Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with severa... See more...
Aliases for PPIA Gene
Aliases for PPIA Gene
External Ids for PPIA Gene
- HGNC: 9253
- Entrez Gene: 5478
- Ensembl: ENSG00000196262
- OMIM: 123840
- UniProtKB: P62937
Previous GeneCards Identifiers for PPIA Gene
- GC07P044482
- GC07P044543
- GC07P044577
- GC07P044609
- GC07P044803
- GC07P044841
- GC07P044798
- GC07P044799
- GC07P044810
- GC07P044811
- GC07P044809
- GC07P044808
- GC07P044800
- GC07P044801
- GC07P044804
- GC07P044805
- GC07P044806
Summaries for PPIA Gene
-
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPIA Gene
PPIA (Peptidylprolyl Isomerase A) is a Protein Coding gene. Diseases associated with PPIA include Hordeolum Externum and Alzheimer Disease 11. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include peptide binding. An important paralog of this gene is PPIAL4C.
UniProtKB/Swiss-Prot Summary for PPIA Gene
-
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Additional gene information for PPIA Gene
- HGNC(9253)
- Entrez Gene(5478)
- Ensembl(ENSG00000196262)
- OMIM(123840)
- UniProtKB(P62937)
- Open Targets Platform(ENSG00000196262)
- Monarch Initiative
- Search for PPIA at DataMed
- Search for PPIA at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPIA Gene
Genomics for PPIA Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PPIA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPIA on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPIA
- Top Transcription factor binding sites by QIAGEN in the PPIA gene promoter:
-
- AML1a
- ATF
- ATF6
- MZF-1
- Nkx3-1 v1
- PPAR-alpha
- SRF
- SRF (504 AA)
- ZIC2
Genomic Locations for PPIA Gene
Genomic Locations for PPIA Gene
- chr7:44,795,960-44,824,564
- (GRCh38/hg38)
- Size:
- 28,605 bases
- Orientation:
- Plus strand
- chr7:44,836,241-44,864,163
- (GRCh37/hg19)
- Size:
- 27,923 bases
- Orientation:
- Plus strand
Genomic View for PPIA Gene
Genes around PPIA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p13 by HGNC
- 7p13 by Entrez Gene
- 7p13 by Ensembl
PPIA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPIA Gene
Proteins for PPIA Gene
-
Protein details for PPIA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62937-PPIA_HUMAN
- Recommended name:
- Peptidyl-prolyl cis-trans isomerase A
- Protein Accession:
- P62937
- A8K220
- P05092
- Q3KQW3
- Q567Q0
- Q6IBU5
- Q96IX3
- Q9BRU4
- Q9BTY9
- Q9UC61
Protein attributes for PPIA Gene
- Size:
- 165 amino acids
- Molecular mass:
- 18012 Da
- Quaternary structure:
-
- Interacts with protein phosphatase PPP3CA/calcineurin A (PubMed:12218175, PubMed:12357034).
- (Microbial infection) Interacts with HIV-1 capsid protein (PubMed:20364129, PubMed:8513493).
Three dimensional structures from OCA and Proteopedia for PPIA Gene
Protein Expression for PPIA Gene
Selected DME Specific Peptides for PPIA Gene
- P62937:
-
- FMCQGGDF
- LSMANAG
- DGEPLGRV
- KFEDENF
- TNGSQFF
- TAENFRAL
- TGEKGFGY
- SIYGEKF
- GPNTNGSQ
- GFGYKGS
- PKTAENF
- GILSMAN
- GGKSIYG
- LDGKHVVFG
- KTEWLDG
- IVEAMERFGSRNGKTSKKITI
Post-translational modifications for PPIA Gene
- Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.
