Aliases for POU2F2 Gene
External Ids for POU2F2 Gene
Previous HGNC Symbols for POU2F2 Gene
Previous GeneCards Identifiers for POU2F2 Gene
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for POU2F2 Gene
POU2F2 (POU Class 2 Homeobox 2) is a Protein Coding gene. Diseases associated with POU2F2 include Herpes Simplex and T-Cell/Histiocyte Rich Large B Cell Lymphoma. Among its related pathways are Development_Glucocorticoid receptor signaling and Tat-mediated elongation of the HIV-1 transcript. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein domain specific binding. An important paralog of this gene is POU2F1.
UniProtKB/Swiss-Prot Summary for POU2F2 Gene
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874).
[Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter.