Aliases for POLR3GL Gene

Aliases for POLR3GL Gene

  • RNA Polymerase III Subunit GL 2 3
  • RNA Polymerase III Subunit G Like 2 3 5
  • Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD)-Like 2 3
  • DNA-Directed RNA Polymerase III Subunit RPC7-Like 3 4
  • DNA-Directed RNA Polymerase III Subunit G-Like 3 4
  • RNA Polymerase III 32 KDa Beta Subunit 3 4
  • RNA Polymerase III Subunit C7-Like 3 4
  • RPC32-Beta 3 4
  • Flj32422 2 3
  • Alternative RNA Polymerase III Subunit 32 3
  • Polymerase (RNA) III Subunit G Like 3
  • RPC32-Like Protein 3
  • RPC32HOM 3
  • POLR3GL 5
  • MGC3200 2

External Ids for POLR3GL Gene

Previous GeneCards Identifiers for POLR3GL Gene

  • GC01M142946
  • GC01M144167
  • GC01M145456
  • GC01M119420

Summaries for POLR3GL Gene

GeneCards Summary for POLR3GL Gene

POLR3GL (RNA Polymerase III Subunit GL) is a Protein Coding gene. Diseases associated with POLR3GL include Hyperostosis and Tooth Agenesis. Among its related pathways are Transcription of tRNA and Innate Immune System. Gene Ontology (GO) annotations related to this gene include RNA polymerase III activity. An important paralog of this gene is ENSG00000280778.

UniProtKB/Swiss-Prot Summary for POLR3GL Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.

Additional gene information for POLR3GL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLR3GL Gene

Genomics for POLR3GL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POLR3GL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J145976 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.4 +22.9 22949 10 CEBPG SP1 CREB1 GATAD2A CTCF ZBTB33 TEAD4 YBX1 PRDM10 REST POLR3GL NBPF20 POLR3C GPR89A PIAS3 ANKRD35 HJV RBM8A LIX1L-AS1 PEX11B
GH01J145954 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.4 1428 11.5 SP1 HNRNPL CREB1 GATAD2A YBX1 ZNF629 PRDM10 REST RFX1 NFKBIZ LIX1L ENSG00000278431 POLR3GL POLR3C ANKRD35 NBPF20 LIX1L-AS1 RBM8A TXNIP GNRHR2
GH01J145974 Promoter/Enhancer 0.5 EPDnew dbSUPER 600.4 +15.9 15891 0.1 POLR3GL MN308980 RF00017-313 ANKRD34A TXNIP ENSG00000280778
GH01J145990 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.7 +36.3 36305 10.5 ARHGAP35 SP1 CREB1 GATAD2A ZBTB33 PRDM10 REST ZNF629 TFE3 LEF1 TXNIP lnc-HFE2-2 piR-42110 POLR3C NBPF20 GPR89A PIAS3 LIX1L-AS1 HJV RBM8A
GH01J145972 Enhancer 0.8 Ensembl 0.4 +13.6 13564 0.8 CEBPG GATAD2A ATF7 REST RCOR2 RXRB IRF2 SP1 CEBPA FOXK2 RF00017-313 POLR3C ANKRD34A MN308980 POLR3GL TXNIP ENSG00000280778
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLR3GL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLR3GL

Top Transcription factor binding sites by QIAGEN in the POLR3GL gene promoter:
  • Bach1
  • HOXA5
  • LCR-F1
  • NF-1
  • Olf-1
  • Pax-4a
  • RelA
  • Sp1
  • Spz1

Genomic Locations for POLR3GL Gene

Genomic Locations for POLR3GL Gene
chr1:145,959,037-145,978,848
(GRCh38/hg38)
Size:
19,812 bases
Orientation:
Plus strand
chr1:145,456,236-145,470,388
(GRCh37/hg19)
Size:
14,153 bases
Orientation:
Minus strand

Genomic View for POLR3GL Gene

Genes around POLR3GL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3GL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3GL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3GL Gene

Proteins for POLR3GL Gene

  • Protein details for POLR3GL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT43-RPC7L_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC7-like
    Protein Accession:
    Q9BT43
    Secondary Accessions:
    • B1MVG5

    Protein attributes for POLR3GL Gene

    Size:
    218 amino acids
    Molecular mass:
    25334 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Found a trimeric complex with POLR3C and POLR3G (PubMed:24107381). Directly interacts with POLR3C (PubMed:21358628, PubMed:24107381, PubMed:26394183).

    Three dimensional structures from OCA and Proteopedia for POLR3GL Gene

neXtProt entry for POLR3GL Gene

Post-translational modifications for POLR3GL Gene

  • Ubiquitination at Lys93
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR3GL Gene

No data available for DME Specific Peptides for POLR3GL Gene

Domains & Families for POLR3GL Gene

Gene Families for POLR3GL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for POLR3GL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for POLR3GL Gene

GenScript: Design optimal peptide antigens:
  • DNA-directed RNA polymerase III subunit G-like (RPC7L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BT43

UniProtKB/Swiss-Prot:

RPC7L_HUMAN :
  • Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3GL: view

Function for POLR3GL Gene

Molecular function for POLR3GL Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.

