Aliases for PPIA Gene
Aliases for PPIA Gene
External Ids for PPIA Gene
- HGNC: 9253
- Entrez Gene: 5478
- Ensembl: ENSG00000196262
- OMIM: 123840
- UniProtKB: P62937
Previous GeneCards Identifiers for PPIA Gene
- GC07P044482
- GC07P044543
- GC07P044577
- GC07P044609
- GC07P044803
- GC07P044841
- GC07P044798
- GC07P044799
- GC07P044800
- GC07P044801
- GC07P044804
- GC07P044805
- GC07P044806
- GC07P044807
Summaries for PPIA Gene
-
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPIA Gene
PPIA (Peptidylprolyl Isomerase A) is a Protein Coding gene. Diseases associated with PPIA include Diffuse Intrinsic Pontine Glioma and Ogden Syndrome. Among its related pathways are Uncoating of the HIV Virion and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include peptide binding. An important paralog of this gene is PPIAL4C.
UniProtKB/Swiss-Prot for PPIA Gene
-
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Additional gene information for PPIA Gene
- Monarch Initiative
- Search for PPIA at DataMed
- Search for PPIA at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIA Gene
Genomics for PPIA Gene
GeneHancer (GH) Regulatory Elements for PPIA Gene
Promoters and enhancers for PPIA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPIA on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PPIA gene promoter:
-
- ZIC2
- AML1a
- ATF
- PPAR-alpha
- SRF (504 AA)
- SRF
- ATF6
- MZF-1
- Nkx3-1 v1
Regulatory Element Products
Genomic Locations for PPIA Gene
Genomic Locations for PPIA Gene
- chr7:44,796,636-44,824,564
- (GRCh38/hg38)
- Size:
- 27,929 bases
- Orientation:
- Plus strand
- chr7:44,836,241-44,864,163
- (GRCh37/hg19)
- Size:
- 27,923 bases
- Orientation:
- Plus strand
Genomic View for PPIA Gene
Genes around PPIA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p13 by Entrez Gene
- 7p13 by HGNC
- 7p13 by Ensembl
PPIA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPIA Gene
Proteins for PPIA Gene
-
Protein details for PPIA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62937-PPIA_HUMAN
- Recommended name:
- Peptidyl-prolyl cis-trans isomerase A
- Protein Accession:
- P62937
- A8K220
- P05092
- Q3KQW3
- Q567Q0
- Q6IBU5
- Q96IX3
- Q9BRU4
- Q9BTY9
- Q9UC61
Protein attributes for PPIA Gene
- Size:
- 165 amino acids
- Molecular mass:
- 18012 Da
- Quaternary structure:
-
- Interacts with HIV-1 Capsid protein.
Three dimensional structures from OCA and Proteopedia for PPIA Gene
Protein Expression for PPIA Gene
Post-translational modifications for PPIA Gene
- Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.
