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Aliases for POTEB2 Gene

Aliases for POTEB2 Gene

  • POTE Ankyrin Domain Family Member B2 2 3 3 5
  • Prostate, Ovary, Testis-Expressed Protein On Chromosome 15 3
  • POTE Ankyrin Domain Family, Member B2 2
  • POTE Ankyrin Domain Family Member B 3
  • ANKRD26-Like Family B Member 1 3
  • POTE-15 3
  • POTEB 3

External Ids for POTEB2 Gene

Previous GeneCards Identifiers for POTEB2 Gene

  • GC15M021042
  • GC15M020841
  • GC15M020842
  • GC15M020845
  • GC15M020846
  • GC15M020848
  • GC15M020849
  • GC15M020850
  • GC15M020852

Summaries for POTEB2 Gene

GeneCards Summary for POTEB2 Gene

POTEB2 (POTE Ankyrin Domain Family Member B2) is a Protein Coding gene. An important paralog of this gene is POTEB.

Additional gene information for POTEB2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POTEB2 Gene

Genomics for POTEB2 Gene

Genomic Locations for POTEB2 Gene

Genomic Locations for POTEB2 Gene
chr15:20,835,372-20,866,431
(GRCh38/hg38)
Size:
31,060 bases
Orientation:
Minus strand
chr15:21,040,701-21,071,662
(GRCh37/hg19)
Size:
30,962 bases
Orientation:
Minus strand

Genomic View for POTEB2 Gene

Genes around POTEB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POTEB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POTEB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POTEB2 Gene

No data available for GeneHancer (GH) Regulatory Elements for POTEB2 Gene

Proteins for POTEB2 Gene

  • Protein details for POTEB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    H3BUK9-POTB2_HUMAN
    Recommended name:
    POTE ankyrin domain family member B2
    Protein Accession:
    H3BUK9

    Protein attributes for POTEB2 Gene

    Size:
    544 amino acids
    Molecular mass:
    61708 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POTEB2 Gene

Post-translational modifications for POTEB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POTEB2 Gene

No data available for DME Specific Peptides for POTEB2 Gene

Domains & Families for POTEB2 Gene

Gene Families for POTEB2 Gene

Protein Domains for POTEB2 Gene

Graphical View of Domain Structure for InterPro Entry

H3BUK9

UniProtKB/Swiss-Prot:

POTB2_HUMAN :
  • Belongs to the POTE family.
Family:
  • Belongs to the POTE family.
genes like me logo Genes that share domains with POTEB2: view

No data available for Suggested Antigen Peptide Sequences for POTEB2 Gene

Function for POTEB2 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEB2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POTEB2 Gene

Localization for POTEB2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for POTEB2 Gene

Pathways & Interactions for POTEB2 Gene

SuperPathways for POTEB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for POTEB2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for POTEB2 Gene

Drugs & Compounds for POTEB2 Gene

No Compound Related Data Available

Transcripts for POTEB2 Gene

mRNA/cDNA for POTEB2 Gene

(4) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POTEB2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POTEB2 Gene

No ASD Table

Relevant External Links for POTEB2 Gene

GeneLoc Exon Structure for
POTEB2
ECgene alternative splicing isoforms for
POTEB2

Expression for POTEB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POTEB2 Gene

mRNA differential expression in normal tissues according to GTEx for POTEB2 Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for POTEB2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POTEB2 Gene



Protein tissue co-expression partners for POTEB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of POTEB2 Gene:

POTEB2
genes like me logo Genes that share expression patterns with POTEB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POTEB2 Gene

Orthologs for POTEB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POTEB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 43 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 12 (a)
ManyToMany
-- 34
  • 9 (a)
ManyToMany
-- 34
  • 7 (a)
ManyToMany
-- 34
  • 6 (a)
ManyToMany
-- 34
  • 5 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm1758 34
  • 35 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 6 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 6 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 11 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ANKRD7 34
  • 6 (a)
OneToMany
Species where no ortholog for POTEB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POTEB2 Gene

ENSEMBL:
Gene Tree for POTEB2 (if available)
TreeFam:
Gene Tree for POTEB2 (if available)

Paralogs for POTEB2 Gene

Variants for POTEB2 Gene

Sequence variations from dbSNP and Humsavar for POTEB2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1001887639 -- 20,848,250(-) T/G genic_downstream_transcript_variant, intron_variant
rs1002402180 -- 20,845,233(-) A/G genic_downstream_transcript_variant, intron_variant
rs1002992197 -- 20,865,541(-) C/T intron_variant
rs1003286851 -- 20,867,849(-) C/T upstream_transcript_variant
rs1003882557 -- 20,839,758(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for POTEB2 Gene

Variant ID Type Subtype PubMed ID
nsv984125 CNV duplication 23825009
nsv977771 CNV duplication 23825009
nsv976880 CNV duplication 23825009
nsv952318 CNV duplication 24416366
nsv9179 CNV gain+loss 18304495
nsv832916 CNV gain+loss 17160897
nsv832915 CNV gain+loss 17160897
nsv827221 CNV gain 20364138
nsv821678 CNV loss 15273396
nsv819770 CNV gain 19587683
nsv819612 CNV gain 19587683
nsv817667 CNV gain 17921354
nsv7260 OTHER inversion 18451855
nsv567604 CNV loss 21841781
nsv567598 CNV gain 21841781
nsv567597 CNV loss 21841781
nsv567312 CNV gain 21841781
nsv514765 CNV gain 21397061
nsv511040 OTHER inversion 20534489
nsv475421 CNV novel sequence insertion 20440878
nsv471675 CNV gain+loss 15918152
nsv471537 CNV gain 19718026
nsv471373 CNV gain 19718026
nsv469642 CNV gain 16826518
nsv436198 CNV deletion 17901297
nsv433282 CNV loss 18776910
nsv433281 CNV loss 18776910
nsv428296 CNV gain+loss 18775914
nsv1160227 CNV duplication 26073780
nsv1160218 CNV duplication 26073780
nsv1152117 CNV duplication 26484159
nsv1148204 CNV duplication 26484159
nsv1145973 CNV duplication 26484159
nsv1145855 CNV duplication 26484159
nsv1132396 CNV duplication 24896259
nsv1131081 CNV deletion 24896259
nsv1121887 CNV deletion 24896259
nsv1077793 CNV duplication 25765185
nsv1055063 CNV gain+loss 25217958
nsv1044952 CNV loss 25217958
nsv1043213 CNV gain+loss 25217958
nsv1041388 CNV gain+loss 25217958
esv988919 CNV loss 20482838
esv3892629 CNV loss 25118596
esv3892612 CNV gain 25118596
esv3892609 CNV gain 25118596
esv3892607 CNV gain 25118596
esv3892595 CNV gain+loss 25118596
esv3584865 CNV gain 24956385
esv3584854 CNV gain 24956385
esv3584832 CNV gain 24956385
esv3584810 CNV gain 24956385
esv3584679 CNV loss 24956385
esv33051 CNV gain+loss 17666407
esv29956 CNV loss 18421352
esv2751492 CNV gain 17911159
esv2751488 CNV loss 17911159
esv21579 CNV gain+loss 19812545
esv1004259 OTHER inversion 20482838
dgv96e55 CNV loss 17911159
dgv95e55 CNV loss 17911159
dgv93e55 CNV gain 17911159
dgv92e55 CNV gain 17911159
dgv91e55 CNV gain 17911159
dgv43n16 CNV insertion 17901297
dgv4244n54 CNV loss 21841781
dgv4240n54 CNV loss 21841781
dgv4239n54 CNV loss 21841781
dgv4238n54 CNV gain 21841781
dgv4237n54 CNV loss 21841781
dgv4236n54 CNV loss 21841781
dgv4235n54 CNV loss 21841781
dgv4234n54 CNV loss 21841781
dgv4233n54 CNV gain 21841781
dgv4232n54 CNV gain 21841781
dgv4231n54 CNV gain 21841781
dgv4230n54 CNV loss 21841781
dgv4226n54 CNV loss 21841781
dgv4225n54 CNV loss 21841781
dgv4224n54 CNV loss 21841781
dgv4223n54 CNV gain+loss 21841781
dgv4222n54 CNV gain 21841781
dgv4221n54 CNV loss 21841781
dgv4220n54 CNV gain+loss 21841781
dgv4217n54 CNV loss 21841781
dgv4213n54 CNV loss 21841781
dgv4211n54 CNV gain 21841781
dgv4210n54 CNV gain 21841781
dgv418n67 CNV gain 20364138
dgv4183n54 CNV loss 21841781
dgv4182n54 CNV loss 21841781
dgv4180n54 CNV gain 21841781
dgv4166n54 CNV gain 21841781
dgv4164n54 CNV loss 21841781
dgv4162n54 CNV loss 21841781
dgv2368n100 CNV loss 25217958
dgv2367n100 CNV gain 25217958
dgv2365n100 CNV gain+loss 25217958
dgv2364n100 CNV gain 25217958
dgv2363n100 CNV loss 25217958
dgv2357n100 CNV gain+loss 25217958
dgv2355n100 CNV gain 25217958
dgv2347n100 CNV loss 25217958
dgv2344n100 CNV loss 25217958
