This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with severa... See more...

Aliases for PPIA Gene

Aliases for PPIA Gene

  • Peptidylprolyl Isomerase A 2 3 5
  • CYPA 2 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase A 3 4
  • Cyclosporin A-Binding Protein 3 4
  • Cyclophilin A 2 4
  • Rotamase A 3 4
  • EC 5.2.1.8 4 50
  • PPIase A 3 4
  • Epididymis Secretory Sperm Binding Protein Li 69p 3
  • Peptidylprolyl Isomerase A (Cyclophilin A) 3
  • T Cell Cyclophilin 3
  • HEL-S-69p 3
  • CYPH 3
  • PPIA 5

External Ids for PPIA Gene

Previous GeneCards Identifiers for PPIA Gene

  • GC07P044482
  • GC07P044543
  • GC07P044577
  • GC07P044609
  • GC07P044803
  • GC07P044841
  • GC07P044798
  • GC07P044799
  • GC07P044810
  • GC07P044811
  • GC07P044809
  • GC07P044808
  • GC07P044800
  • GC07P044801
  • GC07P044804
  • GC07P044805
  • GC07P044806

Summaries for PPIA Gene

Entrez Gene Summary for PPIA Gene

  • This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIA Gene

PPIA (Peptidylprolyl Isomerase A) is a Protein Coding gene. Diseases associated with PPIA include Influenza and Hepatitis C Virus. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include peptide binding. An important paralog of this gene is PPIAL4C.

UniProtKB/Swiss-Prot Summary for PPIA Gene

  • Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:25678563, PubMed:21593166). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:30328013, PubMed:22347431).
  • (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292).
  • (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner.

Gene Wiki entry for PPIA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPIA Gene

Genomics for PPIA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPIA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPIA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPIA

Top Transcription factor binding sites by QIAGEN in the PPIA gene promoter:
  • AML1a
  • ATF
  • ATF6
  • MZF-1
  • Nkx3-1 v1
  • PPAR-alpha
  • SRF
  • SRF (504 AA)
  • ZIC2

Genomic Locations for PPIA Gene

Latest Assembly
chr7:44,795,960-44,824,564
(GRCh38/hg38)
Size:
28,605 bases
Orientation:
Plus strand

Previous Assembly
chr7:44,836,280-44,842,716
(GRCh37/hg19 by Entrez Gene)
Size:
6,437 bases
Orientation:
Plus strand

chr7:44,836,279-44,864,163
(GRCh37/hg19 by Ensembl)
Size:
27,885 bases
Orientation:
Plus strand

Genomic View for PPIA Gene

Genes around PPIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIA Gene

Proteins for PPIA Gene

  • Protein details for PPIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62937-PPIA_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A
    Protein Accession:
    P62937
    Secondary Accessions:
    • A8K220
    • P05092
    • Q3KQW3
    • Q567Q0
    • Q6IBU5
    • Q96IX3
    • Q9BRU4
    • Q9BTY9
    • Q9UC61

    Protein attributes for PPIA Gene

    Size:
    165 amino acids
    Molecular mass:
    18012 Da
    Quaternary structure:
    • Interacts with protein phosphatase PPP3CA/calcineurin A (PubMed:12218175, PubMed:12357034). Interacts with PRPF19 isoform 2 (via N-terminus) (By similarity). Interacts with isoform 2 of BSG/CD147 (PubMed:15688292, PubMed:11353871, PubMed:11943775, PubMed:21245143). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (PubMed:31063815). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (PubMed:26095851). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (PubMed:25678563). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (PubMed:25678563).
    • (Microbial infection) Interacts with HIV-1 capsid protein (PubMed:20364129, PubMed:8513493).
    • (Microbial infection) Interacts with human SARS coronavirus nucleoprotein.
    • (Microbial infection) Interacts with measles virus nucleoprotein.
    • (Microbial infection) Interacts with influenza A virus matrix protein 1.
    • (Microbial infection) Interacts with HCV NS5A; the interaction stimulates RNA-binding ability of NS5A and is dependent on the peptidyl-prolyl cis-trans isomerase activity of PPIA/CYPA.

    Three dimensional structures from OCA and Proteopedia for PPIA Gene

    Alternative splice isoforms for PPIA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIA Gene

Selected DME Specific Peptides for PPIA Gene

P62937:
  • FMCQGGDF
  • LSMANAG
  • DGEPLGRV
  • KFEDENF
  • TNGSQFF
  • TAENFRAL
  • TGEKGFGY
  • SIYGEKF
  • GPNTNGSQ
  • GFGYKGS
  • PKTAENF
  • GILSMAN
  • GGKSIYG
  • LDGKHVVFG
  • KTEWLDG
  • IVEAMERFGSRNGKTSKKITI

Post-translational modifications for PPIA Gene

  • Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (PubMed:20364129, Ref.12). Acetylation at Lys-125 favors its interaction with TARDBP (PubMed:25678563).
  • Glycosylation at Asn108
  • Ubiquitination at Lys76, Lys82, Lys91, Lys31, Lys44, Lys49, Lys118, Lys125, Lys131, Lys133, and Lys155
  • Modification sites at PhosphoSitePlus

Domains & Families for PPIA Gene

Gene Families for PPIA Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PPIA Gene

InterPro:
Blocks:
  • Peptidyl-prolyl cis-trans isomerase, cyclophilin type

Suggested Antigen Peptide Sequences for PPIA Gene

GenScript: Design optimal peptide antigens:
  • Peptidyl-prolyl cis-trans isomerase (A8K220_HUMAN)
  • Peptidyl-prolyl cis-trans isomerase (B4DM82_HUMAN)
  • Peptidyl-prolyl cis-trans isomerase (C9J5S7_HUMAN)
  • Rotamase A (PPIA_HUMAN)
  • cDNA FLJ75025, highly similar to Homo sapiens peptidylprolyl isomerase A (cyclophilin A) (PPIA), transcript variant 2, mRNA (Q567Q0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62937

UniProtKB/Swiss-Prot:

PPIA_HUMAN :
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIA: view

Function for PPIA Gene

Molecular function for PPIA Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:25678563, PubMed:21593166). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:30328013, PubMed:22347431).
UniProtKB/Swiss-Prot Function:
(Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:25678563, ECO:0000305|PubMed:19207730, ECO:0000305|PubMed:26095851};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
GENATLAS Biochemistry:
cyclophilin A,major intracellular receptor for the immunosuppressive agent cyclosporine A,with intrinsic peptidyl-prolyl cis-trans isomerase activity

Enzyme Numbers (IUBMB) for PPIA Gene

Phenotypes From GWAS Catalog for PPIA Gene

Gene Ontology (GO) - Molecular Function for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA,IMP 2001362
GO:0005178 integrin binding ISS --
GO:0005515 protein binding IPI 11353871
GO:0016018 cyclosporin A binding IMP 2001362
genes like me logo Genes that share ontologies with PPIA: view
genes like me logo Genes that share phenotypes with PPIA: view

Animal Models for PPIA Gene

MGI Knock Outs for PPIA:
  • Ppia Ppia<tm1Lubn>

miRNA for PPIA Gene

miRTarBase miRNAs that target PPIA

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIA Gene

Localization for PPIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIA Gene

Cytoplasm. Secreted. Nucleus. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that includes Rho GTPase signaling, actin remodeling, and myosin II activation. {ECO:0000269 PubMed:16527992}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA 16502470
GO:0005634 nucleus IEA,IDA 25678563
GO:0005737 cytoplasm IBA,IDA 26095851
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPIA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPIA Gene

Pathways & Interactions for PPIA Gene

genes like me logo Genes that share pathways with PPIA: view

Pathways by source for PPIA Gene

1 KEGG pathway for PPIA Gene
1 GeneGo (Thomson Reuters) pathway for PPIA Gene
  • Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
1 Cell Signaling Technology pathway for PPIA Gene

Gene Ontology (GO) - Biological Process for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 15130913
GO:0000413 protein peptidyl-prolyl isomerization IEA,IDA 14993672
GO:0001933 negative regulation of protein phosphorylation IDA 26095851
GO:0001934 positive regulation of protein phosphorylation IDA 11943775
GO:0006278 RNA-dependent DNA biosynthetic process TAS --
genes like me logo Genes that share ontologies with PPIA: view

No data available for SIGNOR curated interactions for PPIA Gene

Drugs & Compounds for PPIA Gene

(16) Drugs for PPIA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Target, inhibitor, binder Immunosuppressive agent, Calcineurin inhibitor 0
Copper Approved, Investigational Pharma Target 276
Dihydroartemisinin Approved, Experimental, Investigational Pharma Target, ligand 123
Voclosporin Approved, Investigational Pharma inhibitor 0
(3r)-1-Acetyl-3-Methylpiperidine Experimental Pharma Target 0

(2) Additional Compounds for PPIA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for PPIA Gene

Compound Action Cas Number
Cyclosporin A Immunosuppressive agent 59865-13-3
TMN 355 cyclophilin A inhibitor 1186372-20-2
genes like me logo Genes that share compounds with PPIA: view

Transcripts for PPIA Gene

mRNA/cDNA for PPIA Gene

4 REFSEQ mRNAs :
32 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIA

Alternative Splicing Database (ASD) splice patterns (SP) for PPIA Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for PPIA Gene

GeneLoc Exon Structure for
PPIA

Expression for PPIA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPIA Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPIA Gene



Protein tissue co-expression partners for PPIA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPIA

SOURCE GeneReport for Unigene cluster for PPIA Gene:

Hs.356331

Evidence on tissue expression from TISSUES for PPIA Gene

  • Nervous system(5)
  • Liver(5)
  • Lung(4.9)
  • Skin(4.9)
  • Blood(4.9)
  • Pancreas(4.8)
  • Intestine(4.8)
  • Eye(4.6)
  • Kidney(4.6)
  • Stomach(4.3)
  • Heart(4)
  • Muscle(4)
  • Bone(3.6)
  • Spleen(3.4)
  • Lymph node(3.2)
  • Bone marrow(3.1)
  • Adrenal gland(2.9)
  • Thyroid gland(2.8)
  • Gall bladder(2.4)
genes like me logo Genes that share expression patterns with PPIA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIA Gene

Orthologs for PPIA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPIA 29 30
  • 99.39 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm10123 30
  • 96 (a)
OneToMany
Ppia 29 16 30
  • 92.48 (n)
OneToMany
Gm5160 30
  • 85 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia LOC100337215 29
  • 94.51 (n)
PPIA 30
  • 93 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 93 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Ppia 29
  • 92.68 (n)
Dog
(Canis familiaris)
Mammalia PPIA 29 30
  • 88.28 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 83 (a)
OneToMany
Chicken
(Gallus gallus)
Aves PPIA 29 30
  • 81.71 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 90 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100496569 29
  • 67.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398630 29
Zebrafish
(Danio rerio)
Actinopterygii ppiaa 29
  • 69.92 (n)
PPIA 30
  • 1 (a)
OneToMany
wufd61c06 29
Fruit Fly
(Drosophila melanogaster)
Insecta Cyp1 31
  • 74 (a)
CG7768 31
  • 74 (a)
CG5071 30
  • 7 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cyp-3 31
  • 67 (a)
cyn-1 29
  • 65.43 (n)
cyp-7 31
  • 64 (a)
cyp-8 31
  • 52 (a)
T22F3.12 30
  • 45 (a)
ManyToMany
Y17G9B.4 30
  • 22 (a)
ManyToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER156C 29
  • 63.96 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04565g 29
  • 61.62 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR3 29
  • 59.33 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ROC2 29
  • 66.46 (n)
Soybean
(Glycine max)
eudicotyledons Gma.12280 29
Rice
(Oryza sativa)
Liliopsida Os09g0571400 29
  • 66.05 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2570 30
  • 5 (a)
OneToMany
Species where no ortholog for PPIA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PPIA Gene

ENSEMBL:
Gene Tree for PPIA (if available)
TreeFam:
Gene Tree for PPIA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPIA: view image
Alliance of Genome Resources:
Additional Orthologs for PPIA

Paralogs for PPIA Gene

(24) SIMAP similar genes for PPIA Gene using alignment to 5 proteins:

  • PPIA_HUMAN
  • C9J5S7_HUMAN
  • E5RIZ5_HUMAN
  • F8WE65_HUMAN
  • Q567Q0_HUMAN

Pseudogenes.org Pseudogenes for PPIA Gene

genes like me logo Genes that share paralogs with PPIA: view

Variants for PPIA Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPIA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PPIA Gene

Variant ID Type Subtype PubMed ID
nsv830985 CNV loss 17160897
nsv970472 CNV duplication 23825009

Variation tolerance for PPIA Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIA Gene

Human Gene Mutation Database (HGMD)
PPIA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIA
Leiden Open Variation Database (LOVD)
PPIA

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPIA Gene

Disorders for PPIA Gene

MalaCards: The human disease database

(11) MalaCards diseases for PPIA Gene - From: COP and GCD

Disorder Aliases PubMed IDs
influenza
  • flu
hepatitis c virus
  • hepatitis c virus, susceptibility to
carnitine-acylcarnitine translocase deficiency
  • cactd
lyme disease
  • bannwarth syndrome
diamond-blackfan anemia 5
  • dba5
- elite association - COSMIC cancer census association via MalaCards
Search PPIA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PPIA

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
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No data available for UniProtKB/Swiss-Prot and Genatlas for PPIA Gene

Publications for PPIA Gene

  1. Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (PMID: 17590083) An P … Winkler CA (PLoS pathogens 2007) 3 22 40
  2. Characterization of the human cyclophilin gene and of related processed pseudogenes. (PMID: 2197089) Haendler B … Hofer E (European journal of biochemistry 1990) 2 3 4
  3. Cyclophilin A-FoxO1 signaling pathway in endothelial cell apoptosis. (PMID: 31063815) Xie Y … Ge J (Cellular signalling 2019) 3 4
  4. CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus. (PMID: 30328013) Mahesutihan M … Sun L (Virologica Sinica 2018) 3 4
  5. Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes. (PMID: 25678563) Lauranzano E … Bonetto V (Brain : a journal of neurology 2015) 3 4

Products for PPIA Gene

Sources for PPIA Gene