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This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
POSTN (Periostin) is a Protein Coding gene. Diseases associated with POSTN include Melorheostosis and Myocardial Infarction. Among its related pathways are Amplification and Expansion of Oncogenic Pathways as Metastatic Traits and Hypothesized Pathways in Pathogenesis of Cardiovascular Disease. Gene Ontology (GO) annotations related to this gene include heparin binding and cell adhesion molecule binding. An important paralog of this gene is TGFBI.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH13J037594 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 605.4 | +1.8 | 1788 | 6.1 | MNT JUND CEBPB POLR2A SMARCA4 NANOG POU5F1 | POSTN HSALNG0096438 TRPC4 MN298678-021 CSNK1A1L | |
GH13J037491 | Enhancer | 1 | FANTOM5 Ensembl ENCODE dbSUPER | 9.1 | +105.7 | 105743 | 3 | ATF7 SMARCA4 ATF2 | POSTN LINC01048 piR-53029-031 CSNK1A1L | |
GH13J037526 | Enhancer | 0.9 | FANTOM5 Ensembl ENCODE dbSUPER | 8.7 | +71.6 | 71646 | 1.2 | PRDM1 ZNF366 SMARCA4 | POSTN LINC00547 piR-31311-008 CSNK1A1L | |
GH13J037445 | Enhancer | 0.8 | FANTOM5 Ensembl ENCODE | 6.6 | +151.4 | 151382 | 3.7 | FOS BHLHE40 MAFK | POSTN lnc-POSTN-3 piR-51137-033 lnc-EXOSC8-1 CSNK1A1L | |
GH13J037530 | Promoter/Enhancer | 1.1 | EPDnew Ensembl ENCODE dbSUPER | 4.2 | +65.9 | 65878 | 4.5 | CEBPB FOS MAFK NFE2L2 | LINC00547 POSTN MN298678-021 piR-31311-008 CSNK1A1L |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005201 | extracellular matrix structural constituent | RCA | 20551380 |
GO:0005515 | protein binding | IPI | 19478074 |
GO:0008201 | heparin binding | ISS | -- |
GO:0046872 | metal ion binding | IDA | 18450759 |
GO:0050839 | cell adhesion molecule binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005802 | trans-Golgi network | IDA | 19478074 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Amplification and Expansion of Oncogenic Pathways as Metastatic Traits | ||
2 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001666 | response to hypoxia | IEA | -- |
GO:0001953 | negative regulation of cell-matrix adhesion | IEA | -- |
GO:0003073 | regulation of systemic arterial blood pressure | IEA | -- |
GO:0007155 | cell adhesion | IBA,IDA | 12235007 |
GO:0008593 | regulation of Notch signaling pathway | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6556 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | · | 19c | ^ | 20a | · | 20b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | · | 23c | · | 23d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | - | ||||||||||||
SP3: | |||||||||||||
SP4: | - | - | |||||||||||
SP5: | - | - | |||||||||||
SP6: | - | - | |||||||||||
SP7: | |||||||||||||
SP8: | |||||||||||||
SP9: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | POSTN 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | POSTN 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | POSTN 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | POSTN 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | POSTN 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Postn 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Postn 30 |
|
||
Chicken (Gallus gallus) |
Aves | POSTN 30 |
|
||
OSF-2 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | POSTN 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | postn 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | postnb 30 31 |
|
OneToMany | |
postna 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Fas1 31 |
|
ManyToMany | |
mfas 31 |
|
ManyToMany | |||
CG43333 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | F26E4.7 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709654 | Benign: not provided | 37,592,110(-) | G/A | SYNONYMOUS_VARIANT | |
722406 | Benign: not provided | 37,584,822(-) | G/A | SYNONYMOUS_VARIANT | |
757603 | Likely Benign: not provided | 37,584,738(-) | A/G | SYNONYMOUS_VARIANT | |
779644 | Benign: not provided | 37,590,444(-) | C/T | SYNONYMOUS_VARIANT | |
782576 | Benign: not provided | 37,569,335(-) | A/G | MISSENSE_VARIANT,INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
melorheostosis |
|
|
myocardial infarction |
|
|
esophagus carcinoma in situ |
|
|
esophagitis |
|
|
fibrous dysplasia |
|
|