Aliases for POU3F2 Gene
External Ids for POU3F2 Gene
Previous HGNC Symbols for POU3F2 Gene
Previous GeneCards Identifiers for POU3F2 Gene
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]
GeneCards Summary for POU3F2 Gene
POU3F2 (POU Class 3 Homeobox 2) is a Protein Coding gene. Diseases associated with POU3F2 include Microphthalmia and Melanoma. Among its related pathways are MECP2 and Associated Rett Syndrome and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding. An important paralog of this gene is POU3F3.
UniProtKB/Swiss-Prot Summary for POU3F2 Gene
Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity).