Aliases for POM121L2 Gene
Aliases for POM121L2 Gene
- POM121 Transmembrane Nucleoporin Like 2 2 3 5
- POM121 Membrane Glycoprotein-Like 2 2 3
- POM121-Like Protein 2 3 4
- POM121L 3 4
- POM121 Membrane Glycoprotein (Rat Homolog)-Like 2 3
- OM121 Membrane Glycoprotein (Rat Homolog)-Like 2 3
- POM121 Membrane Glycoprotein-Like 2 (Rat) 2
- POM121 Transmembrane Nucleoporin-Like 2 2
- POM121-L 3
External Ids for POM121L2 Gene
- HGNC: 13973
- Entrez Gene: 94026
- Ensembl: ENSG00000158553
- UniProtKB: Q96KW2
Previous GeneCards Identifiers for POM121L2 Gene
- GC06U990290
- GC06M027335
- GC06M027385
- GC06M027386
- GC06M027387
- GC06M027253
- GC06M027084
Summaries for POM121L2 Gene
GeneCards Summary for POM121L2 Gene
POM121L2 (POM121 Transmembrane Nucleoporin Like 2) is a Protein Coding gene. Among its related pathways are RNA transport. An important paralog of this gene is POM121C.
Additional gene information for POM121L2 Gene
- Monarch Initiative
- Search for POM121L2 at DataMed
- Search for POM121L2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POM121L2 Gene
Genomics for POM121L2 Gene
GeneHancer (GH) Regulatory Elements for POM121L2 Gene
Promoters and enhancers for POM121L2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around POM121L2 on UCSC Golden Path with GeneCards custom track
Genomic Locations for POM121L2 Gene
Genomic Locations for POM121L2 Gene
- chr6:27,285,903-27,312,232
- (GRCh38/hg38)
- Size:
- 26,330 bases
- Orientation:
- Minus strand
- chr6:27,253,682-27,280,011
- (GRCh37/hg19)
- Size:
- 26,330 bases
- Orientation:
- Minus strand
Genomic View for POM121L2 Gene
Genes around POM121L2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
POM121L2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POM121L2 Gene
Proteins for POM121L2 Gene
-
Protein details for POM121L2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96KW2-P12L2_HUMAN
- Recommended name:
- POM121-like protein 2
- Protein Accession:
- Q96KW2
- C9J1I7
Protein attributes for POM121L2 Gene
- Size:
- 1035 amino acids
- Molecular mass:
- 109912 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for POM121L2 Gene
Other Protein References for POM121L2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for POM121L2
- Invitrogen Antibodies for POM121L2 (AFLGC-POM121L2)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for POM121L2
- Origene Custom Protein Services for POM121L2
- Novus Biologicals proteins for POM121L2
No data available for DME Specific Peptides for POM121L2 Gene
Domains & Families for POM121L2 Gene
Gene Families for POM121L2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for POM121L2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for POM121L2 Gene
- GenScript: Design optimal peptide antigens:
-
- POM121-like protein 2 (P12L2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96KW2- Family:
-
- Belongs to the POM121 family.
Function for POM121L2 Gene
Phenotypes From GWAS Catalog for POM121L2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008139 | nuclear localization sequence binding | IBA | 21873635 |
| GO:0017056 | structural constituent of nuclear pore | IBA | 21873635 |
Phenotypes for POM121L2 Gene
- GenomeRNAi human phenotypes for POM121L2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for POM121L2 - Select products 50% OFF >
- * POM121L2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * POM121L2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for POM121L2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POM121L2
- genomics-online: gRNA clones - Search results for available POM121L2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for POM121L2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for POM121L2
- Browse OriGene Inhibitory RNA Products For POM121L2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POM121L2
- genomics-online: shRNA clones - Search results for available POM121L2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for POM121L2 - Select products 50% OFF >
- * POM121L2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * POM121L2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for POM121L2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POM121L2
- genomics-online: cdna clones - Search results for available POM121L2 gene related products
- orf clones - Search results for available POM121L2 gene related products
Cell Line Products
-
Horizon Cell Lines for POM121L2
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POM121L2 Gene
Localization for POM121L2 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005643 | nuclear pore | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for POM121L2 Gene
Pathways & Interactions for POM121L2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RNA transport | ||
Pathways by source for POM121L2 Gene
1 KEGG pathway for POM121L2 Gene
Interacting Proteins for POM121L2 Gene
GPS-Prot Interaction Network for POM121L2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006606 | protein import into nucleus | IBA | 21873635 |
No data available for SIGNOR curated interactions for POM121L2 Gene
Transcripts for POM121L2 Gene
mRNA/cDNA for POM121L2 Gene
- (1) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000429945 462 bps (ENST00000429945.1)
- ENST00000444565 3108 bps (ENST00000444565.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for POM121L2 - Select products 50% OFF >
- * POM121L2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * POM121L2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for POM121L2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POM121L2
- genomics-online: gRNA clones - Search results for available POM121L2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for POM121L2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for POM121L2
- Browse OriGene Inhibitory RNA Products For POM121L2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POM121L2
- genomics-online: shRNA clones - Search results for available POM121L2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for POM121L2 - Select products 50% OFF >
- * POM121L2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * POM121L2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for POM121L2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POM121L2
- genomics-online: cdna clones - Search results for available POM121L2 gene related products
- orf clones - Search results for available POM121L2 gene related products
Expression for POM121L2 Gene
mRNA differential expression in normal tissues according to GTEx for POM121L2 Gene
This gene is overexpressed in Testis (x44.8).
