Aliases for POTEE Gene

Aliases for POTEE Gene

  • POTE Ankyrin Domain Family Member E 2 3 4 5
  • POTE-2 2 3 4
  • POTE2 2 3 4
  • Prostate, Ovary, Testis-Expressed Protein On Chromosome 2 3 4
  • Cancer/Testis Antigen Family 104, Member 2 2 3
  • ANKRD26-Like Family C Member 1A 3 4
  • POTE2gamma 2 3
  • CT104.2 2 3
  • A26C1A 3 4
  • A26C1 2 3
  • Protein Expressed In Prostate, Ovary, Testis, And Placenta 2 3
  • POTE Ankyrin Domain Family, Member E 2
  • ANKRD26-Like Family C, Member 1A 2
  • POTEE 5

External Ids for POTEE Gene

Previous HGNC Symbols for POTEE Gene

  • A26C1A

Previous GeneCards Identifiers for POTEE Gene

  • GC02P131695
  • GC02P131980
  • GC02M123138
  • GC02P131219
  • GC02P131255
  • GC02P131784
  • GC02P131845
  • GC02P131828
  • GC02P132458
  • GC02P131290
  • GC02P131323
  • GC02P131353
  • GC02P131389
  • GC02P131577
  • GC02P131635
  • GC02P131685
  • GC02P131737
  • GC02P132746
  • GC02P133049

Summaries for POTEE Gene

GeneCards Summary for POTEE Gene

POTEE (POTE Ankyrin Domain Family Member E) is a Protein Coding gene. An important paralog of this gene is POTEF.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POTEE Gene

Genomics for POTEE Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POTEE Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J131209 Promoter 1.4 EPDnew Ensembl 250.7 -0.5 -535 4.4 NCOR1 IKZF1 TBP MNT TAF9B SIN3B NBN NKRF TRIM25 ZBTB5 ENSG00000285819 POTEE lnc-POTEE-1 FAM168B FAR2P4 MZT2A KLF2P4 MED15P8 PLEKHB2
GH02J131223 Promoter/Enhancer 0.5 EPDnew Ensembl 250.4 +14.3 14265 2 piR-57404-002 POTEE piR-52735-004 PLEKHB2 RAB6D
GH02J131217 Promoter 0.3 EPDnew 250.4 +8.2 8186 0.1 piR-52735-004 POTEE lnc-POTEE-1 PLEKHB2 RAB6D
GH02J131264 Promoter 0.3 EPDnew 250.2 +54.7 54712 0.1 piR-52496-004 piR-56489-006 POTEE RAB6D PLEKHB2
GH02J131263 Promoter 0.3 EPDnew 250.2 +54.1 54069 0.1 piR-52496-004 piR-56489-006 POTEE piR-48911-002 RAB6D PLEKHB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POTEE on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POTEE

Top Transcription factor binding sites by QIAGEN in the POTEE gene promoter:
  • AhR
  • AP-4
  • Arnt
  • E47
  • HSF1 (long)
  • HSF1short
  • Nkx2-2
  • RFX1
  • RORalpha1
  • Tal-1

Genomic Locations for POTEE Gene

Latest Assembly
55,743 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
55,743 bases
Plus strand

(GRCh37/hg19 by Ensembl)
47,084 bases
Plus strand

Genomic View for POTEE Gene

Genes around POTEE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEE Gene

Proteins for POTEE Gene

  • Protein details for POTEE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    POTE ankyrin domain family member E
    Protein Accession:
    Secondary Accessions:
    • Q6S8J4
    • Q6S8J5
    • Q6S8J8

    Protein attributes for POTEE Gene

    1075 amino acids
    Molecular mass:
    121363 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for POTEE Gene


neXtProt entry for POTEE Gene

Post-translational modifications for POTEE Gene

  • Ubiquitination at Lys114 and Lys116
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for POTEE Gene

Domains & Families for POTEE Gene

Gene Families for POTEE Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for POTEE Gene

Suggested Antigen Peptide Sequences for POTEE Gene

GenScript: Design optimal peptide antigens:
  • Prostate, ovary, testis-expressed protein on chromosome 2 (POTEE_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • In the N-terminal section; belongs to the POTE family.
  • In the N-terminal section; belongs to the POTE family.
  • In the C-terminal section; belongs to the actin family.
genes like me logo Genes that share domains with POTEE: view

Function for POTEE Gene

Gene Ontology (GO) - Molecular Function for POTEE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with POTEE: view
genes like me logo Genes that share phenotypes with POTEE: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEE

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POTEE Gene

Localization for POTEE Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POTEE gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 3
plasma membrane 1
cytoskeleton 1
golgi apparatus 1
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for POTEE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0070062 extracellular exosome HDA 23533145
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with POTEE: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for POTEE Gene