-
Glycosylation at Asn108
- NX_P62937 (NX_P62937-1)
-
Ubiquitination at Lys76, Lys82, Lys91, Lys31, Lys44, Lys49, Lys118, Lys125, Lys131, Lys133, and Lys155
- NX_P62937 (NX_P62937-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PPIA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PPIA Antibody
- NSJ Bioreagents Cyclophilin A Antibody
- Creative Diagnostics Anti-Cyclosporin A monoclonal antibody, clone ESB.34
- Novus Biologicals Antibodies for PPIA
-
Abcam antibodies for PPIA
- Invitrogen Antibodies for PPIA (AFLGC-Ppia)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPIA
- Sino Biological Antibodies for PPIA
Protein Products
- Creative Biomart Recombinant Human PPIA, His-tagged
- Search Origene for MassSpec and Protein Over-expression Lysates for PPIA
- Origene Custom Protein Services for PPIA
- Sino Biological Recombinant Proteins for PPIA
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for PPIA
-
Abcam proteins for PPIA
Domains & Families for PPIA Gene
Gene Families for PPIA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for PPIA Gene
- InterPro:
- Blocks:
-
- Peptidyl-prolyl cis-trans isomerase, cyclophilin type
- ProtoNet:
Suggested Antigen Peptide Sequences for PPIA Gene
- GenScript: Design optimal peptide antigens:
-
- Peptidyl-prolyl cis-trans isomerase (A8K220_HUMAN)
- Peptidyl-prolyl cis-trans isomerase (B4DM82_HUMAN)
- Peptidyl-prolyl cis-trans isomerase (C9J5S7_HUMAN)
- Rotamase A (PPIA_HUMAN)
- cDNA FLJ75025, highly similar to Homo sapiens peptidylprolyl isomerase A (cyclophilin A) (PPIA), transcript variant 2, mRNA (Q567Q0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62937UniProtKB/Swiss-Prot:
PPIA_HUMAN :- Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
- Family:
-
- Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Function for PPIA Gene
Molecular function for PPIA Gene
- UniProtKB/Swiss-Prot Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000269|PubMed:20676357};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
- GENATLAS Biochemistry:
- cyclophilin A,major intracellular receptor for the immunosuppressive agent cyclosporine A,with intrinsic peptidyl-prolyl cis-trans isomerase activity
Enzyme Numbers (IUBMB) for PPIA Gene
Phenotypes From GWAS Catalog for PPIA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IBA,IDA | 14993672 |
| GO:0005515 | protein binding | IPI | 12218175 |
| GO:0016018 | cyclosporin A binding | IDA | 12218175 |
| GO:0016853 | isomerase activity | IEA | -- |
Phenotypes for PPIA Gene
- MGI mutant phenotypes for PPIA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PPIA:
-
- no effect
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased IL-8 secretion
- Increased shRNA abundance (Z-score > 2)
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased viability in pancreas lineage
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
Animal Models for PPIA Gene
- MGI Knock Outs for PPIA:
-
- Ppia Ppia<tm1Lubn>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPIA - Select products 50% OFF >
- * PPIA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPIA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPIA
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIA
miRNA for PPIA Gene
- miRTarBase miRNAs that target PPIA
-
- hsa-miR-1-3p (MIRT023905)
- hsa-miR-1307-3p (MIRT035823)
- hsa-miR-320b (MIRT036191)
- hsa-miR-1226-3p (MIRT036511)
- hsa-miR-760 (MIRT036733)
- hsa-miR-455-3p (MIRT037899)
- hsa-miR-423-5p (MIRT038051)
- hsa-miR-342-5p (MIRT038227)
- hsa-miR-30c-1-3p (MIRT038540)
- hsa-miR-31-3p (MIRT038938)
- hsa-miR-18a-3p (MIRT040751)
- hsa-miR-324-5p (MIRT043038)
- hsa-miR-106b-5p (MIRT044321)
- hsa-miR-320a (MIRT044403)
- hsa-miR-218-5p (MIRT046998)
- hsa-miR-197-3p (MIRT048054)
- hsa-miR-26a-5p (MIRT050185)
- hsa-miR-18a-5p (MIRT050690)
- hsa-miR-17-3p (MIRT050789)
- hsa-miR-3200-3p (MIRT052825)
- rno-miR-378a-5p (MIRT054691)
- rno-miR-378a-3p (MIRT054692)
- hsa-miR-1200 (MIRT452655)
- hsa-miR-876-3p (MIRT452656)
- hsa-miR-323a-5p (MIRT452657)
- hsa-miR-548v (MIRT452658)
- hsa-miR-610 (MIRT452659)
- hsa-miR-1252-5p (MIRT452660)
- hsa-miR-7978 (MIRT452661)
- hsa-miR-4456 (MIRT452662)
- hsa-miR-548q (MIRT452663)
- hsa-miR-4299 (MIRT452664)
- hsa-miR-6845-3p (MIRT452665)
- hsa-miR-1976 (MIRT452666)
- hsa-miR-3653-5p (MIRT452667)
- hsa-miR-544b (MIRT452668)
- hsa-miR-4324 (MIRT452669)
