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The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011] See more...
Aliases for POU4F2 Gene
Aliases for POU4F2 Gene
External Ids for POU4F2 Gene
- HGNC: 9219
- Entrez Gene: 5458
- Ensembl: ENSG00000151615
- OMIM: 113725
- UniProtKB: Q12837
Previous HGNC Symbols for POU4F2 Gene
- BRN3B
Previous GeneCards Identifiers for POU4F2 Gene
- GC04P148362
- GC04P147935
- GC04P148137
- GC04P147917
- GC04P147779
- GC04P147560
- GC04P143287
Summaries for POU4F2 Gene
-
The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]
GeneCards Summary for POU4F2 Gene
POU4F2 (POU Class 4 Homeobox 2) is a Protein Coding gene. Diseases associated with POU4F2 include Differentiating Neuroblastoma and Thrombophlebitis Migrans. Among its related pathways are Gene Expression and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is POU4F1.
UniProtKB/Swiss-Prot Summary for POU4F2 Gene
-
Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:19266028, PubMed:23805044). Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity).
Additional gene information for POU4F2 Gene
- HGNC(9219)
- Entrez Gene(5458)
- Ensembl(ENSG00000151615)
- OMIM(113725)
- UniProtKB(Q12837)
- Open Targets Platform(ENSG00000151615)
- Search for POU4F2 at DataMed
- Search for POU4F2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POU4F2 Gene
Genomics for POU4F2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for POU4F2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around POU4F2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POU4F2
- Top Transcription factor binding sites by QIAGEN in the POU4F2 gene promoter:
-
- ATF-2
- CRE-BP1
- Ik-2
- NRSF form 1
- NRSF form 2
- p53
- RSRFC4
- SRY
Genomic Locations for POU4F2 Gene
Genomic Locations for POU4F2 Gene
- chr4:146,638,893-146,642,474
- (GRCh38/hg38)
- Size:
- 3,582 bases
- Orientation:
- Plus strand
- chr4:147,560,045-147,563,626
- (GRCh37/hg19)
- Size:
- 3,582 bases
- Orientation:
- Plus strand
Genomic View for POU4F2 Gene
Genes around POU4F2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q31.22 by HGNC
- 4q31.22 by Entrez Gene
- 4q31.22 by Ensembl
POU4F2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POU4F2 Gene
Proteins for POU4F2 Gene
-
Protein details for POU4F2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12837-PO4F2_HUMAN
- Recommended name:
- POU domain, class 4, transcription factor 2
- Protein Accession:
- Q12837
- B1PJR6
- B2RC84
- Q13883
- Q14987
Protein attributes for POU4F2 Gene
- Size:
- 409 amino acids
- Molecular mass:
- 43087 Da
- Quaternary structure:
-
- Interacts with POU4F1; this interaction inhibits both POU4F1 DNA-binding and transcriptional activities. Interacts (C-terminus) with ESR1 (via DNA-binding domain); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner. Interacts (via C-terminus) with TP53 (via N-terminus). Interacts with DLX1 (via homeobox DNA-binding domain); this interaction suppresses DLX1-mediated transcriptional activity in postnatal retina enhancing retinal ganglion cell (RGC) differentiation. Interacts with DLX2 (via homeobox DNA-binding domain); this interaction enhances RGC differentiation. Interacts (via C-terminus) with ISL1 (via C-terminus). Interacts with ISL2. Interacts with LHX2.
Protein Expression for POU4F2 Gene
Post-translational modifications for POU4F2 Gene
Other Protein References for POU4F2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for POU4F2
-
Abcam antibodies for POU4F2
- Invitrogen Antibodies for POU4F2 (AFLGC-POU4F2)
-
Biorbyt antibodies for POU4F2
-
Santa Cruz Biotechnology (SCBT) Antibodies for POU4F2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for POU4F2
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No data available for DME Specific Peptides for POU4F2 Gene
Domains & Families for POU4F2 Gene
Gene Families for POU4F2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for POU4F2 Gene
- InterPro:
- Blocks:
-
- POU domain
- POU
- ProtoNet:
Suggested Antigen Peptide Sequences for POU4F2 Gene
- GenScript: Design optimal peptide antigens:
-
- Brain-specific homeobox/POU domain protein 3B (PO4F2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q12837UniProtKB/Swiss-Prot:
PO4F2_HUMAN :- The N-terminal transcriptional activation region is sufficient to induce transcriptional activity.
- Belongs to the POU transcription factor family. Class-4 subfamily.
- Domain:
-
- The N-terminal transcriptional activation region is sufficient to induce transcriptional activity.
- The POU-specific domain and POU homeodomain regions are necessary for DNA-binding activity and transcriptional repression.
- The polyhistidine motif acts as a targeting signal to nuclear speckles.
- Family:
-
- Belongs to the POU transcription factor family. Class-4 subfamily.
Function for POU4F2 Gene
Molecular function for POU4F2 Gene
- UniProtKB/Swiss-Prot Function:
- Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:19266028, PubMed:23805044). Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity).
- GENATLAS Biochemistry:
- POU domain,class 4,transcription factor 2,expressed in a subset of retinal ganglion cells
Phenotypes From GWAS Catalog for POU4F2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 17637757 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IDA,ISM | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA,ISS | -- |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA,ISS | 17145718 |
| GO:0002039 | p53 binding | IEA | -- |
Phenotypes for POU4F2 Gene
- MGI mutant phenotypes for POU4F2:
- inferred from 11 alleles
- GenomeRNAi human phenotypes for POU4F2:
Animal Models for POU4F2 Gene
Animal Model Products
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CRISPR Products
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-
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miRNA for POU4F2 Gene
- miRTarBase miRNAs that target POU4F2
miRNA Products
Inhibitory RNA Products
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for POU4F2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POU4F2 Gene
Localization for POU4F2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU4F2 Gene
- Nucleus. Nucleus speckle. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA,ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IGI | 17145718 |
| GO:0005719 | nuclear euchromatin | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for POU4F2 Gene
Pathways & Interactions for POU4F2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of TP53 Activity | ||
| 2 | Gene Expression |
.48
|
|
| 3 | Direct p53 effectors | ||
Pathways by source for POU4F2 Gene
1 BioSystems pathway for POU4F2 Gene
Interacting Proteins for POU4F2 Gene
Selected Interacting proteins:
Q12837-PO4F2_HUMAN
ENSP00000281321
for POU4F2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for POU4F2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,ISS | -- |
| GO:0000165 | MAPK cascade | IDA | 21241485 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
Transcripts for POU4F2 Gene
mRNA/cDNA for POU4F2 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000281321 3144 nts (view in UCSC)
CRISPR Products
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for POU4F2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for POU4F2
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Clone Products
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- Sino Biological Human cDNA Clone for POU4F2
- Addgene plasmids for POU4F2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POU4F2
Relevant External Links for POU4F2 Gene
- GeneLoc Exon Structure for
- POU4F2
Expression for POU4F2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Immature Ganglion Cells Ganglion Cell Layer
- Mature Ganglion Cells Ganglion Cell Layer
- Ganglion Precursor Cells Ganglion Cell Layer
- Retinal cells(Eiraku M et. al. 2012)
-
Neurons
- Immature Ganglion Cells Ganglion Cell Layer
- Mature Ganglion Cells Ganglion Cell Layer
- Ganglion Precursor Cells Ganglion Cell Layer
- Neural Tube (Nervous System)
- NULL (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for POU4F2 Gene
This gene is overexpressed in Testis (x32.8) and Brain - Substantia nigra (x11.0).
This gene is overexpressed in Lavage (68.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POU4F2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POU4F2
SOURCE GeneReport for Unigene cluster for POU4F2 Gene:
Hs.266mRNA Expression by UniProt/SwissProt for POU4F2 Gene:
Q12837-PO4F2_HUMAN
Tissue specificity:
Expressed in the brain (PubMed:7691107). Expressed in the ganglion cell layer of the retina (PubMed:7691107).
Evidence on tissue expression from TISSUES for POU4F2 Gene
- Eye(4.6)
- Nervous system(2.4)
Primer Products
-
OriGene qPCR primer pairs for POU4F2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for POU4F2 Gene
Orthologs for POU4F2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | POU4F2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | POU4F2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | POU4F2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | POU4F2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pou4f2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Pou4f2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | POU4F2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | BRN3 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pou4f2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pou4f2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | acj6 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | unc-86 31 32 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for POU4F2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for POU4F2 Gene
- ENSEMBL:
- Gene Tree for POU4F2 (if available)
- TreeFam:
- Gene Tree for POU4F2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for POU4F2: view image
Paralogs for POU4F2 Gene
Paralogs for POU4F2 Gene
(6) SIMAP similar genes for POU4F2 Gene using alignment to 1 proteins:
- PO4F2_HUMAN
Variants for POU4F2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POU4F2 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 781733 | Benign: not provided | 146,640,520(+) | G/T | SYNONYMOUS_VARIANT | |
| 790312 | Benign: not provided | 146,639,995(+) | C/A | MISSENSE_VARIANT | |
| rs13152799 | - | p.Ile40Thr |
Residual Variation Intolerance Score:
32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.04;
75.08% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for POU4F2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- POU4F2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU4F2 Gene
Disorders for POU4F2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| differentiating neuroblastoma |
|
|
| thrombophlebitis migrans |
|
|
| optic nerve hypoplasia, bilateral |
|
|
| ischemic neuropathy |
|
|
| optic nerve disease |
|
|
Search POU4F2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for POU4F2
No data available for UniProtKB/Swiss-Prot and Genatlas for POU4F2 Gene
Publications for POU4F2 Gene
- The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells. (PMID: 11526481) Dennis JH … Latchman DS (Oncogene 2001) 3 4 23
- Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. (PMID: 7691107) Xiang M … Nathans J (Neuron 1993) 3 4 23
- The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain. (PMID: 8332509) Ring CJ … Latchman DS (Nucleic acids research 1993) 2 3 4
- RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. (PMID: 23805044) Zhang L … Esumi N (Molecular vision 2013) 3 4
- Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. (PMID: 19266028) Salichs E … de la Luna S (PLoS genetics 2009) 3 4
ExternalLinks
Products for POU4F2 Gene
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Sources for POU4F2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
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- (33) SGD
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- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (55) TGDB
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- (59) ProSpec
- (60) Sino Biological
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- (64) Proteopedia
- (65) MOPED
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
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- (70) SIMAP
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- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
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- (80) MaxQB
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- (82) BioGPS
- (83) Illumina
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- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (104) diseasecard
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- (122) ENCODE
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
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- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
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- (154) Biorbyt
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- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB