Aliases for POTEI Gene

Aliases for POTEI Gene

  • POTE Ankyrin Domain Family Member I 2 3 4 5
  • POTE2beta 2 3
  • POTE Ankyrin Domain Family, Member I 2
  • POTEI 5

External Ids for POTEI Gene

Previous GeneCards Identifiers for POTEI Gene

  • GC02M131217

Summaries for POTEI Gene

GeneCards Summary for POTEI Gene

POTEI (POTE Ankyrin Domain Family Member I) is a Protein Coding gene. An important paralog of this gene is POTEF.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POTEI Gene

Genomics for POTEI Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POTEI Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J130510 Enhancer 0.3 Ensembl dbSUPER 250.7 -1.8 -1817 1 POTEI piR-37362-001 CFC1B
GH02J130509 Promoter 0.3 EPDnew 250.7 +0.0 22 0.1 POTEI HSALNG0018822 PTPN18
GH02J130389 Promoter/Enhancer 1.8 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 0.1 +118.5 118524 2.8 ZNF600 CEBPA ZIC2 YY1 MXD4 SMAD5 KLF11 ZNF341 KMT2B SP2 HSALNG0018813 PTPN18 FAR2P2 AMER3 CCDC115 LOC105373618 POTEI
GH02J130369 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.1 +137.1 137121 5.6 SP1 ZNF207 IKZF1 NCOR1 MYC JUND ZNF592 POLR2A NFIC ZIC2 HSALNG0018810 PTPN18 SMPD4 HSALNG0018811 HSALNG0018807-001 POTEI
GH02J130428 Promoter 1.1 Ensembl CraniofacialAtlas 0.2 +81.5 81506 2 REST ELF1 CTCF SMARCA4 NRF1 FOXP1 GMEB1 GTF2F1 RNF2 CTBP1 KLF2P2 lnc-PTPN18-3 PTPN18 CYP4F62P FAR2P2 lnc-POTEI-2 POTEI
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POTEI on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POTEI

Genomic Locations for POTEI Gene

Latest Assembly
chr2:130,459,455-130,509,707
(GRCh38/hg38)
Size:
50,253 bases
Orientation:
Minus strand

Previous Assembly
chr2:131,217,028-131,267,280
(GRCh37/hg19 by Entrez Gene)
Size:
50,253 bases
Orientation:
Minus strand

chr2:131,217,028-131,267,239
(GRCh37/hg19 by Ensembl)
Size:
50,212 bases
Orientation:
Minus strand

Genomic View for POTEI Gene

Genes around POTEI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEI Gene

Proteins for POTEI Gene

  • Protein details for POTEI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG38-POTEI_HUMAN
    Recommended name:
    POTE ankyrin domain family member I
    Protein Accession:
    P0CG38

    Protein attributes for POTEI Gene

    Size:
    1075 amino acids
    Molecular mass:
    121282 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POTEI Gene

Post-translational modifications for POTEI Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POTEI Gene

Domains & Families for POTEI Gene

Gene Families for POTEI Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for POTEI Gene

GenScript: Design optimal peptide antigens:
  • POTE ankyrin domain family member I (POTEI_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CG38

UniProtKB/Swiss-Prot:

POTEI_HUMAN :
  • In the N-terminal section; belongs to the POTE family.
Family:
  • In the N-terminal section; belongs to the POTE family.
  • In the C-terminal section; belongs to the actin family.
genes like me logo Genes that share domains with POTEI: view

Function for POTEI Gene

Gene Ontology (GO) - Molecular Function for POTEI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with POTEI: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEI

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POTEI Gene

Localization for POTEI Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POTEI gene
Compartment Confidence
extracellular 4
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for POTEI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with POTEI: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for POTEI Gene

Pathways & Interactions for POTEI Gene

PathCards logo

SuperPathways for POTEI Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTEI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis HEP 23580065
genes like me logo Genes that share ontologies with POTEI: view

No data available for Pathways by source and SIGNOR curated interactions for POTEI Gene

Drugs & Compounds for POTEI Gene

No Compound Related Data Available

Transcripts for POTEI Gene

mRNA/cDNA for POTEI Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEI

Alternative Splicing Database (ASD) splice patterns (SP) for POTEI Gene

No ASD Table

Relevant External Links for POTEI Gene

GeneLoc Exon Structure for
POTEI

Expression for POTEI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POTEI Gene

mRNA differential expression in normal tissues according to GTEx for POTEI Gene

This gene is overexpressed in Testis (x28.5), Prostate (x7.7), and Heart - Atrial Appendage (x5.5).

Protein differential expression in normal tissues from HIPED for POTEI Gene

This gene is overexpressed in Spleen (19.0), Skin (11.7), Brain (11.2), Heart (8.8), Lung (8.0), and Saliva (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POTEI Gene



Protein tissue co-expression partners for POTEI Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for POTEI Gene:

Hs.558782
genes like me logo Genes that share expression patterns with POTEI: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEI Gene

Orthologs for POTEI Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POTEI Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia POTEI 29
  • 98.39 (n)
-- 30
  • 97 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Potef 29
  • 85.6 (n)
Dog
(Canis familiaris)
Mammalia -- 30
  • 41 (a)
ManyToMany
-- 30
  • 38 (a)
ManyToMany
-- 30
  • 37 (a)
ManyToMany
-- 30
  • 13 (a)
ManyToMany
-- 30
  • 11 (a)
ManyToMany
-- 30
  • 10 (a)
ManyToMany
-- 30
  • 10 (a)
ManyToMany
-- 30
  • 8 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Gm1758 30
  • 34 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 10 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 8 (a)
OneToMany
Chicken
(Gallus gallus)
Aves LOC776816 29
  • 86.13 (n)
-- 30
  • 12 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 37 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii ANKRD7 30
  • 8 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Act42A 29
  • 80.04 (n)
Worm
(Caenorhabditis elegans)
Secernentea act-5 29
  • 77.6 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ACT11 29
  • 72.56 (n)
Rice
(Oryza sativa)
Liliopsida Os05g0106600 29
  • 73.91 (n)
Species where no ortholog for POTEI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for POTEI Gene

ENSEMBL:
Gene Tree for POTEI (if available)
TreeFam:
Gene Tree for POTEI (if available)
Alliance of Genome Resources:
Additional Orthologs for POTEI

Paralogs for POTEI Gene

Pseudogenes.org Pseudogenes for POTEI Gene

genes like me logo Genes that share paralogs with POTEI: view

Variants for POTEI Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for POTEI Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for POTEI Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv2034n106 CNV deletion 24896259
esv2759092 CNV gain+loss 17122850
esv3893326 CNV gain 25118596
nsv1005664 CNV loss 25217958
nsv10170 CNV gain+loss 18304495
nsv1072029 CNV deletion 25765185
nsv1072030 CNV deletion 25765185
nsv1072976 CNV deletion 25765185
nsv1072977 CNV deletion 25765185
nsv1112770 CNV deletion 24896259
nsv1118877 CNV deletion 24896259
nsv1126565 CNV deletion 24896259
nsv1139735 CNV duplication 24896259
nsv1144913 CNV deletion 24896259
nsv1144914 CNV deletion 24896259
nsv1147463 OTHER inversion 26484159
nsv428403 CNV loss 18775914
nsv7327 OTHER inversion 18451855
nsv953164 CNV deletion 24416366
nsv961645 CNV duplication 23825009
nsv961646 CNV duplication 23825009
nsv963846 CNV duplication 23825009
nsv979119 CNV duplication 23825009
nsv979262 CNV duplication 23825009

Variation tolerance for POTEI Gene

Gene Damage Index Score: 8.15; 84.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POTEI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POTEI
Leiden Open Variation Database (LOVD)
POTEI

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POTEI Gene

Disorders for POTEI Gene

Additional Disease Information for POTEI

No disorders were found for POTEI Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEI Gene

Publications for POTEI Gene

  1. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PMID: 16364570) Hahn Y … Lee B (Gene 2006) 2 3
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription. (PMID: 30413534) Wang F … Mei Y (The Journal of biological chemistry 2019) 3
  4. CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer. (PMID: 31501420) Liu Y … Sun F (Cell death & disease 2019) 3
  5. Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2. (PMID: 31617661) Botham A … Schimmer A (Proteomics 2019) 3

Products for POTEI Gene

Sources for POTEI Gene