Aliases for POU2F1 Gene
External Ids for POU2F1 Gene
Previous HGNC Symbols for POU2F1 Gene
Previous GeneCards Identifiers for POU2F1 Gene
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
GeneCards Summary for POU2F1 Gene
POU2F1 (POU Class 2 Homeobox 1) is a Protein Coding gene. Diseases associated with POU2F1 include Herpes Simplex and Subacute Leukemia. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and RNA Polymerase III Transcription Initiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is POU2F2.
UniProtKB/Swiss-Prot Summary for POU2F1 Gene
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.