Free for academic non-profit institutions. Other users need a Commercial license

Aliases for POU3F3 Gene

Aliases for POU3F3 Gene

  • POU Class 3 Homeobox 3 2 3 5
  • Brain-Specific Homeobox/POU Domain Protein 1 3 4
  • Octamer-Binding Transcription Factor 8 3 4
  • Octamer-Binding Protein 8 3 4
  • Brain-1 3 4
  • Oct-8 3 4
  • BRN1 3 4
  • OTF8 3 4
  • POU Domain, Class 3, Transcription Factor 3 3
  • POU Domain Class 3, Transcription Factor 3 2
  • Brn-1 4
  • OTF-8 4

External Ids for POU3F3 Gene

Previous GeneCards Identifiers for POU3F3 Gene

  • GC02P103336
  • GC02P103924
  • GC02P105076
  • GC02P105093
  • GC02P104930
  • GC02P105471
  • GC02P099242

Summaries for POU3F3 Gene

Entrez Gene Summary for POU3F3 Gene

  • This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015]

GeneCards Summary for POU3F3 Gene

POU3F3 (POU Class 3 Homeobox 3) is a Protein Coding gene. Diseases associated with POU3F3 include Central Nervous System Tuberculosis and Agraphia. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and HMG box domain binding. An important paralog of this gene is POU3F2.

UniProtKB/Swiss-Prot for POU3F3 Gene

  • Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5-ATTTGCAT-3) (By similarity).

Additional gene information for POU3F3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU3F3 Gene

Genomics for POU3F3 Gene

GeneHancer (GH) Regulatory Elements for POU3F3 Gene

Promoters and enhancers for POU3F3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I104854 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 850 3.6 RING1 SUZ12 HLF ZNF335 CBX8 HDAC2 CTBP2 KLF9 PRDM1 EZH2 GC02P104857 POU3F3 ENSG00000272994 MRPS9 ENSG00000269707
GH02I104845 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 22.7 -10.3 -10288 0.6 KLF17 ZNF335 GLIS2 SP3 ZNF398 ZEB2 ZNF843 ZNF341 ZBTB26 ZBTB17 POU3F3 MRPS9 LINC01158 GPR45 GC02M104827
GH02I104873 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +17.9 17937 0.5 CTCF MXI1 SUZ12 BACH1 ZNF48 RAD21 HIC1 ZNF335 ZFHX2 ZNF213 LINC01159 POU3F3 GPR45 ENSG00000269707 GC02P104945
GH02I104848 Enhancer 1.4 VISTA FANTOM5 dbSUPER 8.3 -5.7 -5707 2.6 CTCF MXI1 PKNOX1 FOXA2 SIN3A FEZF1 RAD21 ETS1 CTBP1 ZNF213 POU3F3 GPR45 LINC01158 GC02M104827
GH02I104842 Enhancer 0.9 FANTOM5 dbSUPER 10.9 -12.3 -12338 0.4 CTCF MXI1 LEF1 ARNT SUZ12 BACH1 ZNF335 GLIS2 POLR2A ZBTB48 POU3F3 GPR45 GC02M104827 LINC01158
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around POU3F3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POU3F3 gene promoter:

Genomic Locations for POU3F3 Gene

Genomic Locations for POU3F3 Gene
3,064 bases
Plus strand

Genomic View for POU3F3 Gene

Genes around POU3F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU3F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU3F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU3F3 Gene

Proteins for POU3F3 Gene

  • Protein details for POU3F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    POU domain, class 3, transcription factor 3
    Protein Accession:
    Secondary Accessions:
    • P78379
    • Q4ZG25

    Protein attributes for POU3F3 Gene

    500 amino acids
    Molecular mass:
    50327 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POU3F3 Gene

Post-translational modifications for POU3F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU3F3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POU3F3 Gene

Domains & Families for POU3F3 Gene

Gene Families for POU3F3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for POU3F3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the POU transcription factor family. Class-3 subfamily.
  • Belongs to the POU transcription factor family. Class-3 subfamily.
genes like me logo Genes that share domains with POU3F3: view

Function for POU3F3 Gene

Molecular function for POU3F3 Gene

GENATLAS Biochemistry:
POU domain,class 3,transcription factor 3,expressed in brain
UniProtKB/Swiss-Prot Function:
Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5-ATTTGCAT-3) (By similarity).

