Aliases for PPEF2 Gene
External Ids for PPEF2 Gene
Previous GeneCards Identifiers for PPEF2 Gene
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPEF2 Gene
PPEF2 (Protein Phosphatase With EF-Hand Domain 2) is a Protein Coding gene. Diseases associated with PPEF2 include Retinal Degeneration and Hypophosphatasia, Adult. Among its related pathways are Visual Cycle in Retinal Rods. Gene Ontology (GO) annotations related to this gene include calcium ion binding and iron ion binding. An important paralog of this gene is PPEF1.
UniProtKB/Swiss-Prot Summary for PPEF2 Gene
May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.