Pathways & Interactions for POTEE Gene

PathCards logo

SuperPathways for POTEE Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTEE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis HEP 23580065
GO:0021762 substantia nigra development HEP 22926577
genes like me logo Genes that share ontologies with POTEE: view

No data available for Pathways by source and SIGNOR curated interactions for POTEE Gene

Drugs & Compounds for POTEE Gene

No Compound Related Data Available

Transcripts for POTEE Gene

mRNA/cDNA for POTEE Gene

6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEE

Alternative Splicing Database (ASD) splice patterns (SP) for POTEE Gene

No ASD Table

Relevant External Links for POTEE Gene

GeneLoc Exon Structure for

Expression for POTEE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POTEE Gene

mRNA differential expression in normal tissues according to GTEx for POTEE Gene

This gene is overexpressed in Testis (x31.7) and Prostate (x6.2).

Protein differential expression in normal tissues from HIPED for POTEE Gene

This gene is overexpressed in Skin (23.1), Saliva (16.5), Brain (12.1), and Lung (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POTEE Gene

Protein tissue co-expression partners for POTEE Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POTEE

SOURCE GeneReport for Unigene cluster for POTEE Gene:

genes like me logo Genes that share expression patterns with POTEE: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEE Gene

Orthologs for POTEE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POTEE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia POTEF 29
  • 98.6 (n)
-- 30
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC100361457 29
  • 85.69 (n)
(Canis familiaris)
Mammalia -- 30
  • 41 (a)
-- 30
  • 38 (a)
-- 30
  • 37 (a)
-- 30
  • 13 (a)
-- 30
  • 11 (a)
-- 30
  • 10 (a)
-- 30
  • 10 (a)
-- 30
  • 8 (a)
(Mus musculus)
Mammalia Gm20946 30
  • 25 (a)
(Bos Taurus)
Mammalia -- 30
  • 10 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 8 (a)
(Monodelphis domestica)
Mammalia -- 30
  • 7 (a)
(Gallus gallus)
Aves ACTBL2 29
  • 74.6 (n)
-- 30
  • 12 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 37 (a)
(Danio rerio)
Actinopterygii zgc:86725 29
  • 78.79 (n)
  • 8 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta Act88F 29
  • 82.71 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001676 29
  • 78.34 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ACT3 29
  • 73.01 (n)
(Oryza sativa)
Liliopsida Os03g0836000 29
  • 73.28 (n)
Species where no ortholog for POTEE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for POTEE Gene

Gene Tree for POTEE (if available)
Gene Tree for POTEE (if available)
Evolutionary constrained regions (ECRs) for POTEE: view image
Alliance of Genome Resources:
Additional Orthologs for POTEE

Paralogs for POTEE Gene

Variants for POTEE Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for POTEE Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for POTEE Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4074n100 CNV gain 25217958
dgv4075n100 CNV gain 25217958
dgv4077n100 CNV gain 25217958
dgv4078n100 CNV gain 25217958
dgv4079n100 CNV loss 25217958
dgv616e201 CNV deletion 23290073
dgv731e199 CNV deletion 23128226
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv2760576 CNV gain+loss 21179565
esv34412 CNV gain 17911159
esv3575300 CNV gain 25503493
esv3584078 CNV loss 25503493
esv3592465 CNV loss 21293372
esv3592466 CNV gain 21293372
esv3893348 CNV gain 25118596
nsv1010808 CNV gain 25217958
nsv1014723 CNV loss 25217958
nsv10180 CNV loss 18304495
nsv1147463 OTHER inversion 26484159
nsv428404 CNV loss 18775914
nsv524021 CNV loss 19592680
nsv583139 CNV loss 21841781
nsv7327 OTHER inversion 18451855
nsv961885 CNV duplication 23825009
nsv962007 CNV duplication 23825009
nsv963849 CNV duplication 23825009
nsv963850 CNV duplication 23825009
nsv979265 CNV duplication 23825009
nsv979266 CNV duplication 23825009
nsv998424 CNV loss 25217958

Variation tolerance for POTEE Gene

Gene Damage Index Score: 4.64; 65.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POTEE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POTEE Gene

Disorders for POTEE Gene

Additional Disease Information for POTEE

No disorders were found for POTEE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEE Gene

Publications for POTEE Gene

  1. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PMID: 15276201) Bera TK … Pastan I (Gene 2004) 3 4
  2. A High-Density Human Mitochondrial Proximity Interaction Network. (PMID: 32877691) Antonicka H … Shoubridge EA (Cell metabolism 2020) 3
  3. ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents. (PMID: 32780723) Lan W … Iovanna J (JCI insight 2020) 3
  4. Splicing Regulator p54nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma. (PMID: 31815296) Hu Z … He X (Hepatology (Baltimore, Md.) 2020) 3
  5. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. (PMID: 32203420) Müller PM … Rocks O (Nature cell biology 2020) 3

Products for POTEE Gene

Sources for POTEE Gene