Aliases for POTEKP Gene

Aliases for POTEKP Gene

  • POTE Ankyrin Domain Family Member K, Pseudogene 2 3 5
  • Actin, Beta-Like 3 2 3
  • Kappa-Actin 3 4
  • POTE2delta 2 3
  • ACTBL3 3 4
  • POTE Ankyrin Domain Family, Member K, Pseudogene 2
  • POTE Ankyrin Domain Family, Member K 2
  • POTE Ankyrin Domain Family Member K 4
  • Putative Beta-Actin-Like Protein 3 4
  • Beta-Actin-Like Protein 3 3
  • Actin-Like Protein 3
  • POTEKP 5
  • FKSG30 2
  • POTEK 3
  • ACT 3

External Ids for POTEKP Gene

Previous HGNC Symbols for POTEKP Gene

  • ACTBL3
  • POTEK

Previous GeneCards Identifiers for POTEKP Gene

  • GC02P132069
  • GC02P132350
  • GC02P124342

Summaries for POTEKP Gene

GeneCards Summary for POTEKP Gene

POTEKP (POTE Ankyrin Domain Family Member K, Pseudogene) is a Pseudogene. Among its related pathways are Response to elevated platelet cytosolic Ca2+.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POTEKP Gene

Genomics for POTEKP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POTEKP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J131583 Enhancer 0.5 Ensembl 0.4 -7.0 -6951 1.2 BCL11A IRF4 BHLHE40 NR2F1 IKZF1 SPI1 IKZF2 EED RUNX3 HSALNG0018906 CCDC74A POTEKP lnc-CCDC74A-7 ENSG00000286208 ANKRD30BL
GH02J131622 Enhancer 0.5 Ensembl 0.3 +31.4 31449 0.8 SPI1 NR2F6 CEBPB SMARCE1 CEBPG CCDC74A piR-48252-002 lnc-CCDC74A-8 POTEKP ANKRD30BL
GH02J131595 Enhancer 0.2 Ensembl 0.7 +4.5 4549 1 POTEKP RF00026-553 RNU6-617P CCDC74A ANKRD30BL
GH02J131598 Enhancer 0.2 Ensembl 0.4 +5.7 5749 0.6 NBEAP2 MZT2A RF00026-553 RNU6-617P POTEKP CCDC74A ANKRD30BL
GH02J131602 Enhancer 0.2 Ensembl 0.4 +10.8 10849 0.4 RNU6-617P RF00026-553 MZT2A HSALNG0018907 POTEKP CCDC74A ANKRD30BL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POTEKP on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for POTEKP Gene

Latest Assembly
chr2:131,591,752-131,628,147
(GRCh38/hg38)
Size:
36,396 bases
Orientation:
Plus strand

Previous Assembly
chr2:132,349,615-132,384,002
(GRCh37/hg19 by Entrez Gene)
Size:
34,388 bases
Orientation:
Plus strand

chr2:132,349,325-132,384,839
(GRCh37/hg19 by Ensembl)
Size:
35,515 bases
Orientation:
Plus strand

Genomic View for POTEKP Gene

Genes around POTEKP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEKP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEKP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEKP Gene

Proteins for POTEKP Gene

  • Protein details for POTEKP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYX7-ACTBM_HUMAN
    Recommended name:
    Putative beta-actin-like protein 3
    Protein Accession:
    Q9BYX7
    Secondary Accessions:
    • Q562N5

    Protein attributes for POTEKP Gene

    Size:
    375 amino acids
    Molecular mass:
    42016 Da
    Quaternary structure:
    • Interacts with PFN1 and PFDN1. Does not interact with PFN2.

neXtProt entry for POTEKP Gene

Post-translational modifications for POTEKP Gene

  • Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
  • Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POTEKP Gene

Domains & Families for POTEKP Gene

Gene Families for POTEKP Gene

Protein Domains for POTEKP Gene

InterPro:
Blocks:
  • Actin/actin-like

Suggested Antigen Peptide Sequences for POTEKP Gene

GenScript: Design optimal peptide antigens:
  • POTE ankyrin domain family member K (ACTBM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BYX7

UniProtKB/Swiss-Prot:

ACTBM_HUMAN :
  • Belongs to the actin family.
Family:
  • Belongs to the actin family.
genes like me logo Genes that share domains with POTEKP: view

Function for POTEKP Gene

Phenotypes From GWAS Catalog for POTEKP Gene

Gene Ontology (GO) - Molecular Function for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0098973 structural constituent of postsynaptic actin cytoskeleton IBA 21873635
genes like me logo Genes that share ontologies with POTEKP: view
genes like me logo Genes that share phenotypes with POTEKP: view

Animal Models for research

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POTEKP Gene

Localization for POTEKP Gene

Subcellular locations from UniProtKB/Swiss-Prot for POTEKP Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005884 actin filament IBA 21873635
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with POTEKP: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for POTEKP Gene

Pathways & Interactions for POTEKP Gene

genes like me logo Genes that share pathways with POTEKP: view

Interacting Proteins for POTEKP Gene

Selected Interacting proteins: Q9BYX7-ACTBM_HUMAN for POTEKP Gene via IID

Gene Ontology (GO) - Biological Process for POTEKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0098974 postsynaptic actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with POTEKP: view

No data available for SIGNOR curated interactions for POTEKP Gene

Drugs & Compounds for POTEKP Gene

No Compound Related Data Available

Transcripts for POTEKP Gene

mRNA/cDNA for POTEKP Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEKP

Alternative Splicing Database (ASD) splice patterns (SP) for POTEKP Gene

No ASD Table

Relevant External Links for POTEKP Gene

GeneLoc Exon Structure for
POTEKP

Expression for POTEKP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POTEKP Gene

mRNA differential expression in normal tissues according to GTEx for POTEKP Gene

This gene is overexpressed in Testis (x29.5) and Breast - Mammary Tissue (x16.3).

Protein differential expression in normal tissues from HIPED for POTEKP Gene

This gene is overexpressed in Urinary Bladder (48.4) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POTEKP Gene



Protein tissue co-expression partners for POTEKP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POTEKP

SOURCE GeneReport for Unigene cluster for POTEKP Gene:

Hs.631267

mRNA Expression by UniProt/SwissProt for POTEKP Gene:

Q9BYX7-ACTBM_HUMAN
Tissue specificity: Expressed in some hepatocellular carcinomas.
genes like me logo Genes that share expression patterns with POTEKP: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEKP Gene

Orthologs for POTEKP Gene

Evolution for POTEKP Gene

ENSEMBL:
Gene Tree for POTEKP (if available)
TreeFam:
Gene Tree for POTEKP (if available)
Alliance of Genome Resources:
Additional Orthologs for POTEKP

No data available for Orthologs for POTEKP Gene

Paralogs for POTEKP Gene

(31) SIMAP similar genes for POTEKP Gene using alignment to 1 proteins:

  • ACTBM_HUMAN
genes like me logo Genes that share paralogs with POTEKP: view

No data available for Paralogs for POTEKP Gene

Variants for POTEKP Gene

Structural Variations from Database of Genomic Variants (DGV) for POTEKP Gene

Variant ID Type Subtype PubMed ID
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv2762850 CNV gain 21179565
esv34704 CNV gain 17911159
esv3592488 CNV gain 21293372
esv3592489 CNV gain 21293372
nsv1004760 CNV gain 25217958
nsv1011967 CNV gain 25217958
nsv1014682 CNV loss 25217958
nsv10186 CNV loss 18304495
nsv428404 CNV loss 18775914
nsv483103 CNV gain+loss 15286789
nsv820012 CNV loss 19587683
nsv961887 CNV duplication 23825009
nsv962008 CNV duplication 23825009
nsv962009 CNV duplication 23825009
nsv979268 CNV duplication 23825009
nsv997248 CNV loss 25217958

Additional Variant Information for POTEKP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POTEKP
Leiden Open Variation Database (LOVD)
POTEKP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Variation tolerance for POTEKP Gene

Disorders for POTEKP Gene

Additional Disease Information for POTEKP

No disorders were found for POTEKP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEKP Gene

Publications for POTEKP Gene

  1. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PMID: 16364570) Hahn Y … Lee B (Gene 2006) 2 3
  2. Identification of a novel actin isoform in hepatocellular carcinoma. (PMID: 16824795) Chang KW … Yeh CT (Hepatology research : the official journal of the Japan Society of Hepatology 2006) 3 4
  3. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  4. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. (PMID: 31536960) Moutaoufik MT … Babu M (iScience 2019) 3
  5. CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer. (PMID: 31501420) Liu Y … Sun F (Cell death & disease 2019) 3

Products for POTEKP Gene

Sources for POTEKP Gene