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Aliases for PPIAL4A Gene
Aliases for PPIAL4A Gene
- Peptidylprolyl Isomerase A Like 4A 2 3 5
- COAS2 2 3 4
- Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4B 2 3
- Cyclophilin Homolog Overexpressed In Liver Cancer 3 4
- Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4A 3 4
- Chromosome One-Amplified Sequence 2 3 4
- EC 5.2.1.8 4 51
- PPIAL4B 3 4
- COAS-2 3 4
- Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4A 3
- Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4 2
- Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4A/B/C 3
- Peptidylprolyl Cis-Trans Isomerase A-Like 4B 3
- Chromosome 1-Amplified Sequence 2 3
- Cyclophilin-LC (COAS2) 3
- PPIase A-Like 4B 3
- PPIase A-Like 4G 3
- PPIase A-Like 4A 4
- EC 5.2.1.8'); 51
- PPIAL4A 5
- PPIAL4 3
External Ids for PPIAL4A Gene
- HGNC: 24369
- Entrez Gene: 653505
- Ensembl: ENSG00000263353
- UniProtKB: Q9Y536
Previous HGNC Symbols for PPIAL4A Gene
- PPIAL4
- PPIAL4B
Previous GeneCards Identifiers for PPIAL4A Gene
- GC01M146419
- GC01M147954
Summaries for PPIAL4A Gene
GeneCards Summary for PPIAL4A Gene
PPIAL4A (Peptidylprolyl Isomerase A Like 4A) is a Protein Coding gene. Diseases associated with PPIAL4A include Well-Differentiated Liposarcoma. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIAL4C.
UniProtKB/Swiss-Prot Summary for PPIAL4A Gene
-
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Additional gene information for PPIAL4A Gene
- HGNC(24369)
- Entrez Gene(653505)
- Ensembl(ENSG00000263353)
- UniProtKB(Q9Y536)
- Open Targets Platform(ENSG00000263353)
- Search for PPIAL4A at DataMed
- Search for PPIAL4A at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPIAL4A Gene
Genomics for PPIAL4A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PPIAL4A Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J120890 | Promoter | 0.3 | Ensembl | 600.7 | +1.7 | 1655 | 0.4 | PPIAL4A piR-60985-007 SRGAP2C | ||
| GH01J120911 | Promoter | 1.3 | EPDnew Ensembl | 0.4 | +23.9 | 23855 | 5.2 | ZNF629 ZNF692 IKZF2 ZNF600 KLF9 SP2 DPF2 RELB ZXDB CTBP1 | ENSG00000281741 LOC100996720 LINC00623 PPIAL4A SRGAP2C | |
| GH01J120849 | Promoter/Enhancer | 1.6 | Ensembl ENCODE CraniofacialAtlas | 0.3 | -39.2 | -39245 | 3.4 | ARHGAP35 CREB1 POLR2A BACH1 TARDBP DDX20 MTA2 ZNF143 ZNF24 SMAD5 | ENSG00000287979 RNVU1-19 lnc-FAM72B-16 PPIAL4A NBPF26 | |
| GH01J120843 | Promoter/Enhancer | 1.5 | FANTOM5 ENCODE CraniofacialAtlas | 0.3 | -45.2 | -45201 | 1.7 | GATAD2A IKZF1 ZNF174 LARP7 ZNF143 POLR3G PKNOX1 MTA1 REST IRF2 | MN296860 TRN-GTT7-1 piR-33470-001 lnc-FAM72B-16 PPIAL4A NBPF26 | |
| GH01J120941 | Promoter | 0.5 | Ensembl | 0.2 | +52.8 | 52755 | 2.6 | PKNOX1 MEIS2 | RNVU1-4 lnc-PPIAL4A-2 LINC00623 PPIAL4A SRGAP2C |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPIAL4A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPIAL4A
- Top Transcription factor binding sites by QIAGEN in the PPIAL4A gene promoter:
-
- CUTL1
- NF-1
- NF-1/L
- Nkx2-5
- Nkx3-1
- Nkx3-1 v1
- Pbx1a
- PPAR-alpha
- S8
- ZIC2
Genomic Locations for PPIAL4A Gene
Genomic Locations for PPIAL4A Gene
- chr1:120,889,746-120,890,405
- (GRCh38/hg38)
- Size:
- 660 bases
- Orientation:
- Plus strand
- chr1:147,954,635-147,955,419
- (GRCh37/hg19)
- Size:
- 785 bases
- Orientation:
- Minus strand
Genomic View for PPIAL4A Gene
Genes around PPIAL4A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p11.2 by HGNC
- 1p11.2 by Entrez Gene
- 1p11.2 by Ensembl
PPIAL4A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPIAL4A Gene
Proteins for PPIAL4A Gene
-
Protein details for PPIAL4A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y536-PAL4A_HUMAN
- Recommended name:
- Peptidyl-prolyl cis-trans isomerase A-like 4A
- Protein Accession:
- Q9Y536
Protein attributes for PPIAL4A Gene
- Size:
- 164 amino acids
- Molecular mass:
- 18182 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.
