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Aliases for PPARD Gene

Aliases for PPARD Gene

  • Peroxisome Proliferator Activated Receptor Delta 2 3 5
  • Peroxisome Proliferator-Activated Receptor Delta 2 3
  • Peroxisome Proliferator-Activated Receptor Beta 3 4
  • Nuclear Receptor Subfamily 1 Group C Member 2 3 4
  • Nuclear Hormone Receptor 1 3 4
  • PPAR-Delta 3 4
  • PPAR-Beta 3 4
  • NR1C2 3 4
  • PPARB 3 4
  • NUC1 3 4
  • NUCI 3 4
  • Peroxisome Proliferative Activated Receptor, Delta 2
  • PPARD/MYO1D Fusion 3
  • NUCII 3
  • FAAR 3

External Ids for PPARD Gene

Previous GeneCards Identifiers for PPARD Gene

  • GC06U990097
  • GC06P035306
  • GC06P035357
  • GC06P035418
  • GC06P035031
  • GC06P035310
  • GC06P035472
  • GC06P035533
  • GC06P037761
  • GC06P038385
  • GC06P038975
  • GC06P039563
  • GC06P040124

Summaries for PPARD Gene

Entrez Gene Summary for PPARD Gene

  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

GeneCards Summary for PPARD Gene

PPARD (Peroxisome Proliferator Activated Receptor Delta) is a Protein Coding gene. Diseases associated with PPARD include Diabetic Cataract and Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2. Among its related pathways are Ectoderm Differentiation and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is PPARA.

UniProtKB/Swiss-Prot for PPARD Gene

  • Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

Tocris Summary for PPARD Gene

  • Peroxisome proliferator-activated receptor delta (PPARdelta), also known as PPARbeta, is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

Gene Wiki entry for PPARD Gene

Additional gene information for PPARD Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPARD Gene

Genomics for PPARD Gene

GeneHancer (GH) Regulatory Elements for PPARD Gene

Promoters and enhancers for PPARD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I035341 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 561.3 +0.7 690 3.2 HDGF HNRNPUL1 PKNOX1 MLX ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 PPARD FANCE TAF11 FKBP5 RPS10 RPL10A TEAD3 BRPF3 ENSG00000219023 MAPK14
GH06I035366 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 31.7 +27.0 26979 5.3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 IRF4 SLC30A9 FOS PPARD DEF6 UHRF1BP1 SNRPC ARMC12 C6orf106 ZNF76 RPL10A GC06P042385
GH06I035467 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.1 +127.6 127582 5.4 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 RPL10A MIR7111 TAF11 BRPF3 ZNF76 ENSG00000272374 FANCE PPARD ARMC12 ANKS1A
GH06I035723 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.9 +386.5 386539 10.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 MCM3 SP3 NFYC FKBP5 TAF11 SRSF3 ZNF76 ENSG00000272374 RPL10A STK38 ENSG00000219023 FANCE PPARD
GH06I035317 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 11.9 -23.9 -23918 1.6 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 ZNF548 SP3 SP5 ZNF76 TAF11 ENSG00000272374 DEF6 PPARD TCP11 TEAD3 TULP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPARD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPARD gene promoter:

Genomic Locations for PPARD Gene

Genomic Locations for PPARD Gene
chr6:35,342,558-35,428,191
(GRCh38/hg38)
Size:
85,634 bases
Orientation:
Plus strand
chr6:35,310,335-35,395,968
(GRCh37/hg19)

Genomic View for PPARD Gene

Genes around PPARD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPARD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPARD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPARD Gene

Proteins for PPARD Gene

  • Protein details for PPARD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03181-PPARD_HUMAN
    Recommended name:
    Peroxisome proliferator-activated receptor delta
    Protein Accession:
    Q03181
    Secondary Accessions:
    • A8K6J6
    • B4E3V3
    • B6ZGS1
    • B7Z3W1
    • E9PE18
    • Q5D1P0
    • Q7Z5K0
    • Q9BUD4

    Protein attributes for PPARD Gene

    Size:
    441 amino acids
    Molecular mass:
    49903 Da
    Quaternary structure:
    • Heterodimer with the retinoid X receptor.

    Three dimensional structures from OCA and Proteopedia for PPARD Gene

    Alternative splice isoforms for PPARD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPARD Gene

Post-translational modifications for PPARD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPARD Gene

Domains & Families for PPARD Gene

Gene Families for PPARD Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

Q03181

UniProtKB/Swiss-Prot:

PPARD_HUMAN :
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with PPARD: view

Function for PPARD Gene

Molecular function for PPARD Gene

GENATLAS Biochemistry:
Peroxisome proliferator-activated receptor delta,heterodimerizing with RXR*,steroid/thyroid hormone receptor superfamily,expressed in preadipocyte and expressed at low level in colorectal mucosa,highly expressed in CR carcinomal,down- regulated by APC through beta-catenin/TCF4 inactivation,target of nonsteroidal inflammatory drugs
UniProtKB/Swiss-Prot Function:
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

Phenotypes From GWAS Catalog for PPARD Gene

Gene Ontology (GO) - Molecular Function for PPARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS --
GO:0003677 DNA binding ISS --
GO:0003700 DNA binding transcription factor activity NAS 11551955
GO:0003707 steroid hormone receptor activity IEA,TAS --
GO:0003713 transcription coactivator activity IEA --
genes like me logo Genes that share ontologies with PPARD: view
genes like me logo Genes that share phenotypes with PPARD: view

Animal Models for PPARD Gene

MGI Knock Outs for PPARD:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPARD

CRISPR Products

Clone Products

  • Addgene plasmids for PPARD

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPARD Gene

Localization for PPARD Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPARD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPARD gene
Compartment Confidence
nucleus 5
peroxisome 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PPARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISS --
GO:0005634 nucleus NAS 11551955
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PPARD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPARD Gene

Pathways & Interactions for PPARD Gene

genes like me logo Genes that share pathways with PPARD: view

SIGNOR curated interactions for PPARD Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PPARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0001890 placenta development IEA --
GO:0006006 glucose metabolic process NAS 15793256
GO:0006029 proteoglycan metabolic process IEA --
GO:0006091 generation of precursor metabolites and energy TAS 1333051
genes like me logo Genes that share ontologies with PPARD: view

Drugs & Compounds for PPARD Gene

(88) Drugs for PPARD Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bezafibrate Approved, Investigational Pharma Agonist, Target, agonist 14
Fenofibrate Approved Pharma Target 173
Pioglitazone Approved, Investigational Pharma Full agonist, Agonist, Target 446
Sulindac Approved, Investigational Pharma Target, negative modulator Anti-inflammatory agent;COX inhibitor 36
Treprostinil Approved, Investigational Pharma Full agonist, Agonist, Target, agonist 92

(58) Additional Compounds for PPARD Gene - From: HMDB, Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
GW 0742
317318-84-6
all-trans-retinoic acid
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • Acide retinoique (French)
Full agonist, Agonist 302-79-4
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2

(5) Tocris Compounds for PPARD Gene

Compound Action Cas Number
GSK 0660 Selective PPARdelta antagonist 1014691-61-2
GSK 3787 Potent and selective PPARdelta antagonist 188591-46-0
GW 0742 Highly selective, potent PPARdelta agonist 317318-84-6
GW 501516 Potent and selective PPARdelta agonist 317318-70-0
L-165,041 Potent PPARdelta agonist 79558-09-1

(28) ApexBio Compounds for PPARD Gene

Compound Action Cas Number
15-deoxy-Δ-12,14-Prostaglandin J2 87893-55-8
2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2- methylphenoxy)acetic acid 317318-70-0
Aleglitazar PPARα/PPARγagonist 475479-34-6
AUDA 479413-70-2
BADGE 1675-54-3
Balaglitazone PPAR-γ partial agonist 199113-98-9
Bezafibrate 41859-67-0
Ciglitazone 74772-77-3
Ciprofibrate 52214-84-3
CP 775146 702680-17-9
Fenofibrate 49562-28-9
Gemfibrozil 25812-30-0
GSK 0660 1014691-61-2
GSK3787 PPARβ/δ antagonist,novel and irreversible 188591-46-0
GW 7647 265129-71-3
GW0742 PPARδ/β agonist,potent and selective 317318-84-6
GW501516 PPARβ agonist,selective and potent 317318-70-0
GW9662 PPARγ antagonist 22978-25-2
Inolitazone dihydrochloride PPARγ agonist,high-affinity and novel 223132-38-5
L-165041 PPARβ/δ agonist,cell permeable,potent and selective 79558-09-1
nTZDpa 118414-59-8
Pioglitazone 111025-46-8
Rosiglitazone HCl 302543-62-0
Rosiglitazone maleate PPARγ agonist,high-affinity and selective,potent insulin sensitizer 155141-29-0
S26948 353280-43-0
SR 1664 1338259-05-4
SR 202 PPAR antagonist 76541-72-5
Tesaglitazar 251565-85-2
genes like me logo Genes that share compounds with PPARD: view