Gene Ontology (GO) - Molecular Function for POLR3GL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed 5'-3' RNA polymerase activity IEA --
GO:0005515 protein binding IPI 20154270
genes like me logo Genes that share ontologies with POLR3GL: view
genes like me logo Genes that share phenotypes with POLR3GL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR3GL

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR3GL Gene

Localization for POLR3GL Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3GL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR3GL gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
golgi apparatus 2
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for POLR3GL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 colocalizes_with nuclear chromatin IDA 24107381
GO:0005634 nucleus IEA,IDA 20154270
GO:0005654 nucleoplasm TAS --
GO:0005666 RNA polymerase III complex IDA 24107381
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3GL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for POLR3GL Gene

Pathways & Interactions for POLR3GL Gene

genes like me logo Genes that share pathways with POLR3GL: view

Pathways by source for POLR3GL Gene

2 Qiagen pathways for POLR3GL Gene
  • Assembly of RNA Polymerase-III Initiation Complex
  • Transcription of tRNA

Gene Ontology (GO) - Biological Process for POLR3GL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription by RNA polymerase III IDA 20154270
GO:0032481 positive regulation of type I interferon production TAS --
genes like me logo Genes that share ontologies with POLR3GL: view

No data available for SIGNOR curated interactions for POLR3GL Gene

Drugs & Compounds for POLR3GL Gene

(5) Drugs for POLR3GL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for POLR3GL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with POLR3GL: view

Transcripts for POLR3GL Gene

mRNA/cDNA for POLR3GL Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR3GL

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3GL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1:
SP2: -
SP3: - -
SP4:

Relevant External Links for POLR3GL Gene

GeneLoc Exon Structure for
POLR3GL

Expression for POLR3GL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLR3GL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR3GL Gene

This gene is overexpressed in Lymph node (23.0), NK cells (12.9), CD8 Tcells (9.1), Retina (8.4), Fetal ovary (8.4), and Testis (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR3GL Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLR3GL

SOURCE GeneReport for Unigene cluster for POLR3GL Gene:

Hs.591456

mRNA Expression by UniProt/SwissProt for POLR3GL Gene:

Q9BT43-RPC7L_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for POLR3GL Gene

  • Muscle(4.5)
  • Eye(4.1)
  • Liver(2.3)
  • Heart(2.2)
  • Nervous system(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with POLR3GL: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR3GL Gene

Orthologs for POLR3GL Gene

This gene was present in the common ancestor of chordates.

Orthologs for POLR3GL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia POLR3GL 30 31
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia POLR3GL 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia POLR3GL 30 31
  • 94.8 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Polr3gl 30 17 31
  • 89.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Polr3gl 30
  • 89.45 (n)
Oppossum
(Monodelphis domestica)
Mammalia POLR3GL 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia POLR3GL 31
  • 48 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia polr3gl 30
  • 68.95 (n)
Str.9606 30
Zebrafish
(Danio rerio)
Actinopterygii polr3gla 30
  • 65.2 (n)
polr3glb 31
  • 65 (a)
OneToOne
Species where no ortholog for POLR3GL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for POLR3GL Gene

ENSEMBL:
Gene Tree for POLR3GL (if available)
TreeFam:
Gene Tree for POLR3GL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR3GL: view image

Paralogs for POLR3GL Gene

Paralogs for POLR3GL Gene

(1) SIMAP similar genes for POLR3GL Gene using alignment to 2 proteins:

  • RPC7L_HUMAN
  • A6NGX6_HUMAN
genes like me logo Genes that share paralogs with POLR3GL: view

Variants for POLR3GL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POLR3GL Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1553763618 Likely Pathogenic: Oligodontia; Abnormal facial shape; Short stature; Hyperostosis 145,977,482(+) G/A SPLICE_ACCEPTOR_VARIANT
rs782661984 Likely Pathogenic: Oligodontia; Abnormal facial shape; Short stature; Hyperostosis 145,974,824(+) G/A SPLICE_ACCEPTOR_VARIANT

Additional dbSNP identifiers (rs#s) for POLR3GL Gene

Structural Variations from Database of Genomic Variants (DGV) for POLR3GL Gene

Variant ID Type Subtype PubMed ID
nsv1005055 CNV loss 25217958
nsv509457 CNV insertion 20534489
nsv950948 CNV duplication 24416366

Variation tolerance for POLR3GL Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR3GL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR3GL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3GL Gene

Disorders for POLR3GL Gene

MalaCards: The human disease database

(2) MalaCards diseases for POLR3GL Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hyperostosis
  • bone hypertrophy
tooth agenesis
  • familial tooth agenesis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with POLR3GL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR3GL Gene

Publications for POLR3GL Gene

  1. Gene duplication and neofunctionalization: POLR3G and POLR3GL. (PMID: 24107381) Renaud M … Hernandez N (Genome research 2014) 2 3 4
  2. Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation. (PMID: 21358628) Lefèvre S … Fribourg S (Nature structural & molecular biology 2011) 3 4
  3. Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation. (PMID: 20154270) Haurie V … Teichmann M (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for POLR3GL Gene

Sources for POLR3GL Gene