This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsis... See more...

Aliases for PPARD Gene

Aliases for PPARD Gene

  • Peroxisome Proliferator Activated Receptor Delta 2 3 5
  • Peroxisome Proliferator-Activated Receptor Delta 2 3 4
  • NR1C2 2 3 4
  • NUC1 2 3 4
  • Peroxisome Proliferator-Activated Receptor Beta 3 4
  • Nuclear Receptor Subfamily 1 Group C Member 2 3 4
  • Nuclear Hormone Receptor 1 3 4
  • PPAR-Delta 3 4
  • PPAR-Beta 3 4
  • NUCII 2 3
  • PPARB 3 4
  • FAAR 2 3
  • NUCI 3 4
  • Peroxisome Proliferative Activated Receptor, Delta 2
  • PPARD/MYO1D Fusion 3
  • PPARD 5

External Ids for PPARD Gene

Previous GeneCards Identifiers for PPARD Gene

  • GC06U990097
  • GC06P035306
  • GC06P035357
  • GC06P035418
  • GC06P035031
  • GC06P035310
  • GC06P035472
  • GC06P035533
  • GC06P042785
  • GC06P043121
  • GC06P043340
  • GC06P046031
  • GC06P037761
  • GC06P038385
  • GC06P038975
  • GC06P039563
  • GC06P040124
  • GC06P041189
  • GC06P041875
  • GC06P042518
  • GC06P047435
  • GC06P049491

Summaries for PPARD Gene

Entrez Gene Summary for PPARD Gene

  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

GeneCards Summary for PPARD Gene

PPARD (Peroxisome Proliferator Activated Receptor Delta) is a Protein Coding gene. Diseases associated with PPARD include Diabetic Cataract and Abdominal Obesity-Metabolic Syndrome 1. Among its related pathways are Signaling by Retinoic Acid and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is PPARA.

UniProtKB/Swiss-Prot Summary for PPARD Gene

  • Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

Tocris Summary for PPARD Gene

  • Peroxisome proliferator-activated receptor delta (PPARdelta), also known as PPARbeta, is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

Gene Wiki entry for PPARD Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPARD Gene

Genomics for PPARD Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPARD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPARD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPARD

Top Transcription factor binding sites by QIAGEN in the PPARD gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • c-Rel
  • PPAR-gamma1
  • PPAR-gamma2
  • TBP
  • TFIID

Genomic Locations for PPARD Gene

Latest Assembly
chr6:35,342,558-35,428,191
(GRCh38/hg38)
Size:
85,634 bases
Orientation:
Plus strand

Previous Assembly
chr6:35,310,335-35,395,955
(GRCh37/hg19 by Entrez Gene)
Size:
85,621 bases
Orientation:
Plus strand

chr6:35,310,335-35,395,968
(GRCh37/hg19 by Ensembl)
Size:
85,634 bases
Orientation:
Plus strand

Genomic View for PPARD Gene

Genes around PPARD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPARD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPARD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPARD Gene

Proteins for PPARD Gene

  • Protein details for PPARD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03181-PPARD_HUMAN
    Recommended name:
    Peroxisome proliferator-activated receptor delta
    Protein Accession:
    Q03181
    Secondary Accessions:
    • A8K6J6
    • B4E3V3
    • B6ZGS1
    • B7Z3W1
    • E9PE18
    • Q5D1P0
    • Q7Z5K0
    • Q9BUD4

    Protein attributes for PPARD Gene

    Size:
    441 amino acids
    Molecular mass:
    49903 Da
    Quaternary structure:
    • Heterodimer with the retinoid X receptor. Interacts (via domain NR LBD) with CRY1 and CRY2 in a ligand-dependent manner (By similarity).

    Three dimensional structures from OCA and Proteopedia for PPARD Gene

    Alternative splice isoforms for PPARD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPARD Gene

Post-translational modifications for PPARD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

No data available for DME Specific Peptides for PPARD Gene

Domains & Families for PPARD Gene

Gene Families for PPARD Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for PPARD Gene

InterPro:
Blocks:
  • Steroid hormone receptor signature
  • Peroxisome proliferator-activated receptor (1C nuclear receptor) signature
  • Peroxisome proliferator-activated receptor beta signature

Suggested Antigen Peptide Sequences for PPARD Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61623, highly similar to Peroxisome proliferator-activated receptor delta (B7Z3W1_HUMAN)
  • Peroxisome proliferator-activated nuclear receptor beta/delta variant 2 (F1D8S7_HUMAN)
  • Peroxisome proliferator-activated receptor beta (PPARD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q03181

UniProtKB/Swiss-Prot:

PPARD_HUMAN :
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with PPARD: view

Function for PPARD Gene

Molecular function for PPARD Gene

UniProtKB/Swiss-Prot Function:
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
GENATLAS Biochemistry:
Peroxisome proliferator-activated receptor delta,heterodimerizing with RXR*,steroid/thyroid hormone receptor superfamily,expressed in preadipocyte and expressed at low level in colorectal mucosa,highly expressed in CR carcinomal,down- regulated by APC through beta-catenin/TCF4 inactivation,target of nonsteroidal inflammatory drugs

Phenotypes From GWAS Catalog for PPARD Gene

Gene Ontology (GO) - Molecular Function for PPARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001103 RNA polymerase II repressing transcription factor binding IBA 21873635
GO:0001223 transcription coactivator binding IPI 15001550
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific ISS --
genes like me logo Genes that share ontologies with PPARD: view
genes like me logo Genes that share phenotypes with PPARD: view

Animal Models for PPARD Gene

MGI Knock Outs for PPARD:

Animal Models for research

  • Taconic Biosciences Mouse Models for PPARD

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPARD

Clone products for research

  • Addgene plasmids for PPARD

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPARD Gene

Localization for PPARD Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPARD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPARD gene
Compartment Confidence
nucleus 5
peroxisome 3
plasma membrane 2
extracellular 2
mitochondrion 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PPARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISS --
GO:0005634 nucleus NAS 11551955
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PPARD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPARD Gene

Pathways & Interactions for PPARD Gene

genes like me logo Genes that share pathways with PPARD: view

Pathways by source for PPARD Gene

1 GeneGo (Thomson Reuters) pathway for PPARD Gene
  • Transcription PPAR Pathway
2 Qiagen pathways for PPARD Gene
  • PPAR Pathway
  • WNT Signaling

SIGNOR curated interactions for PPARD Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0001890 placenta development IEA --
GO:0006006 glucose metabolic process NAS 15793256
GO:0006029 proteoglycan metabolic process IEA --
GO:0006091 generation of precursor metabolites and energy TAS 1333051
genes like me logo Genes that share ontologies with PPARD: view

Drugs & Compounds for PPARD Gene

(87) Drugs for PPARD Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bezafibrate Approved, Investigational Pharma Target, agonist 20
Sulindac Approved, Investigational Pharma Target, negative modulator Anti-inflammatory agent;COX inhibitor 39
Treprostinil Approved, Investigational Pharma Target, agonist 113
Icosapent Approved Nutra Target, agonist Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation 0
Tretinoin Approved, Investigational Nutra Agonist, Full agonist, binder 288

(55) Additional Compounds for PPARD Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9
GW 0742
317318-84-6
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • Dodecenoyl-CoA
  • Dodecenoyl+2-dodecenoyl, (e)-isomer
  • Dodecenoyl-coenzyme A
  • Dodecenoyl+2-dodecenoyl
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1

(5) Tocris Compounds for PPARD Gene

Compound Action Cas Number
GSK 0660 Selective PPARdelta antagonist 1014691-61-2
GSK 3787 Potent and selective PPARdelta antagonist 188591-46-0
GW 0742 Highly selective, potent PPARdelta agonist 317318-84-6
GW 501516 Potent and selective PPARdelta agonist 317318-70-0
L-165,041 Potent PPARdelta agonist 79558-09-1

(25) ApexBio Compounds for PPARD Gene

Compound Action Cas Number
15-deoxy-Δ-12,14-Prostaglandin J2 87893-55-8
AUDA 479413-70-2
BADGE 1675-54-3
Balaglitazone PPAR-γ partial agonist 199113-98-9
Bezafibrate 41859-67-0
Ciglitazone 74772-77-3
Ciprofibrate 52214-84-3
CP 775146 702680-17-9
Fenofibrate 49562-28-9
Gemfibrozil 25812-30-0
GSK 0660 1014691-61-2
GSK3787 PPARβ/δ antagonist,novel and irreversible 188591-46-0
GW 7647 265129-71-3
GW0742 PPARδ/β agonist,potent and selective 317318-84-6
GW501516 PPARβ agonist,selective and potent 317318-70-0
GW9662 PPARγ antagonist 22978-25-2
Inolitazone dihydrochloride PPARγ agonist,high-affinity and novel 223132-38-5
L-165041 PPARβ/δ agonist,cell permeable,potent and selective 79558-09-1
Pioglitazone 111025-46-8
Rosiglitazone HCl 302543-62-0
Rosiglitazone maleate PPARγ agonist,high-affinity and selective,potent insulin sensitizer 155141-29-0
S26948 353280-43-0
SR 1664 1338259-05-4
SR 202 PPAR antagonist 76541-72-5
Tesaglitazar 251565-85-2
genes like me logo Genes that share compounds with PPARD: view

