Aliases for POSTN Gene
Aliases for POSTN Gene
External Ids for POSTN Gene
- HGNC: 16953
- Entrez Gene: 10631
- Ensembl: ENSG00000133110
- OMIM: 608777
- UniProtKB: Q15063
Previous GeneCards Identifiers for POSTN Gene
- GC13M035934
- GC13M037034
- GC13M038136
- GC13M018936
Summaries for POSTN Gene
-
This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
GeneCards Summary for POSTN Gene
POSTN (Periostin) is a Protein Coding gene. Diseases associated with POSTN include Melorheostosis and Hypertensive Nephropathy. Among its related pathways are Hypothesized Pathways in Pathogenesis of Cardiovascular Disease and Amplification and Expansion of Oncogenic Pathways as Metastatic Traits. Gene Ontology (GO) annotations related to this gene include heparin binding and cell adhesion molecule binding. An important paralog of this gene is TGFBI.
UniProtKB/Swiss-Prot for POSTN Gene
-
Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).
Additional gene information for POSTN Gene
- Monarch Initiative
- Search for POSTN at DataMed
- Search for POSTN at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POSTN Gene
Genomics for POSTN Gene
GeneHancer (GH) Regulatory Elements for POSTN Gene
Promoters and enhancers for POSTN Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH13J037594 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE dbSUPER | 655.5 | +1.8 | 1788 | 6.1 | NANOG POLR2A POU5F1 MNT | POSTN TRPC4 LINC00547 | |
| GH13J037491 | Enhancer | 0.9 | FANTOM5 ENCODE dbSUPER | 9.1 | +105.9 | 105922 | 2.6 | ATF7 ATF2 | POSTN LINC01048 LINC00547 | |
| GH13J037306 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 5 | +291.8 | 291793 | 1.3 | JUND MZF1 FOS FEZF1 | POSTN GC13P037280 LINC01048 | |
| GH13J037616 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 4.6 | -18.7 | -18745 | 3.1 | JUN CEBPB FEZF1 EP300 ZIC2 OSR2 SP1 MAFF JUND TCF7L2 | TRPC4 POSTN GC13P037655 | |
| GH13J037445 | Enhancer | 0.6 | FANTOM5 ENCODE | 6.6 | +151.3 | 151340 | 3.6 | FOS | POSTN LINC01048 GC13P037280 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around POSTN on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the POSTN gene promoter:
-
- SRY
- Evi-1
- E2F-1
- E2F
- HOXA5
- GATA-3
- Lmo2
- LHX3b
- Lhx3a
- Nkx2-2
Regulatory Element Products
Genomic Locations for POSTN Gene
Genomic Locations for POSTN Gene
- chr13:37,562,582-37,598,844
- (GRCh38/hg38)
- Size:
- 36,263 bases
- Orientation:
- Minus strand
- chr13:38,136,719-38,172,981
- (GRCh37/hg19)
- Size:
- 36,263 bases
- Orientation:
- Minus strand
Genomic View for POSTN Gene
Genes around POSTN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q13.3 by Entrez Gene
- 13q13.3 by HGNC
- 13q13.3 by Ensembl
POSTN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POSTN Gene
Proteins for POSTN Gene
-
Protein details for POSTN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15063-POSTN_HUMAN
- Recommended name:
- Periostin
- Protein Accession:
- Q15063
- B1ALD8
- C0IMJ1
- C0IMJ2
- C0IMJ4
- D2KRH7
- F5H628
- Q15064
- Q29XZ0
- Q3KPJ5
- Q5VSY5
- Q8IZF9
Protein attributes for POSTN Gene
- Size:
- 836 amino acids
- Molecular mass:
- 93314 Da
- Quaternary structure:
-
- Interacts with BMP1 and fibronectin.
Protein Expression for POSTN Gene
Post-translational modifications for POSTN Gene
- Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding (PubMed:18450759). According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833).
