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Aliases for PPIAL4A Gene

Aliases for PPIAL4A Gene

  • Peptidylprolyl Isomerase A Like 4A 2 3 5
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4B 2 3
  • Cyclophilin Homolog Overexpressed In Liver Cancer 3 4
  • Chromosome One-Amplified Sequence 2 3 4
  • EC 4 56
  • PPIAL4B 3 4
  • COAS-2 3 4
  • COAS2 3 4
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4A 3
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4 2
  • Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4A/B/C 3
  • Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4A 3
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4B 3
  • Chromosome 1-Amplified Sequence 2 3
  • Cyclophilin-LC (COAS2) 3
  • PPIase A-Like 4B 3
  • PPIase A-Like 4G 3
  • PPIase A-Like 4A 4
  • PPIAL4 3

External Ids for PPIAL4A Gene

Previous HGNC Symbols for PPIAL4A Gene

  • PPIAL4

Previous GeneCards Identifiers for PPIAL4A Gene

  • GC01M146419
  • GC01M147954

Summaries for PPIAL4A Gene

GeneCards Summary for PPIAL4A Gene

PPIAL4A (Peptidylprolyl Isomerase A Like 4A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIAL4C.

UniProtKB/Swiss-Prot for PPIAL4A Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Additional gene information for PPIAL4A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIAL4A Gene

Genomics for PPIAL4A Gene

GeneHancer (GH) Regulatory Elements for PPIAL4A Gene

Promoters and enhancers for PPIAL4A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I120889 Promoter 0.5 EPDnew 550.8 +0.0 8 0.1 PPIAL4A LOC105378945 LINC00623
GH01I120890 Enhancer 0.2 Ensembl 550.8 +1.9 1855 1.6 PPIAL4A LOC105378945 LINC00623
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPIAL4A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPIAL4A gene promoter:

Genomic Locations for PPIAL4A Gene

Genomic Locations for PPIAL4A Gene
785 bases
Plus strand

Genomic View for PPIAL4A Gene

Genes around PPIAL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIAL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIAL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIAL4A Gene

Proteins for PPIAL4A Gene

  • Protein details for PPIAL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A-like 4A
    Protein Accession:

    Protein attributes for PPIAL4A Gene

    164 amino acids
    Molecular mass:
    18182 Da
    Quaternary structure:
    No Data Available
    • It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.

neXtProt entry for PPIAL4A Gene

Selected DME Specific Peptides for PPIAL4A Gene


Post-translational modifications for PPIAL4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPIAL4A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPIAL4A Gene

Gene Families for PPIAL4A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIAL4A: view

No data available for Suggested Antigen Peptide Sequences for PPIAL4A Gene

Function for PPIAL4A Gene

Molecular function for PPIAL4A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIAL4A Gene

Gene Ontology (GO) - Molecular Function for PPIAL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIAL4A: view

Phenotypes for PPIAL4A Gene

genes like me logo Genes that share phenotypes with PPIAL4A: view

Animal Model Products

miRNA for PPIAL4A Gene

miRTarBase miRNAs that target PPIAL4A

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIAL4A Gene

Localization for PPIAL4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4A Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIAL4A gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PPIAL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA,HDA 23533145
genes like me logo Genes that share ontologies with PPIAL4A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPIAL4A Gene

Pathways & Interactions for PPIAL4A Gene

SuperPathways for PPIAL4A Gene

No Data Available

Interacting Proteins for PPIAL4A Gene

Selected Interacting proteins: Q9Y536-PAL4A_HUMAN for PPIAL4A Gene via IID

Gene Ontology (GO) - Biological Process for PPIAL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIAL4A: view

No data available for Pathways by source and SIGNOR curated interactions for PPIAL4A Gene

Drugs & Compounds for PPIAL4A Gene

No Compound Related Data Available

Transcripts for PPIAL4A Gene

mRNA/cDNA for PPIAL4A Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIAL4A Gene

No ASD Table

Relevant External Links for PPIAL4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIAL4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIAL4A Gene

Protein differential expression in normal tissues from HIPED for PPIAL4A Gene

This gene is overexpressed in Skin (30.7), Serum (11.1), Brain (8.5), and Lung (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPIAL4A Gene

Protein tissue co-expression partners for PPIAL4A Gene

NURSA nuclear receptor signaling pathways regulating expression of PPIAL4A Gene:


mRNA Expression by UniProt/SwissProt for PPIAL4A Gene:

Tissue specificity: Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressed in pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas.
genes like me logo Genes that share expression patterns with PPIAL4A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIAL4A Gene

Orthologs for PPIAL4A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PPIAL4A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100612700 33
  • 97.96 (n)
Species where no ortholog for PPIAL4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPIAL4A Gene

Gene Tree for PPIAL4A (if available)
Gene Tree for PPIAL4A (if available)

Paralogs for PPIAL4A Gene

(20) SIMAP similar genes for PPIAL4A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPIAL4A: view

Variants for PPIAL4A Gene

Sequence variations from dbSNP and Humsavar for PPIAL4A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs2257913 -- 120,890,629(+) A/G downstream_transcript_variant
rs2814238 -- 120,889,742(+) A/C upstream_transcript_variant
rs2814239 -- 120,889,797(+) A/G 5_prime_UTR_variant
rs2814240 -- 120,889,919(+) G/A coding_sequence_variant, synonymous_variant
rs385569 -- 120,890,911(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPIAL4A Gene

Variant ID Type Subtype PubMed ID
dgv96e212 CNV loss 25503493
dgv97e212 CNV loss 25503493
nsv1078901 CNV deletion 25765185
nsv524681 CNV gain 19592680
nsv547684 CNV loss 21841781

Variation tolerance for PPIAL4A Gene

Gene Damage Index Score: 5.35; 70.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIAL4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIAL4A Gene

Disorders for PPIAL4A Gene

Additional Disease Information for PPIAL4A

No disorders were found for PPIAL4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIAL4A Gene

Publications for PPIAL4A Gene

  1. Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. (PMID: 11948409) Meza-Zepeda LA … Myklebost O (Oncogene 2002) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Cyclophilin A mediates the ox-LDL-induced activation and apoptosis of macrophages via autophagy. (PMID: 28038796) Xue Z … Yan J (International journal of cardiology 2017) 3 58
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58

Products for PPIAL4A Gene

Sources for PPIAL4A Gene

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