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Aliases for POU2F1 Gene

Aliases for POU2F1 Gene

  • POU Class 2 Homeobox 1 2 3 5
  • POU Domain, Class 2, Transcription Factor 1 3 4
  • Octamer-Binding Transcription Factor 1 3 4
  • Octamer-Binding Protein 1 3 4
  • Oct-1 3 4
  • NF-A1 3 4
  • OTF-1 3 4
  • OTF1 3 4
  • OCT1 3 4
  • POU Domain Class 2, Transcription Factor 1 2
  • Octamer-Binding Transcription Factor-1 3
  • POU Class 2 Homeobox 1 Isoform Oct-1R 3
  • Oct-1B 3

External Ids for POU2F1 Gene

Previous HGNC Symbols for POU2F1 Gene

  • OTF1

Previous GeneCards Identifiers for POU2F1 Gene

  • GC01P164826
  • GC01P162840
  • GC01P163886
  • GC01P164377
  • GC01P163921
  • GC01P165456
  • GC01P138436

Summaries for POU2F1 Gene

Entrez Gene Summary for POU2F1 Gene

  • The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]

GeneCards Summary for POU2F1 Gene

POU2F1 (POU Class 2 Homeobox 1) is a Protein Coding gene. Diseases associated with POU2F1 include Herpes Simplex. Among its related pathways are Glucocorticoid receptor regulatory network and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is POU2F2.

UniProtKB/Swiss-Prot for POU2F1 Gene

  • Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.

Gene Wiki entry for POU2F1 Gene

Additional gene information for POU2F1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU2F1 Gene

Genomics for POU2F1 Gene

GeneHancer (GH) Regulatory Elements for POU2F1 Gene

Promoters and enhancers for POU2F1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J167327 Promoter/Enhancer 2.2 VISTA EPDnew Ensembl ENCODE 600.1 +109.6 109644 5.5 ZNF652 CBFA2T2 ZNF148 CEBPG MLLT1 SMARCA4 IKZF1 RFX1 IKZF2 RELA POU2F1 LINC01363 ENSG00000272033
GH01J167219 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 620.1 +0.9 919 5.5 SP1 ELF3 ZFX CC2D1A MNT ZNF148 NKRF MLLT1 GTF2F1 ZNF384 POU2F1 ENSG00000272205 DUTP6 ENSG00000215835 MPZL1 ENSG00000272033
GH01J167713 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 57.4 +494.4 494359 4.4 CC2D1A ELF3 ZFX CTCF ZKSCAN8 MNT ZNF148 NKRF MLLT1 GTF2F1 TRP-AGG2-1 TRP-CGG1-1 GC01M167716 POU2F1 MPZL1 DUTP6 TADA1 TIPRL CREG1
GH01J167985 Enhancer 1.3 FANTOM5 Ensembl 73.1 +763.6 763572 1.6 ZNF473 CC2D1A ZKSCAN8 CBFA2T2 MLLT1 ZSCAN21 CDC5L BACH1 TRIM24 SP7 POU2F1 MPZL1 ENSG00000272205 ADCY10 MPC2 RCSD1 GC01P167995 DCAF6
GH01J166838 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 37.5 -381.1 -381136 3.8 CC2D1A ZFX ELF3 MNT CBFA2T2 ZNF148 NKRF POLR2A ZNF121 GTF2F1 POGK POU2F1 DUTP6 ENSG00000215835 GC01P166768
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POU2F1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POU2F1 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • Nkx2-5
  • SRF
  • SRF (504 AA)
  • STAT5A

Genomic Locations for POU2F1 Gene

Genomic Locations for POU2F1 Gene
chr1:167,220,829-167,427,345
(GRCh38/hg38)
Size:
206,517 bases
Orientation:
Plus strand
chr1:167,190,066-167,396,582
(GRCh37/hg19)
Size:
206,517 bases
Orientation:
Plus strand

Genomic View for POU2F1 Gene

Genes around POU2F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU2F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU2F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU2F1 Gene

Proteins for POU2F1 Gene

  • Protein details for POU2F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14859-PO2F1_HUMAN
    Recommended name:
    POU domain, class 2, transcription factor 1
    Protein Accession:
    P14859
    Secondary Accessions:
    • B1AL91
    • B1AL93
    • B4E029
    • J3KP77
    • Q5TBT7
    • Q6PK46
    • Q8NEU9
    • Q9BPV1

    Protein attributes for POU2F1 Gene

    Size:
    743 amino acids
    Molecular mass:
    76472 Da
    Quaternary structure:
    • Interacts with NR3C1, AR, PGR and HCFC1. Associates with the herpes simplex virus VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes.