NURSA nuclear receptor signaling pathways regulating expression of POM121L2 Gene:
POM121L2SOURCE GeneReport for Unigene cluster for POM121L2 Gene:
Hs.729955Primer Products
-
OriGene qPCR primer pairs for POM121L2
- genomics-online: primer clones - Search results for available POM121L2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POM121L2 Gene
Orthologs for POM121L2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | POM121L2 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | POM121L2 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pom121l2 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pom121l2 32 |
|
||
| dog (Canis familiaris) |
Mammalia | POM121L2 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 33 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | pom121 33 |
|
OneToMany |
- Species where no ortholog for POM121L2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for POM121L2 Gene
- ENSEMBL:
- Gene Tree for POM121L2 (if available)
- TreeFam:
- Gene Tree for POM121L2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for POM121L2: view image
Paralogs for POM121L2 Gene
(5) SIMAP similar genes for POM121L2 Gene using alignment to 3 proteins:
- P12L2_HUMAN
- C9J1I7_HUMAN
- H7C418_HUMAN
Pseudogenes.org Pseudogenes for POM121L2 Gene
Variants for POM121L2 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001596414 | -- | 27,310,900(-) | G/A/C | coding_sequence_variant, missense_variant | |
| rs1001670603 | -- | 27,308,602(-) | G/T | downstream_transcript_variant | |
| rs1001717866 | -- | 27,309,006(-) | G/T | downstream_transcript_variant | |
| rs1002668382 | -- | 27,310,380(-) | G/A/T | coding_sequence_variant, synonymous_variant | |
| rs1002719195 | -- | 27,310,706(-) | C/T | coding_sequence_variant, missense_variant |
Gene Damage Index Score:
12.79;
94.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for POM121L2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- POM121L2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for POM121L2 Gene
Disorders for POM121L2 Gene
Additional Disease Information for POM121L2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for POM121L2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POM121L2 Gene
Publications for POM121L2 Gene
- Common variants on chromosome 6p22.1 are associated with schizophrenia. (PMID: 19571809) Shi J … Gejman PV (Nature 2009) 3 43 56
- A comprehensive family-based replication study of schizophrenia genes. (PMID: 23894747) Aberg KA … van den Oord EJ (JAMA psychiatry 2013) 3 56
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4 56
ExternalLinks
Products for POM121L2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for POM121L2
- Origene Custom Protein Services for POM121L2
- Origene sirna, shrna, and RNAi products in human, mouse, rat for POM121L2
- Browse OriGene Inhibitory RNA Products For POM121L2
- OriGene qPCR primer pairs for POM121L2
- OriGene CRISPR knockouts for POM121L2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For POM121L2
- Sino Biological Human cDNA Clone for POM121L2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for POM121L2
- Novus Biologicals proteins for POM121L2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for POM121L2 (AFLGC-POM121L2)
- Horizon Cell Lines for POM121L2
- genomics-online: cdna clones - Search results for available POM121L2 gene related products
- orf clones - Search results for available POM121L2 gene related products
- genomics-online: gRNA clones - Search results for available POM121L2 gene related products
- genomics-online: primer clones - Search results for available POM121L2 gene related products
- genomics-online: shRNA clones - Search results for available POM121L2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POM121L2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POM121L2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for POM121L2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POM121L2
Sources for POM121L2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource