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Aliases for POU5F1B Gene

Aliases for POU5F1B Gene

  • POU Class 5 Homeobox 1B 2 3 5
  • POU Class 5 Homeobox 1 Pseudogene 1 2 3
  • POU5FLC20 3 4
  • OCT4-PG1 3 4
  • POU5F1P1 3 4
  • POU5FLC8 3 4
  • OCT4PG1 3 4
  • OTF3P1 3 4
  • OTF3C 3 4
  • POU Domain, Class 5, Transcription Factor 1 Pseudogene 1 3
  • POU Domain Class 5, Transcription Factor 1 Pseudogene 1 2
  • Putative POU Domain, Class 5, Transcription Factor 1B 3
  • Octamer-Binding Transcription Factor 3-Like 4
  • POU Domain Transcription Factor OCT4-Pg1 3
  • Octamer Binding Protein 3_like Sequence 3
  • POU Domain Transcription Factor Oct-4 3
  • Octamer-Binding Protein 3-Like 4
  • POU 5 Domain Protein 3
  • POU5F1P4 3

External Ids for POU5F1B Gene

Previous HGNC Symbols for POU5F1B Gene

  • OTF3P1
  • POU5F1P1

Previous GeneCards Identifiers for POU5F1B Gene

  • GC08P128499
  • GC08P123746
  • GC08P128426

Summaries for POU5F1B Gene

Entrez Gene Summary for POU5F1B Gene

  • This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]

GeneCards Summary for POU5F1B Gene

POU5F1B (POU Class 5 Homeobox 1B) is a Protein Coding gene. Among its related pathways are Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is POU5F1.

UniProtKB/Swiss-Prot for POU5F1B Gene

  • Shows weak transcriptional activator activity.

Additional gene information for POU5F1B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU5F1B Gene

Genomics for POU5F1B Gene

GeneHancer (GH) Regulatory Elements for POU5F1B Gene

Promoters and enhancers for POU5F1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I127415 Promoter 0.5 EPDnew 550.8 +1.5 1516 0.1 POU5F1B CASC8
GH08I127426 Enhancer 0.6 Ensembl ENCODE 0.4 +12.8 12848 1.8 PKNOX1 CEBPG CASC8 POU5F1B
GH08I127477 Enhancer 0.7 Ensembl ENCODE 0.2 +64.6 64615 2.6 GATA3 JUND POLR2A JUN FOSL2 FOS EP300 CASC8 POU5F1B
GH08I127457 Enhancer 0.4 Ensembl ENCODE 0.3 +44.1 44074 0.9 CASC8 POU5F1B
GH08I127471 Enhancer 0.5 ENCODE 0.2 +58.4 58413 1.5 FOXP2 EBF1 ZFX RUNX3 CASC8 POU5F1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around POU5F1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POU5F1B gene promoter:

Genomic Locations for POU5F1B Gene

Genomic Locations for POU5F1B Gene
5,780 bases
Plus strand

Genomic View for POU5F1B Gene

Genes around POU5F1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU5F1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU5F1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU5F1B Gene

Proteins for POU5F1B Gene

  • Protein details for POU5F1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative POU domain, class 5, transcription factor 1B
    Protein Accession:
    Secondary Accessions:
    • D5K9S4
    • D5K9S9
    • D5K9T0
    • D5K9T1
    • D5K9T3
    • D5K9U3
    • D5K9U6
    • D5K9V4
    • D5K9V6
    • D5K9W0
    • D5K9W2
    • D5K9W7
    • D5K9X2
    • D5K9X3
    • D5K9X5
    • D5K9X8
    • D5K9X9
    • E9LRB1
    • E9LRB2
    • E9LRH5
    • E9LRH6
    • E9LRH7
    • E9LRK4
    • E9LRK5
    • E9LRK7
    • E9LRK8
    • E9LRM7
    • E9LRM9
    • E9LRN2
    • E9LRN4
    • E9LRN5
    • E9LRP8
    • E9LRQ0
    • E9LRQ2
    • E9LRQ3
    • E9LRQ4
    • E9LRQ5
    • E9LRS3
    • Q2VIK6
    • Q9BZV7
    • Q9BZV9

    Protein attributes for POU5F1B Gene

    359 amino acids
    Molecular mass:
    38588 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POU5F1B Gene

Post-translational modifications for POU5F1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU5F1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POU5F1B Gene

Domains & Families for POU5F1B Gene

Gene Families for POU5F1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the POU transcription factor family. Class-5 subfamily.
  • Belongs to the POU transcription factor family. Class-5 subfamily.
genes like me logo Genes that share domains with POU5F1B: view

Function for POU5F1B Gene

Molecular function for POU5F1B Gene

UniProtKB/Swiss-Prot Function:
Shows weak transcriptional activator activity.

