Aliases for PPFIBP1 Gene
External Ids for PPFIBP1 Gene
Previous GeneCards Identifiers for PPFIBP1 Gene
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPFIBP1 Gene
PPFIBP1 (PPFIA Binding Protein 1) is a Protein Coding gene. Diseases associated with PPFIBP1 include Inflammatory Myofibroblastic Tumor and Fuchs' Endothelial Dystrophy. Among its related pathways are Neuroscience and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include integrase activity. An important paralog of this gene is PPFIBP2.
UniProtKB/Swiss-Prot Summary for PPFIBP1 Gene
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.