Aliases for POMC Gene
- Proopiomelanocortin 2 3 5
- Opiomelanocortin Prepropeptide 2 3
- Adrenocorticotropic Hormone 2 3
- Corticotropin-Lipotropin 3 4
- Pro-Opiomelanocortin 3 4
- Adrenocorticotropin 2 3
- Beta-Endorphin 2 3
- Corticotropin-Like Intermediary Peptide 3
- Alpha-Melanocyte-Stimulating Hormone 3
- Alpha-Melanocyte Stimulating Hormone 2
- Beta-Melanocyte-Stimulating Hormone 3
- Beta-Melanocyte Stimulating Hormone 2
- Proopiomelanocortin Preproprotein 3
- Melanotropin Alpha 3
- Melanotropin Gamma 3
- Pro-ACTH-Endorphin 3
External Ids for POMC Gene
Previous GeneCards Identifiers for POMC Gene
This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]
GeneCards Summary for POMC Gene
POMC (Proopiomelanocortin) is a Protein Coding gene. Diseases associated with POMC include Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Signaling by GPCR and Development_Leptin signaling via JAK/STAT and MAPK cascades. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and G protein-coupled receptor binding.
UniProtKB/Swiss-Prot Summary for POMC Gene
[Corticotropin]: Stimulates the adrenal glands to release cortisol.
[Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
[Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes.
[Beta-endorphin]: Endogenous orexigenic opiate.
[Met-enkephalin]: Endogenous opiate.
Melanocortin receptors are activated by members of the melanocortin family: alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins are involved in a range of physiological functions, including pigmentation and inflammation.