- Glycosylation at Asn599
- Modification sites at PhosphoSitePlus
Other Protein References for POSTN Gene
Antibody Products
- R&D Systems Antibodies for POSTN (Periostin/OSF-2)
- Novus Biologicals Antibodies for POSTN
-
Abcam antibodies for POSTN
- Invitrogen Antibodies for POSTN
- GeneTex POSTN Antibody for POSTN
-
Santa Cruz Biotechnology (SCBT) Antibodies for POSTN
- Sino Biological Antibodies for POSTN
Protein Products
- R&D Systems Proteins and Enzymes for POSTN (Periostin/OSF-2)
-
OriGene Purified Proteins for POSTN
- Search Origene for MassSpec and Protein Over-expression Lysates for POSTN
- Origene Custom Protein Services for POSTN
- Sino Biological Recombinant Proteins for POSTN
- Sino Biological Cell Lysates for POSTN
- ProSpec Recombinant Proteins for POSTN
- GeneTex Proteins for POSTN
-
ProSci Proteins for POSTN
-
Abcam proteins for POSTN
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for POSTN (Periostin/OSF-2)
-
Abcam assays for POSTN
No data available for DME Specific Peptides for POSTN Gene
Domains & Families for POSTN Gene
Gene Families for POSTN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for POSTN Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for POSTN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for POSTN Gene
Function for POSTN Gene
Molecular function for POSTN Gene
- UniProtKB/Swiss-Prot Function:
- Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).
Phenotypes From GWAS Catalog for POSTN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19478074 |
| GO:0008201 | heparin binding | ISS | -- |
| GO:0046872 | metal ion binding | IDA | 18450759 |
| GO:0050839 | cell adhesion molecule binding | IBA | -- |
Phenotypes for POSTN Gene
- MGI mutant phenotypes for POSTN:
-
inferred from 4 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- homeostasis/metabolism phenotype
- behavior/neurological phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- reproductive system phenotype
- skeleton phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for POSTN:
Animal Models for POSTN Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for POSTN
- Cyagen custom Knockout/knockin (KOKI) mouse models for POSTN
-
CRISPR Products
-
OriGene CRISPR knockouts for POSTN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POSTN
- genomics-online: gRNA clones - Search results for 160 available POSTN gene related products
- Overview of 160 available POSTN gene related products
- Applied Biological Materials CRISPR for POSTN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for POSTN
- GenScript: Design CRISPR guide RNA sequences for POSTN
miRNA for POSTN Gene
- miRTarBase miRNAs that target POSTN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for POSTN
- Browse OriGene Inhibitory RNA Products For POSTN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POSTN
- genomics-online: shRNA clones - Search results for 160 available POSTN gene related products
- Overview of 160 available POSTN gene related products
Clone Products
-
OriGene ORF clones in human for POSTN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for POSTN
- VectorBuilder custom plasmid, inducible vectors for POSTN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POSTN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POSTN
- Applied Biological Materials Clones for POSTN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for POSTN (Periostin/OSF-2)
Cell Line Products
-
Horizon Cell Lines for POSTN
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POSTN Gene
Localization for POSTN Gene
Subcellular locations from UniProtKB/Swiss-Prot for POSTN Gene
- Golgi apparatus. Secreted. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi. {ECO:0000250 UniProtKB:Q62009}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| golgi apparatus | 4 |
| endoplasmic reticulum | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
- Golgi apparatus (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IBA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005802 | trans-Golgi network | IDA | 19478074 |
Pathways & Interactions for POSTN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Amplification and Expansion of Oncogenic Pathways as Metastatic Traits | ||
| 2 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease | ||
Pathways by source for POSTN Gene
2 BioSystems pathways for POSTN Gene
Interacting Proteins for POSTN Gene
Selected Interacting proteins:
ENSP00000369071
Q15063-POSTN_HUMAN
for POSTN Gene via
STRING
IID
MINT
GPS-Prot Interaction Network for POSTN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | TAS | 8363580 |