Phenotypes From GWAS Catalog for POU3F3 Gene

Gene Ontology (GO) - Molecular Function for POU3F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS,IEA --
GO:0043565 sequence-specific DNA binding ISS --
GO:0071837 HMG box domain binding IEA --
genes like me logo Genes that share ontologies with POU3F3: view
genes like me logo Genes that share phenotypes with POU3F3: view

Animal Models for POU3F3 Gene

MGI Knock Outs for POU3F3:
Targeted motifs for POU3F3 Gene
HOMER Transcription Factor Regulatory Elements motif POU3F3
  • Consensus sequence: TATGCWAATBAV Submotif: canonical Cell Type: NPC GEO ID: GSE35496

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for POU3F3 Gene

Localization for POU3F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU3F3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POU3F3 gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POU3F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IDA --
genes like me logo Genes that share ontologies with POU3F3: view

Pathways & Interactions for POU3F3 Gene

SuperPathways for POU3F3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for POU3F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with POU3F3: view

No data available for Pathways by source and SIGNOR curated interactions for POU3F3 Gene

Drugs & Compounds for POU3F3 Gene

No Compound Related Data Available

Transcripts for POU3F3 Gene

mRNA/cDNA for POU3F3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU3F3 Gene

POU class 3 homeobox 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU3F3 Gene

No ASD Table

Relevant External Links for POU3F3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POU3F3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POU3F3 Gene

mRNA differential expression in normal tissues according to GTEx for POU3F3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3), Brain - Hippocampus (x4.3), Brain - Substantia nigra (x4.3), Brain - Anterior cingulate cortex (BA24) (x4.1), Brain - Amygdala (x4.1), and Brain - Caudate (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for POU3F3 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POU3F3 Gene

Protein tissue co-expression partners for POU3F3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POU3F3 Gene:


SOURCE GeneReport for Unigene cluster for POU3F3 Gene:


mRNA Expression by UniProt/SwissProt for POU3F3 Gene:

Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for POU3F3 Gene

  • Nervous system(4.5)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with POU3F3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for POU3F3 Gene

Orthologs for POU3F3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POU3F3 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia POU3F3 34
  • 95 (a)
(Rattus norvegicus)
Mammalia Pou3f3 33
  • 89.6 (n)
(Mus musculus)
Mammalia Pou3f3 33 16 34
  • 89.54 (n)
(Canis familiaris)
Mammalia POU3F3 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
(Anolis carolinensis)
Reptilia POU3F3 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497507 33
  • 76.51 (n)
(Danio rerio)
Actinopterygii pou3f3a 34
  • 75 (a)
pou3f3b 33 34
  • 74.92 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta vvl 35 34
  • 81 (a)
nub 35
  • 64 (a)
pdm2 35
  • 61 (a)
(Caenorhabditis elegans)
Secernentea ceh-6 35
  • 69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOX1 36
Species where no ortholog for POU3F3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU3F3 Gene

Gene Tree for POU3F3 (if available)
Gene Tree for POU3F3 (if available)

Paralogs for POU3F3 Gene

(10) SIMAP similar genes for POU3F3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU3F3: view

Variants for POU3F3 Gene

Sequence variations from dbSNP and Humsavar for POU3F3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000158095 -- 104,854,577(+) G/T 5_prime_UTR_variant
rs1000510406 -- 104,854,375(+) C/G 5_prime_UTR_variant
rs1001458361 -- 104,853,799(+) G/A upstream_transcript_variant
rs1002427502 -- 104,854,194(+) G/A/C 5_prime_UTR_variant
rs1002448633 -- 104,853,270(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for POU3F3 Gene

Variant ID Type Subtype PubMed ID
dgv658n67 CNV gain 20364138
esv2660782 CNV deletion 23128226
esv2661949 CNV deletion 23128226
nsv1072960 CNV deletion 25765185
nsv1126557 CNV deletion 24896259
nsv1136303 CNV deletion 24896259
nsv829586 CNV gain 20364138
nsv829587 CNV loss 20364138
nsv829589 CNV gain 20364138
nsv829597 CNV gain 20364138

Variation tolerance for POU3F3 Gene

Gene Damage Index Score: 1.20; 24.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POU3F3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU3F3 Gene

Disorders for POU3F3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for POU3F3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
central nervous system tuberculosis
  • intracranial tuberculoma
epidemic typhus
  • sylvatic typhus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for POU3F3

genes like me logo Genes that share disorders with POU3F3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POU3F3 Gene

Publications for POU3F3 Gene

  1. Cooperative function of POU proteins and SOX proteins in glial cells. (PMID: 9632656) Kuhlbrodt K … Wegner M (The Journal of biological chemistry 1998) 3 22 58
  2. Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals. (PMID: 8703082) Sumiyama K … Ueda S (Journal of molecular evolution 1996) 3 4 58
  3. Expression of a large family of POU-domain regulatory genes in mammalian brain development. (PMID: 2739723) He X … Rosenfeld MG (Nature 1989) 3 4 58
  4. Knockdown of linc-POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer. (PMID: 26510906) Shan TD … Chen QK (Oncotarget 2016) 3 58
  5. Functional linc-POU3F3 is overexpressed and contributes to tumorigenesis in glioma. (PMID: 25445282) Guo H … Zhu X (Gene 2015) 3 58

Products for POU3F3 Gene

Sources for POU3F3 Gene

Loading form....