- Glycosylation at Asn108
- Ubiquitination at posLast=155155, posLast=133133, posLast=131131, Lys91, posLast=8282, Lys49, and Lys31
- Modification sites at PhosphoSitePlus
Other Protein References for PPIA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PPIA (Cyclophilin A)
- Novus Biologicals Antibodies for PPIA
-
Abcam antibodies for PPIA
- Invitrogen Antibodies for PPIA
- GeneTex PPIA Antibody for PPIA
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPIA
- Sino Biological Antibodies for PPIA
Protein Products
- R&D Systems Proteins and Enzymes for PPIA (Cyclophilin A)
-
OriGene Purified Proteins for PPIA
- Search Origene for MassSpec and Protein Over-expression Lysates for PPIA
- Origene Custom Protein Services for PPIA
- Sino Biological Recombinant Proteins for PPIA
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for PPIA
- Search GeneTex for Proteins for PPIA
-
Abcam proteins for PPIA
Assay Products
No data available for DME Specific Peptides for PPIA Gene
Domains & Families for PPIA Gene
Gene Families for PPIA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PPIA Gene
Suggested Antigen Peptide Sequences for PPIA Gene
- GenScript: Design optimal peptide antigens:
-
- Peptidyl-prolyl cis-trans isomerase (A8K220_HUMAN)
- Peptidyl-prolyl cis-trans isomerase (B4DM82_HUMAN)
- Peptidyl-prolyl cis-trans isomerase (C9J5S7_HUMAN)
- Rotamase A (PPIA_HUMAN)
- cDNA FLJ75025, highly similar to Homo sapiens peptidylprolyl isomerase A (cyclophilin A) (PPIA), transcript variant 2, mRNA (Q567Q0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62937UniProtKB/Swiss-Prot:
PPIA_HUMAN :- Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
- Family:
-
- Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Function for PPIA Gene
Molecular function for PPIA Gene
- UniProtKB/Swiss-Prot Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
- GENATLAS Biochemistry:
- cyclophilin A,major intracellular receptor for the immunosuppressive agent cyclosporine A,with intrinsic peptidyl-prolyl cis-trans isomerase activity
Enzyme Numbers (IUBMB) for PPIA Gene
Phenotypes From GWAS Catalog for PPIA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IDA | 14993672 |
| GO:0005515 | protein binding | IPI | 12218175 |
| GO:0016018 | cyclosporin A binding | IDA | 12218175 |
| GO:0016853 | isomerase activity | IEA | -- |
Phenotypes for PPIA Gene
- MGI mutant phenotypes for PPIA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PPIA:
-
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased IL-8 secretion
- Increased transferrin (TF) endocytosis
Animal Models for PPIA Gene
- MGI Knock Outs for PPIA:
-
- Ppia Ppia<tm1Lubn>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPIA
-
CRISPR Products
-
OriGene CRISPR knockouts for PPIA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPIA
- genomics-online: gRNA clones - Search results for 188 available PPIA gene related products
- Overview of 188 available PPIA gene related products
- Applied Biological Materials CRISPR for PPIA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIA
- GenScript: Design CRISPR guide RNA sequences for PPIA
miRNA for PPIA Gene
- miRTarBase miRNAs that target PPIA
-
- hsa-mir-1-3p (MIRT023905)
- hsa-mir-1307-3p (MIRT035823)
- hsa-mir-320b (MIRT036191)
- hsa-mir-1226-3p (MIRT036511)
- hsa-mir-760 (MIRT036733)
- hsa-mir-455-3p (MIRT037899)
- hsa-mir-423-5p (MIRT038051)
- hsa-mir-342-5p (MIRT038227)
- hsa-mir-30c-1-3p (MIRT038540)
- hsa-mir-31-3p (MIRT038938)
- hsa-mir-18a-3p (MIRT040751)
- hsa-mir-324-5p (MIRT043038)
- hsa-mir-106b-5p (MIRT044321)
- hsa-mir-320a (MIRT044403)
- hsa-mir-218-5p (MIRT046998)
- hsa-mir-197-3p (MIRT048054)
- hsa-mir-26a-5p (MIRT050185)
- hsa-mir-18a-5p (MIRT050690)
- hsa-mir-17-3p (MIRT050789)
- hsa-mir-3200-3p (MIRT052825)
- hsa-mir-1200 (MIRT452655)
- hsa-mir-876-3p (MIRT452656)
- hsa-mir-323a-5p (MIRT452657)
- hsa-mir-548v (MIRT452658)
- hsa-mir-610 (MIRT452659)
