Aliases for PPA2 Gene
External Ids for PPA2 Gene
Previous GeneCards Identifiers for PPA2 Gene
The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPA2 Gene
PPA2 (Pyrophosphatase (Inorganic) 2) is a Protein Coding gene. Diseases associated with PPA2 include Sudden Cardiac Failure, Alcohol-Induced and Sudden Cardiac Failure, Infantile. Among its related pathways are Gene Expression and Metabolism. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and inorganic diphosphatase activity. An important paralog of this gene is PPA1.
UniProtKB/Swiss-Prot for PPA2 Gene
Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598).