Aliases for POU5F1 Gene
Aliases for POU5F1 Gene
- POU Class 5 Homeobox 1 Transcript Variant OCT4B2 3
- POU Class 5 Homeobox 1 Transcript Variant OCT4B3 3
- POU Class 5 Homeobox 1 Transcript Variant OCT4B4 3
- POU Class 5 Homeobox 1 Transcript Variant OCT4B5 3
- POU Class 5 Homeobox 1 Transcript Variant OCT4B6 3
- POU Domain, Class 5, Transcription Factor 1 3
- POU Domain Class 5, Transcription Factor 1 2
- POU Domain Transcription Factor OCT4 3
- POU ClassV Homeobox 1 Variant 2 3
- OTF4 3
External Ids for POU5F1 Gene
- HGNC: 9221
- Entrez Gene: 5460
- Ensembl: ENSG00000204531
- OMIM: 164177
- UniProtKB: Q01860
Previous HGNC Symbols for POU5F1 Gene
- OTF3
Previous GeneCards Identifiers for POU5F1 Gene
- GC08P127435
- GC06M031188
- GC06M030902
- GC06M031238
- GC06M031240
- GC06M031133
- GC06M030934
Summaries for POU5F1 Gene
-
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]
GeneCards Summary for POU5F1 Gene
POU5F1 (POU Class 5 Homeobox 1) is a Protein Coding gene. Diseases associated with POU5F1 include Embryonal Carcinoma and Teratoma. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is POU5F1B.
UniProtKB/Swiss-Prot for POU5F1 Gene
-
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Additional gene information for POU5F1 Gene
- Monarch Initiative
- Search for POU5F1 at DataMed
- Search for POU5F1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU5F1 Gene
Genomics for POU5F1 Gene
GeneHancer (GH) Regulatory Elements for POU5F1 Gene
Promoters and enhancers for POU5F1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around POU5F1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the POU5F1 gene promoter:
-
- AP-1
- Nkx2-5
- STAT3
- MyoD
Regulatory Element Products
Genomic Locations for POU5F1 Gene
Genomic Locations for POU5F1 Gene
- chr6:31,164,337-31,180,731
- (GRCh38/hg38)
- Size:
- 16,395 bases
- Orientation:
- Minus strand
- chr6:31,132,114-31,148,508
- (GRCh37/hg19)
- Size:
- 16,395 bases
- Orientation:
- Minus strand
Genomic View for POU5F1 Gene
Genes around POU5F1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by Entrez Gene
- 6p21.33 by HGNC
- 6p21.33 by Ensembl
POU5F1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POU5F1 Gene
Proteins for POU5F1 Gene
-
Protein details for POU5F1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01860-PO5F1_HUMAN
- Recommended name:
- POU domain, class 5, transcription factor 1
- Protein Accession:
- Q01860
- A6NCS1
- A6NLL8
- D2IYK4
- P31359
- Q15167
- Q15168
- Q16422
- Q5STF3
- Q5STF4
Protein attributes for POU5F1 Gene
- Size:
- 360 amino acids
- Molecular mass:
- 38571 Da
- Quaternary structure:
-
- Interacts with UBE2I and ZSCAN10 (By similarity). Interacts with PKM. Interacts with WWP2. Interacts with PCGF1 (PubMed:26687479). Interacts with ESRRB; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter; the interaction is DNA independent (By similarity). Interacts with ZNF322 (By similarity).
- Miscellaneous:
-
- Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them, localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.
Protein Expression for POU5F1 Gene
Post-translational modifications for POU5F1 Gene
- Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity).
- Ubiquitinated; undergoes Lys-63-linked polyubiquitination by WWP2 leading to proteasomal degradation.
- ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for POU5F1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for POU5F1 (Oct-3/4)
- R&D Systems Antibodies for POU5F1 (Oct-4A)
-
Custom Antibody ServicesOriGene Antibodies for POU5F1
- TA500035
- AM03171SU-N
- AM03173PU-N
- AM03173PU-S
- AM06408SU-N
- AM06533SU-N
- AM06559SU-N
- AM32251SU-N
- AP00249PU-N
- AP01492PU-N
- AP06256PU-N
- AP11910PU-N
- AP22409PU-N
- AP23147PU-N
- AP26064PU-N
- AP26064PU-S
- TA301457
- TA302555
- TA306913
- TA319164
- TA320446
- TA324014
- TA324706
- TA326116
- TA327717
- TA327954
- TA336803
- TA347019
- TA347444
- TA353993
- TA353994
- CF500035
- TA506797
- CF506797
- TA506798
- CF506798
- Novus Biologicals Antibodies for POU5F1
-
Abcam antibodies for POU5F1
- Invitrogen Antibodies for POU5F1
- antibodies-online: Search results for 461 available OCT4 Antibodies ranked by validation data
- Compare Top OCT4 Antibodies
-
Recommended
- 306 WB Antibodies (anti-human)
- 43 FACS Antibodies (anti-human)
- 15 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 IF/ICC Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 1 ICS Antibody (anti-human)
- 53 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IF Antibody (anti-rat)
- 133 WB Antibodies (anti-mouse)
- 30 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 1 ICS Antibody (anti-mouse)
- GeneTex POU5F1 Antibody for POU5F1
-
Boster Bio Antibodies for POU5F1
-
Custom Antibody ServicesProSci Antibodies for POU5F1
-
Santa Cruz Biotechnology (SCBT) Antibodies for POU5F1
- Sino Biological Antibodies for POU5F1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for POU5F1
- Origene Custom Protein Services for POU5F1
- ProSpec Recombinant Proteins for POU5F1
- Search GeneTex for Proteins for POU5F1
-
Abcam proteins for POU5F1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for POU5F1 (Oct-3/4)
-
Abcam assays for POU5F1
No data available for DME Specific Peptides for POU5F1 Gene
Domains & Families for POU5F1 Gene
Gene Families for POU5F1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for POU5F1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU5F1 Gene
- GenScript: Design optimal peptide antigens:
-
- POU domain class 5 transcription factor 1 (A7WPL9_HUMAN)
- POU domain class 5 transcription factor 1 (A7WPM0_HUMAN)
- Putative truncated POU domain class 5 transcription factor 1 (A7WPM1_HUMAN)
- POU domain class 5 transcription factor 1 (A7WPM2_HUMAN)
- Putative truncated POU domain class 5 transcription factor 1 (A7WPM3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q01860UniProtKB/Swiss-Prot:
PO5F1_HUMAN :- The POU-specific domain mediates interaction with PKM.
- Belongs to the POU transcription factor family. Class-5 subfamily.
- Domain:
-
- The POU-specific domain mediates interaction with PKM.
- Family:
-
- Belongs to the POU transcription factor family. Class-5 subfamily.
Function for POU5F1 Gene
Molecular function for POU5F1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
- UniProtKB/Swiss-Prot Induction:
- Transcriptional activity is positively regulated by PKM.
- GENATLAS Biochemistry:
- POU domain,class 5,transcription factor 1,expressed in neuronal cells,with OCT5 likely a proteolytic product of OCT3
LifeMap Function Summary for POU5F1 Gene
POU5F1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
Phenotypes From GWAS Catalog for POU5F1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 19409607 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISS,NAS | 19274049 |
| GO:0001158 | enhancer sequence-specific DNA binding | ISS | -- |
| GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 19409607 |
| GO:0003677 | DNA binding | IEA,IDA | 16153702 |
Phenotypes for POU5F1 Gene
- MGI mutant phenotypes for POU5F1:
-
inferred from 8 alleles
- digestive/alimentary phenotype
- nervous system phenotype
- behavior/neurological phenotype
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- embryo phenotype
- normal phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for POU5F1:
-
- Decreased NANOG protein expression
- Decreased OCT4 protein expression
- Decreased POU5F1-GFP protein expression
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- no effect
- Decreased Aire reporter expression
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Increased viability
Animal Models for POU5F1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for POU5F1
-
CRISPR Products
-
OriGene CRISPR knockouts for POU5F1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POU5F1
- genomics-online: gRNA clones - Search results for 142 available OCT4 gene related products
- Overview of 142 available OCT4 gene related products
- Applied Biological Materials CRISPR for POU5F1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU5F1
- GenScript: Design CRISPR guide RNA sequences for POU5F1
miRNA for POU5F1 Gene
- miRTarBase miRNAs that target POU5F1
-
- hsa-mir-145-5p (MIRT004904)
- hsa-mir-128-3p (MIRT022019)
- hsa-mir-335-5p (MIRT052915)
- hsa-mir-34a-5p (MIRT054853)
- hsa-mir-203b-3p (MIRT716324)
- hsa-mir-7158-3p (MIRT716325)
- hsa-mir-642a-5p (MIRT716326)
- hsa-mir-6754-3p (MIRT716327)
- hsa-mir-412-3p (MIRT716328)
- hsa-mir-6734-3p (MIRT716329)
- hsa-mir-4667-3p (MIRT716330)
- hsa-mir-1470 (MIRT716331)
Targeted motifs for POU5F1 Gene
HOMER Transcription Factor Regulatory Elements motif POU5F1
- Consensus sequence: ATTTGCATAA Submotif: canonical Cell Type: mES GEO ID: GSE11431
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for POU5F1
- Browse OriGene Inhibitory RNA Products For POU5F1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POU5F1
- genomics-online: shRNA clones - Search results for 142 available OCT4 gene related products
- Overview of 142 available OCT4 gene related products
Clone Products
-
OriGene ORF clones in human for POU5F1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for POU5F1
- VectorBuilder custom plasmid, inducible vectors for POU5F1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POU5F1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for POU5F1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POU5F1
- Applied Biological Materials Clones for POU5F1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for POU5F1 (Oct-3/4)
- R&D Systems cDNA Clones for POU5F1 (Oct-4B)
Cell Line Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for POU5F1 Gene
Localization for POU5F1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU5F1 Gene
- Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISS | -- |
| GO:0005634 | nucleus | IDA,IEA | 18000303 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 18281244 |
| GO:0005739 | mitochondrion | IDA | -- |
Pathways & Interactions for POU5F1 Gene
Pathways by source for POU5F1 Gene
7 BioSystems pathways for POU5F1 Gene
4 Reactome pathways for POU5F1 Gene
1 KEGG pathway for POU5F1 Gene
1 GeneGo (Thomson Reuters) pathway for POU5F1 Gene
1 R&D Systems pathway for POU5F1 Gene
5 Qiagen pathways for POU5F1 Gene
1 Cell Signaling Technology pathway for POU5F1 Gene
Interacting Proteins for POU5F1 Gene
Selected Interacting proteins:
Q01860-PO5F1_HUMAN
ENSP00000259915
for POU5F1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for POU5F1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 19409607 |
| GO:0001714 | endodermal cell fate specification | IDA | 20713518 |
| GO:0001824 | blastocyst development | ISS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA,IDA | 16153702 |
Drugs & Compounds for POU5F1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for POU5F1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| OAC1 | Oct4 activator | 300586-90-7 |
Transcripts for POU5F1 Gene
mRNA/cDNA for POU5F1 Gene
- (5) REFSEQ mRNAs :
- (40) Additional mRNA sequences :
- (9) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000259915 1420 bps (uc003nsv.4)
- ENST00000441888 1055 bps (uc063mzi.1)
- ENST00000471529 1723 bps (uc063mzk.1)
- ENST00000606567 1236 bps (uc063mzl.1)
- ENST00000512818 1233 bps (uc063mzm.1)
Unigene Clusters for POU5F1 Gene
- POU class 5 homeobox 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for POU5F1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POU5F1
- genomics-online: gRNA clones - Search results for 142 available OCT4 gene related products
- Overview of 142 available OCT4 gene related products
- Applied Biological Materials CRISPR for POU5F1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU5F1
- GenScript: Design CRISPR guide RNA sequences for POU5F1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for POU5F1
- Browse OriGene Inhibitory RNA Products For POU5F1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POU5F1
- genomics-online: shRNA clones - Search results for 142 available OCT4 gene related products
- Overview of 142 available OCT4 gene related products
Clone Products
-
OriGene ORF clones in human for POU5F1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for POU5F1
- VectorBuilder custom plasmid, inducible vectors for POU5F1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POU5F1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for POU5F1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POU5F1
- Applied Biological Materials Clones for POU5F1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for POU5F1 (Oct-3/4)
- R&D Systems cDNA Clones for POU5F1 (Oct-4B)
Expression for POU5F1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- Inner Cell Mass Cells Inner Cell Mass
- 2-Cell Embryo Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- NULL (Uncategorized)
-
Gonad
- Primary Oocyte Primary Follicle
- Primordial Germ Cell Precursors Epiblast
- Primary Oocyte Primordial Follicle
- Spermatogonial Stem Cells Seminiferous Tubules
- Spermatogonium Type A Seminiferous Tubules
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Cord Blood
- Amniotic Mesenchymal Stromal Cells Amniotic Membrane
- Mesenchymal Stem Cells Whartons Jelly
- Mesenchymal Stem Cells Amniotic Fluid
- Whartons jelly-derived mesenchymal stem cells
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
- Primordial Germ Cell Precursors Epiblast
- Intraembryonic Epiblast Cells Epiblast
- Early Epiblast Cells Epiblast
- Epiblast Stem Cell line 7
-
Ovary (Reproductive System)
- Primary Oocyte Primary Follicle
- Primary Oocyte Primordial Follicle
- Ovarian Somatic Cells Ovigerous Cord
- Secondary Oocyte Antral Follicle
- Oogonia Ovigerous Cord
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- 2-Cell Embryo Zygote
- Morula Cells Morula
- Trophoblast Cells Trophoblast
- 8-Cell Embryo Morula
-
Amnion (Extraembryonic Tissues)
- Amniotic Mesenchymal Stromal Cells Amniotic Membrane
- Mesenchymal Stem Cells Amniotic Fluid
- Amniotic Epithelial Cells Amniotic Membrane
- Amniotic fluid stem cells
- Amnion-derived mesenchymal stem cells
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- 2-Cell Embryo Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- 4-Cell Embryo Zygote
- Umbilical Cord (Extraembryonic Tissues)
- Epithelial Cells
- Tooth (Integumentary System)
-
Testis (Reproductive System)
- Spermatogonial Stem Cells Seminiferous Tubules
- Spermatogonium Type A Seminiferous Tubules
- XY Germ Cells Testis Cord
- Brain (Nervous System)
- Primitive Streak (Early Embryonic Tissues)
- Endoderm (Gastrulation Derivatives)
- Blood (Hematopoietic System)
- Placenta (Extraembryonic Tissues)
- Eye (Sensory Organs)
- Kidney (Urinary System)
- Adipose (Muscoskeletal System)
- Germ Cells (Reproductive System)
- Uterus (Reproductive System)
- Pancreas (Endocrine System)
- Hair (Integumentary System)
- Heart (Cardiovascular System)
- Neural Ectoderm (Nervous System)
- Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for POU5F1 Gene
This gene is overexpressed in Kidney - Cortex (x7.0), Bladder (x6.1), and Pancreas (x4.4).
This gene is overexpressed in Fetal ovary (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POU5F1 Gene
NURSA nuclear receptor signaling pathways regulating expression of POU5F1 Gene:
POU5F1SOURCE GeneReport for Unigene cluster for POU5F1 Gene:
Hs.249184mRNA Expression by UniProt/SwissProt for POU5F1 Gene:
Q01860-PO5F1_HUMAN
Tissue specificity:
Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.