- hsa-mir-1252-5p (MIRT452660)
- hsa-mir-7978 (MIRT452661)
- hsa-mir-4456 (MIRT452662)
- hsa-mir-548q (MIRT452663)
- hsa-mir-4299 (MIRT452664)
- hsa-mir-6845-3p (MIRT452665)
- hsa-mir-1976 (MIRT452666)
- hsa-mir-3653-5p (MIRT452667)
- hsa-mir-544b (MIRT452668)
- hsa-mir-4324 (MIRT452669)
- hsa-mir-4662a-3p (MIRT452670)
- hsa-mir-4668-5p (MIRT526481)
- hsa-mir-3148 (MIRT526482)
- hsa-mir-548ay-3p (MIRT526483)
- hsa-mir-548at-3p (MIRT526484)
- hsa-mir-548z (MIRT526485)
- hsa-mir-548h-3p (MIRT526486)
- hsa-mir-548d-3p (MIRT526487)
- hsa-mir-548bb-3p (MIRT526488)
- hsa-mir-548ac (MIRT526489)
- hsa-mir-6783-5p (MIRT615272)
- hsa-mir-1184 (MIRT761201)
- hsa-mir-1249-5p (MIRT761606)
- hsa-mir-186-3p (MIRT763196)
- hsa-mir-1914-3p (MIRT763398)
- hsa-mir-363-5p (MIRT766230)
- hsa-mir-3907 (MIRT767580)
- hsa-mir-4418 (MIRT768736)
- hsa-mir-4471 (MIRT769473)
- hsa-mir-4651 (MIRT770735)
- hsa-mir-4664-5p (MIRT770815)
- hsa-mir-4802-3p (MIRT772555)
- hsa-mir-509-3-5p (MIRT773264)
- hsa-mir-509-5p (MIRT773302)
- hsa-mir-5194 (MIRT773624)
- hsa-mir-570-3p (MIRT775236)
- hsa-mir-6068 (MIRT775425)
- hsa-mir-608 (MIRT775761)
- hsa-mir-651-3p (MIRT777025)
- hsa-mir-6515-5p (MIRT777041)
- hsa-mir-6737-5p (MIRT778095)
- hsa-mir-6738-5p (MIRT778103)
- hsa-mir-6745 (MIRT778198)
- hsa-mir-6747-5p (MIRT778317)
- hsa-mir-6750-5p (MIRT778342)
- hsa-mir-6782-5p (MIRT779062)
- hsa-mir-6797-5p (MIRT779371)
- hsa-mir-6812-5p (MIRT779775)
- hsa-mir-6819-5p (MIRT779854)
- hsa-mir-6822-5p (MIRT779867)
- hsa-mir-6830-5p (MIRT780002)
- hsa-mir-6880-5p (MIRT780846)
- hsa-mir-6890-5p (MIRT781157)
- hsa-mir-7847-3p (MIRT782162)
- hsa-mir-8059 (MIRT782333)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPIA
- Browse OriGene Inhibitory RNA Products For PPIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIA
- genomics-online: shRNA clones - Search results for 188 available PPIA gene related products
- Overview of 188 available PPIA gene related products
Clone Products
- Sino Biological Human cDNA Clone for PPIA
- VectorBuilder custom plasmid, inducible vectors for PPIA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPIA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PPIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPIA
- Applied Biological Materials Clones for PPIA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIA Gene
Localization for PPIA Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPIA Gene
- Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | HDA | 16502470 |
| GO:0005634 | nucleus | HDA | 16780588 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPIA Gene
Pathways & Interactions for PPIA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.91
.64
.45
|
|
| 2 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 3 | Uncoating of the HIV Virion | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | Necroptosis | ||
Pathways by source for PPIA Gene
1 BioSystems pathway for PPIA Gene
25 Reactome pathways for PPIA Gene
1 PharmGKB pathway for PPIA Gene
1 KEGG pathway for PPIA Gene
1 GeneGo (Thomson Reuters) pathway for PPIA Gene
1 Cell Signaling Technology pathway for PPIA Gene
Interacting Proteins for PPIA Gene
Selected Interacting proteins:
P62937-PPIA_HUMAN
ENSP00000419425
for PPIA Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PPIA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | IDA | 14993672 |
| GO:0006278 | RNA-dependent DNA biosynthetic process | TAS | -- |
| GO:0006457 | protein folding | TAS | 2179953 |
| GO:0016032 | viral process | IEA | -- |
| GO:0019058 | viral life cycle | TAS | -- |
No data available for SIGNOR curated interactions for PPIA Gene
Drugs & Compounds for PPIA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cyclosporin A | Approved, Investigational, Vet_approved | Pharma | Antagonist, Inhibition, Inhibitor, inhibitor, Target | Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor | 0 | |
| L-Proline | Approved | Nutra | Target, binder | 0 | ||