Phenotypes From GWAS Catalog for POU5F1B Gene

Gene Ontology (GO) - Molecular Function for POU5F1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity TAS 1408763
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with POU5F1B: view
genes like me logo Genes that share phenotypes with POU5F1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POU5F1B Gene

Localization for POU5F1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU5F1B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POU5F1B gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POU5F1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with POU5F1B: view

Pathways & Interactions for POU5F1B Gene

genes like me logo Genes that share pathways with POU5F1B: view

Pathways by source for POU5F1B Gene

Interacting Proteins for POU5F1B Gene

Selected Interacting proteins: Q06416-P5F1B_HUMAN for POU5F1B Gene via IID

Gene Ontology (GO) - Biological Process for POU5F1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 1408763
genes like me logo Genes that share ontologies with POU5F1B: view

No data available for SIGNOR curated interactions for POU5F1B Gene

Drugs & Compounds for POU5F1B Gene

No Compound Related Data Available

Transcripts for POU5F1B Gene

mRNA/cDNA for POU5F1B Gene

(1) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU5F1B Gene

POU class 5 homeobox 1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU5F1B Gene

No ASD Table

Relevant External Links for POU5F1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POU5F1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POU5F1B Gene

NURSA nuclear receptor signaling pathways regulating expression of POU5F1B Gene:


SOURCE GeneReport for Unigene cluster for POU5F1B Gene:


mRNA Expression by UniProt/SwissProt for POU5F1B Gene:

Tissue specificity: Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues.

Evidence on tissue expression from TISSUES for POU5F1B Gene

  • Liver(4.1)
  • Kidney(4)
genes like me logo Genes that share expression patterns with POU5F1B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for POU5F1B Gene

Orthologs for POU5F1B Gene

This gene was present in the common ancestor of animals.

Orthologs for POU5F1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia POU5F1B 33
  • 97.96 (n)
(Bos Taurus)
Mammalia POU5F1 34
  • 89 (a)
-- 34
  • 67 (a)
(Canis familiaris)
Mammalia -- 34
  • 88 (a)
(Mus musculus)
Mammalia Pou5f1 34
  • 83 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
(Gallus gallus)
Aves POUV 34
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
(Danio rerio)
Actinopterygii pou5f3 34
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta acj6 34
  • 22 (a)
(Caenorhabditis elegans)
Secernentea unc-86 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
Species where no ortholog for POU5F1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for POU5F1B Gene

Gene Tree for POU5F1B (if available)
Gene Tree for POU5F1B (if available)

Paralogs for POU5F1B Gene

(12) SIMAP similar genes for POU5F1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU5F1B: view

Variants for POU5F1B Gene

Sequence variations from dbSNP and Humsavar for POU5F1B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1001668645 -- 127,415,202(+) C/T upstream_transcript_variant
rs1002209669 -- 127,417,480(+) G/T downstream_transcript_variant
rs1002261884 -- 127,417,703(+) T/A downstream_transcript_variant
rs1002743416 -- 127,414,082(+) G/C upstream_transcript_variant
rs1003096032 -- 127,413,830(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for POU5F1B Gene

Variant ID Type Subtype PubMed ID
nsv499795 OTHER inversion 21111241
nsv7419 OTHER inversion 18451855
nsv981980 CNV duplication 23825009

Variation tolerance for POU5F1B Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.29; 97.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POU5F1B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU5F1B Gene

Disorders for POU5F1B Gene

Additional Disease Information for POU5F1B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for POU5F1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POU5F1B Gene

Publications for POU5F1B Gene

  1. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PMID: 1408763) Takeda J … Bell GI (Nucleic acids research 1992) 2 3 4 58
  2. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark SL … van den Oord EJ (Psychological medicine 2012) 3 44 58
  3. The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1. (PMID: 18949397) Panagopoulos I … Mertens F (Oncology reports 2008) 3 4 58
  4. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. (PMID: 17401363) Yeager M … Thomas G (Nature genetics 2007) 3 44 58
  5. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. (PMID: 17401366) Gudmundsson J … Stefansson K (Nature genetics 2007) 3 44 58

Products for POU5F1B Gene

Sources for POU5F1B Gene

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