Evidence on tissue expression from TISSUES for POU5F1 Gene
- Blood(4.4)
- Heart(4.4)
- Muscle(4.4)
- Kidney(4.3)
- Lung(4.3)
- Nervous system(2.3)
- Bone marrow(2.2)
- Liver(2.1)
- Skin(2.1)
- Bone(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for POU5F1
-
OriGene qPCR primer pairs for POU5F1
- genomics-online: primer clones - Search results for 142 available OCT4 gene related products
- Overview of 142 available OCT4 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for POU5F1 Gene
Orthologs for POU5F1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | POU5F1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| POU5F1 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | POU5F1 34 33 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Pou5f1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pou5f1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | POUV 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23276 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pou5f3 34 |
|
OneToMany | |
| pou5f1 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | acj6 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | unc-86 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for POU5F1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for POU5F1 Gene
- ENSEMBL:
- Gene Tree for POU5F1 (if available)
- TreeFam:
- Gene Tree for POU5F1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for POU5F1: view image
Paralogs for POU5F1 Gene
Paralogs for POU5F1 Gene
(14) SIMAP similar genes for POU5F1 Gene using alignment to 53 proteins:
- PO5F1_HUMAN
- A7WPL9_HUMAN
- A7WPM0_HUMAN
- A7WPM1_HUMAN
- A7WPM2_HUMAN
- A7WPM3_HUMAN
- A7WPM4_HUMAN
- A7WPM5_HUMAN
- A7WPM6_HUMAN
- A7WPM7_HUMAN
- A7WPM8_HUMAN
- A7WPM9_HUMAN
- A7WPN0_HUMAN
- B5B8N7_HUMAN
- B5B8N8_HUMAN
- B5B8N9_HUMAN
- B5B8P0_HUMAN
- B5B8P1_HUMAN
- B5B8P2_HUMAN
- B5B8P3_HUMAN
- B5B8P4_HUMAN
- B5B8P5_HUMAN
- B5B8P6_HUMAN
- B5B8P7_HUMAN
- B5B8P8_HUMAN
- B5B8P9_HUMAN
- B5B8Q0_HUMAN
- B5B8Q1_HUMAN
- B5B8Q2_HUMAN
- B5B8Q3_HUMAN
- B5B8Q4_HUMAN
- C3RUE0_HUMAN
- D2IYK3_HUMAN
- D5K9Q3_HUMAN
- D5K9Q6_HUMAN
- D5K9Q7_HUMAN
- D5K9Q9_HUMAN
- D5K9R1_HUMAN
- D5K9R2_HUMAN
- D5K9R3_HUMAN
- D5K9R4_HUMAN
- D5K9R5_HUMAN
- D5K9R7_HUMAN
- D5K9R8_HUMAN
- D5K9R9_HUMAN
- D5K9S1_HUMAN
- E9LR73_HUMAN
- E9LR75_HUMAN
- E9LR77_HUMAN
- E9LR79_HUMAN
- F2Z381_HUMAN
- M1S623_HUMAN
- U3KQH6_HUMAN
Pseudogenes.org Pseudogenes for POU5F1 Gene
Variants for POU5F1 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000615578 | -- | 31,164,140(-) | A/G | downstream_transcript_variant | |
| rs1001282425 | -- | 31,167,846(-) | G/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1001547868 | -- | 31,165,347(-) | C/T | intron_variant | |
| rs1001781252 | -- | 31,172,373(-) | GG/G | upstream_transcript_variant | |
| rs1002148625 | -- | 31,172,618(-) | GGG/GG | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1174e214 | CNV | gain | 21293372 |
| dgv1175e214 | CNV | gain | 21293372 |
| esv2731791 | CNV | deletion | 23290073 |
| esv2759414 | CNV | gain+loss | 17122850 |
| esv3411275 | CNV | duplication | 20981092 |
| esv3608531 | CNV | loss | 21293372 |
| esv3608532 | CNV | gain | 21293372 |
| nsv1074389 | CNV | deletion | 25765185 |
| nsv1122126 | CNV | deletion | 24896259 |
| nsv1144137 | CNV | deletion | 24896259 |
| nsv428140 | CNV | gain+loss | 18775914 |
| nsv524061 | CNV | loss | 19592680 |
| nsv525933 | CNV | loss | 19592680 |
| nsv601264 | CNV | loss | 21841781 |
| nsv601481 | CNV | loss | 21841781 |
| nsv970105 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.20;
39.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for POU5F1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU5F1 Gene
Disorders for POU5F1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| embryonal carcinoma |
|
|
| teratoma |
|
|
| germ cell and embryonal cancer |
|
|
| central nervous system germinoma |
|
|
| central nervous system germ cell tumor |
|
|
Search POU5F1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for POU5F1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for POU5F1 Gene
Publications for POU5F1 Gene
- Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PMID: 1408763) Takeda J … Bell GI (Nucleic acids research 1992) 2 3 4 22 58
- Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. (PMID: 18191611) Lee J … Kim J (The international journal of biochemistry & cell biology 2008) 3 4 22 58
- Oct4 pseudogenes are transcribed in cancers. (PMID: 16229821) Suo G … Dai J (Biochemical and biophysical research communications 2005) 3 4 22 58
- A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. (PMID: 12653732) Chang YT … Wong CK (The British journal of dermatology 2003) 3 22 44 58
- The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G … Cagney G (Scientific reports 2015) 3 4 58
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