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Aliases for POTED Gene

Aliases for POTED Gene

  • POTE Ankyrin Domain Family Member D 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 21 3 4
  • Cancer/Testis Antigen Family 104, Member 1 2 3
  • Prostate, Ovary, Testis-Expressed Protein 3 4
  • ANKRD26-Like Family B Member 3 3 4
  • Ankyrin Repeat Domain 21 2 3
  • ANKRD21 3 4
  • A26B3 3 4
  • POTE 3 4
  • Expressed In Prostate, Ovary, Testis, And Placenta 3
  • POTE Ankyrin Domain Family, Member D 2
  • ANKRD26-Like Family B, Member 3 2
  • Protein POTE 4
  • CT104.1 3
  • POTE-21 3
  • POTE21 3

External Ids for POTED Gene

Previous HGNC Symbols for POTED Gene

  • ANKRD21
  • A26B3

Previous GeneCards Identifiers for POTED Gene

  • GC21P013910
  • GC21P014982

Summaries for POTED Gene

GeneCards Summary for POTED Gene

POTED (POTE Ankyrin Domain Family Member D) is a Protein Coding gene. Diseases associated with POTED include Holoprosencephaly 3. An important paralog of this gene is LOC100288966.

Additional gene information for POTED Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTED Gene

Genomics for POTED Gene

GeneHancer (GH) Regulatory Elements for POTED Gene

Promoters and enhancers for POTED Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I013610 Promoter 0.5 EPDnew 550.8 +0.3 288 0.1 POTED GC21P013622
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around POTED on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POTED gene promoter:

Genomic Locations for POTED Gene

Genomic Locations for POTED Gene
31,728 bases
Plus strand

Genomic View for POTED Gene

Genes around POTED on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTED Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTED Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTED Gene

Proteins for POTED Gene

  • Protein details for POTED Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    POTE ankyrin domain family member D
    Protein Accession:
    Secondary Accessions:
    • C9JCF7

    Protein attributes for POTED Gene

    584 amino acids
    Molecular mass:
    66394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POTED Gene

Post-translational modifications for POTED Gene

No Post-translational modifications

Other Protein References for POTED Gene

No data available for DME Specific Peptides for POTED Gene

Domains & Families for POTED Gene

Gene Families for POTED Gene

Protein Domains for POTED Gene

Suggested Antigen Peptide Sequences for POTED Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the POTE family.
  • Belongs to the POTE family.
genes like me logo Genes that share domains with POTED: view

Function for POTED Gene

genes like me logo Genes that share phenotypes with POTED: view

miRNA for POTED Gene

miRTarBase miRNAs that target POTED

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POTED Gene

Localization for POTED Gene

Subcellular locations from UniProtKB/Swiss-Prot for POTED Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POTED gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for POTED Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with POTED: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for POTED Gene

Pathways & Interactions for POTED Gene

SuperPathways for POTED Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTED Gene


No data available for Pathways by source and SIGNOR curated interactions for POTED Gene

Drugs & Compounds for POTED Gene

No Compound Related Data Available

Transcripts for POTED Gene

mRNA/cDNA for POTED Gene

(3) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POTED Gene

No ASD Table

Relevant External Links for POTED Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POTED Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POTED Gene

mRNA differential expression in normal tissues according to GTEx for POTED Gene

This gene is overexpressed in Testis (x52.9).

Protein differential expression in normal tissues from HIPED for POTED Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POTED Gene

Protein tissue co-expression partners for POTED Gene

NURSA nuclear receptor signaling pathways regulating expression of POTED Gene:


mRNA Expression by UniProt/SwissProt for POTED Gene:

Tissue specificity: Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. Localizes to basal and terminal prostate epithelial cells.
genes like me logo Genes that share expression patterns with POTED: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTED Gene

Orthologs for POTED Gene

This gene was present in the common ancestor of chordates.

