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Aliases for PPIA Gene

Aliases for PPIA Gene

  • Peptidylprolyl Isomerase A 2 3 5
  • Cyclosporin A-Binding Protein 3 4
  • Cyclophilin A 2 4
  • Rotamase A 3 4
  • PPIase A 3 4
  • CYPA 3 4
  • Epididymis Secretory Sperm Binding Protein Li 69p 3
  • Peptidylprolyl Isomerase A (Cyclophilin A) 3
  • Peptidyl-Prolyl Cis-Trans Isomerase A 3
  • T Cell Cyclophilin 3
  • EC 4
  • HEL-S-69p 3
  • CYPH 3

External Ids for PPIA Gene

Previous GeneCards Identifiers for PPIA Gene

  • GC07P044482
  • GC07P044543
  • GC07P044577
  • GC07P044609
  • GC07P044803
  • GC07P044841
  • GC07P044798
  • GC07P044799
  • GC07P044800
  • GC07P044801
  • GC07P044804
  • GC07P044805
  • GC07P044806
  • GC07P044807

Summaries for PPIA Gene

Entrez Gene Summary for PPIA Gene

  • This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIA Gene

PPIA (Peptidylprolyl Isomerase A) is a Protein Coding gene. Diseases associated with PPIA include Diffuse Intrinsic Pontine Glioma and Ogden Syndrome. Among its related pathways are Uncoating of the HIV Virion and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include peptide binding. An important paralog of this gene is PPIAL4C.

UniProtKB/Swiss-Prot for PPIA Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Gene Wiki entry for PPIA Gene

Additional gene information for PPIA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIA Gene

Genomics for PPIA Gene

GeneHancer (GH) Regulatory Elements for PPIA Gene

Promoters and enhancers for PPIA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J044795 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 659.2 +0.8 805 4.1 CLOCK ZFP64 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC PPIA GC07P044796 GC07P044797 LOC105375259 SEPT7P2 DDX56 SNORA5C POLM SNORA5B SNHG15
GH07J044880 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 9.2 +88.5 88459 9.8 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ENSG00000272768 PURB PIR54023 H2AFV LINC01952 SNHG15 MYO1G ENSG00000228596 PPIA ZMIZ2
GH07J044845 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.1 +50.9 50948 4.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC GLIS1 LINC01952 H2AFV CICP20 DDX56 SNORA5C POLM SNORA5B ENSG00000228434 SPDYE1 TMED4
GH07J044856 Enhancer 1.1 Ensembl ENCODE 8.5 +60.5 60481 1.1 HDAC1 PKNOX1 RB1 SIN3A ZNF2 ZNF48 RAD21 RFX5 CHAMP1 ARID2 ENSG00000228596 PPIA H2AFV GC07P044861 LINC01952
GH07J044866 Enhancer 1 ENCODE dbSUPER 9.2 +70.9 70915 1.6 HDAC1 PKNOX1 ATF1 KLF17 ZEB1 ZNF335 ZNF366 SCRT2 FOS ATF7 ENSG00000228596 PPIA H2AFV GC07P044861 GC07M044876
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPIA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPIA gene promoter:
  • ZIC2
  • AML1a
  • ATF
  • PPAR-alpha
  • SRF (504 AA)
  • SRF
  • ATF6
  • MZF-1
  • Nkx3-1 v1

Genomic Locations for PPIA Gene

Genomic Locations for PPIA Gene
27,929 bases
Plus strand
27,923 bases
Plus strand

Genomic View for PPIA Gene

Genes around PPIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIA Gene

Proteins for PPIA Gene

  • Protein details for PPIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A
    Protein Accession:
    Secondary Accessions:
    • A8K220
    • P05092
    • Q3KQW3
    • Q567Q0
    • Q6IBU5
    • Q96IX3
    • Q9BRU4
    • Q9BTY9
    • Q9UC61

    Protein attributes for PPIA Gene

    165 amino acids
    Molecular mass:
    18012 Da
    Quaternary structure:
    • Interacts with HIV-1 Capsid protein.

    Three dimensional structures from OCA and Proteopedia for PPIA Gene

    Alternative splice isoforms for PPIA Gene


neXtProt entry for PPIA Gene

Post-translational modifications for PPIA Gene

  • Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.
  • Glycosylation at Asn108
  • Ubiquitination at posLast=155155, posLast=133133, posLast=131131, Lys91, posLast=8282, Lys49, and Lys31
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPIA Gene

Domains & Families for PPIA Gene

Gene Families for PPIA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIA: view

Function for PPIA Gene

Molecular function for PPIA Gene

UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
GENATLAS Biochemistry:
cyclophilin A,major intracellular receptor for the immunosuppressive agent cyclosporine A,with intrinsic peptidyl-prolyl cis-trans isomerase activity

Enzyme Numbers (IUBMB) for PPIA Gene

Phenotypes From GWAS Catalog for PPIA Gene

Gene Ontology (GO) - Molecular Function for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 14993672
GO:0005515 protein binding IPI 12218175
GO:0016018 cyclosporin A binding IDA 12218175
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIA: view
genes like me logo Genes that share phenotypes with PPIA: view

Animal Models for PPIA Gene

MGI Knock Outs for PPIA:
  • Ppia Ppia<tm1Lubn>

Animal Model Products

miRNA for PPIA Gene

miRTarBase miRNAs that target PPIA

Clone Products

  • Addgene plasmids for PPIA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIA Gene

Localization for PPIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIA Gene

Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPIA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA 16502470
GO:0005634 nucleus HDA 16780588
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPIA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPIA Gene

Pathways & Interactions for PPIA Gene

genes like me logo Genes that share pathways with PPIA: view

Pathways by source for PPIA Gene

Gene Ontology (GO) - Biological Process for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 14993672
GO:0006278 RNA-dependent DNA biosynthetic process TAS --
GO:0006457 protein folding TAS 2179953
GO:0016032 viral process IEA --
GO:0019058 viral life cycle TAS --
genes like me logo Genes that share ontologies with PPIA: view

No data available for SIGNOR curated interactions for PPIA Gene

Drugs & Compounds for PPIA Gene

(16) Drugs for PPIA Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor, inhibitor, Target Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
L-Proline Approved Nutra Target, binder 0
Copper Approved, Investigational Pharma Target 202
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100
(3r)-1-Acetyl-3-Methylpiperidine Experimental Pharma Target 0

(3) Additional Compounds for PPIA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PPIA: view

Transcripts for PPIA Gene

Unigene Clusters for PPIA Gene

Peptidylprolyl isomerase A (cyclophilin A):
Representative Sequences:

Clone Products

  • Addgene plasmids for PPIA

Alternative Splicing Database (ASD) splice patterns (SP) for PPIA Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for PPIA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPIA Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPIA Gene

Protein tissue co-expression partners for PPIA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIA Gene:


SOURCE GeneReport for Unigene cluster for PPIA Gene:


Evidence on tissue expression from TISSUES for PPIA Gene

  • Liver(5)
  • Nervous system(5)
  • Lung(4.9)
  • Blood(4.8)
  • Skin(4.8)
  • Intestine(4.7)
  • Pancreas(4.7)
  • Kidney(4.5)
  • Eye(4.4)
  • Stomach(4.1)
  • Muscle(3.8)
  • Heart(3.3)
  • Bone(3.2)
  • Spleen(3)
  • Lymph node(2.8)
  • Bone marrow(2.5)
  • Adrenal gland(2.1)
  • Gall bladder(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with PPIA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIA Gene

Orthologs for PPIA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPIA 34 33
  • 99.39 (n)
(Mus musculus)
Mammalia Gm10123 34
  • 96 (a)
Ppia 16 34 33
  • 92.48 (n)
Gm5160 34
  • 85 (a)
(Bos Taurus)
Mammalia LOC100337215 33
  • 94.51 (n)
  • 93 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
(Rattus norvegicus)
Mammalia LOC100360977 33
  • 92.68 (n)
(Canis familiaris)
Mammalia PPIA 34 33
  • 88.28 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
(Gallus gallus)
Aves PPIA 34 33
  • 81.71 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496569 33
  • 67.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398630 33
(Danio rerio)
Actinopterygii ppiaa 33
  • 69.92 (n)
  • 1 (a)
wufd61c06 33
fruit fly
(Drosophila melanogaster)
Insecta CG7768 35
  • 74 (a)
Cyp1 35
  • 74 (a)
CG5071 34
  • 7 (a)
(Caenorhabditis elegans)
Secernentea cyp-3 35
  • 67 (a)
cyn-1 33
  • 65.43 (n)
cyp-7 35
  • 64 (a)
cyp-8 35
  • 52 (a)
T22F3.12 34
  • 45 (a)
Y17G9B.4 34
  • 22 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER156C 33
  • 63.96 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04565g 33
  • 61.62 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR3 33
  • 59.33 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ROC2 33
  • 66.46 (n)
(Glycine max)
eudicotyledons Gma.12280 33
(Oryza sativa)
Liliopsida Os09g0571400 33
  • 66.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 34
  • 5 (a)
Species where no ortholog for PPIA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIA Gene

Gene Tree for PPIA (if available)
Gene Tree for PPIA (if available)
Evolutionary constrained regions (ECRs) for PPIA: view image

Paralogs for PPIA Gene

(24) SIMAP similar genes for PPIA Gene using alignment to 5 proteins:

  • C9J5S7_HUMAN
  • F8WE65_HUMAN
  • Q567Q0_HUMAN Pseudogenes for PPIA Gene

genes like me logo Genes that share paralogs with PPIA: view

Variants for PPIA Gene

Sequence variations from dbSNP and Humsavar for PPIA Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000118396 -- 44,794,786(+) C/T upstream_transcript_variant
rs1000249398 -- 44,802,504(+) T/G 3_prime_UTR_variant
rs1000292328 -- 44,799,505(+) T/C intron_variant
rs1000444121 -- 44,797,562(+) T/C intron_variant
rs1000628094 -- 44,797,306(+) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPIA Gene

Variant ID Type Subtype PubMed ID
nsv830985 CNV loss 17160897
nsv970472 CNV duplication 23825009

Variation tolerance for PPIA Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPIA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIA Gene

Disorders for PPIA Gene

MalaCards: The human disease database

(8) MalaCards diseases for PPIA Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diffuse intrinsic pontine glioma
  • dipg
ogden syndrome
  • ogdns
wolfram syndrome 2
  • wfs2
nodular nonsuppurative panniculitis
  • nodular non-suppurative febrile panniculitis
retinitis pigmentosa 14
  • rp14
- elite association - COSMIC cancer census association via MalaCards
Search PPIA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PPIA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PPIA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPIA Gene

Publications for PPIA Gene

  1. Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (PMID: 17590083) An P … Winkler CA (PLoS pathogens 2007) 3 22 44 58
  2. Characterization of the human cyclophilin gene and of related processed pseudogenes. (PMID: 2197089) Haendler B … Hofer E (European journal of biochemistry 1990) 2 3 4 58
  3. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. (PMID: 19758589) Seizer P … May AE (Atherosclerosis 2010) 3 22 58
  4. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. (PMID: 20364129) Lammers M … James LC (Nature chemical biology 2010) 3 4 58
  5. Cyclophilin A: potential functions and therapeutic target for human cancer. (PMID: 19865066) Obchoei S … Chen C (Medical science monitor : international medical journal of experimental and clinical research 2009) 3 22 58

Products for PPIA Gene

  • Addgene plasmids for PPIA

Sources for PPIA Gene