Aliases for PON3 Gene
External Ids for PON3 Gene
Previous GeneCards Identifiers for PON3 Gene
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for PON3 Gene
PON3 (Paraoxonase 3) is a Protein Coding gene. Diseases associated with PON3 include Amyotrophic Lateral Sclerosis 1 and Coronary Heart Disease 1. Among its related pathways are Phase I biotransformations, non P450 and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and strictosidine synthase activity. An important paralog of this gene is PON2.
UniProtKB/Swiss-Prot for PON3 Gene
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.