Aliases for POM121L2 Gene

Aliases for POM121L2 Gene

  • POM121 Transmembrane Nucleoporin Like 2 2 3 5
  • POM121 Membrane Glycoprotein-Like 2 2 3
  • POM121-Like Protein 2 3 4
  • POM121L 3 4
  • POM121 Membrane Glycoprotein (Rat Homolog)-Like 2 3
  • OM121 Membrane Glycoprotein (Rat Homolog)-Like 2 3
  • POM121 Membrane Glycoprotein-Like 2 (Rat) 2
  • POM121 Transmembrane Nucleoporin-Like 2 2
  • POM121-L 3

External Ids for POM121L2 Gene

Previous GeneCards Identifiers for POM121L2 Gene

  • GC06U990290
  • GC06M027335
  • GC06M027385
  • GC06M027386
  • GC06M027387
  • GC06M027253
  • GC06M027084

Summaries for POM121L2 Gene

GeneCards Summary for POM121L2 Gene

POM121L2 (POM121 Transmembrane Nucleoporin Like 2) is a Protein Coding gene. Among its related pathways are RNA transport. An important paralog of this gene is POM121C.

Additional gene information for POM121L2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POM121L2 Gene

Genomics for POM121L2 Gene

GeneHancer (GH) Regulatory Elements for POM121L2 Gene

Promoters and enhancers for POM121L2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POM121L2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for POM121L2 Gene

Genomic Locations for POM121L2 Gene
chr6:27,285,903-27,312,232
(GRCh38/hg38)
Size:
26,330 bases
Orientation:
Minus strand
chr6:27,253,682-27,280,011
(GRCh37/hg19)
Size:
26,330 bases
Orientation:
Minus strand

Genomic View for POM121L2 Gene

Genes around POM121L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POM121L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POM121L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POM121L2 Gene

Proteins for POM121L2 Gene

  • Protein details for POM121L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KW2-P12L2_HUMAN
    Recommended name:
    POM121-like protein 2
    Protein Accession:
    Q96KW2
    Secondary Accessions:
    • C9J1I7

    Protein attributes for POM121L2 Gene

    Size:
    1035 amino acids
    Molecular mass:
    109912 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POM121L2 Gene

Post-translational modifications for POM121L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POM121L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POM121L2 Gene

Domains & Families for POM121L2 Gene

Gene Families for POM121L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for POM121L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for POM121L2 Gene

GenScript: Design optimal peptide antigens:
  • POM121-like protein 2 (P12L2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96KW2

UniProtKB/Swiss-Prot:

P12L2_HUMAN :
  • Belongs to the POM121 family.
Family:
  • Belongs to the POM121 family.
genes like me logo Genes that share domains with POM121L2: view

Function for POM121L2 Gene

Phenotypes From GWAS Catalog for POM121L2 Gene

Gene Ontology (GO) - Molecular Function for POM121L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008139 nuclear localization sequence binding IBA 21873635
GO:0017056 structural constituent of nuclear pore IBA 21873635
genes like me logo Genes that share ontologies with POM121L2: view
genes like me logo Genes that share phenotypes with POM121L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POM121L2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POM121L2 Gene

Localization for POM121L2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POM121L2 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for POM121L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IBA 21873635
genes like me logo Genes that share ontologies with POM121L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for POM121L2 Gene

Pathways & Interactions for POM121L2 Gene

PathCards logo

SuperPathways for POM121L2 Gene

SuperPathway Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with POM121L2: view

Pathways by source for POM121L2 Gene

1 KEGG pathway for POM121L2 Gene

Interacting Proteins for POM121L2 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000392726 for POM121L2 Gene via STRING

Gene Ontology (GO) - Biological Process for POM121L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IBA 21873635
genes like me logo Genes that share ontologies with POM121L2: view

No data available for SIGNOR curated interactions for POM121L2 Gene

Drugs & Compounds for POM121L2 Gene

No Compound Related Data Available

Transcripts for POM121L2 Gene

mRNA/cDNA for POM121L2 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POM121L2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POM121L2 Gene

No ASD Table

Relevant External Links for POM121L2 Gene

GeneLoc Exon Structure for
POM121L2
ECgene alternative splicing isoforms for
POM121L2

Expression for POM121L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POM121L2 Gene

mRNA differential expression in normal tissues according to GTEx for POM121L2 Gene

This gene is overexpressed in Testis (x44.8).

NURSA nuclear receptor signaling pathways regulating expression of POM121L2 Gene:

POM121L2

SOURCE GeneReport for Unigene cluster for POM121L2 Gene:

Hs.729955
genes like me logo Genes that share expression patterns with POM121L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POM121L2 Gene

Orthologs for POM121L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POM121L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POM121L2 33 32
  • 99.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia POM121L2 33 32
  • 78.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pom121l2 17 33 32
  • 68.51 (n)
rat
(Rattus norvegicus)
Mammalia Pom121l2 32
  • 67.96 (n)
dog
(Canis familiaris)
Mammalia POM121L2 33
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 33 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 28 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 33
  • 28 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pom121 33
  • 18 (a)
OneToMany
Species where no ortholog for POM121L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POM121L2 Gene

ENSEMBL:
Gene Tree for POM121L2 (if available)
TreeFam:
Gene Tree for POM121L2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POM121L2: view image

Paralogs for POM121L2 Gene

Paralogs for POM121L2 Gene

(5) SIMAP similar genes for POM121L2 Gene using alignment to 3 proteins:

  • P12L2_HUMAN
  • C9J1I7_HUMAN
  • H7C418_HUMAN

Pseudogenes.org Pseudogenes for POM121L2 Gene

genes like me logo Genes that share paralogs with POM121L2: view

Variants for POM121L2 Gene

Sequence variations from dbSNP and Humsavar for POM121L2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001596414 -- 27,310,900(-) G/A/C coding_sequence_variant, missense_variant
rs1001670603 -- 27,308,602(-) G/T downstream_transcript_variant
rs1001717866 -- 27,309,006(-) G/T downstream_transcript_variant
rs1002668382 -- 27,310,380(-) G/A/T coding_sequence_variant, synonymous_variant
rs1002719195 -- 27,310,706(-) C/T coding_sequence_variant, missense_variant

Variation tolerance for POM121L2 Gene

Gene Damage Index Score: 12.79; 94.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POM121L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POM121L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for POM121L2 Gene

Disorders for POM121L2 Gene

Additional Disease Information for POM121L2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for POM121L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POM121L2 Gene

Publications for POM121L2 Gene

  1. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PMID: 19571809) Shi J … Gejman PV (Nature 2009) 3 43 56
  2. A comprehensive family-based replication study of schizophrenia genes. (PMID: 23894747) Aberg KA … van den Oord EJ (JAMA psychiatry 2013) 3 56
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4 56

Products for POM121L2 Gene

Sources for POM121L2 Gene