Protein Expression for PPIAL4A Gene
Selected DME Specific Peptides for PPIAL4A Gene
- Q9Y536:
-
- FMCQGGDF
- LSMANAG
- TNGSQFF
- TAENFRAL
- SIYGEKF
- GPNTNGSQ
- PKTAENF
- GILSMAN
- KTEWLDG
Post-translational modifications for PPIAL4A Gene
Other Protein References for PPIAL4A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
-
OriGene Purified Proteins for PPIAL4A
- Search Origene for MassSpec and Protein Over-expression Lysates for PPIAL4A
- Origene Custom Protein Services for PPIAL4A
-
Signalway Proteins for PPIAL4A
Domains & Families for PPIAL4A Gene
Gene Families for PPIAL4A Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PPIAL4A Gene
- InterPro:
- Blocks:
-
- Peptidyl-prolyl cis-trans isomerase, cyclophilin type
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
Q9Y536UniProtKB/Swiss-Prot:
PAL4A_HUMAN :- Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
- Family:
-
- Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
No data available for Suggested Antigen Peptide Sequences for PPIAL4A Gene
Function for PPIAL4A Gene
Molecular function for PPIAL4A Gene
- UniProtKB/Swiss-Prot Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8;.
Enzyme Numbers (IUBMB) for PPIAL4A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IBA | 21873635 |
| GO:0016018 | cyclosporin A binding | IBA | 21873635 |
| GO:0016853 | isomerase activity | IEA | -- |
| GO:0051082 | unfolded protein binding | IBA | -- |
Phenotypes for PPIAL4A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPIAL4A - Select products 50% OFF >
- * PPIAL4A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for PPIAL4A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPIAL4A
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIAL4A
miRNA for PPIAL4A Gene
- miRTarBase miRNAs that target PPIAL4A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPIAL4A
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Clone Products
- Applied Biological Materials (abm): Clones for PPIAL4A - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for PPIAL4A
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Cell Line Products
-
Horizon Cell Lines for PPIAL4A
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIAL4A Gene
Localization for PPIAL4A Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4A Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
| GO:0043231 | intracellular membrane-bounded organelle | IBA | 21873635 |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPIAL4A Gene
Pathways & Interactions for PPIAL4A Gene
Interacting Proteins for PPIAL4A Gene
GPS-Prot Interaction Network for PPIAL4A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | IEA,IBA | 21873635 |
| GO:0006457 | protein folding | IEA,IBA | 21873635 |
| GO:0042026 | protein refolding | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PPIAL4A Gene
Transcripts for PPIAL4A Gene
mRNA/cDNA for PPIAL4A Gene
- 1 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000577856 660 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPIAL4A - Select products 50% OFF >
- * PPIAL4A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPIAL4A
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-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIAL4A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPIAL4A
- Browse OriGene Inhibitory RNA Products For PPIAL4A
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Clone Products
- Applied Biological Materials (abm): Clones for PPIAL4A - Select products 50% OFF >
- * PPIAL4A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PPIAL4A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPIAL4A
Relevant External Links for PPIAL4A Gene
- GeneLoc Exon Structure for
- PPIAL4A
Expression for PPIAL4A Gene
This gene is overexpressed in Skin (30.7), Serum (11.1), Brain (8.5), and Lung (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPIAL4A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPIAL4A
mRNA Expression by UniProt/SwissProt for PPIAL4A Gene:
Q9Y536-PAL4A_HUMAN
Tissue specificity:
Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressed in pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas.
Primer Products
-
OriGene qPCR primer pairs for PPIAL4A
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIAL4A Gene
Orthologs for PPIAL4A Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC100612700 30 |
|
- Species where no ortholog for PPIAL4A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Paralogs for PPIAL4A Gene
Paralogs for PPIAL4A Gene
(20) SIMAP similar genes for PPIAL4A Gene using alignment to 1 proteins:
- PAL4A_HUMAN
Variants for PPIAL4A Gene
Gene Damage Index Score:
5.35;
70.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPIAL4A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPIAL4A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPIAL4A Gene
Disorders for PPIAL4A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| well-differentiated liposarcoma |
|
|
Search PPIAL4A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPIAL4A
No data available for UniProtKB/Swiss-Prot and Genatlas for PPIAL4A Gene
Publications for PPIAL4A Gene
- Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. (PMID: 11948409) Meza-Zepeda LA … Myklebost O (Oncogene 2002) 2 3 4
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3
- A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. (PMID: 29128334) Malty RH … Babu M (Cell systems 2017) 3
- Cyclophilin A mediates the ox-LDL-induced activation and apoptosis of macrophages via autophagy. (PMID: 28038796) Xue Z … Yan J (International journal of cardiology 2017) 3
ExternalLinks
Products for PPIAL4A Gene
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- Custom Assay Services
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- OriGene qPCR primer pairs for PPIAL4A
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- Sino Biological Human cDNA Clone for PPIAL4A
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- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for PPIAL4A (AFLGC-PPIAL4A)
- VectorBuilder Custom and pre-made DNA vectors for PPIAL4A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PPIAL4A (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PPIAL4A (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PPIAL4A CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PPIAL4A
- antibodies-online: Show 6 available PPIAL4A Antibodies ranked by validation data
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- antibodies-online: Search results for available PPIAL4A related products ranked by validation data
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- Horizon Cell Lines for PPIAL4A
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for PPIAL4A
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- Signalway Proteins for PPIAL4A
Sources for PPIAL4A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
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- (104) diseasecard
- (105) NIH Rare Diseases
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- (128) SNPedia
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- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
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- (178) MirGeneDB