Aliases for POTEJ Gene

Aliases for POTEJ Gene

  • POTE Ankyrin Domain Family Member J 2 3 4 5
  • POTE2beta 2 3
  • POTE Ankyrin Domain Family, Member J 2
  • POTEJ 5

External Ids for POTEJ Gene

Previous GeneCards Identifiers for POTEJ Gene

  • GC00U926668
  • GC02P131370

Summaries for POTEJ Gene

GeneCards Summary for POTEJ Gene

POTEJ (POTE Ankyrin Domain Family Member J) is a Protein Coding gene. An important paralog of this gene is POTEI.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POTEJ Gene

Genomics for POTEJ Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POTEJ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J130606 Enhancer 0.3 Ensembl dbSUPER 0.7 -2.0 -2012 0.7 POTEJ piR-37362-002 CFC1
GH02J130601 Enhancer 0.4 Ensembl dbSUPER 0.4 -9.0 -8977 1.4 EZH2 ENSG00000277668 piR-36631-002 piR-33922-002 CFC1 POTEJ
GH02J130726 Promoter/Enhancer 1.2 ENCODE CraniofacialAtlas 0.1 +116.6 116633 2.5 SP1 ZNF600 MYC POLR2A ZIC2 REST SMAD5 TBP ZNF341 ZNF217 GPR148 RF00994-515 ENSG00000229797 POTEJ
GH02J130600 Enhancer 0.3 Ensembl dbSUPER 0.4 -11.1 -11077 0.4 CFC1 piR-36631-002 POTEJ
GH02J130693 Promoter 0.7 Ensembl 0.2 +82.3 82323 2 REST CTCF ZNF2 FOXP1 RAD21 TRIM22 ZNF444 KLF2P3 lnc-CFC1-3 FAR2P3 ENSG00000282944 GPR148 POTEJ
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POTEJ on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POTEJ

Genomic Locations for POTEJ Gene

Latest Assembly
chr2:130,611,078-130,658,448
(GRCh38/hg38)
Size:
47,371 bases
Orientation:
Plus strand

Previous Assembly
chr2:131,369,013-131,415,610
(GRCh37/hg19 by Entrez Gene)
Size:
46,598 bases
Orientation:
Plus strand

chr2:131,369,054-131,415,664
(GRCh37/hg19 by Ensembl)
Size:
46,611 bases
Orientation:
Plus strand

Genomic View for POTEJ Gene

Genes around POTEJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEJ Gene

Proteins for POTEJ Gene

  • Protein details for POTEJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG39-POTEJ_HUMAN
    Recommended name:
    POTE ankyrin domain family member J
    Protein Accession:
    P0CG39

    Protein attributes for POTEJ Gene

    Size:
    1038 amino acids
    Molecular mass:
    117390 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POTEJ Gene

Post-translational modifications for POTEJ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POTEJ Gene

No data available for DME Specific Peptides for POTEJ Gene

Domains & Families for POTEJ Gene

Gene Families for POTEJ Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for POTEJ Gene

GenScript: Design optimal peptide antigens:
  • POTE ankyrin domain family member J (POTEJ_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CG39

UniProtKB/Swiss-Prot:

POTEJ_HUMAN :
  • In the N-terminal section; belongs to the POTE family.
Family:
  • In the N-terminal section; belongs to the POTE family.
  • In the C-terminal section; belongs to the actin family.
genes like me logo Genes that share domains with POTEJ: view

Function for POTEJ Gene

Gene Ontology (GO) - Molecular Function for POTEJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with POTEJ: view

miRNA for POTEJ Gene

miRTarBase miRNAs that target POTEJ

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEJ

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POTEJ Gene

Localization for POTEJ Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POTEJ gene
Compartment Confidence
extracellular 4
cytosol 3
nucleus 2
cytoskeleton 1
golgi apparatus 1
plasma membrane 0
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for POTEJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with POTEJ: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for POTEJ Gene

Pathways & Interactions for POTEJ Gene

PathCards logo

SuperPathways for POTEJ Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTEJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis HEP 23580065
genes like me logo Genes that share ontologies with POTEJ: view

