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Aliases for POTEKP Gene

Aliases for POTEKP Gene

  • POTE Ankyrin Domain Family Member K, Pseudogene 2 3 5
  • Actin, Beta-Like 3 2 3
  • Kappa-Actin 3 4
  • ACTBL3 3 4
  • POTE Ankyrin Domain Family, Member K, Pseudogene 2
  • POTE Ankyrin Domain Family, Member K 2
  • POTE Ankyrin Domain Family Member K 4
  • Beta-Actin-Like Protein 3 3
  • Actin-Like Protein 3
  • POTE2delta 3
  • POTEK 3
  • ACT 3

External Ids for POTEKP Gene

Previous HGNC Symbols for POTEKP Gene

  • ACTBL3

Previous GeneCards Identifiers for POTEKP Gene

  • GC02P132069
  • GC02P132350
  • GC02P124342

Summaries for POTEKP Gene

GeneCards Summary for POTEKP Gene

POTEKP (POTE Ankyrin Domain Family Member K, Pseudogene) is a Pseudogene. Among its related pathways are Response to elevated platelet cytosolic Ca2+.

Additional gene information for POTEKP Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTEKP Gene

Genomics for POTEKP Gene

Genomic Locations for POTEKP Gene

Genomic Locations for POTEKP Gene
35,515 bases
Plus strand

Genomic View for POTEKP Gene

Genes around POTEKP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEKP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEKP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEKP Gene

No data available for GeneHancer (GH) Regulatory Elements for POTEKP Gene

Proteins for POTEKP Gene

  • Protein details for POTEKP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative beta-actin-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q562N5

    Protein attributes for POTEKP Gene

    375 amino acids
    Molecular mass:
    42016 Da
    Quaternary structure:
    • Interacts with PFN1 and PFDN1. Does not interact with PFN2.

neXtProt entry for POTEKP Gene

Post-translational modifications for POTEKP Gene

  • Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
  • Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POTEKP Gene

Domains & Families for POTEKP Gene

Gene Families for POTEKP Gene

Protein Domains for POTEKP Gene

Suggested Antigen Peptide Sequences for POTEKP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family.
  • Belongs to the actin family.
genes like me logo Genes that share domains with POTEKP: view

Function for POTEKP Gene

Gene Ontology (GO) - Molecular Function for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with POTEKP: view

Phenotypes for POTEKP Gene

GenomeRNAi human phenotypes for POTEKP:
genes like me logo Genes that share phenotypes with POTEKP: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POTEKP Gene

Localization for POTEKP Gene

Subcellular locations from UniProtKB/Swiss-Prot for POTEKP Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with POTEKP: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for POTEKP Gene

Pathways & Interactions for POTEKP Gene

genes like me logo Genes that share pathways with POTEKP: view

Interacting Proteins for POTEKP Gene

Selected Interacting proteins: Q9BYX7-ACTBM_HUMAN for POTEKP Gene via IID

Gene Ontology (GO) - Biological Process for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
genes like me logo Genes that share ontologies with POTEKP: view

No data available for SIGNOR curated interactions for POTEKP Gene

Drugs & Compounds for POTEKP Gene

No Compound Related Data Available

Transcripts for POTEKP Gene


(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POTEKP Gene

POTE ankyrin domain family, member K, pseudogene:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POTEKP Gene

No ASD Table

Relevant External Links for POTEKP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POTEKP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POTEKP Gene

mRNA differential expression in normal tissues according to GTEx for POTEKP Gene

This gene is overexpressed in Testis (x29.5) and Breast - Mammary Tissue (x16.3).

Protein differential expression in normal tissues from HIPED for POTEKP Gene

This gene is overexpressed in Urinary Bladder (48.4) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POTEKP Gene

Protein tissue co-expression partners for POTEKP Gene

NURSA nuclear receptor signaling pathways regulating expression of POTEKP Gene:


SOURCE GeneReport for Unigene cluster for POTEKP Gene:


mRNA Expression by UniProt/SwissProt for POTEKP Gene:

Tissue specificity: Expressed in some hepatocellular carcinomas.
genes like me logo Genes that share expression patterns with POTEKP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEKP Gene

Orthologs for POTEKP Gene

Evolution for POTEKP Gene

Gene Tree for POTEKP (if available)
Gene Tree for POTEKP (if available)

No data available for Orthologs for POTEKP Gene

Paralogs for POTEKP Gene

genes like me logo Genes that share paralogs with POTEKP: view

No data available for Paralogs for POTEKP Gene

Variants for POTEKP Gene

Sequence variations from dbSNP and Humsavar for POTEKP Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000002212 -- 131,599,845(+) C/A intron_variant
rs1000155224 -- 131,601,685(+) G/C intron_variant
rs1000221579 -- 131,599,654(+) A/T intron_variant
rs1000321531 -- 131,599,414(+) A/G intron_variant
rs1000352250 -- 131,608,742(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for POTEKP Gene

Variant ID Type Subtype PubMed ID
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv2762850 CNV gain 21179565
esv34704 CNV gain 17911159
esv3592488 CNV gain 21293372
esv3592489 CNV gain 21293372
nsv1004760 CNV gain 25217958
nsv1011967 CNV gain 25217958
nsv1014682 CNV loss 25217958
nsv10186 CNV loss 18304495
nsv428404 CNV loss 18775914
nsv483103 CNV gain+loss 15286789
nsv820012 CNV loss 19587683
nsv961887 CNV duplication 23825009
nsv962008 CNV duplication 23825009
nsv962009 CNV duplication 23825009
nsv979268 CNV duplication 23825009
nsv997248 CNV loss 25217958

Additional Variant Information for POTEKP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for POTEKP Gene

Disorders for POTEKP Gene

Additional Disease Information for POTEKP

No disorders were found for POTEKP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEKP Gene

Publications for POTEKP Gene

  1. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PMID: 16364570) Hahn Y … Lee B (Gene 2006) 2 3 58
  2. Identification of a novel actin isoform in hepatocellular carcinoma. (PMID: 16824795) Chang KW … Yeh CT (Hepatology research : the official journal of the Japan Society of Hepatology 2006) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon KS … Liu Q (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 58

Products for POTEKP Gene

Sources for POTEKP Gene

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