Aliases for POTEH Gene

Aliases for POTEH Gene

  • POTE Ankyrin Domain Family Member H 2 3 4 5
  • POTE22 2 3 4
  • Prostate, Ovary, Testis-Expressed Protein On Chromosome 22 3 4
  • Cancer/Testis Antigen Family 104, Member 7 2 3
  • ANKRD26-Like Family C Member 3 3 4
  • Actin, Beta-Like 1 2 3
  • CT104.7 2 3
  • ACTBL1 3 4
  • A26C3 3 4
  • Protein Expressed In Prostate, Ovary, Testis, And Placenta POTE14 Like 3
  • Protein Expressed In Prostate, Ovary, Testis, And Placenta 22 3
  • POTE Ankyrin Domain Family, Member H 2
  • ANKRD26-Like Family C, Member 3 2
  • POTE-22 4
  • POTEH 5

External Ids for POTEH Gene

Previous HGNC Symbols for POTEH Gene

  • ACTBL1
  • A26C3

Previous GeneCards Identifiers for POTEH Gene

  • GC22M014640
  • GC22M016256

Summaries for POTEH Gene

GeneCards Summary for POTEH Gene

POTEH (POTE Ankyrin Domain Family Member H) is a Protein Coding gene. An important paralog of this gene is POTEM.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POTEH Gene

Genomics for POTEH Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POTEH Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J015784 Promoter 0.6 Ensembl 0.2 +95.6 95575 2.8 ZBTB12 MLLT1 RNF2 EMSY DUXAP8 HSALNG0133782 lnc-POTEG-14-002 piR-47211-443 piR-57600-003 PSLNR POTEH CCT8L2
GH22J015750 Promoter 0.3 Ensembl 0.2 +61.0 60975 0.4 GRAMD4P2 lnc-CCT8L2-27 KY994054-039 PSLNR POTEH CCT8L2
GH22J015772 Enhancer 0.3 Ensembl 0.2 +83.0 82974 0.4 FOS lnc-POTEH-5 piR-52457-007 piR-48287-003 LOC107987324 PSLNR POTEH CCT8L2
GH22J015603 Enhancer 0.2 Ensembl 0.2 -86.1 -86125 1.4 ENSG00000230471 HSALNG0133792 LOC112268291 piR-41958-003 OR11H1 POTEH
GH22J015602 Enhancer 0.2 Ensembl 0.2 -87.6 -87556 0.7 HSALNG0133792 ENSG00000230471 LOC112268291 ENSG00000230643 OR11H1 POTEH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POTEH on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POTEH

Top Transcription factor binding sites by QIAGEN in the POTEH gene promoter:
  • AP-1
  • E47
  • ITF-2
  • Nkx2-2
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • PPAR-gamma2
  • Tal-1
  • Tal-1beta

Genomic Locations for POTEH Gene

Latest Assembly
31,606 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
31,606 bases
Minus strand

(GRCh37/hg19 by Ensembl)
31,497 bases
Minus strand

Genomic View for POTEH Gene

Genes around POTEH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEH Gene

Proteins for POTEH Gene

  • Protein details for POTEH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    POTE ankyrin domain family member H
    Protein Accession:
    Secondary Accessions:
    • A2CEK4
    • A6NCI1
    • A9Z1W0

    Protein attributes for POTEH Gene

    545 amino acids
    Molecular mass:
    60965 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for POTEH Gene


neXtProt entry for POTEH Gene

Post-translational modifications for POTEH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POTEH Gene

No data available for DME Specific Peptides for POTEH Gene

Domains & Families for POTEH Gene

Gene Families for POTEH Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for POTEH Gene

  • Ankyrin repeat signature

Suggested Antigen Peptide Sequences for POTEH Gene

GenScript: Design optimal peptide antigens:
  • Prostate, ovary, testis-expressed protein on chromosome 22 (POTEH_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the POTE family.
  • Belongs to the POTE family.
genes like me logo Genes that share domains with POTEH: view

Function for POTEH Gene

Gene Ontology (GO) - Molecular Function for POTEH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with POTEH: view

Phenotypes for POTEH Gene

genes like me logo Genes that share phenotypes with POTEH: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEH

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POTEH Gene

Localization for POTEH Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POTEH gene
Compartment Confidence
plasma membrane 1
nucleus 1
cytosol 1
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for POTEH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with POTEH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for POTEH Gene

Pathways & Interactions for POTEH Gene

PathCards logo

SuperPathways for POTEH Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTEH Gene


No data available for Pathways by source and SIGNOR curated interactions for POTEH Gene

Drugs & Compounds for POTEH Gene

No Compound Related Data Available

Transcripts for POTEH Gene

mRNA/cDNA for POTEH Gene

1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEH

Alternative Splicing Database (ASD) splice patterns (SP) for POTEH Gene

No ASD Table

Relevant External Links for POTEH Gene

GeneLoc Exon Structure for

Expression for POTEH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POTEH Gene

mRNA differential expression in normal tissues according to GTEx for POTEH Gene

This gene is overexpressed in Prostate (x30.4) and Testis (x20.7).