dgv2343n100 CNV gain+loss 25217958
dgv2342n100 CNV loss 25217958
dgv2341n100 CNV gain 25217958
dgv2340n100 CNV gain+loss 25217958
dgv2339n100 CNV gain+loss 25217958
dgv2337n100 CNV loss 25217958
dgv2336n100 CNV loss 25217958
dgv2335n100 CNV loss 25217958
dgv2334n100 CNV gain 25217958
dgv2333n100 CNV loss 25217958
dgv2332n100 CNV gain 25217958
dgv2331n100 CNV gain+loss 25217958
dgv2330n100 CNV loss 25217958
dgv2329n100 CNV loss 25217958
dgv2328n100 CNV gain 25217958
dgv2327n100 CNV gain 25217958
dgv2326n100 CNV gain 25217958
dgv2325n100 CNV gain+loss 25217958
dgv2324n100 CNV gain 25217958
dgv2323n100 CNV loss 25217958
dgv2322n100 CNV loss 25217958
dgv2321n100 CNV gain+loss 25217958
dgv2320n100 CNV loss 25217958
dgv2319n100 CNV loss 25217958
dgv2317n100 CNV gain 25217958
dgv2315n100 CNV gain 25217958
dgv2314n100 CNV loss 25217958
dgv2313n100 CNV loss 25217958
dgv2312n100 CNV gain 25217958
dgv2311n100 CNV loss 25217958
dgv2310n100 CNV gain 25217958
dgv2309n100 CNV gain 25217958
dgv2308n100 CNV loss 25217958
dgv2304n100 CNV gain 25217958
dgv2301n100 CNV loss 25217958
dgv2300n100 CNV loss 25217958
dgv2298n100 CNV gain+loss 25217958
dgv2297n100 CNV gain 25217958
dgv2296n100 CNV loss 25217958
dgv2295n100 CNV loss 25217958
dgv2293n100 CNV loss 25217958
dgv2290n100 CNV gain+loss 25217958
dgv2288n100 CNV gain 25217958
dgv2287n100 CNV gain+loss 25217958
dgv2284n100 CNV gain 25217958
dgv2283n100 CNV gain 25217958
dgv2282n100 CNV gain 25217958
dgv2281n100 CNV gain+loss 25217958
dgv2280n100 CNV loss 25217958
dgv2279n100 CNV loss 25217958
dgv2278n100 CNV gain 25217958
dgv2257n100 CNV gain 25217958
dgv2250n100 CNV gain+loss 25217958
dgv2246n100 CNV gain+loss 25217958
dgv2245n100 CNV loss 25217958
dgv2238n100 CNV gain 25217958
dgv2237n100 CNV gain 25217958
dgv2232n100 CNV loss 25217958
dgv2222n100 CNV gain+loss 25217958
dgv2214n100 CNV gain 25217958
dgv2213n100 CNV loss 25217958
dgv2212n100 CNV gain 25217958
dgv2211n100 CNV loss 25217958
dgv2210n100 CNV gain 25217958
dgv2193n100 CNV gain+loss 25217958
dgv2192n100 CNV loss 25217958
dgv2191n100 CNV gain+loss 25217958
dgv2190n100 CNV gain+loss 25217958
dgv2189n100 CNV gain+loss 25217958
dgv2188n100 CNV loss 25217958
dgv2183n100 CNV loss 25217958
dgv2182n100 CNV gain 25217958
dgv2181n100 CNV gain 25217958
dgv2179n100 CNV gain 25217958
dgv2175n100 CNV gain 25217958
dgv2174n100 CNV gain 25217958
dgv1n1 OTHER inversion 15895083
dgv1360e59 CNV duplication 20981092
dgv1158n106 CNV duplication 24896259

Variation tolerance for POTEB2 Gene

Gene Damage Index Score: 17.55; 98.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POTEB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POTEB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POTEB2 Gene

Disorders for POTEB2 Gene

Additional Disease Information for POTEB2

No disorders were found for POTEB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POTEB2 Gene

Publications for POTEB2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
  4. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. (PMID: 12475935) Bera TK … Pastan I (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for POTEB2 Gene

Sources for POTEB2 Gene

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