- hsa-miR-4662a-3p (MIRT452670)
- hsa-miR-4668-5p (MIRT526481)
- hsa-miR-3148 (MIRT526482)
- hsa-miR-548ay-3p (MIRT526483)
- hsa-miR-548at-3p (MIRT526484)
- hsa-miR-548z (MIRT526485)
- hsa-miR-548h-3p (MIRT526486)
- hsa-miR-548d-3p (MIRT526487)
- hsa-miR-548bb-3p (MIRT526488)
- hsa-miR-548ac (MIRT526489)
- hsa-miR-6783-5p (MIRT615272)
- hsa-miR-1184 (MIRT761201)
- hsa-miR-1249-5p (MIRT761606)
- hsa-miR-186-3p (MIRT763196)
- hsa-miR-1914-3p (MIRT763398)
- hsa-miR-363-5p (MIRT766230)
- hsa-miR-3907 (MIRT767580)
- hsa-miR-4418 (MIRT768736)
- hsa-miR-4471 (MIRT769473)
- hsa-miR-4651 (MIRT770735)
- hsa-miR-4664-5p (MIRT770815)
- hsa-miR-4802-3p (MIRT772555)
- hsa-miR-509-3-5p (MIRT773264)
- hsa-miR-509-5p (MIRT773302)
- hsa-miR-5194 (MIRT773624)
- hsa-miR-570-3p (MIRT775236)
- hsa-miR-6068 (MIRT775425)
- hsa-miR-608 (MIRT775761)
- hsa-miR-651-3p (MIRT777025)
- hsa-miR-6515-5p (MIRT777041)
- hsa-miR-6737-5p (MIRT778095)
- hsa-miR-6738-5p (MIRT778103)
- hsa-miR-6745 (MIRT778198)
- hsa-miR-6747-5p (MIRT778317)
- hsa-miR-6750-5p (MIRT778342)
- hsa-miR-6782-5p (MIRT779062)
- hsa-miR-6797-5p (MIRT779371)
- hsa-miR-6812-5p (MIRT779775)
- hsa-miR-6819-5p (MIRT779854)
- hsa-miR-6822-5p (MIRT779867)
- hsa-miR-6830-5p (MIRT780002)
- hsa-miR-6880-5p (MIRT780846)
- hsa-miR-6890-5p (MIRT781157)
- hsa-miR-7847-3p (MIRT782162)
- hsa-miR-8059 (MIRT782333)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPIA
- Browse OriGene Inhibitory RNA Products For PPIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIA
Clone Products
- Applied Biological Materials (abm): Clones for PPIA - Select products 50% OFF >
- * PPIA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PPIA
- Addgene plasmids for PPIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPIA
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIA Gene
Localization for PPIA Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPIA Gene
- Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | HDA | 16502470 |
| GO:0005634 | nucleus | HDA | 16780588 |
| GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPIA Gene
Pathways & Interactions for PPIA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.91
.65
.45
|
|
| 2 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 3 | Reverse Transcription of HIV RNA | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | NF-kappaB Signaling | ||
Pathways by source for PPIA Gene
1 BioSystems pathway for PPIA Gene
25 Reactome pathways for PPIA Gene
1 PharmGKB pathway for PPIA Gene
1 KEGG pathway for PPIA Gene
1 GeneGo (Thomson Reuters) pathway for PPIA Gene
- Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
1 Cell Signaling Technology pathway for PPIA Gene
Interacting Proteins for PPIA Gene
Selected Interacting proteins:
P62937-PPIA_HUMAN
ENSP00000419425
for PPIA Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PPIA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | IDA | 14993672 |
| GO:0006278 | RNA-dependent DNA biosynthetic process | TAS | -- |
| GO:0006457 | protein folding | TAS | 2179953 |
| GO:0016032 | viral process | IEA | -- |
| GO:0019058 | viral life cycle | TAS | -- |
No data available for SIGNOR curated interactions for PPIA Gene
Drugs & Compounds for PPIA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cyclosporin A | Approved, Investigational, Vet_approved | Pharma | Antagonist, Inhibitor, Inhibition, Target, inhibitor, binder | Immunosuppressive agent, Calcineurin inhibitor | 0 | |
| Copper | Approved, Investigational | Pharma | Target | 249 | ||
| (3r)-1-Acetyl-3-Methylpiperidine | Experimental | Pharma | Target | 0 | ||
| Coumarin 120 | Experimental | Pharma | Target | 0 | ||
| Dihydroartemisinin | Experimental, Investigational | Pharma | Target, ligand | 115 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(2) ApexBio Compounds for PPIA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cyclosporin A | Immunosuppressive agent | 59865-13-3 |
| TMN 355 | cyclophilin A inhibitor | 1186372-20-2 |
Transcripts for PPIA Gene
mRNA/cDNA for PPIA Gene
- 4 REFSEQ mRNAs :
- 32 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000355968 818 nts (view in UCSC)
- ENST00000415933 863 nts (view in UCSC)
- ENST00000451562 544 nts (view in UCSC)
- ENST00000468812 2237 nts (view in UCSC)
- ENST00000479021 552 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPIA - Select products 50% OFF >
