Aliases for POU2F3 Gene
External Ids for POU2F3 Gene
Previous GeneCards Identifiers for POU2F3 Gene
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for POU2F3 Gene
POU2F3 (POU Class 2 Homeobox 3) is a Protein Coding gene. Diseases associated with POU2F3 include Coronary Thrombosis and Spastic Paraplegia 28, Autosomal Recessive. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is POU2F2.
UniProtKB/Swiss-Prot Summary for POU2F3 Gene
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.