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The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]
PPAN (Peter Pan Homolog) is a Protein Coding gene. Diseases associated with PPAN include Kummell's Disease and Narcolepsy. An important paralog of this gene is PPAN-P2RY11.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0019843 | rRNA binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 15302935 |
GO:0005730 | nucleolus | IEA | -- |
GO:0030687 | preribosome, large subunit precursor | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000027 | ribosomal large subunit assembly | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PPAN 30 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | PPAN 30 |
|
||
P2RY11 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | PPAN 30 |
|
||
PPAN-P2RY11 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Ppan 30 17 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Ppan 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PPAN 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PPAN 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppan 30 |
|
||
MGC76273 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7873 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ppan 30 31 |
|
OneToMany | |
Dr.15061 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | ppan 30 31 32 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004556 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | lpd-6 31 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AAL040W 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C14586g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SSF1 30 31 |
|
ManyToMany | |
SSF2 31 |
|
ManyToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PPAN 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os03g0343700 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU04503 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1B9.03c 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2660 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3479 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
779371 | Benign: not provided | 10,111,734(+) | G/A | MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
rs12460842 | Association: Cataplexy and narcolepsy | 10,111,519(+) | A/G | THREE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
rs1551570 | Association: Cataplexy and narcolepsy | 10,107,354(+) | C/T | INTRON_VARIANT | |
rs11559188 | - | p.Gln408Arg | |||
rs2305793 | - | p.Gly358Val |
Disorder | Aliases | PubMed IDs |
---|---|---|
kummell's disease |
|
|
narcolepsy |
|
|
enterocele |
|
|
anterior cerebral artery infarction |
|
|
prolapse of female genital organ |
|
|