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Aliases for POM121 Gene

Aliases for POM121 Gene

  • POM121 Transmembrane Nucleoporin 2 3 5
  • Nuclear Envelope Pore Membrane Protein POM 121A 3 4
  • POM121 Membrane Glycoprotein 2 3
  • Nucleoporin Nup121 3 4
  • POM121A 3 4
  • Nuclear Envelope Pore Membrane Protein POM 121 3
  • Nuclear Pore Membrane Protein 121 KDa 3
  • POM121 Membrane Glycoprotein (Rat) 2
  • Pore Membrane Protein Of 121 KDa 4
  • KIAA0618 4
  • NUP121 4
  • P145 3

External Ids for POM121 Gene

Previous GeneCards Identifiers for POM121 Gene

  • GC07P070990
  • GC07P071750
  • GC07P071762
  • GC07P071794
  • GC07P071987
  • GC07P072349
  • GC07M070166

Summaries for POM121 Gene

Entrez Gene Summary for POM121 Gene

  • This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

GeneCards Summary for POM121 Gene

POM121 (POM121 Transmembrane Nucleoporin) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and SUMOylation. An important paralog of this gene is POM121C.

UniProtKB/Swiss-Prot for POM121 Gene

  • Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).

Gene Wiki entry for POM121 Gene

Additional gene information for POM121 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POM121 Gene

Genomics for POM121 Gene

GeneHancer (GH) Regulatory Elements for POM121 Gene

Promoters and enhancers for POM121 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I072924 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 568 +46.0 45977 2.5 HDGF MLX ARNT ARID4B SIN3A DMAP1 POLR2B E2F8 ZNF207 ZNF143 POM121 ENSG00000272843 POM121B NSUN5P2 STAG3L3 TBL2 NSUN5 PMS2P7 FKBP6 GC07P072947
GH07I072878 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 145 2.2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 POLR2B ZNF143 JUNB POM121 TYW1B GTF2IP4 ENSG00000272843
GH07I072890 Promoter 0.5 EPDnew 550.4 +11.3 11275 0.1 POM121 ENSG00000272843
GH07I072827 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 37 -49.9 -49929 4.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 TYW1B PIR36920 SBDSP1 STAG3L3 POM121B TBL2 POM121 FKBP6 NSUN5P2 BUD23
GH07I073645 Enhancer 1.4 FANTOM5 Ensembl ENCODE 39 +767.6 767577 3.7 MLX ARID4B ZNF48 YY1 SLC30A9 GLIS2 SP3 RXRA SP5 NFYC NSUN5P2 POM121 STAG3L3 GTF2IRD2P1 MIR590 METTL27 POM121B BAZ1B VPS37D DNAJC30
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around POM121 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POM121 gene promoter:

Genomic Locations for POM121 Gene

Genomic Locations for POM121 Gene
72,106 bases
Plus strand

Genomic View for POM121 Gene

Genes around POM121 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POM121 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POM121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POM121 Gene

Proteins for POM121 Gene

  • Protein details for POM121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear envelope pore membrane protein POM 121
    Protein Accession:
    Secondary Accessions:
    • A6NFS9
    • A8CDT4
    • A8K933
    • A8MXF9
    • O75115
    • Q96DI0
    • Q9H9X1
    • Q9Y2N3
    • Q9Y4S7

    Protein attributes for POM121 Gene

    1249 amino acids
    Molecular mass:
    127720 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA31593.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14097.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for POM121 Gene

    Alternative splice isoforms for POM121 Gene


neXtProt entry for POM121 Gene

Post-translational modifications for POM121 Gene

No Post-translational modifications

No data available for DME Specific Peptides for POM121 Gene

Domains & Families for POM121 Gene

Gene Families for POM121 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for POM121 Gene


Suggested Antigen Peptide Sequences for POM121 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains F-X-F-G repeats.
  • Belongs to the POM121 family.
  • Contains F-X-F-G repeats.
  • Belongs to the POM121 family.
genes like me logo Genes that share domains with POM121: view

Function for POM121 Gene

Molecular function for POM121 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).

Phenotypes From GWAS Catalog for POM121 Gene

Gene Ontology (GO) - Molecular Function for POM121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nuclear pore activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0008139 nuclear localization sequence binding IBA --
GO:0017056 structural constituent of nuclear pore IBA --
genes like me logo Genes that share ontologies with POM121: view
genes like me logo Genes that share phenotypes with POM121: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POM121 Gene

Localization for POM121 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POM121 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POM121 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytosol 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for POM121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with POM121: view

Pathways & Interactions for POM121 Gene

SuperPathways for POM121 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with POM121: view

Pathways by source for POM121 Gene

Gene Ontology (GO) - Biological Process for POM121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process TAS --
GO:0006405 RNA export from nucleus IBA --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006606 protein import into nucleus IBA --
genes like me logo Genes that share ontologies with POM121: view

No data available for SIGNOR curated interactions for POM121 Gene

Drugs & Compounds for POM121 Gene

No Compound Related Data Available

Transcripts for POM121 Gene

Unigene Clusters for POM121 Gene

POM121 transmembrane nucleoporin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for POM121 Gene

No ASD Table

Relevant External Links for POM121 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POM121 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POM121 Gene

Protein differential expression in normal tissues from HIPED for POM121 Gene

This gene is overexpressed in Adipocyte (25.6), Placenta (18.9), Peripheral blood mononuclear cells (13.5), and Islet of Langerhans (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POM121 Gene

Protein tissue co-expression partners for POM121 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POM121 Gene:


SOURCE GeneReport for Unigene cluster for POM121 Gene:


Evidence on tissue expression from TISSUES for POM121 Gene

  • Nervous system(4.9)
  • Skin(4.6)
  • Intestine(2.9)
  • Lung(2.4)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with POM121: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POM121 Gene

Orthologs for POM121 Gene

This gene was present in the common ancestor of chordates.

Orthologs for POM121 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia POM121 33
  • 98.39 (n)
-- 34
  • 75 (a)
(Bos Taurus)
Mammalia POM121C 33
  • 78.69 (n)
-- 34
  • 55 (a)
(Canis familiaris)
Mammalia POM121C 33
  • 78.16 (n)
-- 34
  • 46 (a)
(Rattus norvegicus)
Mammalia Pom121 33
  • 74.76 (n)
(Mus musculus)
Mammalia Pom121 33 34
  • 74.53 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 41 (a)
(Gallus gallus)
Aves POM121 33
  • 60.01 (n)
-- 34
  • 43 (a)
(Danio rerio)
Actinopterygii pom121 34
  • 24 (a)
Species where no ortholog for POM121 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POM121 Gene

Gene Tree for POM121 (if available)
Gene Tree for POM121 (if available)

Paralogs for POM121 Gene

(4) SIMAP similar genes for POM121 Gene using alignment to 1 proteins: Pseudogenes for POM121 Gene

genes like me logo Genes that share paralogs with POM121: view

Variants for POM121 Gene

Sequence variations from dbSNP and Humsavar for POM121 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs10226353 -- 72,903,124(+) G/A genic_upstream_transcript_variant, intron_variant
rs10231271 -- 72,893,994(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs10263660 -- 72,897,808(+) C/T genic_upstream_transcript_variant, intron_variant
rs10263853 -- 72,897,807(+) G/T genic_upstream_transcript_variant, intron_variant
rs1044501 -- 72,947,839(+) T/C/G 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for POM121 Gene

Variant ID Type Subtype PubMed ID
nsv981523 CNV duplication 23825009
nsv950544 CNV deletion 24416366
nsv8134 CNV loss 18304495
nsv520573 CNV gain+loss 19592680
nsv469793 CNV gain 16826518
nsv469664 CNV loss 16826518
nsv428171 CNV gain 18775914
nsv1161563 CNV deletion 26073780
nsv1030447 CNV loss 25217958
nsv1029162 CNV loss 25217958
nsv1023115 CNV gain 25217958
nsv1018460 CNV gain+loss 25217958
nsv1018175 CNV gain 25217958
nsv1017637 CNV loss 25217958
esv3613678 CNV loss 21293372
esv3613677 CNV gain 21293372
esv3571921 CNV loss 25503493
esv3571919 CNV loss 25503493
esv34349 CNV gain 17911159
esv2764061 CNV gain+loss 21179565
esv2759537 CNV gain+loss 17122850
esv1311182 CNV deletion 17803354
dgv6464n100 CNV gain 25217958
dgv6462n100 CNV gain 25217958
dgv6460n100 CNV gain 25217958

Variation tolerance for POM121 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POM121 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POM121 Gene

Disorders for POM121 Gene

Additional Disease Information for POM121

No disorders were found for POM121 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POM121 Gene

Publications for POM121 Gene

  1. Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes. (PMID: 17900573) Funakoshi T … Imamoto N (FEBS letters 2007) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope. (PMID: 19782045) Kind B … Huebner A (Biochemical and biophysical research communications 2009) 3 22 58
  4. Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. (PMID: 19620630) Anderson DJ … Hetzer MW (The Journal of cell biology 2009) 3 22 58
  5. Capture of AT-rich chromatin by ELYS recruits POM121 and NDC1 to initiate nuclear pore assembly. (PMID: 18596237) Rasala BA … Forbes DJ (Molecular biology of the cell 2008) 3 22 58

Products for POM121 Gene

Sources for POM121 Gene

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