Orthologs for POTED Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 95 (a)
(Canis familiaris)
Mammalia -- 34
  • 42 (a)
-- 34
  • 38 (a)
-- 34
  • 37 (a)
-- 34
  • 12 (a)
-- 34
  • 9 (a)
-- 34
  • 7 (a)
-- 34
  • 6 (a)
-- 34
  • 6 (a)
(Mus musculus)
Mammalia Gm21119 34
  • 21 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 13 (a)
(Bos Taurus)
Mammalia -- 34
  • 6 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 6 (a)
(Gallus gallus)
Aves -- 34
  • 11 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
(Danio rerio)
Actinopterygii ANKRD7 34
  • 6 (a)
Species where no ortholog for POTED was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POTED Gene

Gene Tree for POTED (if available)
Gene Tree for POTED (if available)

Paralogs for POTED Gene

Variants for POTED Gene

Sequence variations from dbSNP and Humsavar for POTED Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000078076 -- 13,616,664(+) G/T intron_variant
rs1000262860 -- 13,631,122(+) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1002102035 -- 13,629,895(+) AGAGAG/AG 3_prime_UTR_variant, coding_sequence_variant, frameshift, genic_downstream_transcript_variant
rs1002537844 -- 13,628,453(+) G/T genic_downstream_transcript_variant, intron_variant, splice_donor_variant
rs1003161650 -- 13,623,672(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for POTED Gene

Variant ID Type Subtype PubMed ID
nsv9849 CNV gain+loss 18304495
nsv979521 CNV duplication 23825009
nsv965993 CNV duplication 23825009
nsv834044 CNV gain+loss 17160897
nsv828821 CNV gain 20364138
nsv828819 CNV gain 20364138
nsv587014 CNV loss 21841781
nsv587013 CNV loss 21841781
nsv587012 CNV loss 21841781
nsv587001 CNV loss 21841781
nsv586992 CNV gain 21841781
nsv515654 CNV gain+loss 19592680
nsv512633 CNV loss 21212237
nsv471708 CNV loss 15918152
nsv470876 CNV loss 18288195
nsv470875 CNV gain 18288195
nsv469617 CNV gain 16826518
nsv442489 CNV loss 18776908
nsv428383 CNV loss 18775914
nsv1073113 CNV deletion 25765185
nsv1062730 CNV loss 25217958
nsv1059711 CNV gain 25217958
nsv1058202 CNV loss 25217958
nsv1057704 CNV loss 25217958
nsv1056303 CNV gain 25217958
nsv1056086 CNV loss 25217958
esv3893367 CNV gain 25118596
esv3893364 CNV gain+loss 25118596
esv3646398 CNV loss 21293372
esv3575379 CNV gain 25503493
esv3568104 CNV loss 25503493
esv3568103 CNV loss 25503493
esv3568102 CNV loss 25503493
esv3404908 CNV duplication 20981092
esv3391843 CNV duplication 20981092
esv3373409 CNV duplication 20981092
esv3366121 CNV duplication 20981092
esv2758809 CNV gain+loss 17122850
esv2751923 CNV loss 17911159
esv2674621 CNV deletion 23128226
esv21968 CNV gain 19812545
dgv93e203 CNV gain+loss 21179565
dgv803e199 CNV deletion 23128226
dgv7757n54 CNV gain 21841781
dgv7756n54 CNV loss 21841781
dgv7753n54 CNV loss 21841781
dgv7751n54 CNV gain 21841781
dgv4387n100 CNV gain 25217958
dgv4386n100 CNV gain 25217958
dgv4385n100 CNV gain 25217958
dgv4384n100 CNV gain 25217958
dgv4383n100 CNV gain+loss 25217958
dgv4382n100 CNV gain 25217958
dgv4381n100 CNV loss 25217958
dgv4379n100 CNV loss 25217958
dgv4378n100 CNV gain 25217958
dgv4377n100 CNV gain 25217958
dgv36n64 CNV loss 17921354
dgv2471e59 CNV duplication 20981092
dgv2470e59 CNV duplication 20981092
dgv2359n106 CNV deletion 24896259

Variation tolerance for POTED Gene

Gene Damage Index Score: 2.92; 48.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POTED Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POTED Gene

Disorders for POTED Gene

MalaCards: The human disease database

(1) MalaCards diseases for POTED Gene - From: DISEASES

Disorder Aliases PubMed IDs
holoprosencephaly 3
  • hpe3
- elite association - COSMIC cancer census association via MalaCards
Search POTED in MalaCards View complete list of genes associated with diseases

Additional Disease Information for POTED

genes like me logo Genes that share disorders with POTED: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POTED Gene

Publications for POTED Gene

  1. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PMID: 16364570) Hahn Y … Lee B (Gene 2006) 2 3 22 58
  2. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PMID: 15276201) Bera TK … Pastan I (Gene 2004) 2 3 4 58
  3. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. (PMID: 12475935) Bera TK … Pastan I (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 4 58
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for POTED Gene

Sources for POTED Gene

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