Aliases for POU2F3 Gene
External Ids for POU2F3 Gene
Previous GeneCards Identifiers for POU2F3 Gene
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for POU2F3 Gene
POU2F3 (POU Class 2 Homeobox 3) is a Protein Coding gene. Diseases associated with POU2F3 include Cervical Cancer and Blood Coagulation Disease. Among its related pathways are Influenza A. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is POU2F1.
UniProtKB/Swiss-Prot for POU2F3 Gene
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.