Aliases for POU6F2 Gene
External Ids for POU6F2 Gene
Previous GeneCards Identifiers for POU6F2 Gene
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
GeneCards Summary for POU6F2 Gene
POU6F2 (POU Class 6 Homeobox 2) is a Protein Coding gene. Diseases associated with POU6F2 include Wilms Tumor 5 and Wilms Tumor 1. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is POU6F1.
UniProtKB/Swiss-Prot Summary for POU6F2 Gene
Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.