No data available for Pathways by source and SIGNOR curated interactions for POTEJ Gene

Drugs & Compounds for POTEJ Gene

No Compound Related Data Available

Transcripts for POTEJ Gene

mRNA/cDNA for POTEJ Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEJ

Alternative Splicing Database (ASD) splice patterns (SP) for POTEJ Gene

No ASD Table

Relevant External Links for POTEJ Gene

GeneLoc Exon Structure for
POTEJ

Expression for POTEJ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POTEJ Gene

mRNA differential expression in normal tissues according to GTEx for POTEJ Gene

This gene is overexpressed in Testis (x23.7), Prostate (x7.4), Heart - Atrial Appendage (x4.5), and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for POTEJ Gene

This gene is overexpressed in Heart (16.2), Brain (14.9), Skin (13.7), Saliva (10.8), and Lung (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POTEJ Gene



Protein tissue co-expression partners for POTEJ Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POTEJ

SOURCE GeneReport for Unigene cluster for POTEJ Gene:

Hs.558829
genes like me logo Genes that share expression patterns with POTEJ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEJ Gene

Orthologs for POTEJ Gene

This gene was present in the common ancestor of chordates.

Orthologs for POTEJ Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 93 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 41 (a)
ManyToMany
-- 30
  • 38 (a)
ManyToMany
-- 30
  • 37 (a)
ManyToMany
-- 30
  • 13 (a)
ManyToMany
-- 30
  • 11 (a)
ManyToMany
-- 30
  • 10 (a)
ManyToMany
-- 30
  • 10 (a)
ManyToMany
-- 30
  • 8 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Gm1758 30
  • 34 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 10 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 8 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 12 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 37 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii ANKRD7 30
  • 8 (a)
OneToMany
Species where no ortholog for POTEJ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for POTEJ Gene

ENSEMBL:
Gene Tree for POTEJ (if available)
TreeFam:
Gene Tree for POTEJ (if available)
Alliance of Genome Resources:
Additional Orthologs for POTEJ

Paralogs for POTEJ Gene

Pseudogenes.org Pseudogenes for POTEJ Gene

genes like me logo Genes that share paralogs with POTEJ: view

Variants for POTEJ Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for POTEJ Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for POTEJ Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4074n100 CNV gain 25217958
esv2670824 CNV deletion 23128226
esv2720768 CNV deletion 23290073
esv2759092 CNV gain+loss 17122850
esv2760576 CNV gain+loss 21179565
esv3379519 CNV duplication 20981092
esv3592455 CNV loss 21293372
nsv1005664 CNV loss 25217958
nsv10172 CNV loss 18304495
nsv1076496 CNV duplication 25765185
nsv1077892 CNV duplication 25765185
nsv1078469 CNV duplication 25765185
nsv1124813 CNV duplication 24896259
nsv1128813 CNV duplication 24896259
nsv1132510 CNV duplication 24896259
nsv1147463 OTHER inversion 26484159
nsv1148026 CNV duplication 26484159
nsv1152210 CNV duplication 26484159
nsv428403 CNV loss 18775914
nsv7327 OTHER inversion 18451855
nsv953165 CNV duplication 24416366
nsv961510 CNV duplication 23825009
nsv962006 CNV duplication 23825009
nsv963847 CNV duplication 23825009
nsv963848 CNV duplication 23825009
nsv979263 CNV duplication 23825009

Variation tolerance for POTEJ Gene

Gene Damage Index Score: 7.35; 81.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POTEJ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POTEJ
Leiden Open Variation Database (LOVD)
POTEJ

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POTEJ Gene

Disorders for POTEJ Gene

Additional Disease Information for POTEJ

No disorders were found for POTEJ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEJ Gene

Publications for POTEJ Gene

  1. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PMID: 16364570) Hahn Y … Lee B (Gene 2006) 2 3
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry. (PMID: 32529326) Sanderson MR … Wevrick R (Human genetics 2020) 3
  4. ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents. (PMID: 32780723) Lan W … Iovanna J (JCI insight 2020) 3
  5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3

Products for POTEJ Gene

Sources for POTEJ Gene