| Copper | Approved, Investigational | Pharma | Target | 202 | ||
| Dihydroartemisinin | Approved, Investigational | Pharma | Target, ligand | 100 | ||
| (3r)-1-Acetyl-3-Methylpiperidine | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(2) ApexBio Compounds for PPIA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cyclosporin A | Immunosuppressive agent | 59865-13-3 |
| TMN 355 | cyclophilin A inhibitor | 1186372-20-2 |
Transcripts for PPIA Gene
mRNA/cDNA for PPIA Gene
- (6) REFSEQ mRNAs :
- (23) Additional mRNA sequences :
- (3717) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000481437 570 bps (uc064djm.1)
- ENST00000451562 544 bps (uc064djn.1)
- ENST00000468812 2238 bps (uc003tlw.4)
- ENST00000489459 907 bps (uc064djo.1)
- ENST00000355968 818 bps (uc064djp.1)
Unigene Clusters for PPIA Gene
- Peptidylprolyl isomerase A (cyclophilin A):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PPIA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPIA
- genomics-online: gRNA clones - Search results for 188 available PPIA gene related products
- Overview of 188 available PPIA gene related products
- Applied Biological Materials CRISPR for PPIA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIA
- GenScript: Design CRISPR guide RNA sequences for PPIA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPIA
- Browse OriGene Inhibitory RNA Products For PPIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIA
- genomics-online: shRNA clones - Search results for 188 available PPIA gene related products
- Overview of 188 available PPIA gene related products
Clone Products
- Sino Biological Human cDNA Clone for PPIA
- VectorBuilder custom plasmid, inducible vectors for PPIA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPIA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PPIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPIA
- Applied Biological Materials Clones for PPIA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: | - | - | |||||||||||||||
| SP4: | - |
Expression for PPIA Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPIA Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PPIA Gene:
PPIASOURCE GeneReport for Unigene cluster for PPIA Gene:
Hs.356331Evidence on tissue expression from TISSUES for PPIA Gene
- Liver(5)
- Nervous system(5)
- Lung(4.9)
- Blood(4.8)
- Skin(4.8)
- Intestine(4.7)
- Pancreas(4.7)
- Kidney(4.5)
- Eye(4.4)
- Stomach(4.1)
- Muscle(3.8)
- Heart(3.3)
- Bone(3.2)
- Spleen(3)
- Lymph node(2.8)
- Bone marrow(2.5)
- Adrenal gland(2.1)
- Gall bladder(2)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PPIA
-
OriGene qPCR primer pairs for PPIA
- genomics-online: primer clones - Search results for 188 available PPIA gene related products
- Overview of 188 available PPIA gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIA Gene
Orthologs for PPIA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PPIA 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gm10123 34 |
|
OneToMany | |
| Ppia 16 34 33 |
|
||||
| Gm5160 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | LOC100337215 33 |
|
||
| PPIA 34 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| rat (Rattus norvegicus) |
Mammalia | LOC100360977 33 |
|
||
| dog (Canis familiaris) |
Mammalia | PPIA 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | PPIA 34 33 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100496569 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398630 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ppiaa 33 |
|
||
| PPIA 34 |
|
OneToMany | |||
| wufd61c06 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7768 35 |
|
|
|
| Cyp1 35 |
|
|
|||
| CG5071 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | cyp-3 35 |
|
|
|
| cyn-1 33 |
|
||||
| cyp-7 35 |
|
|
|||
| cyp-8 35 |
|
|
|||
| T22F3.12 34 |
|
ManyToMany | |||
| Y17G9B.4 34 |
|
ManyToMany | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER156C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B04565g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CPR3 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | ROC2 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.12280 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os09g0571400 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2570 34 |
|
OneToMany |
- Species where no ortholog for PPIA was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PPIA Gene
- ENSEMBL:
- Gene Tree for PPIA (if available)
- TreeFam:
- Gene Tree for PPIA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPIA: view image
Paralogs for PPIA Gene
Paralogs for PPIA Gene
(24) SIMAP similar genes for PPIA Gene using alignment to 5 proteins:
- PPIA_HUMAN
- C9J5S7_HUMAN
- E5RIZ5_HUMAN
- F8WE65_HUMAN
- Q567Q0_HUMAN
Pseudogenes.org Pseudogenes for PPIA Gene
- PGOHUM00000290347
- PGOHUM00000290518
- PGOHUM00000290883
- PGOHUM00000291115
- PGOHUM00000291323
- PGOHUM00000291441
- PGOHUM00000291600
- PGOHUM00000291877
- PGOHUM00000291883
- PGOHUM00000292025
- PGOHUM00000292051
- PGOHUM00000292144
- PGOHUM00000292161
- PGOHUM00000292390
- PGOHUM00000292634
- PGOHUM00000292685
- PGOHUM00000293293
- PGOHUM00000293299
- PGOHUM00000293669
- PGOHUM00000293888
- PGOHUM00000293902
- PGOHUM00000293908
- PGOHUM00000294268
- PGOHUM00000294274
- PGOHUM00000294431
- PGOHUM00000294514
- PGOHUM00000294531
- PGOHUM00000294573
- PGOHUM00000294630
- PGOHUM00000294731
- PGOHUM00000295068
- PGOHUM00000295210
- PGOHUM00000295326
- PGOHUM00000295587
- PGOHUM00000295652
- PGOHUM00000295769
- PGOHUM00000296307
- PGOHUM00000296308
- PGOHUM00000296612
- PGOHUM00000296905
- PGOHUM00000297116
- PGOHUM00000297124
- PGOHUM00000297144
- PGOHUM00000297231
- PGOHUM00000297858
- PGOHUM00000298232
- PGOHUM00000298375
- PGOHUM00000298390
- PGOHUM00000298442
- PGOHUM00000298462
- PGOHUM00000298680
- PGOHUM00000298798
- PGOHUM00000298856
- PGOHUM00000298857
- PGOHUM00000299032
- PGOHUM00000299044
- PGOHUM00000299046
- PGOHUM00000299124
- PGOHUM00000299194
- PGOHUM00000299283
- PGOHUM00000299422
- PGOHUM00000299446
- PGOHUM00000299625
- PGOHUM00000299656
- PGOHUM00000300363
- PGOHUM00000300569
- PGOHUM00000300661
- PGOHUM00000300977
- PGOHUM00000301327
- PGOHUM00000301328
- PGOHUM00000301680
- PGOHUM00000302083
- PGOHUM00000302358
- PGOHUM00000302472
- PGOHUM00000302820
- PGOHUM00000303146
- PGOHUM00000303562
- PGOHUM00000303575
- PGOHUM00000303941
- PGOHUM00000304024
- PGOHUM00000304105
- PGOHUM00000306644
- PGOHUM00000304774
- PGOHUM00000304780
- PGOHUM00000305390
- PGOHUM00000289017
- PGOHUM00000289018
- PGOHUM00000306856
- PGOHUM00000306857
- PGOHUM00000289180
- PGOHUM00000289181
- PGOHUM00000289278
- PGOHUM00000289279
- PGOHUM00000289370
- PGOHUM00000289371
- PGOHUM00000289460
- PGOHUM00000289461
- PGOHUM00000306956
- PGOHUM00000306957
- PGOHUM00000289756
- PGOHUM00000289786
- PGOHUM00000289909
- PGOHUM00000289986
- PGOHUM00000289996
- PGOHUM00000290017
- PGOHUM00000290286
Variants for PPIA Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000118396 | -- | 44,794,786(+) | C/T | upstream_transcript_variant | |
| rs1000249398 | -- | 44,802,504(+) | T/G | 3_prime_UTR_variant | |
| rs1000292328 | -- | 44,799,505(+) | T/C | intron_variant | |
| rs1000444121 | -- | 44,797,562(+) | T/C | intron_variant | |
| rs1000628094 | -- | 44,797,306(+) | G/A/T | intron_variant |
Residual Variation Intolerance Score:
46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.14;
3.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPIA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIA Gene
Disorders for PPIA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diffuse intrinsic pontine glioma |
|
|
| ogden syndrome |
|
|
| wolfram syndrome 2 |
|
|
| nodular nonsuppurative panniculitis |
|
|
| retinitis pigmentosa 14 |
|
|
Search PPIA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPIA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PPIA Gene
Publications for PPIA Gene
- Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (PMID: 17590083) An P … Winkler CA (PLoS pathogens 2007) 3 22 44 58
- Characterization of the human cyclophilin gene and of related processed pseudogenes. (PMID: 2197089) Haendler B … Hofer E (European journal of biochemistry 1990) 2 3 4 58
- EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. (PMID: 19758589) Seizer P … May AE (Atherosclerosis 2010) 3 22 58
- Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. (PMID: 20364129) Lammers M … James LC (Nature chemical biology 2010) 3 4 58
- Cyclophilin A: potential functions and therapeutic target for human cancer. (PMID: 19865066) Obchoei S … Chen C (Medical science monitor : international medical journal of experimental and clinical research 2009) 3 22 58
Products for PPIA Gene
- R&D Systems Antibodies for PPIA (Cyclophilin A)
- R&D Systems Proteins and Enzymes for PPIA (Cyclophilin A)
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PPIA
- Search Origene for MassSpec and Protein Over-expression Lysates for PPIA
- Origene Custom Protein Services for PPIA
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- Browse OriGene Inhibitory RNA Products For PPIA
- OriGene qPCR primer pairs and template standards for PPIA
- OriGene qPCR primer pairs for PPIA
- OriGene CRISPR knockouts for PPIA
- OriGene ORF clones in human for PPIA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PPIA
- GenScript: Next-day shipping of latest version cDNA ORF clones for PPIA in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PPIA
- GenScript Custom Assay Services for PPIA
- GenScript Custom overexpressing Cell Line Services for PPIA
- GenScript: Design CRISPR guide RNA sequences for PPIA
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PPIA
- Sino Biological Human cDNA Clone for PPIA
- Sino Biological Recombinant Proteins for PPIA
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PPIA
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PPIA
- Novus Biologicals proteins and lysates for PPIA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PPIA
- Abcam proteins for PPIA
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for PPIA
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPIA
- VectorBuilder custom plasmid, inducible vectors for PPIA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPIA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PPIA
- antibodies-online: Search results for 234 available PPIA Antibodies ranked by validation data
- Compare Top PPIA Antibodies
- antibodies-online: Search results for 53 available PPIA Elisa Kits ranked by validation data
- Compare Top PPIA Elisa Kits
- antibodies-online: Search results for 57 available PPIA Proteins ranked by validation data
- Compare Top PPIA Proteins
- GeneTex PPIA Antibody for PPIA
- Search GeneTex for Proteins for PPIA
- Santa Cruz Biotechnology (SCBT) Antibodies for PPIA
- Search Santa Cruz Biotechnology (SCBT) for PPIA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PPIA
- genomics-online: cdna clones - Search results for 188 available PPIA gene related products
- Overview of 188 available PPIA gene related products
- orf clones - Search results for 188 available PPIA gene related products
- Overview of 188 available PPIA gene related products
- genomics-online: gRNA clones - Search results for 188 available PPIA gene related products
- Overview of 188 available PPIA gene related products
- genomics-online: primer clones - Search results for 188 available PPIA gene related products
- Overview of 188 available PPIA gene related products
- genomics-online: shRNA clones - Search results for 188 available PPIA gene related products
- Overview of 188 available PPIA gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPIA
- GeneCopoeia miRNA 3'UTR Target clone products for PPIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPIA