Aliases for POP1 Gene
External Ids for POP1 Gene
Previous GeneCards Identifiers for POP1 Gene
This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
GeneCards Summary for POP1 Gene
POP1 (POP1 Homolog, Ribonuclease P/MRP Subunit) is a Protein Coding gene. Diseases associated with POP1 include Anauxetic Dysplasia 2 and Anauxetic Dysplasia 1. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include ribonuclease MRP activity.
UniProtKB/Swiss-Prot for POP1 Gene
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5-ends. Also a component of RNase MRP.