    Three dimensional structures from OCA and Proteopedia for POU2F1 Gene

    Alternative splice isoforms for POU2F1 Gene

neXtProt entry for POU2F1 Gene

Post-translational modifications for POU2F1 Gene

No data available for DME Specific Peptides for POU2F1 Gene

Domains & Families for POU2F1 Gene

Gene Families for POU2F1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for POU2F1 Gene

GenScript: Design optimal peptide antigens:
  • POU class 2 homeobox 1 (B1AL92_HUMAN)
  • cDNA FLJ59165, highly similar to POU domain, class 2, transcription factor 1 (B4DYN6_HUMAN)
  • cDNA FLJ57693, highly similar to POU domain, class 2, transcription factor 1 (B4E029_HUMAN)
  • Octamer-binding transcription factor 1 (PO2F1_HUMAN)
  • Oct-1B (Q16075_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14859

UniProtKB/Swiss-Prot:

PO2F1_HUMAN :
  • Belongs to the POU transcription factor family. Class-2 subfamily.
Family:
  • Belongs to the POU transcription factor family. Class-2 subfamily.
genes like me logo Genes that share domains with POU2F1: view

Function for POU2F1 Gene

Molecular function for POU2F1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
GENATLAS Biochemistry:
POU domain,class 2,transcription factor 1

Phenotypes From GWAS Catalog for POU2F1 Gene

Gene Ontology (GO) - Molecular Function for POU2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP 10329190
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IMP 10541551
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS,IMP 19274049
GO:0003677 DNA binding IEA,IDA 9199328
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with POU2F1: view
genes like me logo Genes that share phenotypes with POU2F1: view

Animal Models for POU2F1 Gene

MGI Knock Outs for POU2F1:

Animal Model Products

CRISPR Products

miRNA for POU2F1 Gene

miRTarBase miRNAs that target POU2F1

Transcription Factor Targets for POU2F1 Gene

Selected GeneGlobe predicted Target genes for POU2F1

Clone Products

  • Applied Biological Materials (abm): Clones for POU2F1 - Now 50% OFF >
  • * POU2F1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * POU2F1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for POU2F1 Gene

Localization for POU2F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU2F1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POU2F1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (3)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for POU2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 9242494
GO:0005654 nucleoplasm TAS,IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0090575 RNA polymerase II transcription factor complex IMP 10329190
genes like me logo Genes that share ontologies with POU2F1: view

Pathways & Interactions for POU2F1 Gene

genes like me logo Genes that share pathways with POU2F1: view

SIGNOR curated interactions for POU2F1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for POU2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0042795 snRNA transcription by RNA polymerase II TAS --
GO:0045892 negative regulation of transcription, DNA-templated IDA 11891224
GO:0045944 positive regulation of transcription by RNA polymerase II IMP 11380252
genes like me logo Genes that share ontologies with POU2F1: view

Drugs & Compounds for POU2F1 Gene

(6) Drugs for POU2F1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for POU2F1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with POU2F1: view

Transcripts for POU2F1 Gene

Unigene Clusters for POU2F1 Gene

POU class 2 homeobox 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for POU2F1 - Now 50% OFF >
  • * POU2F1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * POU2F1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for POU2F1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: -
SP5: - - - - -
SP6:
SP7: - - - - - - - - - - - -
SP8: -
SP9: - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - -
SP12:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for POU2F1 Gene

GeneLoc Exon Structure for
POU2F1
ECgene alternative splicing isoforms for
POU2F1