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001953 | negative regulation of cell-matrix adhesion | IEA | -- |
| GO:0003073 | regulation of systemic arterial blood pressure | IEA | -- |
| GO:0007155 | cell adhesion | IDA,IEA | 12235007 |
No data available for SIGNOR curated interactions for POSTN Gene
Drugs & Compounds for POSTN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for POSTN Gene
mRNA/cDNA for POSTN Gene
- (11) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (395) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000379749 3210 bps (uc058wmq.1)
- ENST00000379747 3373 bps (uc001uwo.5)
- ENST00000379743 3196 bps (uc010teu.3)
- ENST00000379742 3071 bps (uc001uwp.5)
- ENST00000478947 1159 bps (uc058wmr.1)
Unigene Clusters for POSTN Gene
CRISPR Products
-
OriGene CRISPR knockouts for POSTN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POSTN
- genomics-online: gRNA clones - Search results for 160 available POSTN gene related products
- Overview of 160 available POSTN gene related products
- Applied Biological Materials CRISPR for POSTN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for POSTN
- GenScript: Design CRISPR guide RNA sequences for POSTN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for POSTN
- Browse OriGene Inhibitory RNA Products For POSTN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POSTN
- genomics-online: shRNA clones - Search results for 160 available POSTN gene related products
- Overview of 160 available POSTN gene related products
Clone Products
-
OriGene ORF clones in human for POSTN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for POSTN
- VectorBuilder custom plasmid, inducible vectors for POSTN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POSTN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POSTN
- Applied Biological Materials Clones for POSTN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for POSTN (Periostin/OSF-2)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | · | 19c | ^ | 20a | · | 20b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | · | 23c | · | 23d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | - | ||||||||||||
| SP3: | |||||||||||||
| SP4: | - | - | |||||||||||
| SP5: | - | - | |||||||||||
| SP6: | - | - | |||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: |
Expression for POSTN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Intramembranous Preosteoblasts Membranous Facial Bones
- Endochondral Preosteoblasts Endochondral Facial Bones
- Endochondral Preosteoblasts Caudal Facial Endochondral Bones
- Intramembranous Preosteoblasts Rostral Skull Membranous Bones
- Endochondral Preosteoblasts Rostral Endochondral Facial Bones
- Fibroblasts
- Cartilage (Muscoskeletal System)
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
- Mature Cardiac Fibroblasts Myocardium
- Atrioventricular Canal Cells Atrioventricular Canal
- Cardiac Fibroblasts Myocardium
- Atrioventricular Endocardial Cushion
- Brain (Nervous System)
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Bulge Stem Cells Bulge
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Presumptive Podocytes Podocyte Layer
- Basal Keratinocytes Embryonic Epidermis
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Presumptive Podocytes Podocyte Layer
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
- Hepatocytes Liver Lobule
- Hepatocyte-like cells(Si-Tayeb K et. al. 2010)
- Dermis (Integumentary System)
- NULL (Uncategorized)
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Eye (Sensory Organs)
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
- Corneal Epithelium
-
Neurons
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
- Midbrain dopaminergic-like neurons(Kriks S et. al. 2011)
- Neural Crest (Gastrulation Derivatives)
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
- Lung (Respiratory System)
- Adipose (Muscoskeletal System)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Trophoblast (Extraembryonic Tissues)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Smooth Muscle (Muscoskeletal System)
-
Gall Bladder (Hepatobiliary System)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for POSTN Gene
This gene is overexpressed in Artery - Coronary (x4.6), Artery - Aorta (x4.4), and Heart - Atrial Appendage (x4.2).
This gene is overexpressed in Breast (37.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POSTN Gene
NURSA nuclear receptor signaling pathways regulating expression of POSTN Gene:
POSTNSOURCE GeneReport for Unigene cluster for POSTN Gene:
Hs.136348mRNA Expression by UniProt/SwissProt for POSTN Gene:
Q15063-POSTN_HUMAN
Tissue specificity:
Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.
