Aliases for POTEE Gene

Aliases for POTEE Gene

  • POTE Ankyrin Domain Family Member E 2 3 4 5
  • POTE-2 2 3 4
  • POTE2 2 3 4
  • Prostate, Ovary, Testis-Expressed Protein On Chromosome 2 3 4
  • Cancer/Testis Antigen Family 104, Member 2 2 3
  • ANKRD26-Like Family C Member 1A 3 4
  • POTE2gamma 2 3
  • CT104.2 2 3
  • A26C1A 3 4
  • A26C1 2 3
  • Protein Expressed In Prostate, Ovary, Testis, And Placenta 2 3
  • POTE Ankyrin Domain Family, Member E 2
  • ANKRD26-Like Family C, Member 1A 2
  • POTEE 5

External Ids for POTEE Gene

Previous HGNC Symbols for POTEE Gene

  • A26C1A

Previous GeneCards Identifiers for POTEE Gene

  • GC02P131695
  • GC02P131980
  • GC02M123138
  • GC02P131219
  • GC02P131255
  • GC02P131784
  • GC02P131845
  • GC02P131828
  • GC02P132458
  • GC02P131290
  • GC02P131323
  • GC02P131353
  • GC02P131389
  • GC02P131577
  • GC02P131635
  • GC02P131685
  • GC02P131737

Summaries for POTEE Gene

GeneCards Summary for POTEE Gene

POTEE (POTE Ankyrin Domain Family Member E) is a Protein Coding gene. An important paralog of this gene is POTEF.

Additional gene information for POTEE Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POTEE Gene

Genomics for POTEE Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POTEE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J131209 Promoter 1.4 EPDnew Ensembl 600.7 -0.2 -235 3.8 ARHGAP35 ZNF512 IKZF1 DDX20 PRDM1 MTA2 PKNOX1 NR2C1 BRD9 ZNF24 ENSG00000285819 POTEE lnc-POTEE-1 FAM168B FAR2P4 MZT2A KLF2P4 PLEKHB2
GH02J131223 Promoter/Enhancer 0.5 EPDnew Ensembl 600.4 +14.3 14265 2 piR-57404-002 POTEE piR-52735-004 PLEKHB2 RAB6D
GH02J131217 Promoter 0.3 EPDnew 600.4 +8.2 8186 0.1 piR-52735-004 POTEE lnc-POTEE-1 PLEKHB2 RAB6D
GH02J131263 Promoter 0.3 EPDnew 600.2 +54.1 54069 0.1 piR-52496-004 piR-56489-006 POTEE piR-48911-002 RAB6D PLEKHB2
GH02J131264 Promoter 0.3 EPDnew 600.2 +54.7 54712 0.1 piR-52496-004 piR-56489-006 POTEE RAB6D PLEKHB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POTEE on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POTEE

Top Transcription factor binding sites by QIAGEN in the POTEE gene promoter:
  • AhR
  • AP-4
  • Arnt
  • E47
  • HSF1 (long)
  • HSF1short
  • Nkx2-2
  • RFX1
  • RORalpha1
  • Tal-1

Genomic Locations for POTEE Gene

Genomic Locations for POTEE Gene
chr2:131,209,536-131,265,278
(GRCh38/hg38)
Size:
55,743 bases
Orientation:
Plus strand
chr2:131,975,882-132,022,965
(GRCh37/hg19)
Size:
47,084 bases
Orientation:
Plus strand

Genomic View for POTEE Gene

Genes around POTEE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEE Gene

Proteins for POTEE Gene

  • Protein details for POTEE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6S8J3-POTEE_HUMAN
    Recommended name:
    POTE ankyrin domain family member E
    Protein Accession:
    Q6S8J3
    Secondary Accessions:
    • Q6S8J4
    • Q6S8J5
    • Q6S8J8

    Protein attributes for POTEE Gene

    Size:
    1075 amino acids
    Molecular mass:
    121363 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for POTEE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POTEE Gene

Post-translational modifications for POTEE Gene

  • Ubiquitination at Lys114 and Lys116
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for POTEE Gene

Domains & Families for POTEE Gene

Gene Families for POTEE Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for POTEE Gene

Suggested Antigen Peptide Sequences for POTEE Gene

GenScript: Design optimal peptide antigens:
  • Prostate, ovary, testis-expressed protein on chromosome 2 (POTEE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6S8J3

UniProtKB/Swiss-Prot:

POTEE_HUMAN :
  • In the N-terminal section; belongs to the POTE family.
Family:
  • In the N-terminal section; belongs to the POTE family.
  • In the C-terminal section; belongs to the actin family.
genes like me logo Genes that share domains with POTEE: view

Function for POTEE Gene

Gene Ontology (GO) - Molecular Function for POTEE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with POTEE: view
genes like me logo Genes that share phenotypes with POTEE: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEE

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POTEE Gene

Localization for POTEE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POTEE gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 3
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for POTEE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0070062 extracellular exosome HDA 23533145
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with POTEE: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for POTEE Gene

Pathways & Interactions for POTEE Gene

PathCards logo

SuperPathways for POTEE Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTEE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis HEP 23580065
GO:0021762 substantia nigra development HEP 22926577
genes like me logo Genes that share ontologies with POTEE: view

No data available for Pathways by source and SIGNOR curated interactions for POTEE Gene

Drugs & Compounds for POTEE Gene

No Compound Related Data Available

Transcripts for POTEE Gene

mRNA/cDNA for POTEE Gene

4 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEE

Alternative Splicing Database (ASD) splice patterns (SP) for POTEE Gene

No ASD Table

Relevant External Links for POTEE Gene

GeneLoc Exon Structure for
POTEE

Expression for POTEE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POTEE Gene

mRNA differential expression in normal tissues according to GTEx for POTEE Gene

This gene is overexpressed in Testis (x31.7) and Prostate (x6.2).

Protein differential expression in normal tissues from HIPED for POTEE Gene

This gene is overexpressed in Skin (23.1), Saliva (16.5), Brain (12.1), and Lung (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POTEE Gene



Protein tissue co-expression partners for POTEE Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POTEE

SOURCE GeneReport for Unigene cluster for POTEE Gene:

Hs.686146
genes like me logo Genes that share expression patterns with POTEE: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEE Gene

Orthologs for POTEE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POTEE Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia POTEF 30
  • 98.6 (n)
-- 31
  • 98 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia LOC100361457 30
  • 85.69 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 41 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 13 (a)
ManyToMany
-- 31
  • 11 (a)
ManyToMany
-- 31
  • 10 (a)
ManyToMany
-- 31
  • 10 (a)
ManyToMany
-- 31
  • 8 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Gm20946 31
  • 25 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 10 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 8 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 7 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves ACTBL2 30
  • 74.6 (n)
-- 31
  • 12 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 37 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii zgc:86725 30
  • 78.79 (n)
ANKRD7 31
  • 8 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Act88F 30
  • 82.71 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001676 30
  • 78.34 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ACT3 30
  • 73.01 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0836000 30
  • 73.28 (n)
Species where no ortholog for POTEE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for POTEE Gene

ENSEMBL:
Gene Tree for POTEE (if available)
TreeFam:
Gene Tree for POTEE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POTEE: view image

Paralogs for POTEE Gene

Variants for POTEE Gene

Additional dbSNP identifiers (rs#s) for POTEE Gene

Structural Variations from Database of Genomic Variants (DGV) for POTEE Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4074n100 CNV gain 25217958
dgv4075n100 CNV gain 25217958
dgv4077n100 CNV gain 25217958
dgv4078n100 CNV gain 25217958
dgv4079n100 CNV loss 25217958
dgv616e201 CNV deletion 23290073
dgv731e199 CNV deletion 23128226
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv2760576 CNV gain+loss 21179565
esv34412 CNV gain 17911159
esv3575300 CNV gain 25503493
esv3584078 CNV loss 25503493
esv3592465 CNV loss 21293372
esv3592466 CNV gain 21293372
esv3893348 CNV gain 25118596
nsv1010808 CNV gain 25217958
nsv1014723 CNV loss 25217958
nsv10180 CNV loss 18304495
nsv1147463 OTHER inversion 26484159
nsv428404 CNV loss 18775914
nsv524021 CNV loss 19592680
nsv583139 CNV loss 21841781
nsv7327 OTHER inversion 18451855
nsv961885 CNV duplication 23825009
nsv962007 CNV duplication 23825009
nsv963849 CNV duplication 23825009
nsv963850 CNV duplication 23825009
nsv979265 CNV duplication 23825009
nsv979266 CNV duplication 23825009
nsv998424 CNV loss 25217958

Variation tolerance for POTEE Gene

Gene Damage Index Score: 4.64; 65.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POTEE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POTEE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POTEE Gene

Disorders for POTEE Gene

No disorders were found for POTEE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEE Gene

Publications for POTEE Gene

  1. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PMID: 15276201) Bera TK … Pastan I (Gene 2004) 3 4
  2. Identification of MΦ specific POTEE expression: Its role in mTORC2 activation via protein-protein interaction in TAMs. (PMID: 30420269) Vekariya U … Tripathi RK (Cellular immunology 2019) 3
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3

Products for POTEE Gene

Sources for POTEE Gene