Aliases for POLR3H Gene
External Ids for POLR3H Gene
Previous GeneCards Identifiers for POLR3H Gene
GeneCards Summary for POLR3H Gene
POLR3H (RNA Polymerase III Subunit H) is a Protein Coding gene. Diseases associated with POLR3H include 46,Xx Sex Reversal 1 and Infantile Cerebellar-Retinal Degeneration. Among its related pathways are RNA Polymerase III Transcription Initiation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase III activity. An important paralog of this gene is TWISTNB.
UniProtKB/Swiss-Prot Summary for POLR3H Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).