Drug products for research

Transcripts for PPARD Gene

mRNA/cDNA for PPARD Gene

5 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPARD

Clone products for research

  • Addgene plasmids for PPARD

Alternative Splicing Database (ASD) splice patterns (SP) for PPARD Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - -
SP15: -
SP16:

ExUns: 15c · 15d ^ 16a · 16b ^ 17a · 17b
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for PPARD Gene

GeneLoc Exon Structure for
PPARD

Expression for PPARD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPARD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPARD Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPARD Gene



Protein tissue co-expression partners for PPARD Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPARD

SOURCE GeneReport for Unigene cluster for PPARD Gene:

Hs.696032

mRNA Expression by UniProt/SwissProt for PPARD Gene:

Q03181-PPARD_HUMAN
Tissue specificity: Ubiquitous with maximal levels in placenta and skeletal muscle.

Evidence on tissue expression from TISSUES for PPARD Gene

  • Nervous system(4.9)
  • Spleen(4.4)
  • Muscle(2.6)
  • Skin(2.4)
  • Intestine(2.3)
  • Heart(2.3)
  • Blood(2.3)
  • Thyroid gland(2.1)
  • Liver(2.1)
  • Kidney(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with PPARD: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPARD Gene

Orthologs for PPARD Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPARD Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPARD 29 30
  • 99.32 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPARD 30
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PPARD 29 30
  • 91.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPARD 29 30
  • 91.69 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ppard 29 16 30
  • 89.51 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPARD 30
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppard 29
  • 88.78 (n)
Chicken
(Gallus gallus)
Aves PPARD 29 30
  • 83.05 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPARD 30
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppard 29
  • 69 (n)
Str.16577 29
Zebrafish
(Danio rerio)
Actinopterygii ppardb 29 30
  • 74.45 (n)
OneToMany
pparda 30
  • 64 (a)
OneToMany
-- 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12140 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 25 (a)
OneToMany
Species where no ortholog for PPARD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PPARD Gene

ENSEMBL:
Gene Tree for PPARD (if available)
TreeFam:
Gene Tree for PPARD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPARD: view image
Alliance of Genome Resources:
Additional Orthologs for PPARD

Paralogs for PPARD Gene

(14) SIMAP similar genes for PPARD Gene using alignment to 3 proteins:

  • PPARD_HUMAN
  • F5H830_HUMAN
  • L8EBG7_HUMAN
genes like me logo Genes that share paralogs with PPARD: view

Variants for PPARD Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPARD Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PPARD Gene

Variant ID Type Subtype PubMed ID
esv2661487 CNV deletion 23128226
esv3449331 CNV insertion 20981092
esv3567626 CNV deletion 23714750
esv3608676 CNV loss 21293372
esv3608678 CNV loss 21293372
nsv462907 CNV loss 19166990
nsv470812 CNV loss 18288195
nsv519370 CNV loss 19592680
nsv528351 CNV loss 19592680
nsv602907 CNV loss 21841781
nsv602908 CNV loss 21841781
nsv602909 CNV loss 21841781
nsv602910 CNV loss 21841781
nsv830641 CNV loss 17160897

Variation tolerance for PPARD Gene

Residual Variation Intolerance Score: 5.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPARD Gene

Human Gene Mutation Database (HGMD)
PPARD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPARD
Leiden Open Variation Database (LOVD)
PPARD

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPARD Gene

Disorders for PPARD Gene

MalaCards: The human disease database

(11) MalaCards diseases for PPARD Gene - From: COP and GCD

Disorder Aliases PubMed IDs
diabetic cataract
  • cataract - diabetic
abdominal obesity-metabolic syndrome 1
  • aoms1
colorectal cancer
  • crc
lipid metabolism disorder
  • dyslipidemia
type 2 diabetes mellitus
  • t2d
- elite association - COSMIC cancer census association via MalaCards
Search PPARD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PPARD

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PPARD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPARD Gene

Publications for PPARD Gene

  1. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. (PMID: 10198642) Xu HE … Milburn MV (Molecular cell 1999) 3 4 22 25
  2. Associations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon runners. (PMID: 20044476) Tsianos GI … Ioannidis JP (Journal of applied physiology (Bethesda, Md. : 1985) 2010) 3 22 40
  3. Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: a genetics of diabetes audit and research Tayside study. (PMID: 20200337) Burch LR … Palmer CN (The Journal of clinical endocrinology and metabolism 2010) 3 22 40
  4. The role of genetic variation in peroxisome proliferator-activated receptors in the polycystic ovary syndrome (PCOS): an original case-control study followed by systematic review and meta-analysis of existing evidence. (PMID: 19681917) San-Millán JL … Escobar-Morreale HF (Clinical endocrinology 2010) 3 22 40
  5. Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. (PMID: 19208777) Kotronen A … Fisher RM (European journal of endocrinology 2009) 3 22 40

Products for PPARD Gene