Drug Products

Transcripts for PPARD Gene

Unigene Clusters for PPARD Gene

Peroxisome proliferator-activated receptor delta:
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for PPARD

Alternative Splicing Database (ASD) splice patterns (SP) for PPARD Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - -
SP15: -
SP16:

ExUns: 15c · 15d ^ 16a · 16b ^ 17a · 17b
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for PPARD Gene

GeneLoc Exon Structure for
PPARD
ECgene alternative splicing isoforms for
PPARD

Expression for PPARD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPARD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPARD Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPARD Gene



Protein tissue co-expression partners for PPARD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPARD Gene:

PPARD

SOURCE GeneReport for Unigene cluster for PPARD Gene:

Hs.696032

mRNA Expression by UniProt/SwissProt for PPARD Gene:

Q03181-PPARD_HUMAN
Tissue specificity: Ubiquitous with maximal levels in placenta and skeletal muscle.

Evidence on tissue expression from TISSUES for PPARD Gene

  • Nervous system(4.9)
  • Spleen(4.2)
  • Muscle(2.6)
  • Intestine(2.2)
  • Blood(2)
  • Heart(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with PPARD: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPARD Gene

Orthologs for PPARD Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPARD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPARD 34 33
  • 99.32 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPARD 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPARD 33 34
  • 91.93 (n)
dog
(Canis familiaris)
Mammalia PPARD 33 34
  • 91.69 (n)
mouse
(Mus musculus)
Mammalia Ppard 33 16 34
  • 89.51 (n)
oppossum
(Monodelphis domestica)
Mammalia PPARD 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppard 33
  • 88.78 (n)
chicken
(Gallus gallus)
Aves PPARD 33 34
  • 83.05 (n)
lizard
(Anolis carolinensis)
Reptilia PPARD 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppard 33
  • 69 (n)
Str.16577 33
zebrafish
(Danio rerio)
Actinopterygii ppardb 33 34
  • 74.45 (n)
pparda 34
  • 64 (a)
OneToMany
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12140 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToMany
Species where no ortholog for PPARD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPARD Gene

ENSEMBL:
Gene Tree for PPARD (if available)
TreeFam:
Gene Tree for PPARD (if available)

Paralogs for PPARD Gene

Paralogs for PPARD Gene

(14) SIMAP similar genes for PPARD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PPARD: view

Variants for PPARD Gene

Sequence variations from dbSNP and Humsavar for PPARD Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000019728 -- 35,403,674(+) A/C intron_variant
rs1000051294 -- 35,361,049(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000080536 -- 35,397,827(+) C/T intron_variant
rs1000097614 -- 35,350,634(+) T/C/G genic_upstream_transcript_variant, intron_variant
rs1000133157 -- 35,398,043(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPARD Gene

Variant ID Type Subtype PubMed ID
esv2661487 CNV deletion 23128226
esv3449331 CNV insertion 20981092
esv3567626 CNV deletion 23714750
esv3608676 CNV loss 21293372
esv3608678 CNV loss 21293372
nsv462907 CNV loss 19166990
nsv470812 CNV loss 18288195
nsv519370 CNV loss 19592680
nsv528351 CNV loss 19592680
nsv602907 CNV loss 21841781
nsv602908 CNV loss 21841781
nsv602909 CNV loss 21841781
nsv602910 CNV loss 21841781
nsv830641 CNV loss 17160897

Variation tolerance for PPARD Gene

Residual Variation Intolerance Score: 5.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPARD Gene

Human Gene Mutation Database (HGMD)
PPARD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPARD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPARD Gene

Disorders for PPARD Gene

MalaCards: The human disease database

(5) MalaCards diseases for PPARD Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PPARD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PPARD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PPARD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPARD Gene

Publications for PPARD Gene

  1. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. (PMID: 10198642) Xu HE … Milburn MV (Molecular cell 1999) 3 4 22 25 58
  2. Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: a genetics of diabetes audit and research Tayside study. (PMID: 20200337) Burch LR … Palmer CN (The Journal of clinical endocrinology and metabolism 2010) 3 22 44 58
  3. Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. (PMID: 19208777) Kotronen A … Fisher RM (European journal of endocrinology 2009) 3 22 44 58
  4. RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study. (PMID: 19303973) Müssig K … Häring HU (Metabolism: clinical and experimental 2009) 3 22 44 58
  5. A single nucleotide polymorphism on exon-4 of the gene encoding PPARdelta is associated with reduced height in adults and children. (PMID: 19383774) Burch LR … Palmer CN (The Journal of clinical endocrinology and metabolism 2009) 3 22 44 58

Products for PPARD Gene

  • Addgene plasmids for PPARD