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This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
PPIA (Peptidylprolyl Isomerase A) is a Protein Coding gene. Diseases associated with PPIA include Wolfram Syndrome 2 and Ogden Syndrome. Among its related pathways are Prolactin Signaling Pathway and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include peptide binding. An important paralog of this gene is PPIAL4C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IBA,IDA | 14993672 |
GO:0005515 | protein binding | IPI | 12218175 |
GO:0016018 | cyclosporin A binding | IDA | 12218175 |
GO:0016853 | isomerase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | HDA | 16502470 |
GO:0005634 | nucleus | HDA | 16780588 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HIV Life Cycle |
.91
.64
.45
|
|
2 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
3 | Uncoating of the HIV Virion | ||
4 | Innate Immune System |
.61
|
|
5 | NF-kappaB Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000413 | protein peptidyl-prolyl isomerization | IDA | 14993672 |
GO:0006278 | RNA-dependent DNA biosynthetic process | TAS | -- |
GO:0006457 | protein folding | TAS | 2179953 |
GO:0016032 | viral process | IEA | -- |
GO:0019058 | viral life cycle | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cyclosporin A | Approved, Investigational, Vet_approved | Pharma | Antagonist, Inhibition, Inhibitor, Target, inhibitor | Immunosuppressive agent, Calcineurin inhibitor | 0 | |
Proline | Approved | Nutra | Target, binder | 37 | ||
Copper | Approved, Investigational | Pharma | Target | 227 | ||
(3r)-1-Acetyl-3-Methylpiperidine | Experimental | Pharma | Target | 0 | ||
(3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl- | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Cyclosporin A | Immunosuppressive agent | 59865-13-3 |
TMN 355 | cyclophilin A inhibitor | 1186372-20-2 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||
SP2: | - | ||||||||||||||||
SP3: | - | - | |||||||||||||||
SP4: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PPIA 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Gm10123 33 |
|
OneToMany | |
Ppia 17 33 32 |
|
||||
Gm5160 33 |
|
OneToMany | |||
cow (Bos Taurus) |
Mammalia | LOC100337215 32 |
|
||
PPIA 33 |
|
OneToOne | |||
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
ManyToMany | |
rat (Rattus norvegicus) |
Mammalia | Ppia 32 |
|
||
dog (Canis familiaris) |
Mammalia | PPIA 33 32 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | PPIA 33 32 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100496569 32 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398630 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ppiaa 32 |
|
||
PPIA 33 |
|
OneToMany | |||
wufd61c06 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | CG7768 34 |
|
|
|
Cyp1 34 |
|
|
|||
CG5071 33 |
|
OneToMany | |||
worm (Caenorhabditis elegans) |
Secernentea | cyp-3 34 |
|
|
|
cyn-1 32 |
|
||||
cyp-7 34 |
|
|
|||
cyp-8 34 |
|
|
|||
T22F3.12 33 |
|
ManyToMany | |||
Y17G9B.4 33 |
|
ManyToMany | |||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER156C 32 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B04565g 32 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CPR3 32 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | ROC2 32 |
|
||
soybean (Glycine max) |
eudicotyledons | Gma.12280 32 |
|
||
rice (Oryza sativa) |
Liliopsida | Os09g0571400 32 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2570 33 |
|
OneToMany |
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000118396 | -- | 44,794,786(+) | C/T | upstream_transcript_variant | |
rs1000249398 | -- | 44,802,504(+) | T/G | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
rs1000292328 | -- | 44,799,505(+) | T/C | intron_variant, non_coding_transcript_variant | |
rs1000444121 | -- | 44,797,562(+) | T/C | intron_variant | |
rs1000628094 | -- | 44,797,306(+) | G/A/T | intron_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
wolfram syndrome 2 |
|
|
ogden syndrome |
|
|
nodular nonsuppurative panniculitis |
|
|
retinitis pigmentosa 14 |
|
|
in situ carcinoma |
|
|