- * PPIA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPIA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPIA
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPIA
- Browse OriGene Inhibitory RNA Products For PPIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIA
Clone Products
- Applied Biological Materials (abm): Clones for PPIA - Select products 50% OFF >
- * PPIA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PPIA
- Addgene plasmids for PPIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPIA
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: | - | - | |||||||||||||||
| SP4: | - |
Relevant External Links for PPIA Gene
- GeneLoc Exon Structure for
- PPIA
Expression for PPIA Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPIA Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPIA
SOURCE GeneReport for Unigene cluster for PPIA Gene:
Hs.356331Evidence on tissue expression from TISSUES for PPIA Gene
- Nervous system(5)
- Liver(5)
- Lung(4.9)
- Skin(4.9)
- Blood(4.9)
- Pancreas(4.8)
- Intestine(4.8)
- Eye(4.6)
- Kidney(4.6)
- Stomach(4.4)
- Heart(4.1)
- Muscle(4.1)
- Bone(3.7)
- Spleen(3.5)
- Lymph node(3.4)
- Bone marrow(3.2)
- Adrenal gland(3)
- Thyroid gland(3)
- Gall bladder(2.6)
Primer Products
-
OriGene qPCR primer pairs for PPIA
-
OriGene qPCR primer pairs and template standards for PPIA
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIA Gene
Orthologs for PPIA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PPIA 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gm10123 31 |
|
OneToMany | |
| Ppia 30 17 31 |
|
OneToMany | |||
| Gm5160 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | LOC100337215 30 |
|
||
| PPIA 31 |
|
OneToOne | |||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Rat (Rattus norvegicus) |
Mammalia | Ppia 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | PPIA 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | PPIA 30 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100496569 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398630 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ppiaa 30 |
|
||
| PPIA 31 |
|
OneToMany | |||
| wufd61c06 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cyp1 32 |
|
|
|
| CG7768 32 |
|
|
|||
| CG5071 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | cyp-3 32 |
|
|
|
| cyn-1 30 |
|
||||
| cyp-7 32 |
|
|
|||
| cyp-8 32 |
|
|
|||
| T22F3.12 31 |
|
ManyToMany | |||
| Y17G9B.4 31 |
|
ManyToMany | |||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER156C 30 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B04565g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CPR3 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ROC2 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.12280 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os09g0571400 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2570 31 |
|
OneToMany |
- Species where no ortholog for PPIA was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PPIA Gene
- ENSEMBL:
- Gene Tree for PPIA (if available)
- TreeFam:
- Gene Tree for PPIA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPIA: view image
Paralogs for PPIA Gene
Paralogs for PPIA Gene
(24) SIMAP similar genes for PPIA Gene using alignment to 5 proteins:
- PPIA_HUMAN
- C9J5S7_HUMAN
- E5RIZ5_HUMAN
- F8WE65_HUMAN
- Q567Q0_HUMAN
Pseudogenes.org Pseudogenes for PPIA Gene
- PGOHUM00000290347
- PGOHUM00000290518
- PGOHUM00000290883
- PGOHUM00000291115
- PGOHUM00000291323
- PGOHUM00000291441
- PGOHUM00000291600
- PGOHUM00000291877
- PGOHUM00000291883
- PGOHUM00000292025
- PGOHUM00000292051
- PGOHUM00000292144
- PGOHUM00000292161
- PGOHUM00000292390
- PGOHUM00000292634
- PGOHUM00000292685
- PGOHUM00000293293
- PGOHUM00000293299
- PGOHUM00000293669
- PGOHUM00000293888
- PGOHUM00000293902
- PGOHUM00000293908
- PGOHUM00000294268
- PGOHUM00000294274
- PGOHUM00000294431
- PGOHUM00000294514
- PGOHUM00000294531
- PGOHUM00000294573
- PGOHUM00000294630
- PGOHUM00000294731
- PGOHUM00000295068
- PGOHUM00000295210
- PGOHUM00000295326
- PGOHUM00000295587
- PGOHUM00000295652
- PGOHUM00000295769
- PGOHUM00000296307
- PGOHUM00000296308
- PGOHUM00000296612
- PGOHUM00000296905
- PGOHUM00000297116
- PGOHUM00000297124
- PGOHUM00000297144
- PGOHUM00000297231
- PGOHUM00000297858
- PGOHUM00000298232
- PGOHUM00000298375
- PGOHUM00000298390