Evidence on tissue expression from TISSUES for POSTN Gene
- Liver(4.5)
- Bone marrow(4.3)
- Heart(3.3)
- Skin(3.1)
- Muscle(3)
- Bone(2.9)
- Eye(2.7)
- Lung(2.7)
- Pancreas(2.7)
- Blood(2.2)
- Intestine(2.2)
- Kidney(2.1)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for POSTN
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for POSTN Gene
Orthologs for POSTN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | POSTN 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | POSTN 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | POSTN 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | POSTN 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | POSTN 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Postn 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Postn 33 |
|
||
| chicken (Gallus gallus) |
Aves | POSTN 33 |
|
||
| OSF-2 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | POSTN 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | postn 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | postnb 34 33 |
|
OneToMany | |
| postna 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Fas1 34 |
|
ManyToMany | |
| mfas 34 |
|
ManyToMany | |||
| CG43333 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | F26E4.7 34 |
|
OneToMany |
- Species where no ortholog for POSTN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for POSTN Gene
- ENSEMBL:
- Gene Tree for POSTN (if available)
- TreeFam:
- Gene Tree for POSTN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for POSTN: view image
Paralogs for POSTN Gene
Variants for POSTN Gene
| SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000013140 | -- | 37,575,322(-) | G/A | intron_variant | |
| rs1000082205 | -- | 37,568,498(-) | C/T | intron_variant | |
| rs1000141435 | -- | 37,597,866(-) | A/G | intron_variant | |
| rs1000237939 | -- | 37,581,474(-) | C/T | intron_variant | |
| rs1000293330 | -- | 37,583,770(-) | A/G | intron_variant |
Residual Variation Intolerance Score:
12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.17;
75.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for POSTN Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POSTN Gene
Disorders for POSTN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melorheostosis |
|
|
| hypertensive nephropathy |
|
|
| dressler's syndrome |
|
|
| juxtacortical osteosarcoma |
|
|
| esophagitis |
|
|
Search POSTN in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for POSTN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for POSTN Gene
Publications for POSTN Gene
- Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. (PMID: 12235007) Gillan L … Chang DD (Cancer research 2002) 2 3 4 22 58
- Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. (PMID: 8363580) Takeshita S … Amann E (The Biochemical journal 1993) 2 3 4 22 58
- Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. (PMID: 18450759) Coutu DL … Galipeau J (The Journal of biological chemistry 2008) 3 4 22 58
- Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis. (PMID: 16807673) Försti A … Hemminki K (Breast cancer research and treatment 2007) 3 22 44 58
- Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. (PMID: 15082792) Shao R … Wang XF (Molecular and cellular biology 2004) 3 4 22 58
Products for POSTN Gene
- R&D Systems Antibodies for POSTN (Periostin/OSF-2)
- R&D Systems Proteins and Enzymes for POSTN (Periostin/OSF-2)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for POSTN (Periostin/OSF-2)
- R&D Systems cDNA Clones for POSTN (Periostin/OSF-2)
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- GenScript: Design CRISPR guide RNA sequences for POSTN
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- Sino Biological Human cDNA Clone for POSTN
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- ProSpec Recombinant Proteins for POSTN
- Taconic Biosciences Mouse Models for POSTN
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for POSTN
- Cyagen custom Knockout/knockin (KOKI) mouse models for POSTN
- VectorBuilder custom plasmid, inducible vectors for POSTN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POSTN
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 181 available POSTN Antibodies ranked by validation data
- Compare Top POSTN Antibodies
- antibodies-online: Search results for 62 available POSTN Elisa Kits ranked by validation data
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- antibodies-online: Search results for 32 available POSTN Proteins ranked by validation data
- Compare Top POSTN Proteins
- GeneTex POSTN Antibody for POSTN
- GeneTex Proteins for POSTN
- Santa Cruz Biotechnology (SCBT) Antibodies for POSTN
- Search Santa Cruz Biotechnology (SCBT) for POSTN siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for POSTN
- Horizon Cell Lines for POSTN
- genomics-online: cdna clones - Search results for 160 available POSTN gene related products
- Overview of 160 available POSTN gene related products
- orf clones - Search results for 160 available POSTN gene related products
- Overview of 160 available POSTN gene related products
- genomics-online: gRNA clones - Search results for 160 available POSTN gene related products
- Overview of 160 available POSTN gene related products
- genomics-online: primer clones - Search results for 160 available POSTN gene related products
- Overview of 160 available POSTN gene related products
- genomics-online: shRNA clones - Search results for 160 available POSTN gene related products
- Overview of 160 available POSTN gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POSTN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POSTN
- GeneCopoeia miRNA 3'UTR Target clone products for POSTN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POSTN
Sources for POSTN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
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- (158) Applied Biosystems
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- (164) LncRNADisease
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