Expression for POU2F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POU2F1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POU2F1 Gene

This gene is overexpressed in Stomach (22.2), Blymphocyte (10.3), Pancreas (8.1), and Skin (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POU2F1 Gene



Protein tissue co-expression partners for POU2F1 Gene

NURSA nuclear receptor signaling pathways regulating expression of POU2F1 Gene:

POU2F1

SOURCE GeneReport for Unigene cluster for POU2F1 Gene:

Hs.283402

mRNA Expression by UniProt/SwissProt for POU2F1 Gene:

P14859-PO2F1_HUMAN
Tissue specificity: Ubiquitous. Isoform 2 is lymphocyte-specific.

Evidence on tissue expression from TISSUES for POU2F1 Gene

  • Liver(4.2)
  • Lung(4.2)
  • Skin(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with POU2F1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for POU2F1 Gene

Orthologs for POU2F1 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU2F1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POU2F1 35 34
  • 99.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia POU2F1 35 34
  • 93 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POU2F1 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POU2F1 35 34
  • 91.36 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pou2f1 34
  • 91.34 (n)
mouse
(Mus musculus)
Mammalia Pou2f1 17 35 34
  • 90.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POU2F1 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHOCT-1 35
  • 96 (a)
OneToOne
POU2F1 34
  • 88.96 (n)
lizard
(Anolis carolinensis)
Reptilia POU2F1 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pou2f1 34
  • 80.84 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1265 34
zebrafish
(Danio rerio)
Actinopterygii pou2f1b 35 34
  • 70.79 (n)
OneToOne
oct1 34
fruit fly
(Drosophila melanogaster)
Insecta pdm2 35 36
  • 23 (a)
ManyToMany
nub 35 36
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-18 35
  • 27 (a)
OneToMany
Species where no ortholog for POU2F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POU2F1 Gene

ENSEMBL:
Gene Tree for POU2F1 (if available)
TreeFam:
Gene Tree for POU2F1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POU2F1: view image

Paralogs for POU2F1 Gene

(16) SIMAP similar genes for POU2F1 Gene using alignment to 3 proteins:

  • PO2F1_HUMAN
  • B4DYN6_HUMAN
  • J3KP77_HUMAN
genes like me logo Genes that share paralogs with POU2F1: view

Variants for POU2F1 Gene

Sequence variations from dbSNP and Humsavar for POU2F1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035816 A breast cancer sample p.Ser88Phe
rs1000001985 -- 167,239,452(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000018039 -- 167,415,370(+) T/A genic_downstream_transcript_variant, intron_variant
rs1000033177 -- 167,300,246(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000040519 -- 167,220,514(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for POU2F1 Gene

Variant ID Type Subtype PubMed ID
esv2719195 CNV deletion 23290073
esv3890749 CNV gain 25118596
nsv1000229 CNV loss 25217958
nsv1014857 CNV gain 25217958
nsv1078309 CNV deletion 25765185
nsv1078878 OTHER inversion 25765185
nsv1113191 CNV deletion 24896259
nsv3421 CNV insertion 18451855
nsv3432 CNV insertion 18451855
nsv521232 CNV gain+loss 19592680
nsv831803 CNV loss 17160897
nsv831814 CNV loss 17160897

Variation tolerance for POU2F1 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POU2F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POU2F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU2F1 Gene

Disorders for POU2F1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for POU2F1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for POU2F1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with POU2F1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POU2F1 Gene

Publications for POU2F1 Gene

  1. Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1. (PMID: 14612514) Schild-Poulter C … Haché RJ (Cancer research 2003) 3 4 23 58
  2. Differential phosphorylation of the transcription factor Oct1 during the cell cycle. (PMID: 1887216) Roberts SB … Heintz N (Science (New York, N.Y.) 1991) 2 3 23 58
  3. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. (PMID: 1684878) Segil N … Heintz N (Science (New York, N.Y.) 1991) 3 4 23 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  5. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. (PMID: 20886065) Cleynen I … Vermeire S (PloS one 2010) 3 45 58

Products for POU2F1 Gene