Aliases for PPAT Gene
External Ids for PPAT Gene
Previous GeneCards Identifiers for PPAT Gene
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]
GeneCards Summary for PPAT Gene
PPAT (Phosphoribosyl Pyrophosphate Amidotransferase) is a Protein Coding gene. Diseases associated with PPAT include Phosphoribosylpyrophosphate Synthetase Superactivity and Immunodeficiency 24. Among its related pathways are One carbon pool by folate and AMPK Enzyme Complex Pathway. Gene Ontology (GO) annotations related to this gene include 4 iron, 4 sulfur cluster binding and amidophosphoribosyltransferase activity.