- PGOHUM00000298442
- PGOHUM00000298462
- PGOHUM00000298680
- PGOHUM00000298798
- PGOHUM00000298856
- PGOHUM00000298857
- PGOHUM00000299032
- PGOHUM00000299044
- PGOHUM00000299046
- PGOHUM00000299124
- PGOHUM00000299194
- PGOHUM00000299283
- PGOHUM00000299422
- PGOHUM00000299446
- PGOHUM00000299625
- PGOHUM00000299656
- PGOHUM00000300363
- PGOHUM00000300569
- PGOHUM00000300661
- PGOHUM00000300977
- PGOHUM00000301327
- PGOHUM00000301328
- PGOHUM00000301680
- PGOHUM00000302083
- PGOHUM00000302358
- PGOHUM00000302472
- PGOHUM00000302820
- PGOHUM00000303146
- PGOHUM00000303562
- PGOHUM00000303575
- PGOHUM00000303941
- PGOHUM00000304024
- PGOHUM00000304105
- PGOHUM00000306644
- PGOHUM00000304774
- PGOHUM00000304780
- PGOHUM00000305390
- PGOHUM00000289017
- PGOHUM00000289018
- PGOHUM00000306856
- PGOHUM00000306857
- PGOHUM00000289180
- PGOHUM00000289181
- PGOHUM00000289278
- PGOHUM00000289279
- PGOHUM00000289370
- PGOHUM00000289371
- PGOHUM00000289460
- PGOHUM00000289461
- PGOHUM00000306956
- PGOHUM00000306957
- PGOHUM00000289756
- PGOHUM00000289786
- PGOHUM00000289909
- PGOHUM00000289986
- PGOHUM00000289996
- PGOHUM00000290017
- PGOHUM00000290286
Variants for PPIA Gene
Residual Variation Intolerance Score:
46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.14;
3.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPIA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPIA Gene
Disorders for PPIA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hordeolum externum |
|
|
| alzheimer disease 11 |
|
|
| sexual masochism |
|
|
| carnitine-acylcarnitine translocase deficiency |
|
|
| hepatitis c virus |
|
|
Search PPIA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPIA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PPIA Gene
Publications for PPIA Gene
- Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (PMID: 17590083) An P … Winkler CA (PLoS pathogens 2007) 3 23 41
- Characterization of the human cyclophilin gene and of related processed pseudogenes. (PMID: 2197089) Haendler B … Hofer E (European journal of biochemistry 1990) 2 3 4
- Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. (PMID: 20676357) Davis TL … Dhe-Paganon S (PLoS biology 2010) 3 4
- Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. (PMID: 20364129) Lammers M … James LC (Nature chemical biology 2010) 3 4
- EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. (PMID: 19758589) Seizer P … May AE (Atherosclerosis 2010) 3 23
ExternalLinks
Products for PPIA Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PPIA
- Origene Custom Protein Services for PPIA
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPIA
- Browse OriGene Inhibitory RNA Products For PPIA
- OriGene qPCR primer pairs for PPIA
- OriGene qPCR primer pairs and template standards for PPIA
- OriGene CRISPR knockouts for PPIA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PPIA
- Sino Biological Human cDNA Clone for PPIA
- Sino Biological Recombinant Proteins for PPIA
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PPIA
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PPIA
- Novus Biologicals proteins and lysates for PPIA
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PPIA
- Abcam proteins for PPIA
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ApexBio compounds for PPIA
- VectorBuilder Custom and pre-made DNA vectors for PPIA (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PPIA (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PPIA (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PPIA CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PPIA
- Addgene plasmids for PPIA
- antibodies-online: Show 67 available PPIA Antibodies ranked by validation data
- Compare Top PPIA Antibodies
- antibodies-online: Show 80 available PPIA Elisa Kits ranked by validation data
- Compare Top PPIA Elisa Kits
- Quality Products:
- antibodies-online: Show 58 available PPIA Proteins ranked by validation data
- Compare Top PPIA Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PPIA
- Search Santa Cruz Biotechnology (SCBT) for PPIA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PPIA
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPIA
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PPIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIA
Sources for PPIA Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136)