Protein differential expression in normal tissues from HIPED for POTEH Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POTEH Gene

Protein tissue co-expression partners for POTEH Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POTEH

SOURCE GeneReport for Unigene cluster for POTEH Gene:

genes like me logo Genes that share expression patterns with POTEH: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEH Gene

Orthologs for POTEH Gene

This gene was present in the common ancestor of chordates.

Orthologs for POTEH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 30
  • 84 (a)
-- 30
  • 81 (a)
(Canis familiaris)
Mammalia -- 30
  • 42 (a)
-- 30
  • 38 (a)
-- 30
  • 37 (a)
-- 30
  • 11 (a)
-- 30
  • 7 (a)
-- 30
  • 6 (a)
-- 30
  • 2 (a)
-- 30
(Mus musculus)
Mammalia Gm1758 30
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 4 (a)
(Bos Taurus)
Mammalia -- 30
(Gallus gallus)
Aves -- 30
  • 8 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 36 (a)
(Danio rerio)
Actinopterygii ANKRD7 30
  • 5 (a)
Species where no ortholog for POTEH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for POTEH Gene

Gene Tree for POTEH (if available)
Gene Tree for POTEH (if available)
Alliance of Genome Resources:
Additional Orthologs for POTEH

Paralogs for POTEH Gene

(28) SIMAP similar genes for POTEH Gene using alignment to 2 proteins:

  • H0YG78_HUMAN
genes like me logo Genes that share paralogs with POTEH: view

Variants for POTEH Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for POTEH Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for POTEH Gene

Variant ID Type Subtype PubMed ID
dgv168n111 CNV duplication 26073780
dgv2420n106 CNV duplication 24896259
dgv2529e59 CNV duplication 20981092
dgv2530e59 CNV duplication 20981092
dgv2531e59 CNV duplication 20981092
dgv2532e59 CNV duplication 20981092
dgv2533e59 CNV duplication 20981092
dgv4450n100 CNV gain 25217958
dgv4451n100 CNV gain+loss 25217958
dgv4452n100 CNV loss 25217958
dgv4453n100 CNV gain 25217958
dgv4455n100 CNV loss 25217958
dgv71n68 CNV gain 17160897
dgv7934n54 CNV gain 21841781
dgv98e203 CNV gain+loss 21179565
esv25550 CNV gain+loss 19812545
esv33426 CNV gain+loss 17666407
esv3369988 CNV duplication 20981092
esv3384201 CNV duplication 20981092
esv3411120 CNV duplication 20981092
esv3584775 CNV loss 24956385
esv3893421 CNV gain 25118596
esv995567 CNV loss 20482838
nsv1061008 CNV loss 25217958
nsv1076527 CNV duplication 25765185
nsv1076528 CNV duplication 25765185
nsv1077407 CNV duplication 25765185
nsv1077927 CNV duplication 25765185
nsv1110387 CNV duplication 24896259
nsv1118682 CNV duplication 24896259
nsv1141402 CNV duplication 24896259
nsv1141403 CNV duplication 24896259
nsv1141405 CNV duplication 24896259
nsv1146649 CNV duplication 26484159
nsv1150052 CNV duplication 26484159
nsv1152609 CNV duplication 26484159
nsv1153486 CNV duplication 26484159
nsv469815 CNV gain+loss 16826518
nsv471709 CNV gain+loss 15918152
nsv588004 CNV gain 21841781
nsv821525 CNV duplication 20802225
nsv953668 CNV duplication 24416366
nsv964647 CNV duplication 23825009
nsv966055 CNV duplication 23825009
nsv9866 CNV gain+loss 18304495

Variation tolerance for POTEH Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POTEH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POTEH Gene

Disorders for POTEH Gene

Additional Disease Information for POTEH

No disorders were found for POTEH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEH Gene

Publications for POTEH Gene

  1. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PMID: 15276201) Bera TK … Pastan I (Gene 2004) 2 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4
  3. POTEH hypomethylation, a new epigenetic biomarker for glioma prognosis. (PMID: 21439273) Liu X … Li G (Brain research 2011) 2 3
  4. Expression of POTE protein in human testis detected by novel monoclonal antibodies. (PMID: 17996727) Ise T … Pastan I (Biochemical and biophysical research communications 2008) 22
  5. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. (PMID: 12475935) Bera TK … Pastan I (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for POTEH Gene

Sources for POTEH Gene