D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIAL4D Gene

Publications for PPIAL4D Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58

Products for PPIAL4D Gene

Sources for PPIAL4D Gene

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